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701. Weekly fluconazole for the prevention of mucosal candidiasis in women with HIV infection. A randomized, double-blind, placebo-controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.
作者: P Schuman.;L Capps.;G Peng.;J Vazquez.;W el-Sadr.;A I Goldman.;B Alston.;C L Besch.;A Vaughn.;M A Thompson.;M N Cobb.;T Kerkering.;J D Sobel.
来源: Ann Intern Med. 1997年126卷9期689-96页
Candidiasis is a frequent complication of infection with the human immunodeficiency virus (HIV); however, few data exist about the natural history, prevention, and treatment of mucosal candidiasis in women.
702. Oral propafenone to convert recent-onset atrial fibrillation in patients with and without underlying heart disease. A randomized, controlled trial.
作者: G Boriani.;M Biffi.;A Capucci.;G L Botto.;T Broffoni.;I Rubino.;S Della Casa.;M Sanguinetti.;B Magnani.
来源: Ann Intern Med. 1997年126卷8期621-5页
The effectiveness of oral propafenone in converting recent-onset atrial fibrillation to sinus rhythm has been established by controlled trials. However, it is not clear whether the effectiveness of propafenone is affected by the presence or absence of underlying heart disease.
703. Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. A randomized, controlled trial.
作者: O Hartmann.;A G Le Corroller.;D Blaise.;J Michon.;I Philip.;F Norol.;M Janvier.;J L Pico.;M C Baranzelli.;H Rubie.;C Coze.;A Pinna.;V Méresse.;E Benhamou.
来源: Ann Intern Med. 1997年126卷8期600-7页
Previous studies have suggested that peripheral blood stem cell (PBSC) transplantation has an advantage over autologous bone marrow transplantation.
704. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial.
作者: W J Sandborn.;W J Tremaine.;K P Offord.;G M Lawson.;B T Petersen.;K P Batts.;I T Croghan.;L C Dale.;D R Schroeder.;R D Hurt.
来源: Ann Intern Med. 1997年126卷5期364-71页
Ulcerative colitis is predominantly a disease of nonsmokers. Transdermal nicotine may help control clinical manifestations of this condition.
705. Clinical efficacy of monotherapy with stavudine compared with zidovudine in HIV-infected, zidovudine-experienced patients. A randomized, double-blind, controlled trial. Bristol-Myers Squibb Stavudine/019 Study Group.
作者: S L Spruance.;A T Pavia.;J W Mellors.;R Murphy.;J Gathe.;E Stool.;J G Jemsek.;P Dellamonica.;A Cross.;L Dunkle.
来源: Ann Intern Med. 1997年126卷5期355-63页
Stavudine is a promising antiretroviral agent, but its clinical efficacy has not been determined.
706. Use of testosterone to prevent cyclophosphamide-induced azoospermia.
作者: A Masala.;R Faedda.;S Alagna.;A Satta.;G Chiarelli.;P P Rovasio.;R Ivaldi.;M S Taras.;E Lai.;E Bartoli.
来源: Ann Intern Med. 1997年126卷4期292-5页
Prepubertal patients receiving chemotherapy are relatively resistant to cyclophosphamide-induced germinal cell alterations.
707. Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver transplant recipients. The Boston Center for Liver Transplantation CMVIG Study Group.
作者: M E Falagas.;D R Snydman.;J Griffith.;R Ruthazer.;B G Werner.
来源: Ann Intern Med. 1997年126卷4期275-9页
To reduce the mortality rate associated with liver transplantation, it is important to identify the risk factors for increased mortality among liver transplant recipients. It has been suggested that cytomegalovirus (CMV) infection is one such risk factor, but no studies have examined mortality rates associated with the CMV serologic status of the donor and recipient by using multivariate techniques.
708. Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial. A randomized, controlled trial. Studies of Ocular complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group.
来源: Ann Intern Med. 1997年126卷4期264-74页
Cytomegalovirus (CMV) retinitis is a common infection and a major cause of visual loss in patients with the acquired immunodeficiency syndrome (AIDS).
709. Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial.
作者: J P Lalezari.;R J Stagg.;B D Kuppermann.;G N Holland.;F Kramer.;D V Ives.;M Youle.;M R Robinson.;W L Drew.;H S Jaffe.
来源: Ann Intern Med. 1997年126卷4期257-63页
Cytomegalovirus (CMV) retinitis is the most common intraocular infection in patients with the acquired immunodeficiency syndrome (AIDS). If left untreated, it may lead to progressive destruction of retinal tissue and blindness. Cidofovir is a nucleotide analogue of cytosine that has potent, prolonged in vitro and in vivo activity against herpesviruses, including many CMV isolates that are resistant to ganciclovir and foscarnet.
710. Inefficacy of allopurinol as monotherapy for Colombian cutaneous leishmaniasis. A randomized, controlled trial.
作者: I Velez.;S Agudelo.;E Hendrickx.;J Puerta.;M Grogl.;F Modabber.;J Berman.
来源: Ann Intern Med. 1997年126卷3期232-6页
Hundreds of thousands of cases of cutaneous leishmaniasis occur each year worldwide. Available therapies are parenteral, moderately toxic, and costly.
711. Cardioversion guided by transesophageal echocardiography: the ACUTE Pilot Study. A randomized, controlled trial. Assessment of Cardioversion Using Transesophageal Echocardiography.
作者: A L Klein.;R A Grimm.;I W Black.;D Y Leung.;M K Chung.;S E Vaughn.;R D Murray.;D P Miller.;K L Arheart.
来源: Ann Intern Med. 1997年126卷3期200-9页
Electrical cardioversion in patients with atrial fibrillation is associated with an increased risk for embolic stroke. Screening for atrial thrombi with transesophageal echocardiography (TEE) before cardioversion should, in many patients, safely permit cardioversion to be done earlier than would be possible with prolonged conventional, anticoagulation therapy.
712. Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma. A randomized, double-blind, placebo-controlled trial.
The increasing costs of managing asthma are due in part to the introduction of new medications, such as leukotriene receptor antagonists. These antagonists interfere with the action of leukotrienes, which are implicated in bronchoconstriction and the formation of airway edema in patients with asthma. Leukotriene receptor antagonists must be shown to be clinically and economically effective for their clinical use to be justified.
713. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy.
作者: L Harrison.;M Johnston.;M P Massicotte.;M Crowther.;K Moffat.;J Hirsh.
来源: Ann Intern Med. 1997年126卷2期133-6页
Loading doses of warfarin that are larger than those used for maintenance therapy are widely used in clinical practice, but they have never been prospectively evaluated.
714. Effectiveness of cloxacillin with and without gentamicin in short-term therapy for right-sided Staphylococcus aureus endocarditis. A randomized, controlled trial.
作者: E Ribera.;J Gómez-Jimenez.;E Cortes.;O del Valle.;A Planes.;T Gonzalez-Alujas.;B Almirante.;I Ocaña.;A Pahissa.
来源: Ann Intern Med. 1996年125卷12期969-74页
It is often difficult to administer extended antibiotic therapy in the hospital for right-sided Staphylococcus aureus endocarditis. Although the effectiveness of single-drug therapy given for 4 to 6 weeks and that of two-drug therapy given for 2 weeks have been shown, no data are available on the effectiveness of short-course single-drug therapy.
715. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial.
作者: L M Buckley.;E S Leib.;K S Cartularo.;P M Vacek.;S M Cooper.
来源: Ann Intern Med. 1996年125卷12期961-8页
Therapy with low-dose corticosteroids is commonly used to treat allergic and autoimmune diseases. Long-term use of corticosteroids can lead to loss of bone mineral density and higher risk for vertebral fractures. Calcium and vitamin D3 supplementation is rational therapy for minimizing bone loss, but little evidence for its effectiveness exists.
716. Effect of apheresis of low-density lipoprotein on peripheral vascular disease in hypercholesterolemic patients with coronary artery disease.
Apheresis of low-density lipoprotein (LDL) is an effective lipid-lowering treatment in hypercholesterolemic patients who have coronary artery disease and are refractory to drugs. More aggressive lipid-lowering therapy may further slow the progression of atherosclerosis.
717. Relation of increased arterial blood pressure to mortality and stroke in the context of contemporary thrombolytic therapy for acute myocardial infarction. A randomized trial. GUSTO-I Investigators.
作者: P E Aylward.;R G Wilcox.;J H Horgan.;H D White.;C B Granger.;R M Califf.;E J Topol.
来源: Ann Intern Med. 1996年125卷11期891-900页
Despite concern that hypertension increases the risk for intracranial hemorrhage during thrombolysis for acute myocardial infarction, the exact nature of the risk remains unclear.
718. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial.
作者: H B Baum.;B M Biller.;J S Finkelstein.;K B Cannistraro.;D S Oppenhein.;D A Schoenfeld.;T H Michel.;H Wittink.;A Klibanski.
来源: Ann Intern Med. 1996年125卷11期883-90页
Patients with adult-onset growth hormone deficiency have reduced bone density and increased fat mass. Growth hormone at high doses may decrease body fat in these patients, but the effects of growth hormone at more physiologic doses on bone density and body composition have not been convincingly shown.
719. Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim Study Group.
作者: M Schambelan.;K Mulligan.;C Grunfeld.;E S Daar.;A LaMarca.;D P Kotler.;J Wang.;S A Bozzette.;J B Breitmeyer.
来源: Ann Intern Med. 1996年125卷11期873-82页
Body wasting, particularly loss of body cell mass, is an increasingly prevalent acquired immunodeficiency syndrome (AIDS)-defining condition and is an independent risk factor for death in patients infected with the human immunodeficiency virus (HIV). Treatment with growth hormone for 7 days resulted in weight gain and nitrogen retention, but the long-term effects of this treatment in patients with HIV-associated wasting are not known.
720. Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting. A randomized, double-blind, placebo-controlled trial.
作者: D Waters.;J Danska.;K Hardy.;F Koster.;C Qualls.;D Nickell.;S Nightingale.;N Gesundheit.;D Watson.;D Schade.
来源: Ann Intern Med. 1996年125卷11期865-72页
To increase lean body mass and improve health status in patients with wasting associated with the acquired immunodeficiency syndrome (AIDS) by treatment with recombinant human growth hormone (rhGH), recombinant human insulin-like growth factor 1 (rhIGF-1), or both.
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