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641. Low dose oral pH modified release budesonide for maintenance of steroid induced remission in Crohn's disease. The Budesonide Study Group.
作者: V Gross.;T Andus.;K W Ecker.;A Raedler.;K Loeschke.;M Plauth.;J Rasenack.;A Weber.;M Gierend.;K Ewe.;J Schölmerich.
来源: Gut. 1998年42卷4期493-6页
The relapse rate after steroid induced remission in Crohn's disease is high.
642. Treatment of hepatocellular carcinoma with octreotide: a randomised controlled study.
作者: E Kouroumalis.;P Skordilis.;K Thermos.;A Vasilaki.;J Moschandrea.;O N Manousos.
来源: Gut. 1998年42卷3期442-7页
Standard treatment of inoperable hepatocellular carcinoma has not been established. Somatostatin has been shown to possess antimitotic activity against a variety of non-endocrine tumours.
643. Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis.
作者: A C Windsor.;S Kanwar.;A G Li.;E Barnes.;J A Guthrie.;J I Spark.;F Welsh.;P J Guillou.;J V Reynolds.
来源: Gut. 1998年42卷3期431-5页
In patients with major trauma and burns, total enteral nutrition (TEN) significantly decreases the acute phase response and incidence of septic complications when compared with total parenteral nutrition (TPN). Poor outcome in acute pancreatitis is associated with a high incidence of systemic inflammatory response syndrome (SIRS) and sepsis.
644. Effect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility.
Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined.
645. Effect of increasing the fat content but not the energy load of a meal on gastro-oesophageal reflux and lower oesophageal sphincter motor function.
Although fatty foods are commonly considered detrimental in patients with reflux disease, no objective data exist that substantiate this belief.
646. Effect of gastric acid suppressants on human gastric motility.
作者: H P Parkman.;J L Urbain.;L C Knight.;K L Brown.;D M Trate.;M A Miller.;A H Maurer.;R S Fisher.
来源: Gut. 1998年42卷2期243-50页
The effect of histamine H2 receptor antagonists on gastric emptying is controversial.
647. Use of mesalazine slow release suppositories 1 g three times per week to maintain remission of ulcerative proctitis: a randomised double blind placebo controlled multicentre study.
Daily administration of rectal formulations of mesalazine is effective in preventing relapse of ulcerative proctitis. Maintenance of remission with lower doses would be an advantage.
648. Eradicating Helicobacter pylori reduces hypergastrinaemia during long-term omeprazole treatment.
Both proton pump inhibitor drug treatment and Helicobacter pylori infection cause hypergastrinaemia in man.
649. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region.
Impeded flow of pancreatic juice due to mechanical obstruction of the pancreatic duct in patients with cancer of the pancreatic head region causes exocrine pancreatic insufficiency with steatorrhoea and creatorrhoea. This may contribute to the profound weight loss that often occurs in these patients.
650. Predictive factors for survival of patients with inoperable malignant distal biliary strictures: a practical management guideline.
作者: F Prat.;O Chapat.;B Ducot.;T Ponchon.;J Fritsch.;A D Choury.;G Pelletier.;C Buffet.
来源: Gut. 1998年42卷1期76-80页
Stenting is the treatment of choice for inoperable malignant strictures of the common bile duct. Criteria for the choice of stents (plastic versus metallic) remain controversial because predicting survival is difficult.
651. Actions of the 5-hydroxytryptamine 1 receptor agonist sumatriptan on interdigestive gastrointestinal motility in man.
Pharmacological studies of the enteric nervous system have shown the presence of several subtypes of 5-hydroxytryptamine (5HT) receptor, which might be involved in control of the migrating motor complex.
652. A prospective randomised controlled study of the use of ranitidine in patients with gastric cancer. Yorkshire GI Tumour Group.
作者: J N Primrose.;G V Miller.;S R Preston.;J Gokhale.;N S Ambrose.;U M Ward.;J G Mills.;R S Ehsanullah.;B Darekar.
来源: Gut. 1998年42卷1期17-9页
Does the use of the histamine H2 receptor antagonist ranitidine improve the outcome of patients with gastric cancer?
653. The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a randomised, placebo controlled study in volunteers.
作者: M I van Berge Henegouwen.;T M van Gulik.;L M Akkermans.;J B Jansen.;D J Gouma.
来源: Gut. 1997年41卷6期758-62页
Octreotide is used in many centres to prevent complications after pancreatic surgery. Delayed gastric emptying is a another complication occurring in around 30% of patients after pancreatoduodenectomy (PD) and causes prolonged hospital stay. The influence of octreotide on this complication is doubtful.
654. One week triple therapy for Helicobacter pylori: a multicentre comparative study. Lansoprazole Helicobacter Study Group.
作者: J J Misiewicz.;A W Harris.;K D Bardhan.;S Levi.;C O'Morain.;B T Cooper.;G D Kerr.;M F Dixon.;H Langworthy.;D Piper.
来源: Gut. 1997年41卷6期735-9页
Eradication of Helicobacter pylori cures and prevents the relapse of duodenal ulceration and also results in histological resolution of chronic active gastritis.
655. Atropine inhibits gastric distension and pharyngeal receptor mediated lower oesophageal sphincter relaxation.
Atropine decreases the frequency of transient lower oesophageal sphincter relaxation (TLOSR) through an unknown mechanism. Gastric distension and pharyngeal receptor excitation are two possible sources for the afferent stimulus responsible for TLOSR.
656. Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia.
Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia.
657. Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: a placebo effect?
Uncontrolled studies of lactose intolerant subjects have shown that symptom severity decreases after chronic lactose consumption. Adaptation of the colonic flora might explain this improvement.
658. Stimulus and site specific induction of hiccups in the oesophagus of normal subjects.
Hiccups that are induced by a large meal have been suggested to result from gastric overdistension. The role of the oesophagus in precipitating hiccups has never been defined.
659. A multicentre randomised trial comparing octreotide and injection sclerotherapy in the management and outcome of acute variceal haemorrhage.
作者: S A Jenkins.;R Shields.;M Davies.;E Elias.;A J Turnbull.;M F Bassendine.;O F James.;J P Iredale.;S K Vyas.;M J Arthur.;A N Kingsnorth.;R Sutton.
来源: Gut. 1997年41卷4期526-33页
Few studies have compared vasoactive drugs with endoscopic sclerotherapy in the control of acute variceal haemorrhage. Octreotide is widely used for this purpose, but its value remains undetermined.
660. Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide.
作者: W Schwizer.;J Borovicka.;P Kunz.;R Fraser.;C Kreiss.;M D'Amato.;G Crelier.;P Boesiger.;M Fried.
来源: Gut. 1997年41卷4期500-4页
Exogenous cholecystokinin (CCK) inhibits antral motility and slows gastric emptying (GE) but the effect of endogenous CCK on the gastric motor mechanisms responsible for GE remains unclear.
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