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621. Impact of the Volume-Based Procurement Policy on the Use of Coronary Stents in China: Cross-Sectional Study.
作者: Zhao Yang.;Wei Zhao.;Liangyu Ni.;Linlin Da.;Yongyi Wu.;Yuxi Li.;Qiyun Zhu.;Jianping Li.;Dennis Ross-Degnan.;Bin Jiang.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011374页 622. Response by Doust et al to Letter Regarding Article "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study".
作者: Jenny Doust.;Mohammad Reza Baneshi.;Hsin-Fang Chung.;Louise Forsyth Wilson.;Gita Devi Mishra.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e012021页 623. Letter by Rich-Edwards et al Regarding Article, "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study".
作者: Janet W Rich-Edwards.;Kathryn M Rexrode.;Tiange Liu.;Chuan Hong.;Johanna Quist-Nelson.;Marie-Louise Meng.;Hanne Dahl Vonen.;Michael J Pencina.;Ricardo Henao.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011970页 625. Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial.
作者: Sachin J Shah.;Jay M Iyer.;Leila Agha.;Yuchiao Chang.;Jeffrey M Ashburner.;Steven J Atlas.;David D McManus.;Patrick T Ellinor.;Steven A Lubitz.;Daniel E Singer.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011482页
One-time atrial fibrillation (AF) screening trials in older adults have produced mixed results. In a secondary analysis of the VITAL-AF trial, we aimed to identify a subset of people in whom such screening is effective, using effect-based and risk-based approaches.
626. Association Between Automated Coronary Artery Calcium From Routine Chest Computed Tomography Scans and Cardiovascular Risk in Patients With Colorectal or Gastric Cancer.
作者: Subin Kim.;Seonji Kim.;Min Jae Cha.;Hyo Song Kim.;Han Sang Kim.;Woo Jin Hyung.;Iksung Cho.;Seng Chan You.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e011656页
As cardiovascular disease (CVD) is the leading cause of noncancer mortality in colorectal or gastric cancer patients, it is essential to identify patients at increased CVD risk. Coronary artery calcium (CAC) is an established predictor of atherosclerotic CVD; however, its application is limited in this population. This study evaluates the association between automated CAC scoring using chest computed tomography and atherosclerotic CVD risk in colorectal or gastric cancer patients.
627. Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis.
作者: Jiawen Wang.;Zhen Yuan.;Na Yu.;Qian Jiao.;Honglei Zhou.;Wenjie Liao.;Jiwei Shan.;Shanshan Ruan.;Yi Zhao.;Ya Mo.;Luyao Qi.;Tiejun Li.;Jianjun Fu.;Bowen Ke.;Yufang Xu.;Xuhong Qian.;Jian Zhang.;Zhenjiang Zhao.;Shiliang Li.;Rui Wang.;Honglin Li.
来源: Circulation. 2025年152卷8期519-536页
The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and developmental challenges.
629. Effect of Remote Ischemic Preconditioning on Myocardial Injury in Noncardiac Surgery: The PRINCE Randomized Clinical Trial.
作者: Massimiliano Greco.;Gaetano Lombardi.;Claudia Brusasco.;Marina Pieri.;Agostino Roasio.;Fabrizio Monaco.;Levan Berikashvili.;Alessandro Belletti.;Francesco Meroi.;Stefano Fresilli.;Aituar Kabibulatov.;Giuseppe Giardina.;Andrea Russo.;Federico Mattia Oliva.;Sergey Efremov.;Rosalba Lembo.;Lini Wang.;Simone Vietri.;Elena Momesso.;Filippo D'Amico.;Kristina Kadantseva.;Rosa Labanca.;Pavel Ryzhkov.;Marilena Marmiere.;Valerii Subbotin.;Alessandro Pruna.;Nerlep Rana.;Francesca Livi.;Hugo Mantilla-Gutierrez.;Fabio Guarracino.;Lorenzo Schiavoni.;Ivan Šitum.;Marco Micali.;Stefano Bosso.;Anastasia Smirnova.;Giuseppe Fresta.;Andrey Cherednichenko.;Luigi Beretta.;Giacomo Monti.;Lian Kah Ti.;Pasquale Sansone.;Francesco Corradi.;Maurizio Cecconi.;Andrey Yavorovskiy.;Chong Lei.;Aidos Konkayev.;Tiziana Bove.;Valery Likhvantsev.;Alberto Zangrillo.;Giovanni Landoni.;Rinaldo Bellomo.;Remo Daniel Covello.;Stefano Turi.; .
来源: Circulation. 2025年152卷17期1194-1205页
Major noncardiac surgery is associated with high rates of postoperative myocardial injury and other complications. Remote ischemic preconditioning (RIPC) was reported to decrease these complication rates. However, such supportive evidence lacks robustness.
630. How a Topological Mindset May Offer Extra Control During Mapping and Ablation of Left-Sided Reentrant Atrial Tachycardia.
作者: Mattias Duytschaever.;Maarten De Smet.;Jordi Martens.;Milad El Haddad.;Benjamin De Becker.;Clara Francois.;Rene Tavernier.;Robin Van den Abeele.;Sander Hendrickx.;Nele Vandersickel.;Jean-Benoit Le Polain de Waroux.;Sebastien Knecht.
来源: Circ Arrhythm Electrophysiol. 2025年18卷7期e013780页
Reentry (macro or localized) is historically described as multiple pathways that are separated by barriers (either anatomic or functional) and involve active and passive loops (identified by electro-anatomic and entrainment mapping, EAM/ETM). Some reentrant atrial tachycardia (AT) cases are characterized by challenging activation patterns and unexpected ablation responses. A recent translational study, focusing on topology (TOP) and the role of boundaries, suggests that thinking topology within EAM/ETM might offer extra control during mapping and ablation of reentrant AT. We aimed to propose and prospectively validate a workflow (EAM/ETM+TOP) in which we integrate topological thinking within an EAM/ETM workflow for mapping and ablation of left-sided (left atrium) AT.
631. Feasibility of Machine Learned Intracardiac Electrograms to Predict Postinfarction Ventricular Scar Topography.
作者: Kasun De Silva.;Timothy G Campbell.;Richard G Bennett.;Samual Turnbull.;Ashwin Bhaskaran.;Robert D Anderson.;Christopher Davey.;Alexandra K O'Donohue.;Aaron Schindeler.;Dinesh Selvakumar.;Yasuhito Kotake.;Chi-Jen Hsu.;James J H Chong.;Eddy Kizana.;Saurabh Kumar.
来源: Circ Arrhythm Electrophysiol. 2025年18卷7期e013611页
Accurate delineation of scar patterns is valuable for guiding catheter ablation of ventricular tachycardia. We hypothesized that scar and its pattern of distribution can be determined from intracardiac electrograms using computational signal processing and that further improvements in classification can be achieved with a convolutional neural network.
632. Plasma Proteomics Reveals Dysregulated Pathways Across the Spectrum LMNA Cardiomyopathy.
作者: Usman A Tahir.;Daniel Reichart.;Anisha Purohit.;Jacob L Barber.;Gaurav Tiwari.;Laurie Farrell.;Julia E Marine.;Darius Roy.;Joshen Patel.;Catherine G Ireland.;Carolyn Y Ho.;Christine E Seidman.;Robert E Gerszten.;Neal K Lakdawala.
来源: Circ Genom Precis Med. 2025年18卷4期e004924页
Pathogenic variants in the lamin A/C (LMNA) gene cause an aggressive form of dilated cardiomyopathy (DCM), marked by higher rates of advanced conduction disease, malignant ventricular tachyarrhythmias, and advanced heart failure compared with other causes of nonischemic cardiomyopathy. However, the mechanisms that drive the development and progression of LMNA DCM are incompletely understood.
634. Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement From the American Heart Association.
作者: Lisa Q Rong.;Linda Shore-Lesserson.;Kiran Belani.;Abimbola Faloye.;Enrique Garcia-Sayan.;Jennifer Lawton.;Timothy Maus.;Wanda Miller-Hance.;Alina Nicoara.;Richard Sheu.; .
来源: Circulation. 2025年152卷2期129-145页
Intraoperative transesophageal echocardiography is used with increasing frequency in cardiac surgery for monitoring and diagnostic purposes. Recent data have shown the impact of improved outcomes in patients undergoing cardiac surgery and the use of intraoperative transesophageal echocardiography in managing complex surgical decisions. However, specialty society recommendations have not been updated to reflect these trends. This scientific statement reviews the state-of-the-art practice of intraoperative echocardiography, summarizes the association of the use of intraoperative transesophageal echocardiography with enhanced outcomes, and provides specific perioperative and procedural transesophageal echocardiography considerations in the cardiac surgical population.
635. Prompt Identification of the Location of Gap Conduction in the Mitral Isthmus Following Vein of Marshall Ethanol Infusion and Endocardial Ablation.
作者: Qiaoyuan Li.;Yanguang Li.;Zhuo Liang.;Tao Zhang.;Xu Liu.;Dongping Fang.;Jin Bai.;Jian Li.;Fengxiang Zhang.;Yunlong Wang.
来源: Circ Arrhythm Electrophysiol. 2025年18卷7期e013454页
Mitral isthmus (MI) gap conduction is common despite ethanol infusion into the vein of Marshall (EI-VOM) and endocardial ablation of the MI. This study aimed to investigate the characteristics of electrograms of the distal coronary sinus (CSd) to guide the identification of the gap location in the MI.
638. Impact of Echocardiographic Probability of Pulmonary Hypertension on Prognosis and Outcomes Among Patients With Myeloproliferative Neoplasms.
作者: Orly Leiva.;Steven Soo.;Nathaniel R Smilowitz.;Harmony Reynolds.;Binita Shah.;Samuel Bernard.;Joan How.;Michelle Hyunju Lee.;Gabriela Hobbs.
来源: Circ Cardiovasc Imaging. 2025年18卷8期e017986页
Myeloproliferative neoplasms (MPN) are a group of chronic leukemias that are associated with pulmonary hypertension (PH), which has been associated with increased risk adverse outcomes. The echocardiographic characterization of PH in MPN has not been reported, and the prognostic significance of PH among patients with MPN remains unclear.
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