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601. Letter by Zhang and Lai Regarding Article, "A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients With Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial".603. Differences in Disease Trajectory, Comorbidities, and Mortality in Sarcomeric and Nonsarcomeric Hypertrophic Cardiomyopathy.
作者: Christoffer R Vissing.;Anna Axelsson Raja.;Adam S Helms.;Sara Saberi.;Anjali T Owens.;Joseph W Rossano.;Dominic J Abrams.;Jodie Ingles.;Belinda Gray.;Rachel Lampert.;John C Stendahl.;Neal K Lakdawala.;James S Ware.;Victoria N Parikh.;Michelle Michels.;Lia Crotti.;Thomas D Ryan.;Iacopo Olivotto.;Sharlene M Day.;Henning Bundgaard.;Brian L Claggett.;Carolyn Y Ho.
来源: Circulation. 2026年153卷15期1104-1116页
Sarcomere gene variants are a key cause of hypertrophic cardiomyopathy (HCM), and have been associated with worse prognosis. However, it is unclear how comorbidities influence clinical trajectories, the timing of events, and causes of death in sarcomeric and nonsarcomeric HCM.
604. YAP Induces a Prorenewal Metabolic State in Cardiomyocytes.
作者: Lin Liu.;Jeffrey D Steimle.;Chang-Ru Tsai.;Fansen Meng.;Yuka Morikawa.;Yi Zhao.;Sandra Carmichael.;Xiao Li.;James F Martin.
来源: Circulation. 2026年153卷17期1296-1313页
Cardiomyocytes, as highly specialized and differentiated somatic cells, possess a limited capacity for renewal. Neonatal rodents possess the ability to regenerate cardiomyocytes after injury; however, this regenerative capacity declines rapidly with cardiomyocyte maturation, suggesting an inhibitory network between cellular maturation and cardiomyocyte proliferation. Maturing cardiomyocytes undergo a metabolic shift from predominantly glycolysis in the neonatal state to increased fatty acid oxidation in the mature state, which poses a barrier to cardiomyocyte proliferation and cardiac regenerative repair. YAP, a transcriptional cofactor regulated by the Hippo signaling pathway, promotes cardiac regenerative repair. We investigated the role of YAP in mediating metabolic remodeling to overcome the cardiomyocyte proliferation barrier and enable cardiac regenerative repair after heart injury.
605. PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification.
作者: Xi Zhang.;Yanglin Hao.;Dong Han.;Xin Jin.;Xiaoke Shang.;Li Zhang.;Zheng Gan.;Weicong Ye.;Song Wang.;Xiaohan Li.;Ran Li.;Kexiao Zheng.;Yinghuan Liu.;Zifeng Zou.;Zetong Tao.;Yilong Li.;Yongjun Wang.;Jiahong Xia.;Jie Wu.
来源: Circulation. 2026年153卷21期1637-1660页
Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification remain unclear. Here, we aimed to investigate the role of PRMT3 (protein arginine methyltransferase 3) in valvular calcification and calcific aortic valve disease progression.
606. Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.
作者: Yongneng Zhang.;Sébastien Bonnet.;Steeve Provencher.;Jiyuan Piao.;Alois Haromy.;Yongsheng Liu.;Yuan-Yuan Zhao.;Sandra Breuils-Bonnet.;Sarah-Eve Lemay.;Dawn E Bowles.;Michelle Mendiola Pla.;Gopinath Sutendra.;Evangelos D Michelakis.
来源: Circulation. 2026年153卷19期1494-1515页
Right ventricular failure drives both morbidity and mortality in pulmonary arterial hypertension (PAH), but the mechanism of transition from compensated right ventricle (cRV) to decompensated RV (dRV) is unknown, and some PAH patients develop dRV faster than others.
607. TRIM28 Is an E3 Ligase of IRP2 Suppressing Ischemia/Reperfusion-Induced Myocardial Ferroptosis.
作者: Kun Zhu.;Jing Guo.;Yangli Liu.;Jingchen Li.;Xun Wang.;Rilei Dai.;Xiang Wei.;Dingsheng Jiang.;Le Gao.;Jiaxing Bai.;Rui Cao.;Zhiheng Lin.;Wei Zhou.;Yifan Zhuang.;Yufei Wang.;Leilei Du.;Yang Li.;De-Shen Liu.;Weiwei An.;Qinghua Cui.;Weiping Li.;Chun-Mei Cao.
来源: Circulation. 2026年153卷17期1314-1336页
Myocardial ischemia/reperfusion (I/R) injury is a common and severe clinical complication in patients with ischemic heart disease after reperfusion therapy. Effective therapeutic strategies for myocardial I/R injury remain limited. Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. However, the mechanisms underlying ferroptosis in myocardial I/R injury are not fully understood.
608. Angiography-Derived Fractional Flow Reserve During Percutaneous Coronary Intervention.
作者: Chieh Yang Christopher Koo.;Siling Li.;Rasha Al-Lamee.;David J Cohen.;William F Fearon.;Ajay J Kirtane.;Martin B Leon.;Guy Witberg.;Robert W Yeh.;Eric A Secemsky.
来源: Circ Cardiovasc Interv. 2026年19卷5期e016213页
Angiography-derived fractional flow reserve (Angio-FFR) is an emerging tool for guiding percutaneous coronary intervention (PCI). Its uptake and outcomes compared with pressure wire (PW)-based assessment in the United States are unknown.
609. Hospital-Level Variability in NSTEMI Management: Findings From the NCDR Chest Pain-MI Registry.
作者: Yasser M Sammour.;John A Spertus.;Nathaniel R Smilowitz.;Huaying Dong.;Pratik B Sandesara.;Sachin S Goel.;Safi U Khan.;Alpesh Shah.;Philip Jones.;Natalie Wheeler.;Yang Song.;Tanveer Rab.;William J Nicholson.;Wissam A Jaber.;Rishi K Wadhera.;Neal S Kleiman.
来源: Circ Cardiovasc Interv. 2026年19卷5期e016534页
Although guidelines recommend invasive management for non-ST-segment-elevation myocardial infarction (NSTEMI), there is considerable variability in the application of these recommendations across different hospitals, reflecting a lack of standardized clinical pathways and highlighting ongoing uncertainty in real-world practice. We sought to describe site-level variability in the use and timing of invasive angiography for NSTEMI and its association with in-hospital outcomes.
610. Hemodynamic and Metabolic-Inflammatory Phenotyping Across the Cardiac Index Spectrum in Moderate and Severe Tricuspid Regurgitation: Prognostic Implications.
作者: Matteo Mazzola.;Nicolò De Biase.;Cristina Giannini.;Alessandro Sticchi.;Lavinia Del Punta.;Luna Gargani.;Alessandro Mengozzi.;Agostino Virdis.;Silvia Armenia.;Federica Cappelli.;Emiliano Duranti.;Stefano Taddei.;Rebecca Hahn.;David Messika-Zeitoun.;Stefano Masi.;Marco De Carlo.;Nicola Riccardo Pugliese.
来源: Circ Cardiovasc Imaging. 2026年19卷4期e019444页
Moderate and severe tricuspid regurgitation (TR) is associated with poor outcomes, yet current grading systems do not fully capture circulatory heterogeneity. We investigate the relationship of cardiac index (CI) with rest-exercise hemodynamics, metabolic and inflammatory profiles, and clinical outcomes in moderate and severe TR.
616. Correction to: Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation.
作者: Liwei Liu.;Jinyan Zhang.;Zhen Dong.;Yikai Cui.;Xiaoyi Zou.;Hao Lai.;Jiawei Gu.;Xinyu Weng.;Xuejuan Jin.;Tianyi Qiu.;Zhiqiang Pei.;Wenxuan Hong.;Ya Huang.;Wei Luo.;Lihong Pan.;Xiaolei Sun.;Beijian Zhang.;Adilan Shalamu.;Aijun Sun.;Junbo Ge.
来源: Circulation. 2026年153卷9期e908页 619. Response by Schumacher and Cousino to Letter Regarding Article, "The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20-Center Retrospective Cohort Study".620. Response by de Veld et al to Letter Regarding Article, "Device-Related Complications in Transvenous Versus Subcutaneous Defibrillator Therapy During Long-Term Follow-Up: The PRAETORIAN-XL Trial".
作者: Jolien A de Veld.;Reinoud E Knops.;Louise R A Olde Nordkamp.
来源: Circulation. 2026年153卷9期e267-e268页 |