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601. The positive predictive value of cervical smears in previously screened postmenopausal women: the Heart and Estrogen/progestin Replacement Study (HERS).
作者: G F Sawaya.;D Grady.;K Kerlikowske.;J L Valleur.;V M Barnabei.;K Bass.;T E Snyder.;J H Pickar.;S K Agarwal.;J Mandelblatt.
来源: Ann Intern Med. 2000年133卷12期942-50页
The benefits and risks of performing annual cervical smears on postmenopausal women are not well defined. The independent effect of hormone replacement therapy on development of cytologic abnormalities is unknown.
602. Erythropoietin with iron supplementation to prevent allogeneic blood transfusion in total hip joint arthroplasty. A randomized, controlled trial.
作者: B G Feagan.;C J Wong.;A Kirkley.;D W Johnston.;F C Smith.;P Whitsitt.;S L Wheeler.;C Y Lau.
来源: Ann Intern Med. 2000年133卷11期845-54页
The optimum regimen of epoetin alfa for prevention of allogeneic blood transfusion is unknown.
603. Videotape-based decision aid for colon cancer screening. A randomized, controlled trial.
Rates of colon cancer screening in the United States are low, in part because of poor communication between patients and providers about the availability of effective screening options.
604. A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin. A randomized, controlled trial.
Warfarin is effective in the treatment and prevention of many venous thromboembolic disorders, but it often leads to bleeding.
605. Comparison of oral fluconazole and itraconazole for progressive, nonmeningeal coccidioidomycosis. A randomized, double-blind trial. Mycoses Study Group.
作者: J N Galgiani.;A Catanzaro.;G A Cloud.;R H Johnson.;P L Williams.;L F Mirels.;F Nassar.;J E Lutz.;D A Stevens.;P K Sharkey.;V R Singh.;R A Larsen.;K L Delgado.;C Flanigan.;M G Rinaldi.
来源: Ann Intern Med. 2000年133卷9期676-86页
In previous open-label noncomparative clinical trials, both fluconazole and itraconazole were effective therapy for progressive forms of coccidioidomycosis.
606. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. A randomized, double-blind, placebo-controlled trial.
Thiazide may have beneficial effects on bone mineral density and may reduce risk for hip fracture. However, the existence of a causal role remains uncertain because experimental evidence is limited.
607. Discontinuation of Mycobacterium avium complex prophylaxis in patients with antiretroviral therapy-induced increases in CD4+ cell count. A randomized, double-blind, placebo-controlled trial. AIDS Clinical Trials Group 362 Study Team.
作者: J S Currier.;P L Williams.;S L Koletar.;S E Cohn.;R L Murphy.;A E Heald.;R Hafner.;E L Bassily.;H M Lederman.;C Knirsch.;C A Benson.;H Valdez.;J A Aberg.;J A McCutchan.
来源: Ann Intern Med. 2000年133卷7期493-503页
Patients infected with HIV who experience increases in CD4(+) cell counts are at reduced risk for opportunistic infections. However, the safety of discontinuing prophylaxis against Mycobacterium avium complex has been uncertain.
608. Effects of testosterone and progressive resistance training in eugonadal men with AIDS wasting. A randomized, controlled trial.
作者: S Grinspoon.;C Corcoran.;K Parlman.;M Costello.;D Rosenthal.;E Anderson.;T Stanley.;D Schoenfeld.;B Burrows.;D Hayden.;N Basgoz.;A Klibanski.
来源: Ann Intern Med. 2000年133卷5期348-55页
Substantial loss of muscle mass occurs among men with AIDS wasting.
609. Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. A randomized, controlled trial.
In publicly funded health care systems, a waiting period for such services as coronary artery bypass graft surgery (CABG) is common. The possibility of using the waiting period to improve patient outcomes should be investigated.
610. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial.
作者: A S Prasad.;J T Fitzgerald.;B Bao.;F W Beck.;P H Chandrasekar.
来源: Ann Intern Med. 2000年133卷4期245-52页
Adults and children in the United States get two to six colds per year. Evidence that zinc is effective therapy for colds is inconsistent.
611. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial.
作者: R Ross.;D Dagnone.;P J Jones.;H Smith.;A Paddags.;R Hudson.;I Janssen.
来源: Ann Intern Med. 2000年133卷2期92-103页
The independent effects of diet- or exercise-induced weight loss on the reduction of obesity and related comorbid conditions are not known. The effects of exercise without weight loss on fat distribution and other risk factors are also unclear.
612. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial.
作者: G Sesmilo.;B M Biller.;J Llevadot.;D Hayden.;G Hanson.;N Rifai.;A Klibanski.
来源: Ann Intern Med. 2000年133卷2期111-22页
Growth hormone-deficient adults have increased cardiovascular mortality. Growth hormone replacement may affect cardiovascular risk. Inflammation plays an important role in atherosclerosis, and inflammatory markers are predictive of cardiovascular events.
613. 3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine.
作者: R M Gulick.;J W Mellors.;D Havlir.;J J Eron.;A Meibohm.;J H Condra.;F T Valentine.;D McMahon.;C Gonzalez.;L Jonas.;E A Emini.;J A Chodakewitz.;R Isaacs.;D D Richman.
来源: Ann Intern Med. 2000年133卷1期35-9页
Antiretroviral regimens containing HIV protease inhibitors suppress viremia in HIV-infected patients, but the durability of this effect is not known.
614. Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial.
作者: S K Swan.;D W Rudy.;K C Lasseter.;C F Ryan.;K L Buechel.;L J Lambrecht.;M B Pinto.;S C Dilzer.;O Obrda.;K J Sundblad.;C P Gumbs.;D L Ebel.;H Quan.;P J Larson.;J I Schwartz.;T A Musliner.;B J Gertz.;D C Brater.;S L Yao.
来源: Ann Intern Med. 2000年133卷1期1-9页
Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits. Although agents that do not produce COX-1 activity may have fewer adverse effects, targeted disruption of the COX-2 allele in mice has resulted in severe renal problems, suggesting that COX-2 inhibition may also produce adverse effects.
615. Percutaneous coronary revascularization in elderly patients: impact on functional status and quality of life.
作者: T B Seto.;D A Taira.;R Berezin.;M S Chauhan.;D E Cutlip.;K K Ho.;R E Kuntz.;D J Cohen.
来源: Ann Intern Med. 2000年132卷12期955-8页
Percutaneous coronary intervention (PCI) is frequently performed in elderly patients, but little is known about its impact on overall health and quality of life.
616. Self-study from web-based and printed guideline materials. A randomized, controlled trial among resident physicians.
On-line physician education is increasing, but its efficacy in comparison with existing self-study methods is unknown.
617. Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospora belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial.
In developing countries, Isospora belli and Cyclospora cayetanensis frequently cause chronic diarrhea in HIV-infected patients.
618. Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial.
作者: J R Seibold.;J H Korn.;R Simms.;P J Clements.;L W Moreland.;M D Mayes.;D E Furst.;N Rothfield.;V Steen.;M Weisman.;D Collier.;F M Wigley.;P A Merkel.;M E Csuka.;V Hsu.;S Rocco.;M Erikson.;J Hannigan.;W S Harkonen.;M E Sanders.
来源: Ann Intern Med. 2000年132卷11期871-9页
Relaxin is a pregnancy-related hormone that has tissue remodeling and antifibrotic effects. Systemic sclerosis (scleroderma) is characterized by fibrosis of the skin, vasculature, and internal organs.
619. Ardeparin sodium for extended out-of-hospital prophylaxis against venous thromboembolism after total hip or knee replacement. A randomized, double-blind, placebo-controlled trial.
作者: J A Heit.;C G Elliott.;A A Trowbridge.;B F Morrey.;M Gent.;J Hirsh.
来源: Ann Intern Med. 2000年132卷11期853-61页
The optimal duration of prophylaxis against venous thromboembolism after total hip or knee replacement is uncertain.
620. Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study.
作者: K J Pandya.;R F Raubertas.;P J Flynn.;H E Hynes.;R J Rosenbluth.;J J Kirshner.;H I Pierce.;V Dragalin.;G R Morrow.
来源: Ann Intern Med. 2000年132卷10期788-93页
Hot flashes are the most frequently reported side effect of tamoxifen treatment. Although hormones are an effective treatment, their safety is questionable in women with breast cancer. It is therefore important to evaluate nonhormonal treatments for hot flashes.
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