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586. Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial.
作者: Corita R Grudzen.;Nina Siman.;Allison M Cuthel.;Oluwaseun Adeyemi.;Rebecca Liddicoat Yamarik.;Keith S Goldfeld.; .;Benjamin S Abella.;Fernanda Bellolio.;Sorayah Bourenane.;Abraham A Brody.;Lauren Cameron-Comasco.;Joshua Chodosh.;Julie J Cooper.;Ashley L Deutsch.;Marie Carmelle Elie.;Ahmed Elsayem.;Rosemarie Fernandez.;Jessica Fleischer-Black.;Mauren Gang.;Nicholas Genes.;Rebecca Goett.;Heather Heaton.;Jacob Hill.;Leora Horwitz.;Eric Isaacs.;Karen Jubanyik.;Sangeeta Lamba.;Katharine Lawrence.;Michelle Lin.;Caitlin Loprinzi-Brauer.;Troy Madsen.;Joseph Miller.;Ada Modrek.;Ronny Otero.;Kei Ouchi.;Christopher Richardson.;Lynne D Richardson.;Matthew Ryan.;Elizabeth Schoenfeld.;Matthew Shaw.;Ashley Shreves.;Lauren T Southerland.;Audrey Tan.;Julie Uspal.;Arvind Venkat.;Laura Walker.;Ian Wittman.;Erin Zimny.
来源: JAMA. 2025年333卷7期599-608页
The emergency department (ED) offers an opportunity to initiate palliative care for older adults with serious, life-limiting illness.
591. Screening for Osteoporosis to Prevent Fractures: A Systematic Evidence Review for the US Preventive Services Task Force.
作者: Leila C Kahwati.;Christine E Kistler.;Graham Booth.;Nila Sathe.;Rachel D'Amico Gordon.;Ebiere Okah.;Roberta C Wines.;Meera Viswanathan.
来源: JAMA. 2025年333卷6期509-531页
Fragility fractures result in significant morbidity.
592. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.
作者: .;Wanda K Nicholson.;Michael Silverstein.;John B Wong.;David Chelmow.;Tumaini Rucker Coker.;Esa M Davis.;Carlos Roberto Jaén.;Marie Krousel-Wood.;Sei Lee.;Li Li.;Carol M Mangione.;Gbenga Ogedegbe.;Goutham Rao.;John M Ruiz.;James Stevermer.;Joel Tsevat.;Sandra Millon Underwood.;Sarah Wiehe.
来源: JAMA. 2025年333卷6期498-508页
Osteoporotic fractures are associated with psychological distress, subsequent fractures, loss of independence, reduced ability to perform activities of daily living, and death.
596. Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial.
作者: Jiacheng Huang.;Jie Yang.;Chang Liu.;Linyu Li.;Dahong Yang.;Changwei Guo.;Guoyong Zeng.;Jiaxing Song.;Jinfu Ma.;Xu Xu.;Xiaolei Shi.;Shihai Yang.;Wenzhe Sun.;Zhixi Wang.;Yufeng Tang.;Maojun Jiang.;Li Wang.;Xiangping Cheng.;Jun Luo.;Peiyang Zhou.;Xing Fang.;Guangsen Cheng.;Zhongfan Ruan.;Jinglun Li.;Jincheng Liu.;Bo Lei.;Yaoyu Tian.;Xiaolin Tan.;Guangxiong Yuan.;Jian Wang.;Xinyuan Huang.;Shengling Deng.;Zhenglong Jin.;Xin Zou.;Jie Zhang.;Daoyou Cheng.;Xiaojun Luo.;Jiasheng Liao.;Jian Miao.;Zhenqiang Li.;Yaxuan Sun.;Guohui Jiang.;Deyan Kong.;Shuyu Jiang.;Zhiyuan Wang.;Duolao Wang.;Johannes Kaesmacher.;Thanh N Nguyen.;Raul G Nogueira.;Jeffrey L Saver.;Yangmei Chen.;Wenjie Zi.; .
来源: JAMA. 2025年333卷7期579-588页
The impact of adjunctive intra-arterial tenecteplase administration following near-complete to complete reperfusion by endovascular thrombectomy (EVT) for acute ischemic stroke is unknown.
598. Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial.
作者: Chang Liu.;Changwei Guo.;Fengli Li.;Nizhen Yu.;Jiacheng Huang.;Zhouzhou Peng.;Weilin Kong.;Jiaxing Song.;Xiang Liu.;Shitao Fan.;Chengsong Yue.;Boyu Chen.;Chong Zheng.;Xingyun Yuan.;Jian Sheng.;Youlin Wu.;Bo Sun.;Zengqiang Zhao.;Minzhen Zhu.;Ling Han.;Qiang Shi.;Zhongbin Xia.;Xianjin Shang.;Fengguang Li.;Rongzong Li.;Feixue Yue.;Shunfu Jiang.;Dengwen Song.;Min Song.;Yuanjun Shan.;Chawen Ding.;Li Yao.;Yong Yang.;Junbin Chen.;Wencheng He.;Feibao Pan.;Wensheng Zhang.;Tieying Cai.;Shibo Han.;Wei Li.;Gongbo Li.;Chen Gong.;Liping Huang.;Cheng Huang.;Duolao Wang.;Johannes Kaesmacher.;Thanh N Nguyen.;Raul G Nogueira.;Jeffrey L Saver.;Wenjie Zi.;Yangmei Chen.;Qingwu Yang.; .
来源: JAMA. 2025年333卷7期589-598页
Persisting or new thrombi in the distal arteries and the microcirculation have been reported to limit the benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete to complete reperfusion by thrombectomy improves outcomes among patients with ischemic stroke due to large vessel occlusion.
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