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581. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men.
作者: F Fuentes.;J López-Miranda.;E Sánchez.;F Sánchez.;J Paez.;E Paz-Rojas.;C Marín.;P Gómez.;J Jimenez-Perepérez.;J M Ordovás.;F Pérez-Jiménez.
来源: Ann Intern Med. 2001年134卷12期1115-9页
The regulatory function of the endothelium is altered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a central role in the development of atherosclerosis.
584. The incidence of unrecognized myocardial infarction in women with coronary heart disease.
作者: M G Shlipak.;D A Elmouchi.;D M Herrington.;F Lin.;D Grady.;M A Hlatky.; .
来源: Ann Intern Med. 2001年134卷11期1043-7页
Several cohort studies in populations without coronary heart disease have demonstrated that up to 40% of incident myocardial infarctions are clinically unrecognized.
585. Home monitoring service improves mean arterial pressure in patients with essential hypertension. A randomized, controlled trial.
作者: M A Rogers.;D Small.;D A Buchan.;C A Butch.;C M Stewart.;B E Krenzer.;H L Husovsky.
来源: Ann Intern Med. 2001年134卷11期1024-32页
Technological advances in the distribution of information have opened new avenues for patient care. Few trials, however, have used telemedicine to improve blood pressure in patients with essential hypertension.
586. Treatment with continuous positive airway pressure is not effective in patients with sleep apnea but no daytime sleepiness. a randomized, controlled trial.
作者: F Barbé.;L R Mayoralas.;J Duran.;J F Masa.;A Maimó.;J M Montserrat.;C Monasterio.;M Bosch.;A Ladaria.;M Rubio.;R Rubio.;M Medinas.;L Hernandez.;S Vidal.;N J Douglas.;A G Agustí.
来源: Ann Intern Med. 2001年134卷11期1015-23页
The sleep apnea-hypopnea syndrome is defined by a pathologic number of respiratory events during sleep (the apnea-hypopnea index, defined as the number of apnea and hypopnea episodes per hour) and daytime symptoms (mostly, excessive sleepiness). In patients with the sleep apnea syndrome, treatment with continuous positive airway pressure (CPAP) normalizes both the apnea-hypopnea index and diurnal symptoms. However, the effect of CPAP in persons with a pathologic apnea-hypopnea index without daytime sleepiness is unclear.
588. Effects of long-term postoperative interferon-alpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial.
作者: S Kubo.;S Nishiguchi.;K Hirohashi.;H Tanaka.;T Shuto.;O Yamazaki.;S Shiomi.;A Tamori.;H Oka.;S Igawa.;T Kuroki.;H Kinoshita.
来源: Ann Intern Med. 2001年134卷10期963-7页
Interferon therapy decreases the incidence of hepatocellular carcinoma in patients with chronic hepatitis C.
589. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial.
作者: D Hunt.;P Young.;J Simes.;W Hague.;S Mann.;D Owensby.;G Lane.;A Tonkin.
来源: Ann Intern Med. 2001年134卷10期931-40页
The effect of cholesterol-lowering therapy on death from coronary heart disease in older patients with previous coronary heart disease and average cholesterol levels is uncertain.
590. Symptom management in older primary care patients: feasibility of an experimental, written self-disclosure protocol.
作者: J C Klapow.;S M Schmidt.;L A Taylor.;P Roller.;Q Li.;J W Calhoun.;J Wallander.;J Pennebaker.
来源: Ann Intern Med. 2001年134卷9 Pt 2期905-11页
Distress-driven symptoms are prevalent among older primary care patients and account for a large percentage of office visits and increased medical costs. An experimental written self-disclosure protocol has been shown to reduce symptoms and use of health care services in healthy adults. Written self-disclosure as a method for reducing symptoms has not been evaluated in the primary care setting.
591. Effects of hormone replacement therapy on serum lipids in elderly women. a randomized, placebo-controlled trial.
作者: E F Binder.;D B Williams.;K B Schechtman.;D B Jeffe.;W M Kohrt.
来源: Ann Intern Med. 2001年134卷9 Pt 1期754-60页
Coronary heart disease (CHD) is the leading cause of death among older women. In observational studies, the incidence of CHD has been reduced in postmenopausal women who take hormone replacement therapy (HRT). A low serum level of high-density lipoprotein (HDL) cholesterol is one of the risk factors predictive of death from CHD.
592. The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial.
作者: J F Yale.;T R Valiquett.;M N Ghazzi.;J K Owens-Grillo.;R W Whitcomb.;H L Foyt.
来源: Ann Intern Med. 2001年134卷9 Pt 1期737-45页
The thiazolidinediones are a new class of antidiabetes medication that enhances the actions of insulin in muscle, liver, and adipose tissue. Data have been lacking on their use in combination with both sulfonylurea and metformin among patients for whom insulin is the usual therapeutic alternative for improved glycemic control.
594. Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy study.
作者: S D Solomon.;R J Glynn.;S Greaves.;U Ajani.;J L Rouleau.;F Menapace.;J M Arnold.;C Hennekens.;M A Pfeffer.
来源: Ann Intern Med. 2001年134卷6期451-8页
Patients with reduced left ventricular function and ventricular enlargement after myocardial infarction are at significantly greater risk for congestive heart failure and death. Nevertheless, recovery of ventricular function occurs in a significant proportion of patients after myocardial infarction, and modern reperfusion strategies have been associated with increased recovery of function.
595. Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II.
作者: V J Stevens.;E Obarzanek.;N R Cook.;I M Lee.;L J Appel.;D Smith West.;N C Milas.;M Mattfeldt-Beman.;L Belden.;C Bragg.;M Millstone.;J Raczynski.;A Brewer.;B Singh.;J Cohen.; .
来源: Ann Intern Med. 2001年134卷1期1-11页
Weight loss appears to be an effective method for primary prevention of hypertension. However, the long-term effects of weight loss on blood pressure have not been extensively studied.
596. Assessment of decision support for blood test ordering in primary care. a randomized trial.
作者: M A van Wijk.;J van der Lei.;M Mosseveld.;A M Bohnen.;J H van Bemmel.
来源: Ann Intern Med. 2001年134卷4期274-81页
Different methods for changing blood test-ordering behavior in primary care have been proven effective. However, randomized trials comparing these methods are lacking.
597. Natural history of valvular regurgitation 1 year after discontinuation of dexfenfluramine therapy. A randomized, double-blind, placebo-controlled trial.
Previous studies have reported small increases in the prevalence of low-grade aortic and mitral regurgitation in patients treated with dexfenfluramine compared with placebo. However, whether valvular abnormalities develop or progress 1 year after discontinuation of dexfenfluramine therapy has not been determined.
598. Inhaled human insulin treatment in patients with type 2 diabetes mellitus.
作者: W T Cefalu.;J S Skyler.;I A Kourides.;W H Landschulz.;C C Balagtas.;S Cheng.;R A Gelfand.; .
来源: Ann Intern Med. 2001年134卷3期203-7页
Despite demonstrated benefits, intensive insulin therapy has not gained widespread clinical acceptance for several reasons: Multiple daily injections are inconvenient, adherence is a concern, and the time-activity profile may not mimic normal insulin secretion. As such, alternate means of administering insulin are being evaluated.
599. Subcutaneous enoxaparin once or twice daily compared with intravenous unfractionated heparin for treatment of venous thromboembolic disease.
作者: G Merli.;T E Spiro.;C G Olsson.;U Abildgaard.;B L Davidson.;A Eldor.;D Elias.;A Grigg.;D Musset.;G M Rodgers.;A A Trowbridge.;R D Yusen.;K Zawilska.; .
来源: Ann Intern Med. 2001年134卷3期191-202页
Low-molecular-weight heparins administered subcutaneously once or twice daily have been reported to be as safe and efficacious as intravenous unfractionated heparin in the treatment of acute venous thromboembolic disease.
600. Combined treatment of giant-cell arteritis with methotrexate and prednisone. a randomized, double-blind, placebo-controlled trial.
作者: J A Jover.;C Hernández-García.;I C Morado.;E Vargas.;A Bañares.;B Fernández-Gutiérrez.
来源: Ann Intern Med. 2001年134卷2期106-14页
Corticosteroids remain the cornerstone of therapy for giant-cell arteritis, but relapse during dose tapering and corticosteroid-related adverse events often complicate management of this condition. Although several approaches, including combined therapy with cytotoxic agents, have been suggested to overcome these problems, no study has clearly shown benefits of alternate treatments.
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