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581. Hydrogen peroxide enhanced ultrasound- fistulography in the assessment of enterocutaneous fistulas complicating Crohn's disease.
Proper management of enterocutaneous fistulas complicating Crohn's disease largely depends on the anatomical characteristics of the sinus tracks as well as the coexistence of complications such as abscesses and distal bowel stenosis. The aim of this prospective study was to evaluate the accuracy of a new technique (hydrogen peroxide enhanced ultrasound (US)-fistulography) compared with conventional x ray fistulogram and/or surgical findings in the detection of Crohn's disease associated enterocutaneous fistulas.
582. Flexible sigmoidoscopy or colonoscopy as a screening modality for colorectal adenomas in older age groups? Findings in a cohort of the normal population aged 63-72 years.
Most cases of colorectal cancer originate from adenomas. Removing adenomas has been shown to reduce the incidence of colorectal cancer. The design of cost effective endoscopic screening programmes requires a knowledge of the distribution of adenomas in different age groups.
583. Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac.
作者: J J Keller.;G J Offerhaus.;M Polak.;S N Goodman.;M L Zahurak.;L M Hylind.;S R Hamilton.;F M Giardiello.
来源: Gut. 1999年45卷6期822-8页
Sulindac regresses colorectal adenomas in patients with familial adenomatous polyposis (FAP), although the mechanism of polyp regression is unclear.
584. Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects.
Topical nitrates lower anal sphincter pressure and heal anal fissures, but a majority of patients experience headache. The internal anal sphincter has a calcium dependent mechanism to maintain tone, and also receives an inhibitory extrinsic cholinergic innervation. It may therefore be possible to lower anal sphincter pressure using calcium channel blockers and cholinergic agonists without side effects.
586. Increased activation of lymphocytes infiltrating primary colorectal cancers following immunisation with the anti-idiotypic monoclonal antibody 105AD7.
作者: C A Maxwell-Armstrong.;L G Durrant.;R A Robins.;A M Galvin.;J H Scholefield.;J D Hardcastle.
来源: Gut. 1999年45卷4期593-8页
The anti-idiotypic monoclonal antibody 105AD7 mimics the tumour associated antigen 791Tgp72, expressed on 70-80% of colorectal cancers. Phase I studies have shown that the vaccine is non-toxic, and a number of patients have been immunised prior to resection of their primary tumours.
587. The risks of screening: data from the Nottingham randomised controlled trial of faecal occult blood screening for colorectal cancer.
作者: M H Robinson.;J D Hardcastle.;S M Moss.;S S Amar.;J O Chamberlain.;N C Armitage.;J H Scholefield.;C M Mangham.
来源: Gut. 1999年45卷4期588-92页
To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer.
588. Endoscopic regression of Barrett's oesophagus during omeprazole treatment; a randomised double blind study.
作者: F T Peters.;S Ganesh.;E J Kuipers.;W J Sluiter.;E C Klinkenberg-Knol.;C B Lamers.;J H Kleibeuker.
来源: Gut. 1999年45卷4期489-94页
Barrett's oesophagus, columnar metaplasia of the epithelium, is a premalignant condition with a 50-100-fold increased risk of cancer. The condition is caused by chronic gastro-oesophageal reflux. Regression of metaplasia may decrease the cancer risk.
589. The effects of short term lipid infusion on plasma and hepatic bile lipids in humans.
作者: R Pakula.;F M Konikoff.;A M Moser.;F Greif.;A Tietz.;T Gilat.;M Rubin.
来源: Gut. 1999年45卷3期453-8页
Patients on parenteral nutrition have an increased incidence of gall bladder sludge and gallstone disease, thought to be related to bile stasis. Intravenous lipid emulsions, especially those containing medium chain triglycerides, have also been shown to have a lithogenic effect on the composition of bile in the gall bladder.
590. Long term follow up of patients with chronic pancreatitis and pancreatic stones treated with extracorporeal shock wave lithotripsy.
作者: H E Adamek.;R Jakobs.;A Buttmann.;M U Adamek.;A R Schneider.;J F Riemann.
来源: Gut. 1999年45卷3期402-5页
There have been conflicting reports as to whether pancreatic ductal drainage achieved by endoscopy and lithotripsy improves the clinical outcome of patients with chronic pancreatitis.
591. High prevalence of NSAID enteropathy as shown by a simple faecal test.
作者: J A Tibble.;G Sigthorsson.;R Foster.;D Scott.;M K Fagerhol.;A Roseth.;I Bjarnason.
来源: Gut. 1999年45卷3期362-6页
The diagnosis of non-steroidal anti-inflammatory drug (NSAID) induced enteropathy is difficult, requiring enteroscopy or the use of four day faecal excretion of (111)In labelled white cells.
592. Cholinergic effects on human gastric motility.
作者: H P Parkman.;D M Trate.;L C Knight.;K L Brown.;A H Maurer.;R S Fisher.
来源: Gut. 1999年45卷3期346-54页
Cholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated.
593. Evaluation of laser doppler flowmetry for the study of benign and malignant gastric blood flow in vivo.
作者: M K Schilling.;C Redaelli.;H Friess.;B Blum.;C Signer.;C A Maurer.;M W Büchler.
来源: Gut. 1999年45卷3期341-5页
Tumour vascularisation is a determinant of the development of metastases.
594. A prospective randomised trial of a "test and treat" policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic.
作者: A Heaney.;J S Collins.;R G Watson.;R J McFarland.;K B Bamford.;T C Tham.
来源: Gut. 1999年45卷2期186-90页
Management of dyspepsia remains a controversial area. Although the European Helicobacter pylori study group has advised empirical eradication therapy without oesophagogastroduodenoscopy (OGD) in young H pylori positive dyspeptic patients who do not exhibit alarm symptoms, this strategy has not been subjected to clinical trial.
596. Response to interferon alpha treatment and disappearance of cryoglobulinaemia in patients infected by hepatitis C virus.
作者: P Cresta.;L Musset.;P Cacoub.;L Frangeul.;D Vitour.;T Poynard.;P Opolon.;D T Nguyen.;F Golliot.;J C Piette.;J M Huraux.;F Lunel.
来源: Gut. 1999年45卷1期122-8页
Mixed cryoglobulinaemia is closely associated with hepatitis C virus (HCV) infection.
597. A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis.
The pharmacological inhibition of exocrine pancreatic secretion with the somatostatin analogue octreotide has been advocated as a specific treatment of acute pancreatitis.
598. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition.
作者: J Powell-Tuck.;C P Jamieson.;G E Bettany.;O Obeid.;H V Fawcett.;C Archer.;D L Murphy.
来源: Gut. 1999年45卷1期82-8页
To determine whether the inclusion of 20 g free glutamine as part of the nitrogen source of parenteral feeds reduces length of hospital stay or mortality.
599. Cardiac function and haemodynamics in alcoholic cirrhosis and effects of the transjugular intrahepatic portosystemic stent shunt.
A portosystemic stent shunt may impair cardiac function and haemodynamics.
600. Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension.
作者: L Spahr.;J P Villeneuve.;M P Dufresne.;D Tassé.;B Bui.;B Willems.;D Fenyves.;G Pomier-Layrargues.
来源: Gut. 1999年44卷5期739-42页
Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) are increasingly recognised as separate entities. The pathogenic role of portal hypertension for the development of GAVE is still controversial.
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