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581. Plaque Regression and Endothelial Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER).
作者: Subhash Banerjee.;Ping Luo.;Domenic J Reda.;Faisal Latif.;Jeffrey L Hastings.;Ehrin J Armstrong.;Jayant Bagai.;Mazen Abu-Fadel.;Amutharani Baskar.;Preeti Kamath.;Daniel Lippe.;Yongliang Wei.;Alexandra Scrymgeour.;Theresa C Gleason.;Emmanouil S Brilakis.
来源: Circ Cardiovasc Interv. 2020年13卷8期e008933页
Low-density lipoproteins (LDLs) are removed by extracorporeal filtration during LDL apheresis. It is mainly used in familial hyperlipidemia. The PREMIER trial (Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen) evaluated LDL apheresis in nonfamilial hyperlipidemia acute coronary syndrome patients treated with percutaneous coronary intervention.
582. Diagnostic Yield of Electroanatomic Voltage Mapping in Guiding Endomyocardial Biopsies.
作者: Michela Casella.;Antonio Dello Russo.;Marco Bergonti.;Valentina Catto.;Edoardo Conte.;Elena Sommariva.;Alessio Gasperetti.;Giulia Vettor.;Fabrizio Tundo.;Rita Sicuso.;Stefania Rizzo.;Saima Mushtaq.;Domenico Della Rocca.;Giulio Pompilio.;Luigi Di Biase.;Daniele Andreini.;Andrea Natale.;Cristina Basso.;Claudio Tondo.
来源: Circulation. 2020年142卷13期1249-1260页
Electroanatomic voltage mapping (EVM) is a promising modality for guiding endomyocardial biopsies (EMBs). However, few data support its feasibility and safety. We now report the largest cohort of patients undergoing EVM-guided EMBs to show its diagnostic yield and to compare it with a cardiac magnetic resonance (CMR)-guided approach.
584. One-Year Echocardiographic, Functional, and Quality of Life Outcomes After Ultrasound-Facilitated Catheter-Based Fibrinolysis for Pulmonary Embolism.
作者: Gregory Piazza.;Keith M Sterling.;Victor F Tapson.;Kenneth Ouriel.;Andrew S P Sharp.;Ping-Yu Liu.;Samuel Z Goldhaber.
来源: Circ Cardiovasc Interv. 2020年13卷8期e009012页
Accelerated tPA (tissue-type plasminogen activator) dosing regimens for ultrasound-facilitated, catheter-directed fibrinolysis improve short-term computed tomographic-measured right ventricular (RV)-to-left ventricular diameter ratio in massive and submassive pulmonary embolism. The impact on RV remodeling, functional status, and quality of life over the long-term remains unclear.
585. Electrical Posterior Box Isolation in Persistent Atrial Fibrillation Changed to Paroxysmal Atrial Fibrillation: A Multicenter, Prospective, Randomized Study.
作者: Hui-Nam Pak.;Junbeom Park.;Je-Wook Park.;Song-Yi Yang.;Hee Tae Yu.;Tae-Hoon Kim.;Jae-Sun Uhm.;Jong-Il Choi.;Boyoung Joung.;Moon-Hyoung Lee.;Young-Hoon Kim.;Jaemin Shim.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008531页
Persistent atrial fibrillation (AF) can change to paroxysmal AF after antiarrhythmic drug medication and cardioversion. We investigated whether electrical posterior box isolation (POBI) may improve rhythm outcome of catheter ablation in those patient groups.
586. Effect of Evolocumab on Atherogenic Lipoproteins During the Peri- and Early Postinfarction Period: A Placebo-Controlled, Randomized Trial.
作者: Thorsten M Leucker.;Michael J Blaha.;Steven R Jones.;Michael A Vavuranakis.;Marlene S Williams.;Hong Lai.;Thomas H Schindler.;Jacqueline Latina.;Steven P Schulman.;Gary Gerstenblith.
来源: Circulation. 2020年142卷4期419-421页 587. Applicability of the MADIT-CRT Response Score for Prediction of Long-Term Clinical and Arrhythmic Events by QRS Morphology.
作者: Arwa Younis.;May Goldenberg.;Valentina Kutyifa.;Bronislava Polonsky.;Scott Mcnitt.;Wojciech Zareba.;Gregory Golovchiner.;Mehmet K Aktas.;Alon Barsheshet.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008499页 588. Repeat Atrial Fibrillation Ablation Procedures in the CIRCA-DOSE Study.
作者: Christopher C Cheung.;Marc W Deyell.;Laurent Macle.;Atul Verma.;Jean Champagne.;Peter Leong-Sit.;Paul Novak.;Mariano Badra-Verdu.;John Sapp.;Paul Khairy.;Jason G Andrade.
来源: Circ Arrhythm Electrophysiol. 2020年13卷9期e008480页 589. Markers of Myocardial Stress, Myocardial Injury, and Subclinical Inflammation and the Risk of Sudden Death.
作者: Brendan M Everett.;M V Moorthy.;Jani T Tikkanen.;Nancy R Cook.;Christine M Albert.
来源: Circulation. 2020年142卷12期1148-1158页
The majority of sudden cardiac deaths (SCDs) occur in low-risk populations often as the first manifestation of cardiovascular disease (CVD). Biomarkers are screening tools that may identify subclinical cardiovascular disease and those at elevated risk for SCD. We aimed to determine whether the total to high-density lipoprotein cholesterol ratio, high-sensitivity cardiac troponin I, NT-proBNP (N-terminal pro-B-type natriuretic peptide), or high-sensitivity C-reactive protein individually or in combination could identify individuals at higher SCD risk in large, free-living populations with and without cardiovascular disease.
590. An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia.
作者: Kevin Ng.;Erron W Titus.;Krystien V Lieve.;Thomas M Roston.;Andrea Mazzanti.;Frederick H Deiter.;Isabelle Denjoy.;Jodie Ingles.;Jan Till.;Tomas Robyns.;Sean P Connors.;Christian Steinberg.;Dominic J Abrams.;Benjamin Pang.;Melvin M Scheinman.;J Martijn Bos.;Stephen A Duffett.;Christian van der Werf.;Alice Maltret.;Martin S Green.;Julie Rutberg.;Seshadri Balaji.;Julia Cadrin-Tourigny.;Kate M Orland.;Linda M Knight.;Caitlin Brateng.;Jeremy Wu.;Anthony S Tang.;Allan C Skanes.;Jaimie Manlucu.;Jeff S Healey.;Craig T January.;Andrew D Krahn.;Kathryn K Collins.;Kathleen R Maginot.;Peter Fischbach.;Susan P Etheridge.;Lee L Eckhardt.;Robert M Hamilton.;Michael J Ackerman.;Ferran Rosés I Noguer.;Christopher Semsarian.;Natalia Jura.;Antoine Leenhardt.;Michael H Gollob.;Silvia G Priori.;Shubhayan Sanatani.;Arthur A M Wilde.;Rahul C Deo.;Jason D Roberts.
来源: Circulation. 2020年142卷10期932-947页
Genetic variants in calsequestrin-2 (CASQ2) cause an autosomal recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated reports have identified arrhythmic phenotypes among heterozygotes. Improved insight into the inheritance patterns, arrhythmic risks, and molecular mechanisms of CASQ2-CPVT was sought through an international multicenter collaboration.
591. Independent and Opposing Associations of Habitual Exercise and Chronic PM2.5 Exposures on Hypertension Incidence.
作者: Cui Guo.;Yiqian Zeng.;Ly-Yun Chang.;Zengli Yu.;Yacong Bo.;Changqing Lin.;Alexis Kh Lau.;Tony Tam.;Xiang Qian Lao.
来源: Circulation. 2020年142卷7期645-656页
We investigated the joint associations of habitual physical activity (PA) and long-term exposure to fine particulate matter (PM2.5) with the development of hypertension in a longitudinal cohort in Taiwan.
592. Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement: An Analysis of the PARTNER 2 Trial and Registry.
作者: Erwan Salaun.;Marie-Annick Clavel.;Rebecca T Hahn.;Wael A Jaber.;Federico M Asch.;Leonardo Rodriguez.;Neil J Weissman.;Zachary M Gertz.;Howard C Herrmann.;Abdellaziz Dahou.;Mohamed-Salah Annabi.;Oumhani Toubal.;Mathieu Bernier.;Jonathan Beaudoin.;Jonathon Leipsic.;Philipp Blanke.;Carine Ridard.;Géraldine Ong.;Josep Rodés-Cabau.;John G Webb.;Yiran Zhang.;Maria C Alu.;Pamela S Douglas.;Raj Makkar.;D Craig Miller.;Brian R Lindman.;Vinod H Thourani.;Martin B Leon.;Philippe Pibarot.
来源: Circ Cardiovasc Interv. 2020年13卷7期e008792页
Although aortic valve replacement is associated with a major benefit in high-gradient (HG) severe aortic stenosis (AS), the results in low-gradient (LG, mean gradient <40 mm Hg) AS are conflicting. LG severe AS may be subdivided in classical low-flow (left ventricular ejection fraction <50%) and LG (CLF-LG); paradoxical low-flow (left ventricular ejection fraction ≥50% but stroke volume index <35 mL/m2) and LG; and normal-flow (left ventricular ejection fraction ≥50% and stroke volume index ≥35 mL/m2) and LG. The primary objective is to determine in the PARTNER 2 trial (The Placement of Aortic Transcatheter Valves) and registry the outcomes after aortic valve replacement of the 4 flow-gradient groups.
593. Reduced Rivaroxaban Dose Versus Dual Antiplatelet Therapy After Left Atrial Appendage Closure: ADRIFT a Randomized Pilot Study.
作者: Guillaume Duthoit.;Johanne Silvain.;Eloi Marijon.;Grégory Ducrocq.;Antoine Lepillier.;Corinne Frere.;Solohaja-Faniaha Dimby.;Batric Popovic.;Nicolas Lellouche.;Isabelle Martin-Toutain.;Christian Spaulding.;Eric Brochet.;David Attias.;Jacques Mansourati.;Luc Lorgis.;Didier Klug.;Noura Zannad.;Marie Hauguel-Moreau.;Nassim Braik.;Sandrine Deltour.;Alexandre Ceccaldi.;Hui Wang.;Nadjib Hammoudi.;Delphine Brugier.;Eric Vicaut.;Jean-Michel Juliard.;Gilles Montalescot.
来源: Circ Cardiovasc Interv. 2020年13卷7期e008481页
Percutaneous left atrial appendage closure (LAAC) exposes to the risk of device thrombosis in patients with atrial fibrillation who frequently have a contraindication to full anticoagulation. Thereby, dual antiplatelet therapy (DAPT) is usually preferred. No randomized study has evaluated nonvitamin K antagonist oral anticoagulant after LAAC, and we decided to evaluate the efficacy and safety of reduced doses of rivaroxaban after LAAC.
594. Dapagliflozin and Diuretic Use in Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF.
作者: Alice M Jackson.;Pooja Dewan.;Inder S Anand.;Jan Bělohlávek.;Olof Bengtsson.;Rudolf A de Boer.;Michael Böhm.;David W Boulton.;Vijay K Chopra.;David L DeMets.;Kieran F Docherty.;Andrej Dukát.;Peter J Greasley.;Jonathan G Howlett.;Silvio E Inzucchi.;Tzvetana Katova.;Lars Køber.;Mikhail N Kosiborod.;Anna Maria Langkilde.;Daniel Lindholm.;Charlotta E A Ljungman.;Felipe A Martinez.;Eileen O'Meara.;Marc S Sabatine.;Mikaela Sjöstrand.;Scott D Solomon.;Sergey Tereshchenko.;Subodh Verma.;Pardeep S Jhund.;John J V McMurray.
来源: Circulation. 2020年142卷11期1040-1054页
In the DAPA-HF trial (Dapagliflozin and Prevention of Adverse-Outcomes in Heart Failure), the sodium-glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of worsening heart failure and death in patients with heart failure and reduced ejection fraction. We examined the efficacy and tolerability of dapagliflozin in relation to background diuretic treatment and change in diuretic therapy after randomization to dapagliflozin or placebo.
595. Efficacy of an Adjunctive Electrophysiological Test-Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a Left Atrial Low-Voltage Area.
作者: Hirosuke Yamaji.;Shunichi Higashiya.;Takashi Murakami.;Kazuyoshi Hina.;Hiroshi Kawamura.;Masaaki Murakami.;Shigeshi Kamikawa.;Satoshi Hirohata.;Shozo Kusachi.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008191页
Electrical remodeling precedes structural remodeling. In adjunctive left atrial (LA) low-voltage area (LVA) ablation to pulmonary vein isolation of atrial fibrillation (AF), LA areas without LVA have not been targeted for ablation. We studied the effect of adjunctive LA posterior wall isolation (PWI) on persistent AF without LA-LVA according to electrophysiological testing (EP test).
596. Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial.
作者: Domenico Corradi.;Jeffrey E Saffitz.;Deborah Novelli.;Angeliki Asimaki.;Caterina Simon.;Emanuela Oldoni.;Serge Masson.;Jennifer M T A Meessen.;Rodolfo Monaco.;Roberta Manuguerra.;Roberto Latini.;Peter Libby.;Luigi Tavazzi.;Roberto Marchioli.;Luca Dozza.;Laura Cavallotti.;Aneta Aleksova.;Renato Gregorini.;Dariush Mozaffarian.
来源: Circ Arrhythm Electrophysiol. 2020年13卷8期e008382页
Postoperative atrial fibrillation (POAF) occurs in 30% to 50% of patients undergoing cardiac surgery and is associated with increased morbidity and mortality. Prospective identification of structural/molecular changes in atrial myocardium that correlate with myocardial injury and precede and predict risk of POAF may identify new molecular pathways and targets for prevention of this common morbid complication.
597. Incidence and Factors Associated With Major Amputation in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.
作者: Chandler A Long.;Hillary Mulder.;F Gerry R Fowkes.;Iris Baumgartner.;Jeffrey S Berger.;Brian G Katona.;Kenneth W Mahaffey.;Lars Norgren.;Juuso I Blomster.;Frank W Rockhold.;William R Hiatt.;Manesh R Patel.;W Schuyler Jones.;Mark R Nehler.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷7期e006399页
Peripheral artery disease (PAD) is associated with increased risk of mortality, cardiovascular morbidity, and major amputation. Data on major amputation from a large randomized trial that included a substantial cohort of patients without critical limb ischemia (CLI) have not been described. The objective was to describe the incidence and types of amputations in the EUCLID trial (Examining Use of Ticagrelor in Peripheral Artery Disease) population, subcategorize amputations in the CLI versus no CLI cohorts, and describe the events surrounding major amputation.
598. Cardiac Resynchronization Therapy and Risk of Recurrent Hospitalizations in Patients Without Left Bundle Branch Block: The Long-Term Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy.
作者: Himabindu Vidula.;Elizabeth Lee.;Scott McNitt.;Bronislava Polonsky.;Mehmet Aktas.;Spencer Rosero.;Arwa Younis.;Scott D Solomon.;Wojciech Zareba.;Valentina Kutyifa.;Ilan Goldenberg.
来源: Circ Heart Fail. 2020年13卷7期e006925页
Mild heart failure (HF) patients without left bundle branch block (LBBB) did not derive a significant reduction in risk of a HF event/death in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy). However, the efficacy of CRT with a defibrillator (CRT-D) may be modified after the development of the first hospitalization for HF (HHF). We aimed to study the effect of CRT-D on long-term risk of recurrent HHF in patients without LBBB in MADIT-CRT.
599. Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin.
作者: Pierre Amarenco.;Cristina Hobeanu.;Julien Labreuche.;Hugo Charles.;Maurice Giroud.;Elena Meseguer.;Philippa C Lavallée.;Philippe Gabriel Steg.;Éric Vicaut.;Eric Bruckert.;Pierre-Jean Touboul.
来源: Circulation. 2020年142卷8期748-757页
The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known.
600. Canakinumab After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation: A Pilot Randomized Trial.
作者: Philipp Krisai.;Steffen Blum.;Renate B Schnabel.;Christian Sticherling.;Michael Kühne.;Stefanie von Felten.;Peter Ammann.;Etienne Pruvot.;Christine M Albert.;David Conen.
来源: Circ Arrhythm Electrophysiol. 2020年13卷7期e008197页 |