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41. Development of patient-initiated follow-up resources for UK rheumatology departments: a co-design study with patient and clinician collaboration.
作者: Alice E Jennings.;Ailsa Bosworth.;Mel Brooke.;Joe Eddison.;James Galloway.;Mark G Perry.;Helen Lall.;Rob Law.;Laura C Coates.;Emma Dures.
来源: Lancet Rheumatol. 2026年8卷4期e265-e273页
Patient-initiated follow-up (PIFU) is designed to give patients more control over their follow-up care in rheumatology and relies on patients coming forward to schedule appointments and understand how and when to contact their rheumatology team. Additionally, rheumatology teams need to establish suitable criteria and have systems in place to support PIFU. Resources to inform patients with rheumatic disease about PIFU or to support its implementation in rheumatology clinics is scarce. The aim of this study was to co-design resources with patients and clinicians to support the implementation of PIFU across the UK.
42. Application of a novel Musculoskeletal Ultrasound Sum Score (MUSS) in the follow-up of patients with juvenile idiopathic arthritis.
The objective of this study was to evaluate the novel Musculoskeletal Ultrasound Sum Score (MUSS) as a longitudinal marker of disease activity (DA) in patients with JIA within a treat-to-target management approach.
43. Urological manifestations in familial mediterranean fever excluding renal amyloidosis: a systematic review.
作者: Aziz Kutay Ozcan.;Baris Karaoglan.;Berkay Gundogdu.;Cansu Sahin.;Muhammed Fatih Simsekoglu.;Serdal Ugurlu.
来源: Rheumatology (Oxford). 2026年
To systematically review the spectrum of urological manifestations and fertility outcomes reported in FMF patients, excluding renal amyloidosis-related involvement.
44. Soluble SIGLEC1 as a biomarker of disease activity in idiopathic inflammatory myopathies.
作者: Nathan Barreth.;Valérie Leclair.;Marie Hudson.;Sasha Bernatsky.;Eugene Krustev.;Cristina Moran Toro.;Yvan St Pierre.;Ashley Clarke.;Paul J A Sciore.;Mark Tarnopolsky.;Marvin J Fritzler.;May Y Choi.; .
来源: Rheumatology (Oxford). 2026年
To investigate soluble circulating sialic acid-binding Ig-like lectin 1 (scSIGLEC1), a surrogate biomarker for type I interferon, as a novel biomarker for idiopathic inflammatory myopathies (IIM) disease activity.
45. A treat-to-target strategy versus symptom-driven management of gout in the Netherlands (GO TEST Overture): a multicentre, open-label, pragmatic, superiority, randomised controlled trial.
作者: Anusha Moses.;Martijn A H Oude Voshaar.;Eva H van Geel.;Lydia Schipper.;Iris Rose Peeters.;Reinhard Bos.;Caroline van Durme.;Mart A F J van de Laar.;Tim L Jansen.
来源: Lancet Rheumatol. 2026年
A treat-to-target approach is recommended for gout management, which involves titrating urate-lowering therapy to reach a serum urate target of less than 0·36 mmol/L, but evidence from pragmatic, head-to-head trials comparing a treat-to-target strategy with a symptom-driven approach is scarce. We aimed to address this gap by comparing these two approaches in patients with gout.
46. Rheumatologist assessment in established polymyalgia rheumatica.
作者: Elisabeth Lindrup Nielsen.;Agnete Overgaard Donskov.;Christoffer Søvsø Våben.;Andreas Wiggers Nielsen.;Line Lier Frølund.;Ib Tønder Hansen.;Line Thorndal Moll.;Berit Dalsgaard Nielsen.;Christoffer Mørk.;Ellen-Margrethe Hauge.;Kresten Krarup Keller.
来源: Rheumatology (Oxford). 2026年65卷4期
Patients with established polymyalgia rheumatica (PMR) are often referred from general practitioners (GPs) to rheumatologists. This single-centre cohort study examined the frequency, indications and diagnostic outcomes of patients with established PMR referred to a rheumatology outpatient clinic after initial diagnosis by GPs or rheumatologists in a hospital outpatient setting.
47. Central pain sensitivity is associated with changes in fatigue in RA: data from the CAP-RA study.
作者: Vasileios Georgopoulos.;Stephanie L Smith.;David A Walsh.;Daniel F McWilliams.
来源: Rheumatology (Oxford). 2026年65卷4期
This observational study examined whether central pain sensitivity is associated with fatigue in RA and whether such associations are explained by pain severity or inflammation.
48. Sex-based differences in bDMARD initiation and persistence in spondyloarthritis: a 17-year follow-up study from the REGISPON-3 registry.
作者: Diana Maria Margareta Moldovan.;Lourdes Ladehesa-Pineda.;María Ángeles Puche-Larrubia.;María Carmen Ábalos-Aguilera.;Desirée Ruiz-Vilchez.;Raquel Ena María Granados.;Carlos M Collantes-Sánchez.;Alejandro Escudero-Contreras.; .;Eduardo Collantes-Estévez.;Clementina López-Medina.
来源: Rheumatology (Oxford). 2026年
This study examines sex differences in the initiation and retention rate of biological disease-modifying antirheumatic drugs (bDMARDs) among patients with spondyloarthritis (SpA) over a 17-year follow-up period, and identifies sex-specific predictors of these treatment outcomes.
49. Exploring sleep health and circadian rhythm disruption in Sjögren's disease: an accelerometric and self-reported cross-sectional study.
作者: Caterina Di Pede.;Alessandro Colitta.;Simone Bruno.;Paolo Frumento.;Michelangelo Maestri Tassoni.;Giovanni Fulvio.;Gaetano La Rocca.;Enrica Bonanni.;Marta Mosca.;Rosaria Talarico.;Chiara Baldini.;Ugo Faraguna.
来源: Rheumatology (Oxford). 2026年65卷4期
In a cross-sectional study, we aimed at characterizing possible impairments in sleep health and rest-activity parameters between patients with Sjögren's Disease (SjD) and healthy controls (HCs). Furthermore, we explored possible predictors of such disturbances in the SjD group.
50. Treatment satisfaction, disease severity, and health-care use in patients with axial spondyloarthritis in the United States and Europe.
作者: Elena Nikiphorou.;Alexis Ogdie.;Dan Twigg.;Emily Quiñones.;You-Li Ling.;Joseph C Cappelleri.;Lidia Sanchez-Riera.;Karim R Masri.;Megan Hughes.;Nicola Massey.
来源: Rheumatology (Oxford). 2026年65卷3期
The heterogeneous presentation of axial SpA (axSpA) complicates diagnosis and treatment decisions. This study compared patient symptoms, health-care resource utilization, and physician-patient alignment on disease severity and treatment satisfaction between the USA and five European countries (5EU).
51. Incident rheumatoid arthritis and work loss: a nationwide sibling comparison study.
作者: Heather Miller.;Gustaf Bruze.;Kari Johansson.;Johan Askling.;Martin Neovius.
来源: Rheumatology (Oxford). 2026年
Rheumatoid arthritis (RA) has been associated with substantial work loss, but advances in treatment have improved clinical outcomes for patients over time calling for an updated assessment. We therefore aimed to examine calendar trends in the association between RA diagnosis and work loss.
52. Bimekizumab safety and efficacy in patients with psoriatic arthritis: 3-year results from two phase 3 studies.
作者: Laure Gossec.;Laura C Coates.;Robert B M Landewé.;Philip J Mease.;Joseph F Merola.;Christopher T Ritchlin.;Yoshiya Tanaka.;Akihiko Asahina.;Fabian Proft.;Nadine Goldammer.;Myriam Manente.;Barbara Ink.;Rajan Bajracharya.;Jason Coarse.;Iain B McInnes.
来源: Rheumatology (Oxford). 2026年
Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, has demonstrated tolerability and clinical efficacy in patients with psoriatic arthritis (PsA). Here, we report an additional year of safety and efficacy of bimekizumab to 3 years.
53. The impact of anti-SSA/Ro antibodies on pregnancy outcomes in patients with systemic lupus erythematosus.
作者: Eriho Yamaguchi.;Hideaki Tsuji.;Atsubumi Ogawa.;Yuto Nakakubo.;Takeshi Iwasaki.;Tomohiro Kozuki.;Tsuneyasu Yoshida.;Kunihiro Ichinose.;Takahisa Onishi.;Shigeru Ohno.;Hiroshi Kajiyama.;Takashi Kida.;Ken-Ei Sada.;Shuzo Sato.;Yasuhiro Shimojima.;Ayuko Takatani.;Keisuke Nishimura.;Michio Fujiwara.;Yusuke Matsuo.;Yoshia Miyawaki.;Ryo Yanai.;Ryusuke Yoshimi.;Akira Onishi.;Akio Morinobu.
来源: Rheumatology (Oxford). 2026年
We aimed to investigate the influence of anti-SSA/Ro antibodies and other factors on adverse pregnancy outcomes (APOs) in systemic lupus erythematosus (SLE) patients.
54. Nailfold capillaroscopy improves cardiovascular risk stratification in SSc: an adjustment of the SCORE2 algorithm.
作者: Carlos Valera-Ribera.;Juan José Alegre-Sancho.;Miguel Ángel González-Gay.;Joaquín Lacasa-Molina.;Alida Taberner-Cortés.;Montserrat Robustillo-Villarino.;Javier Narváez.
来源: Rheumatology (Oxford). 2026年65卷3期
SSc is characterized by micro- and macrovascular damage, increasing cardiovascular (CV) risk. The SCORE2 algorithm underestimates CV risk in systemic autoimmune diseases. Nailfold capillaroscopy (NFC) is used to assess SSc-related microvascular damage. We aimed to evaluate whether incorporating NFC findings into SCORE2/SCORE2-OP improves CV risk stratification in SSc.
55. Segmental spinal damage predicts mobility restriction and functional decline in radiographic axial spondyloarthritis: a longitudinal study.
作者: Ismail Sari.;Seunghun Lee.;Sindhu R Johnson.;Robert D Inman.;Nigil Haroon.
来源: Rheumatology (Oxford). 2026年
To quantify the longitudinal association between radiographic spinal damage and spinal mobility and physical function in radiographic axial spondyloarthritis (r-axSpA) using discovertebral unit (DVU)-level analyses.
56. Anti CD19 targeting CAR T cell therapy in ANCA-associated vasculitis.
作者: Luisa Schneider.;Ann-Christin Pecher.;Luca Hensen.;Patrick Krumm.;Rebekka Schairer.;Kristina Reuß.;Wolfgang Bethge.;Claudia Lengerke.;Joerg Henes.
来源: Rheumatology (Oxford). 2026年65卷3期
To present a successful case study of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in a patient with relapsing granulomatosis with polyangiitis (GPA).
57. Vaccination rates in rheumatic diseases: a cross-sectional register study on the role of patient beliefs and physician engagement.
作者: Samia Mehouachi.;Denis Mongin.;Gilles Eperon.;Delphine S Courvoisier.;Kim Lauper.
来源: Rheumatology (Oxford). 2026年
To evaluate the vaccination attitude and behaviour of patients with autoimmune inflammatory rheumatic diseases (AIIRD), and identify factors associated with vaccination status, utilising data from a national register.
58. B-cell monitoring predicts infection risk in childhood systemic lupus erythematosus patients on belimumab.
作者: Jingxiao Guo.;Yanjun Yang.;Lanlan Ge.;Peitong Han.;Fujuan Liu.;Meina Yin.
来源: Rheumatology (Oxford). 2026年
Belimumab improves outcomes in childhood-onset systemic lupus erythematosus (cSLE) but raises infection risks due to B cell modulation. We aimed to evaluate dynamic B cell and immunoglobulin G (IgG) monitoring for predicting infection risk.
59. Time and patient journey to axial spondyloarthritis diagnosis: a retrospective study in French primary care.
作者: Clément Prati.;Arnaud Constantin.;Emmanuelle Dernis.;Jacques Eric Gottenberg.;Marc Rozenblat.;Elise Arnee.;Marie Ducros.;Cheikh Tamberou.;Anneleen Vyncke.;Julie Gandrup Horan.
来源: Rheumatology (Oxford). 2026年65卷3期
Axial spondyloarthritis (axSpA) diagnoses are often delayed, which is associated with poorer patient outcomes. To improve understanding of diagnostic delay in France, we describe the time and patient journey to axSpA diagnosis in primary care.
60. miR-23b-3p deficiency exacerbates immune dysregulation in immunoglobulin A vasculitis by enhancing TLR4-mediated dendritic cell activation.
作者: Yu Shan.;Xianxian Jia.;Yanan Ma.;Gang Luo.;Jingyi Qiao.;Zhenshi Li.;Seunghyun Lee.;Jieqing Zhou.;Liang Zhang.;Xiaoxue Ma.
来源: Rheumatology (Oxford). 2026年
MicroRNAs (miRNAs) play critical roles in regulating immune cell differentiation and maintaining innate and adaptive immune homeostasis. The aim of this study was to determine the mechanisms by which miR-23b-3p modulates crosstalk between innate and adaptive immunity in immunoglobulin A (IgA) vasculitis (IgAV) and to evaluate its therapeutic potential.
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