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41. Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis.
作者: Lotte Boxhoorn.;Robert C Verdonk.;Marc G Besselink.;Marja Boermeester.;Thomas L Bollen.;Stefan Aw Bouwense.;Vincent C Cappendijk.;Wouter L Curvers.;Cornelis H Dejong.;Sven M van Dijk.;Hendrik M van Dullemen.;Casper Hj van Eijck.;Erwin Jm van Geenen.;Muhammed Hadithi.;Wouter L Hazen.;Pieter Honkoop.;Jeanin E van Hooft.;Maarten Ajm Jacobs.;June Ec Kievits.;Marnix Pm Kop.;Eva Kouw.;Sjoerd D Kuiken.;Michiel Ledeboer.;Vincent B Nieuwenhuijs.;Lars E Perk.;Jan-Werner Poley.;Rutger Quispel.;Rogier Jj de Ridder.;Hjalmar C van Santvoort.;Christina J Sperna Weiland.;Martijn Wj Stommel.;Hester C Timmerhuis.;Ben J Witteman.;Devica S Umans.;Niels G Venneman.;Frank P Vleggaar.;Roy Lj van Wanrooij.;Marco J Bruno.;Paul Fockens.;Rogier P Voermans.; .
来源: Gut. 2023年72卷1期66-72页
Lumen-apposing metal stents (LAMS) are believed to clinically improve endoscopic transluminal drainage of infected necrosis when compared with double-pigtail plastic stents. However, comparative data from prospective studies are very limited.
42. Diet or medication in primary care patients with IBS: the DOMINO study - a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute.
作者: Florencia Carbone.;Karen Van den Houte.;Linde Besard.;Céline Tack.;Joris Arts.;Philip Caenepeel.;Hubert Piessevaux.;Alain Vandenberghe.;Christophe Matthys.;Jessica Biesiekierski.;Luc Capiau.;Steven Ceulemans.;Olivier Gernay.;Lydia Jones.;Sophie Maes.;Christian Peetermans.;Willem Raat.;Jeroen Stubbe.;Rudy Van Boxstael.;Olivia Vandeput.;Sophie Van Steenbergen.;Lukas Van Oudenhove.;Tim Vanuytsel.;Michael Jones.;Jan Tack.; .; .
来源: Gut. 2022年71卷11期2226-2232页
In Europe, IBS is commonly treated with musculotropic spasmolytics (eg, otilonium bromide, OB). In tertiary care, a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet provides significant improvement. Yet, dietary treatment remains to be explored in primary care. We evaluated the effect of a smartphone FODMAP-lowering diet application versus OB on symptoms in primary care IBS.
43. Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial.
作者: Jan Martinek.;Rastislav Hustak.;Jan Mares.;Zuzana Vackova.;Julius Spicak.;Eva Kieslichova.;Marie Buncova.;Daniel Pohl.;Sunil Amin.;Jan Tack.
来源: Gut. 2022年71卷11期2170-2178页
Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients with gastroparesis.
44. Over-the-scope-clips versus standard treatment in high-risk patients with acute non-variceal upper gastrointestinal bleeding: a randomised controlled trial (STING-2).
作者: Benjamin Meier.;Andreas Wannhoff.;Ulrike Denzer.;Petros Stathopoulos.;Brigitte Schumacher.;David Albers.;Albrecht Hoffmeister.;Jürgen Feisthammel.;Benjamin Walter.;Alexander Meining.;Edris Wedi.;Markus Zachäus.;Tilman Pickartz.;Armin Küllmer.;Arthur Schmidt.;Karel Caca.
来源: Gut. 2022年71卷7期1251-1258页
Acute non-variceal upper gastrointestinal bleeding (NVUGIB) is managed by standard endoscopic combination therapy, but a few cases remain difficult and carry a high risk of persistent or recurrent bleeding. The aim of our study was to compare first-line over-the-scope-clips (OTSC) therapy with standard endoscopic treatment in these selected patients.
45. Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial.
作者: Christina M Brennan.;Sandeep Nadella.;Xiang Zhao.;Richard J Dima.;Nicole Jordan-Martin.;Breanna R Demestichas.;Sam O Kleeman.;Miriam Ferrer.;Eva Carlotta von Gablenz.;Nicholas Mourikis.;Michael E Rubin.;Harsha Adnani.;Hassal Lee.;Taehoon Ha.;Soma Prum.;Cheryl B Schleicher.;Sharon S Fox.;Michael G Ryan.;Christina Pili.;Gary Goldberg.;James M Crawford.;Sara Goodwin.;Xiaoyue Zhang.;Jonathan B Preall.;Ana S H Costa.;Joseph Conigliaro.;Joseph R Masci.;Jie Yang.;David A Tuveson.;Kevin J Tracey.;Tobias Janowitz.
来源: Gut. 2022年71卷5期879-888页
We assessed whether famotidine improved inflammation and symptomatic recovery in outpatients with mild to moderate COVID-19.
46. Influence of timing of maternal antibiotic administration during caesarean section on infant microbial colonisation: a randomised controlled trial.
作者: Thomas Dierikx.;Daniel Berkhout.;Anat Eck.;Sebastian Tims.;Johan van Limbergen.;Douwe Visser.;Marjon de Boer.;Nanne de Boer.;Daan Touw.;Marc Benninga.;Nine Schierbeek.;Laura Visser.;Jan Knol.;Guus Roeselers.;Johanna de Vries.;Tim de Meij.
来源: Gut. 2022年71卷9期1803-1811页
Revised guidelines for caesarean section (CS) advise maternal antibiotic administration prior to skin incision instead of after umbilical cord clamping, unintentionally exposing the infant to antibiotics antenatally. We aimed to investigate if timing of intrapartum antibiotics contributes to the impairment of microbiota colonisation in CS born infants.
47. Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study.
作者: Annefleur Koopen.;Julia Witjes.;Koen Wortelboer.;Soumia Majait.;Andrei Prodan.;Evgeni Levin.;Hilde Herrema.;Maaike Winkelmeijer.;Steven Aalvink.;Jacques J G H M Bergman.;Stephan Havik.;Bolette Hartmann.;Han Levels.;Per-Olof Bergh.;Jamie van Son.;Manon Balvers.;Diogo Mendes Bastos.;Erik Stroes.;Albert K Groen.;Marcus Henricsson.;Ellis Marleen Kemper.;Jens Holst.;Christopher M Strauch.;Stanley L Hazen.;Fredrik Bäckhed.;Willem M De Vos.;Max Nieuwdorp.;Elena Rampanelli.
来源: Gut. 2022年71卷8期1577-1587页
Although gut dysbiosis is increasingly recognised as a pathophysiological component of metabolic syndrome (MetS), the role and mode of action of specific gut microbes in metabolic health remain elusive. Previously, we identified the commensal butyrogenic Anaerobutyricum soehngenii to be associated with improved insulin sensitivity in subjects with MetS. In this proof-of-concept study, we investigated the potential therapeutic effects of A. soehngenii L2-7 on systemic metabolic responses and duodenal transcriptome profiles in individuals with MetS.
48. Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome.
作者: Christian Bojarski.;Paul Tangermann.;Christian Barmeyer.;Juliane Buchkremer.;Ralf Kiesslich.;Mark Ellrichmann.;Stefan Schreiber.;Carsten Schmidt.;Andreas Stallmach.;Robert Roehle.;Christoph Loddenkemper.;Severin Daum.;Britta Siegmund.;Michael Schumann.;Reiner Ullrich.
来源: Gut. 2022年71卷8期1567-1576页
A considerable proportion of patients with irritable bowel syndrome (IBS) may be wheat-sensitive and respond to a gluten-free diet (GFD) although they do not have coeliac disease. However, a diagnostic test for wheat sensitivity (WS) is missing. Our study evaluated the diagnostic accuracy (sensitivity and specificity) of confocal laser endomicroscopy (CLE) for the identification of WS as primary outcome.
49. Psyllium reduces inulin-induced colonic gas production in IBS: MRI and in vitro fermentation studies.
作者: David Gunn.;Zainab Abbas.;Hannah C Harris.;Giles Major.;Caroline Hoad.;Penny Gowland.;Luca Marciani.;Samantha K Gill.;Fred J Warren.;Megan Rossi.;Jose Maria Remes-Troche.;Kevin Whelan.;Robin C Spiller.
来源: Gut. 2022年71卷5期919-927页
Health-promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with IBS, limiting their intake. Our aim was to test if coadministering psyllium with inulin would reduce gas production.
50. Artificial intelligence and colonoscopy experience: lessons from two randomised trials.
作者: Alessandro Repici.;Marco Spadaccini.;Giulio Antonelli.;Loredana Correale.;Roberta Maselli.;Piera Alessia Galtieri.;Gaia Pellegatta.;Antonio Capogreco.;Sebastian Manuel Milluzzo.;Gianluca Lollo.;Dhanai Di Paolo.;Matteo Badalamenti.;Elisa Ferrara.;Alessandro Fugazza.;Silvia Carrara.;Andrea Anderloni.;Emanuele Rondonotti.;Arnaldo Amato.;Andrea De Gottardi.;Cristiano Spada.;Franco Radaelli.;Victor Savevski.;Michael B Wallace.;Prateek Sharma.;Thomas Rösch.;Cesare Hassan.
来源: Gut. 2022年71卷4期757-765页
Artificial intelligence has been shown to increase adenoma detection rate (ADR) as the main surrogate outcome parameter of colonoscopy quality. To which extent this effect may be related to physician experience is not known. We performed a randomised trial with colonoscopists in their qualification period (AID-2) and compared these data with a previously published randomised trial in expert endoscopists (AID-1).
51. Linked Colour imaging for the detection of polyps in patients with Lynch syndrome: a multicentre, parallel randomised controlled trial.
作者: Britt B S L Houwen.;Yark Hazewinkel.;María Pellisé.;Liseth Rivero-Sánchez.;Francesc Balaguer.;Raf Bisschops.;Sabine Tejpar.;Alessandro Repici.;D Ramsoekh.;Maarten A J M Jacobs.;Ramon-Michel M Schreuder.;Michal Filip Kaminski.;Maria Rupinska.;Pradeep Bhandari.;Martijn G H van Oijen.;Lianne Koens.;Barbara A J Bastiaansen.;Kristien M Tytgat.;Paul Fockens.;Jasper L A Vleugels.;E Dekker.
来源: Gut. 2022年71卷3期553-560页
Despite regular colonoscopy surveillance, colorectal cancers still occur in patients with Lynch syndrome. Thus, detection of all relevant precancerous lesions remains very important. The present study investigates Linked Colour imaging (LCI), an image-enhancing technique, as compared with high-definition white light endoscopy (HD-WLE) for the detection of polyps in this patient group.
52. Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells.
作者: Madusha Peiris.;Rubina Aktar.;David Reed.;Vincent Cibert-Goton.;Ausra Zdanaviciene.;Writaja Halder.;Adam Robinow.;Simon Corke.;Harween Dogra.;Charles H Knowles.;Ashley Blackshaw.
来源: Gut. 2022年71卷5期928-937页
Colonic enteroendocrine cells (EECs) store and release potent anorectic hormones that are key regulators of satiety. EECs express multiple nutrient sensing receptors, particularly for medium-chain fatty acids (MCFAs): GPR84 and FFAR4. Here we show a non-surgical approach with targeted colonic delivery of MCFA, which induces EEC and neuronal activation leading to anorectic effects.
53. Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial.
作者: Raghav Sundar.;Nesaretnam Barr Kumarakulasinghe.;Yiong Huak Chan.;Kazuhiro Yoshida.;Takaki Yoshikawa.;Yohei Miyagi.;Yasushi Rino.;Munetaka Masuda.;Jia Guan.;Junichi Sakamoto.;Shiro Tanaka.;Angie Lay-Keng Tan.;Michal Marek Hoppe.;Anand D Jeyasekharan.;Cedric Chuan Young Ng.;Mark De Simone.;Heike I Grabsch.;Jeeyun Lee.;Takashi Oshima.;Akira Tsuburaya.;Patrick Tan.
来源: Gut. 2022年71卷4期676-685页
To date, there are no predictive biomarkers to guide selection of patients with gastric cancer (GC) who benefit from paclitaxel. Stomach cancer Adjuvant Multi-Institutional group Trial (SAMIT) was a 2×2 factorial randomised phase III study in which patients with GC were randomised to Pac-S-1 (paclitaxel +S-1), Pac-UFT (paclitaxel +UFT), S-1 alone or UFT alone after curative surgery.
54. Endoscopic full-thickness plication for the treatment of PPI-dependent GERD: results from a randomised, sham controlled trial.
作者: Rakesh Kalapala.;Arun Karyampudi.;Zaheer Nabi.;Santosh Darisetty.;Nitin Jagtap.;Mohan Ramchandani.;Rajesh Gupta.;Sundeep Lakhtakia.;Rajesh Goud.;G Venkat Rao.;Prateek Sharma.;D Nageshwar Reddy.
来源: Gut. 2022年71卷4期686-694页
The majority of endoscopic antireflux procedures for GERD are cumbersome to use and randomised long-term data are sparse. We conducted such a trial to determine the efficacy and safety of a novel, easy to use endoscopic full-thickness fundoplication (EFTP) device in patients with GERD.
55. Long-term safety of infants from mothers with chronic hepatitis B treated with tenofovir disoproxil in China.
作者: Calvin Q Pan.;Erhei Dai.;Zhongping Duan.;Guorong Han.;Wenjing Zhao.;Yuming Wang.;Huaihong Zhang.;Baoshen Zhu.;Hongxiu Jiang.;Shuqin Zhang.;Xiaohu Zhang.;Huaibin Zou.;Xiuli Chen.;Yu Chen.
来源: Gut. 2022年71卷4期798-806页
The physical and neuromental development of infants remains uncertain after fetal exposure to tenofovir disoproxil fumarate (TDF) for the prevention of mother-to-child transmission of HBV. We aimed to investigate the safety of TDF therapy during the third trimester of pregnancy.
56. Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.
作者: Siew C Ng.;Zhilu Xu.;Joyce Wing Yan Mak.;Keli Yang.;Qin Liu.;Tao Zuo.;Whitney Tang.;Louis Lau.;Rashid N Lui.;Sunny H Wong.;Yee Kit Tse.;Amy Y L Li.;Kitty Cheung.;Jessica Y L Ching.;Vincent W S Wong.;Alice P S Kong.;Ronald C W Ma.;Elaine Y K Chow.;Simon K H Wong.;Ivan Chak Hang Ho.;Paul K S Chan.;Francis K L Chan.
来源: Gut. 2022年71卷4期716-723页
The impact of faecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome is uncertain. We aimed to study whether combining FMT with lifestyle modification could enhance the engraftment of favourable microbiota in obese patients with type 2 diabetes mellitus (T2DM).
57. Radiology-guided percutaneous approach is superior to EUS for performing liver biopsies.
作者: Ji Young Bang.;Thomas J Ward.;Shady Guirguis.;Konrad Krall.;Francisco Contreras.;Nirag Jhala.;Udayakumar Navaneethan.;Robert H Hawes.;Shyam Varadarajulu.
来源: Gut. 2021年70卷12期2224-2226页 58. Endoscopic radiofrequency ablation or surveillance in patients with Barrett's oesophagus with confirmed low-grade dysplasia: a multicentre randomised trial.
作者: Maximilien Barret.;Mathieu Pioche.;Benoit Terris.;Thierry Ponchon.;Franck Cholet.;Frank Zerbib.;Edouard Chabrun.;Marc Le Rhun.;Emmanuel Coron.;Marc Giovannini.;Fabrice Caillol.;René Laugier.;Jeremie Jacques.;Romain Legros.;Christian Boustiere.;Gabriel Rahmi.;Elodie Metivier-Cesbron.;Geoffroy Vanbiervliet.;Paul Bauret.;Jean Escourrou.;Julien Branche.;Lea Jilet.;Hendy Abdoul.;Nadira Kaddour.;Sarah Leblanc.;Michael Bensoussan.;Frederic Prat.;Stanislas Chaussade.
来源: Gut. 2021年70卷6期1014-1022页
Due to an annual progression rate of Barrett's oesophagus (BO) with low-grade dysplasia (LGD) between 9% and 13% per year endoscopic ablation therapy is preferred to surveillance. Since this recommendation is based on only one randomised trial, we aimed at checking these results by another multicentre randomised trial with a similar design.
59. Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial.
作者: Geltrude Mingrone.;Annieke Cg van Baar.;Jacques Devière.;David Hopkins.;Eduardo Moura.;Cintia Cercato.;Harith Rajagopalan.;Juan Carlos Lopez-Talavera.;Kelly White.;Vijeta Bhambhani.;Guido Costamagna.;Rehan Haidry.;Eduardo Grecco.;Manoel Galvao Neto.;Guruprasad Aithal.;Alessandro Repici.;Bu'Hussain Hayee.;Amyn Haji.;A John Morris.;Raf Bisschops.;Manil D Chouhan.;Naomi S Sakai.;Deepak L Bhatt.;Arun J Sanyal.;J J G H M Bergman.; .
来源: Gut. 2022年71卷2期254-264页
Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR (catheter and system)), on glycaemic control and liver fat content in type 2 diabetes (T2D).
60. Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial.
作者: Anat Yaskolka Meir.;Ehud Rinott.;Gal Tsaban.;Hila Zelicha.;Alon Kaplan.;Philip Rosen.;Ilan Shelef.;Ilan Youngster.;Aryeh Shalev.;Matthias Blüher.;Uta Ceglarek.;Michael Stumvoll.;Kieran Tuohy.;Camilla Diotallevi.;Urska Vrhovsek.;Frank Hu.;Meir Stampfer.;Iris Shai.
来源: Gut. 2021年70卷11期2085-2095页
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss.
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