Advanced cervical cancer (aCC) is associated with a poor prognosis for patients. While immune checkpoint inhibitors (ICIs) have demonstrated potential therapeutic benefits, their effectiveness can be hindered by inherent resistance mechanisms and the onset of immune-related adverse events (irAEs). The strategy of combining ICIs with anti-angiogenic agents has gained traction as a potentially effective treatment approach. Nonetheless, there is a notable absence of robust, systematic evidence to confirm the efficacy and safety of this combination specifically for aCC patients.

Menin inhibitors (MI) are promising targeted therapies for acute myeloid leukemia (AML), particularly in NPM1-mutated and KMT2A-rearranged disease. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of MI-based therapy in adults with relapsed/refractory AML. A search of six databases through January 2026 identified 14 studies including 784 treated patients. Among response-evaluable cohorts (k = 22; n = 579), the pooled overall response rate (ORR) was 54.6% (95% CI 46.4-62.6; I2=63.5%). The pooled complete response (CR) rate was 29.3%, and CR+CRh was 28.5%. Combination therapy with MI plus hypomethylating agent and venetoclax produced higher CR (43.3% vs 19.5%; p = 0.002) and CR+CRh rates (48.6% vs 25.8%; p = 0.007) than monotherapy. Common adverse events included LFT elevation (38.7%), febrile neutropenia (33.6%), and diarrhea (28.8%). Differentiation syndrome occurred in 14.6%, and treatment-related mortality in 5.0%. MI-based therapy demonstrates meaningful activity in heavily pretreated AML, with deeper responses observed using combination strategies.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment with significant improvements in survival rates. With the increase in ICI use in the clinical setting, several case reports and series have described neurological adverse events associated with it. We conducted this systematic review and meta-analysis to estimate the incidence of neurological adverse events among ICI clinical trials.

BCMA- or GPRC5D-directed CD3 bispecific antibodies are important T-cell-redirecting therapies for relapsed/refractory multiple myeloma (RRMM). We evaluated their efficacy, safety, and certainty of evidence.

For patients with advanced non-small cell lung cancer (NSCLC) and programmed cell death 1 ligand 1 (PD-L1) expression of 50% or higher, programmed cell death 1 protein or PD-L1 (PD-[L]1) inhibitor monotherapy is commonly used as first-line therapy; however, whether adding chemotherapy improves outcomes in this population remains unknown.

Immune-related adverse events disrupt immune checkpoint inhibitor therapy and impact quality of life. Peripheral edema is common among patients with cancer, however the causality of peripheral edema can be unclear in the context of multidrug regimens.

The incidences and specific risk factors for cardiovascular adverse events (CVAEs) during osimertinib treatment remain uncertain.

The anti-CD38 monoclonal antibodies Daratumumab and Isatuximab are both approved for use in patients with newly diagnosed multiple myeloma (NDMM) in both the transplant-eligible and transplant-ineligible setting. However, the degree to which high-risk patients in particular benefit from the addition of an anti-CD38 monoclonal antibody to NDMM regimens is not clear. In this meta-analysis we analyzed data from a total of 9 prospective clinical trials (MAIA, ALCYONE, CEPHEUS, IMROZ, OCTANS, CASSIOPEIA, GRIFFIN, PERSEUS, and GMMG-HD7) to evaluate benefit of CD38 antibodies in both standard and high-risk patients. Frontline receipt of an anti-CD38 monoclonal antibody was associated with improved PFS both in patients with standard-risk NDMM (HR 0.51; 95% CI, 0.46-0.58) and high-risk NDMM (HR 0.64, 95% CI, 0.49-0.84). Subgroups of patients with standard-risk disease derived similar benefit from frontline anti-CD38 monoclonal antibody use, whether in a nontransplant study (HR 0.49, 95% CI, 0.43-0.57) or transplant study (HR 0.52, 95% CI, 0.40-0.67). Subgroups of patients with high-risk disease also benefitted, although somewhat more for those treated on transplant studies (HR 0.57, 95% CI, 0.35-0.94) than those treated on nontransplant studies (HR 0.71, 95% CI, 0.53-0.97). Patients with high-risk NDMM and standard-risk NDMM treated on frontline myeloma trials experienced improved PFS with anti-CD38 monoclonal antibody-based regimens, although the effect was less pronounced in high-risk patients treated on nontransplant studies.

This systematic review and meta-analysis consolidates findings from recent randomized controlled trials (RCTs) on the efficacy of first-line immune checkpoint inhibitor plus tyrosine kinase inhibitor (ICI-TKI) combination therapy for metastatic renal cell carcinoma (mRCC). We also explored prognostic biomarkers and clinical factors to inform treatment strategies.

Immune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens-and their consistency across etiologic subgroups [HBV, HCV, and non-HBV/non-HCV (NBNC)]-remain uncertain. This study conducted a Bayesian network meta-analysis (NMA) of recent randomized controlled trials (RCTs) to compare the first-line immunotherapy strategies both overall and by viral etiology.

This systematic review and meta-analysis evaluated the literature-pooled risk of retinal detachment (RD) following intravitreal injection (IVI) of anti-vascular endothelial growth factor (anti-VEGF) agents.

Diabetic retinopathy (DR) and diabetic macular edema (DME) are major causes of vision impairment. The ranibizumab port delivery system (PDS; Susvimo) enables sustained intraocular anti-vascular endothelial growth factor delivery and is designed to reduce treatment burden compared with frequent intravitreal injections.

Loss of skeletal muscle mass (SMM) is common during systemic cancer treatment, but the magnitude and variability across cancer and treatment types remain uncertain. We aimed to describe changes in SMM during systemic cancer treatment supported by pooled quantitative estimates.

Although immune checkpoint inhibitors combined with chemotherapy improve survival in advanced gastric cancer (AGC), comparative evidence across first-line regimens remains insufficient. This study aimed to systematically evaluate their relative efficacy and safety.

Oral mucositis (OM) is a serious complication of antineoplastic therapy and its clinical presentation can range from small erythematous lesions to large, debilitating ulcerative areas. This adverse effect results from the non-specificity of chemotherapeutic agents. This study aims to determine whether corticosteroid protocols reduce the incidence or severity of OM during antineoplastic treatment.

Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for metastatic colorectal cancer (mCRC) exhibiting DNA mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). However, the comparative efficacy and safety of monotherapy versus dual immunotherapy remain inadequately quantified. This meta-analysis aims to evaluate the benefits and risks of these strategies by quantitatively synthesizing data from randomized controlled trials (RCTs) to inform clinical decision-making.

Immune checkpoint inhibitors (ICIs) have advanced the treatment for triple-negative breast cancer (TNBC), but evidence in older adults remains limited. This study assessed the efficacy and safety of ICIs in elderly patients through a systematic review and meta-analysis of randomized clinical trials METHODS: A systematic search identified trials evaluating ICIs in TNBC. Data from nine studies were pooled using random-effects models. Subgroup analyses examined progression-free survival (PFS) and overall survival (OS) in PD-L1-positive tumors and adults aged ≥65 years.

Triple-negative breast cancer (TNBC), an aggressive subtype lacking oestrogen and progesterone receptors and amplification of HER2 receptors, accounts for 12% to 17% of breast cancers. Adjuvant and neoadjuvant chemotherapy improve survival; however, 30% to 40% of early-stage TNBC cases progress to metastatic disease. Recent evidence suggests that combining immune checkpoint inhibitors (PD-1/PD-L1 inhibitors) with chemotherapy may improve pathological complete response and event-free survival.

Neoadjuvant therapy (NAT) is standard treatment for triple-negative breast cancer (TNBC) but toxicity is a major concern. This study aimed to assess the incidence and risk of grade ≥ 3 adverse events (AEs) associated with NAT in nonmetastatic TNBC. We performed a systematic review and meta-analysis registered in PROSPERO (CRD42024562785). Four databases were searched for randomized controlled trials (RCTs) from 2010 to 2025 reporting grade ≥ 3 AEs in TNBC. Pooled prevalence and risk ratios (RRs) were estimated using random-effects models. Six RCTs including 3316 patients were analyzed. Neutropenia was the most common severe AE, with pooled prevalence of 33.5% for ICIs, 23.7% for PARP inhibitors, and 16.0% for platinum regimens. PARP inhibitors significantly increased neutropenia (RR 1.84) and anemia (RR 2.08), while thrombocytopenia risk was also higher (RR 3.56). ICIs were associated with more febrile neutropenia (14.9%) but without a significant risk increase. ALT elevation was more frequent with platinum regimens (6.4%). Fatal AEs were rare (<1%). NAT improves outcomes in TNBC but is associated with substantial severe toxicity. PARP inhibitors carry the greatest hematologic risks, ICIs add immune-related AEs, and platinum regimens showed the lowest AE burden. Biomarker-driven patient selection and vigilant monitoring are essential to optimize safety.

The shift of cancer care to the home setting via oral anticancer therapy has introduced significant challenges to continuity of care and patient safety. Despite its promise, there remains a lack of comprehensive research that characterizes the components of pharmacist interventions and evaluates their impact on clinical outcomes and quality indicators across the continuity of care.