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41. Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population : A Randomized Controlled Trial.
作者: Shuhao Lin.;Sofia Cienfuegos.;Mark Ezpeleta.;Kelsey Gabel.;Vasiliki Pavlou.;Andrea Mulas.;Kaitie Chakos.;Mara McStay.;Jackie Wu.;Lisa Tussing-Humphreys.;Shaina J Alexandria.;Julienne Sanchez.;Terry Unterman.;Krista A Varady.
来源: Ann Intern Med. 2023年176卷7期885-895页
Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.
42. Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 × 2 Factorial Trial.
作者: Xiao-Ke Wu.;Jing-Shu Gao.;Hong-Li Ma.;Yu Wang.;Bei Zhang.;Zhao-Lan Liu.;Jian Li.;Jing Cong.;Hui-Chao Qin.;Xin-Ming Yang.;Qi Wu.;Xiao-Yong Chen.;Zong-Lin Lu.;Ya-Hong Feng.;Xue Qi.;Yan-Xiang Wang.;Lan Yu.;Ying-Mei Cui.;Chun-Mei An.;Li-Li Zhou.;Yu-Hong Hu.;Lu Li.;Yi-Juan Cao.;Ying Yan.;Li Liu.;Yu-Xiu Liu.;Zhi-Shun Liu.;Rebecca C Painter.;Ernest H Y Ng.;Jian-Ping Liu.;Ben Willem J Mol.;Chi Chiu Wang.
来源: Ann Intern Med. 2023年176卷7期922-933页
An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking.
43. Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly : A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial.
作者: Zoe K McQuilten.;Le Thi Phuong Thao.;Sant-Rayn Pasricha.;Andrew S Artz.;Michael Bailey.;Andrew T Chan.;Harvey Jay Cohen.;Jessica E Lockery.;Anne M Murray.;Mark R Nelson.;Hans G Schneider.;Rory Wolfe.;Robyn L Woods.;Erica M Wood.;John J McNeil.
来源: Ann Intern Med. 2023年176卷7期913-921页
Daily low-dose aspirin increases major bleeding; however, few studies have investigated its effect on iron deficiency and anemia.
44. Effects of Implementation of a Supervised Walking Program in Veterans Affairs Hospitals : A Stepped-Wedge, Cluster Randomized Trial.
作者: Susan N Hastings.;Karen M Stechuchak.;Ashley Choate.;Courtney Harold Van Houtven.;Kelli D Allen.;Virginia Wang.;Cathleen Colón-Emeric.;George L Jackson.;Teresa M Damush.;Cassie Meyer.;Caitlin B Kappler.;Helen Hoenig.;Nina Sperber.;Cynthia J Coffman.
来源: Ann Intern Med. 2023年176卷6期743-750页
In trials, hospital walking programs have been shown to improve functional ability after discharge, but little evidence exists about their effectiveness under routine practice conditions.
45. Effectiveness of COVID-19 Treatment With Nirmatrelvir-Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes.
作者: Kristina L Bajema.;Kristin Berry.;Elani Streja.;Nallakkandi Rajeevan.;Yuli Li.;Pradeep Mutalik.;Lei Yan.;Francesca Cunningham.;Denise M Hynes.;Mazhgan Rowneki.;Amy Bohnert.;Edward J Boyko.;Theodore J Iwashyna.;Matthew L Maciejewski.;Thomas F Osborne.;Elizabeth M Viglianti.;Mihaela Aslan.;Grant D Huang.;George N Ioannou.
来源: Ann Intern Med. 2023年176卷6期807-816页
Information about the effectiveness of oral antivirals in preventing short- and long-term COVID-19-related outcomes in the setting of Omicron variant transmission and COVID-19 vaccination is limited.
46. Association of Low-Dose Colchicine With Incidence of Knee and Hip Replacements : Exploratory Analyses From a Randomized, Controlled, Double-Blind Trial.
作者: Michelle W J Heijman.;Aernoud T L Fiolet.;Arend Mosterd.;Jan G P Tijssen.;Bart J F van den Bemt.;Astrid Schut.;John W Eikelboom.;Peter L Thompson.;Cornelia H M van den Ende.;Stefan M Nidorf.;Calin D Popa.;Jan H Cornel.
来源: Ann Intern Med. 2023年176卷6期737-742页
Osteoarthritis is a major contributor to pain and disability worldwide. Given that inflammation plays an important role in the development of osteoarthritis, anti-inflammatory drugs may slow disease progression.
47. Population-Wide Screening for Chronic Kidney Disease : A Cost-Effectiveness Analysis.
作者: Marika M Cusick.;Rebecca L Tisdale.;Glenn M Chertow.;Douglas K Owens.;Jeremy D Goldhaber-Fiebert.
来源: Ann Intern Med. 2023年176卷6期788-797页
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have the potential to alter the natural history of chronic kidney disease (CKD), and they should be included in cost-effectiveness analyses of screening for CKD.
48. Effects of Cognitive Behavioral Therapy and Cash Transfers on Older Persons Living Alone in India : A Randomized Trial.
作者: Madeline McKelway.;Abhijit Banerjee.;Erin Grela.;Frank Schilbach.;Miriam Sequeira.;Garima Sharma.;Girija Vaidyanathan.;Esther Duflo.
来源: Ann Intern Med. 2023年176卷5期632-641页
A growing number of older persons in developing countries live entirely alone and are physically, mentally, and financially vulnerable.
49. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial.
作者: Maura Marcucci.;Thomas W Painter.;David Conen.;Vladimir Lomivorotov.;Daniel I Sessler.;Matthew T V Chan.;Flavia K Borges.;Kate Leslie.;Emmanuelle Duceppe.;María José Martínez-Zapata.;Chew Yin Wang.;Denis Xavier.;Sandra N Ofori.;Michael Ke Wang.;Sergey Efremov.;Giovanni Landoni.;Ydo V Kleinlugtenbelt.;Wojciech Szczeklik.;Denis Schmartz.;Amit X Garg.;Timothy G Short.;Maria Wittmann.;Christian S Meyhoff.;Mohammed Amir.;David Torres.;Ameen Patel.;Kurt Ruetzler.;Joel L Parlow.;Vikas Tandon.;Edith Fleischmann.;Carisi A Polanczyk.;Andre Lamy.;Raja Jayaram.;Sergey V Astrakov.;William Ka Kei Wu.;Chao Chia Cheong.;Sabry Ayad.;Mikhail Kirov.;Miriam de Nadal.;Valery V Likhvantsev.;Pilar Paniagua.;Hector J Aguado.;Kamal Maheshwari.;Richard P Whitlock.;Michael H McGillion.;Jessica Vincent.;Ingrid Copland.;Kumar Balasubramanian.;Bruce M Biccard.;Sadeesh Srinathan.;Samandar Ismoilov.;Shirley Pettit.;David Stillo.;Andrea Kurz.;Emilie P Belley-Côté.;Jessica Spence.;William F McIntyre.;Shrikant I Bangdiwala.;Gordon Guyatt.;Salim Yusuf.;P J Devereaux.; .
来源: Ann Intern Med. 2023年176卷5期605-614页
Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively.
50. Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.
作者: Gilmar Reis.;Eduardo Augusto Dos Santos Moreira Silva.;Daniela Carla Medeiros Silva.;Lehana Thabane.;Vitoria Helena de Souza Campos.;Thiago Santiago Ferreira.;Castilho Vitor Quirino Dos Santos.;Ana Maria Ribeiro Nogueira.;Ana Paula Figueiredo Guimaraes Almeida.;Leonardo Cançado Monteiro Savassi.;Adhemar Dias de Figueiredo Neto.;Carina Bitarães.;Aline Cruz Milagres.;Eduardo Diniz Callegari.;Maria Izabel Campos Simplicio.;Luciene Barra Ribeiro.;Rosemary Oliveira.;Ofir Harari.;Lindsay A Wilson.;Jamie I Forrest.;Hinda Ruton.;Sheila Sprague.;Paula McKay.;Christina M Guo.;Gordon H Guyatt.;Craig R Rayner.;David R Boulware.;Nicole Ezer.;Todd C Lee.;Emily Gibson McDonald.;Mona Bafadhel.;Christopher Butler.;Josue Rodrigues Silva.;Mark Dybul.;Edward J Mills.; .
来源: Ann Intern Med. 2023年176卷5期667-675页
Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.
51. Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19.
作者: Teresa H Evering.;Kara W Chew.;Mark J Giganti.;Carlee Moser.;Mauricio Pinilla.;David Alain Wohl.;Judith S Currier.;Joseph J Eron.;Arzhang Cyrus Javan.;Rachel Bender Ignacio.;David Margolis.;Qing Zhu.;Ji Ma.;Lijie Zhong.;Li Yan.;Ulises D'Andrea Nores.;Keila Hoover.;Bharat Mocherla.;Manish C Choudhary.;Rinki Deo.;Justin Ritz.;William A Fischer.;Courtney V Fletcher.;Jonathan Z Li.;Michael D Hughes.;Davey Smith.;Eric S Daar.; .
来源: Ann Intern Med. 2023年176卷5期658-666页
Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti-SARS-CoV-2 monoclonal antibodies with an extended half-life.
52. Evolving Real-World Effectiveness of Monoclonal Antibodies for Treatment of COVID-19 : A Cohort Study.
作者: Kevin E Kip.;Erin K McCreary.;Kevin Collins.;Tami E Minnier.;Graham M Snyder.;William Garrard.;Jeffrey C McKibben.;Donald M Yealy.;Christopher W Seymour.;David T Huang.;J Ryan Bariola.;Mark Schmidhofer.;Richard J Wadas.;Derek C Angus.;Paula L Kip.;Oscar C Marroquin.
来源: Ann Intern Med. 2023年176卷4期496-504页
Treatment guidelines and U.S. Food and Drug Administration emergency use authorizations (EUAs) of monoclonal antibodies (mAbs) for treatment of high-risk outpatients with mild to moderate COVID-19 changed frequently as different SARS-CoV-2 variants emerged.
53. Facilitating Shared Decision Making Among Black Patients at Risk for Sudden Cardiac Arrest : A Randomized Clinical Trial.
作者: Kevin L Thomas.;Sana M Al-Khatib.;Andrzej S Kosinski.;Samuel F Sears.;Nancy M Allen LaPointe.;Larry R Jackson.;Daniel D Matlock.;Daniel Haithcock.;B Judson Colley.;David S Hirsh.;Eric D Peterson.
来源: Ann Intern Med. 2023年176卷5期615-623页
Racial disparities in implantable cardioverter-defibrillator (ICD) implantation are multifactorial and are partly explained by higher refusal rates.
54. Effect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
作者: Tracy Y Wang.;Abdus S Wahed.;Alison Morris.;Lisa Baumann Kreuziger.;John G Quigley.;Gervasio A Lamas.;Alexandra J Weissman.;Jose Lopez-Sendon.;M Margaret Knudson.;Deborah M Siegal.;Raj S Kasthuri.;Andrew J Alexander.;Lana Wahid.;Bassel Atassi.;Peter J Miller.;Janice W Lawson.;Bela Patel.;Jerry A Krishnan.;Nancy L Shapiro.;Deborah E Martin.;Andrei L Kindzelski.;Eric S Leifer.;Jungnam Joo.;Lingyun Lyu.;Annie Pennella.;Brendan M Everett.;Mark W Geraci.;Kevin J Anstrom.;Thomas L Ortel.; .
来源: Ann Intern Med. 2023年176卷4期515-523页
Patients hospitalized with COVID-19 have an increased incidence of thromboembolism. The role of extended thromboprophylaxis after hospital discharge is unclear.
55. Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Hospitalized Patients With COVID-19 : A Target Trial Emulation Study.
作者: Eric Yuk Fai Wan.;Vincent Ka Chun Yan.;Anna Hoi Ying Mok.;Boyuan Wang.;Wanchun Xu.;Franco Wing Tak Cheng.;Francisco Tsz Tsun Lai.;Celine Sze Ling Chui.;Xue Li.;Carlos King Ho Wong.;Philip Hei Li.;Benjamin John Cowling.;Ivan Fan Ngai Hung.;Chak Sing Lau.;Ian Chi Kei Wong.;Esther Wai Yin Chan.
来源: Ann Intern Med. 2023年176卷4期505-514页
Whether hospitalized patients benefit from COVID-19 oral antivirals is uncertain.
56. Comparison of Over-the-Scope Clips to Standard Endoscopic Treatment as the Initial Treatment in Patients With Bleeding From a Nonvariceal Upper Gastrointestinal Cause : A Randomized Controlled Trial.
作者: James Y W Lau.;Rui Li.;Chen-Huan Tan.;Xiu-Jing Sun.;Hao-Jun Song.;Lan Li.;Feng Ji.;Bu-Jiang Wang.;Dong-Tao Shi.;Wai K Leung.;Imogen Hartley.;Alan Moss.;Karina Y Y Yu.;Bing Y Suen.;Peng Li.;Francis K L Chan.
来源: Ann Intern Med. 2023年176卷4期455-462页
Current endoscopic methods in the control of acute nonvariceal bleeding have a small but clinically significant failure rate. The role of over-the-scope clips (OTSCs) as the first treatment has not been defined.
57. Cold Versus Hot Snare Polypectomy for Small Colorectal Polyps : A Pragmatic Randomized Controlled Trial.
作者: Li-Chun Chang.;Chi-Yang Chang.;Chi-Yi Chen.;Cheng-Hao Tseng.;Peng-Jen Chen.;Chia-Tung Shun.;Wen-Feng Hsu.;Yen-Nien Chen.;Chieh-Chang Chen.;Tien-Yu Huang.;Chia-Hung Tu.;Mei-Jyh Chen.;Chu-Kuang Chou.;Ching-Tai Lee.;Po-Yueh Chen.;Ming-Shiang Wu.;Han-Mo Chiu.
来源: Ann Intern Med. 2023年176卷3期311-319页
Although cold snare polypectomy (CSP) is considered effective in reducing delayed postpolypectomy bleeding risk, direct evidence supporting its safety in the general population remains lacking.
58. Implantable Defibrillator System Shock Function, Mortality, and Cause of Death After Magnetic Resonance Imaging.
作者: Joshua Ra.;Matt T Oberdier.;Masahito Suzuki.;Dhananjay Vaidya.;Yisi Liu.;Rozann Hansford.;Diana McVeigh.;Valeria Weltin.;Susumu Tao.;David R Thiemann.;Saman Nazarian.;Henry R Halperin.
来源: Ann Intern Med. 2023年176卷3期289-297页
Studies have shown that magnetic resonance imaging (MRI) does not have clinically important effects on the device parameters of non-MRI-conditional implantable cardioverter-defibrillators (ICDs). However, data on non-MRI-conditional ICD detection and treatment of arrhythmias after MRI are limited.
59. High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis : A Randomized Controlled Multicenter Trial.
作者: Tom Arild Torstensen.;Håvard Østerås.;Riccardo LoMartire.;Georg Mørtvedt Rugelbak.;Wilhelmus Johannes Andreas Grooten.;Björn Olov Äng.
来源: Ann Intern Med. 2023年176卷2期154-165页
The benefits of exercise in patients with knee osteoarthritis are well documented, but the optimal exercise dose remains unknown.
60. Effectiveness of an Intervention to Improve Decision Making for Older Patients With Advanced Chronic Kidney Disease : A Randomized Controlled Trial.
作者: Keren Ladin.;Hocine Tighiouart.;Olivia Bronzi.;Susan Koch-Weser.;John B Wong.;Sarah Levine.;Arushi Agarwal.;Lucy Ren.;Jack Degnan.;Lexi N Sewall.;Brianna Kuramitsu.;Patrick Fox.;Elisa J Gordon.;Tamara Isakova.;Dena Rifkin.;Ana Rossi.;Daniel E Weiner.
来源: Ann Intern Med. 2023年176卷1期29-38页
Older patients with advanced chronic kidney disease (CKD) face difficult decisions about managing kidney failure, frequently experiencing decisional conflict, regret, and treatment misaligned with preferences.
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