In the era of treat-to-target (T2T), there is an urgent need for surrogate non-invasive markers to monitor patients with inflammatory bowel diseases (IBD). Fecal calprotectin (FC), a non-invasive biomarker reflecting intestinal inflammation, holds potential for improving treatment monitoring. This narrative review aims to provide an overview of the role of FC in assessing responses to biological therapies and the new small molecules.

Few studies have clinically demonstrated the benefits of comprehensive nutritional management incorporating home-based dietary consultation in patients with cirrhosis. This study investigates whether such management can improve the prognosis of cirrhotic patients.

This study aimed to evaluate and compare tumor response, survival outcomes, and prognostic factors in gastric versus rectal GIST patients treated with neoadjuvant IM.

Sleeve gastrectomy (SG) is the most commonly performed metabolic surgery for obesity but is associated with long-term recurrent weight gain (RWG) and recurrence of comorbidities. Ring-augmented sleeve gastrectomy (RASG) has been proposed to improve weight durability by preventing gastric dilation and loss of restriction.

With the introduction of high-resolution manometry (HRM), esophageal motility disorders (EMDs) are now better understood, allowing for a more effective treatment. Carbonated water use was suggested to change esophageal motility. Hence, this study sought to determine the effect of carbonated water on esophagus HRM. In this retrospective study, we used manometry to evaluate the effects of carbonated water on esophageal movement and to investigate the potential impact on the diagnosis and interpretation of motility disorders.

To investigate the correlation between drinking patterns and the occurrence of hematemesis in patients with alcoholic cirrhosis complicated by esophagogastric variceal bleeding (EVB).

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition strongly associated with overweight or obesity, often accompanied by dyslipidemia, insulin resistance, and elevated liver enzymes. Exercise is recommended as a first-line lifestyle intervention, but evidence on the effects of different modalities, frequencies, and durations on metabolic and hepatic markers remains inconsistent. This study conducted a systematic review and meta-analysis to quantify overall effects and compare intervention strategies.

Alcohol abuse is a leading cause of global health care concerns and can cause health loss, disease, and death. In addition to the liver, the pancreas is a vital organ for the metabolism of alcohol, especially nonoxidative metabolism, and alcohol abuse is the leading cause of pancreatic diseases worldwide. Epidemiologic investigations have shown that alcohol consumption is linked to a spectrum of multiple pancreatic disorders, including acute pancreatitis, chronic pancreatitis, pancreatic cancer, and diabetes. Numerous in vitro and in vivo studies have elucidated the key mechanisms related to alcohol-induced pancreatic tissue injury in recent years. Alcohol has hazardous effects on multiple organs, destroying pancreatic acinar, ductal, stellate, and β-cells. These mechanisms, mainly mediated by alcohol and alcohol metabolites, include oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, calcium overload, premature trypsinogen activation, inflammation, and extracellular matrix remodeling, which are complex and interrelated. A deeper understanding of these processes will open new avenues for therapeutic intervention. Although behavioral strategies, such as abstinence, remain essential, pharmacologic and molecularly targeted therapies offer potential complementary approaches. Given the challenges of maintaining sustained abstinence, these adjunctive treatments are critical for slowing or preventing the progression of alcohol-driven pancreatic diseases.

Serum regenerating islet-derived protein 1 alpha (REG1A), a protein associated with pancreatic inflammation, is emerging as a potential biomarker for pancreatitis. This case-control study aimed to evaluate the diagnostic and prognostic value of REG1A in patients with acute pancreatitis (AP) and chronic pancreatitis (CP).

Cold snare polypectomy (CSP) is increasingly popular because of its safety and convenience, but it is currently recognized as the best way to remove diminutive polyps (≤ 5 mm). CSP for nonpedunculated polyps ≥ 10 mm in size has not been well examined. We evaluate the safety and efficacy of CSP for benign-looking intermediate nonpedunculated polyps.

Intestinal methanogen overgrowth (IMO) is increasingly recognized as a contributor to gastrointestinal symptoms in children. This study aimed to investigate the clinical characteristics and endoscopic features of pediatric patients with IMO.

Perinuclear anti-neutrophil cytoplasmic antibody(p-ANCA) positivity may indicate poor response to infliximab (IFX) in ulcerative colitis (UC). Nevertheless, there has been limited research on the effect of proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) in UC patients treated with IFX and vedolizumab (VDZ). This study aimed to investigate the short-term efficacy of PR3-ANCA in patients with moderate-to-severe active UC.

This study aimed to evaluate the clinical outcomes of combined transarterial chemoembolization and microwave ablation for hepatic hemangiomas, focusing on whether the benefits of this minimally invasive approach extend equally to giant (≥10 cm) as well as large (5-9.9 cm) lesions.

This study aimed to identify the risk factors associated with Clostridioides difficile infection (CDI) in patients with ulcerative colitis (UC) and to develop a predictive nomogram.

The use of ciprofol for endoscopic sedation is relatively recent; however, no definitive conclusions have been drawn regarding its optimal dose. This study evaluated the optimal ciprofol dose for sedated endoscopy using a network meta-analysis.