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541. Effect of Empagliflozin on the Clinical Stability of Patients With Heart Failure and a Reduced Ejection Fraction: The EMPEROR-Reduced Trial.
作者: Milton Packer.;Stefan D Anker.;Javed Butler.;Gerasimos Filippatos.;João Pedro Ferreira.;Stuart J Pocock.;Peter Carson.;Inder Anand.;Wolfram Doehner.;Markus Haass.;Michel Komajda.;Alan Miller.;Steen Pehrson.;John R Teerlink.;Martina Brueckmann.;Waheed Jamal.;Cordula Zeller.;Sven Schnaidt.;Faiez Zannad.
来源: Circulation. 2021年143卷4期326-336页
Empagliflozin reduces the risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, with or without diabetes, but additional data are needed about the effect of the drug on inpatient and outpatient events that reflect worsening heart failure.
542. Primary Results From the Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction (UNTOUCHED) Trial.
作者: Michael R Gold.;Pier D Lambiase.;Mikhael F El-Chami.;Reinoud E Knops.;Johan D Aasbo.;Maria Grazia Bongiorni.;Andrea M Russo.;Jean-Claude Deharo.;Martin C Burke.;Jay Dinerman.;Craig S Barr.;Naushad Shaik.;Nathan Carter.;Thomas Stoltz.;Kenneth M Stein.;Amy J Brisben.;Lucas V A Boersma.; .
来源: Circulation. 2021年143卷1期7-17页
The subcutaneous (S) implantable cardioverter-defibrillator (ICD) is safe and effective for sudden cardiac death prevention. However, patients in previous S-ICD studies had fewer comorbidities, had less left ventricular dysfunction, and received more inappropriate shocks (IAS) than in typical transvenous ICD trials. The UNTOUCHED trial (Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction) was designed to evaluate the IAS rate in a more typical, contemporary ICD patient population implanted with the S-ICD using standardized programming and enhanced discrimination algorithms.
543. Closure of Iatrogenic Atrial Septal Defect After Transcatheter Mitral Valve Repair: The Randomized MITHRAS Trial.
作者: Philipp Lurz.;Matthias Unterhuber.;Karl-Philipp Rommel.;Karl-Patrik Kresoja.;Tobias Kister.;Christian Besler.;Karl Fengler.;Marcus Sandri.;Ingo Daehnert.;Holger Thiele.;Maximilian von Roeder.;Stephan Blazek.
来源: Circulation. 2021年143卷3期292-294页 544. Comparison of Self-Expanding Bioprostheses for Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis: SCOPE 2 Randomized Clinical Trial.
作者: Corrado Tamburino.;Sabine Bleiziffer.;Holger Thiele.;Smita Scholtz.;David Hildick-Smith.;Michael Cunnington.;Alexander Wolf.;Marco Barbanti.;Didier Tchetchè.;Philippe Garot.;Paolo Pagnotta.;Martine Gilard.;Francesco Bedogni.;Eric Van Belle.;Mariuca Vasa-Nicotera.;Alaide Chieffo.;Oliver Deutsch.;Jörg Kempfert.;Lars Søndergaard.;Christian Butter.;Ramiro Trillo-Nouche.;Shahram Lotfi.;Helge Möllmann.;Michael Joner.;Mohamed Abdel-Wahab.;Kris Bogaerts.;Christian Hengstenberg.;Davide Capodanno.
来源: Circulation. 2020年142卷25期2431-2442页
Few randomized trials have compared bioprostheses for transcatheter aortic valve replacement, and no trials have compared bioprostheses with supra-annular design. The SCOPE 2 trial (Safety and Efficacy Comparison of Two TAVI Systems in a Prospective Randomized Evaluation 2) was designed to compare the clinical outcomes of the ACURATE neo and CoreValve Evolut bioprostheses for transcatheter aortic valve replacement.
545. Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.
作者: Francesco Franchi.;Fabiana Rollini.;Latonya Been.;Maryuri Briceno.;Naji Maaliki.;Mustafa Wali.;Andrea Rivas.;Andres M Pineda.;Siva Suryadevara.;Daniel Soffer.;Martin M Zenni.;Theodore A Bass.;Dominick J Angiolillo.
来源: Circulation. 2020年142卷15期1500-1502页 546. Association of Disease Progression With Cardiovascular and Limb Outcomes in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.
作者: Jennifer A Rymer.;Hillary Mulder.;Dennis I Narcisse.;Frank Rockhold.;William R Hiatt.;F Gerry Fowkes.;Iris Baumgartner.;Jeffrey S Berger.;Brian G Katona.;Kenneth Mahaffey.;Lars Norgren.;Juuso I Blomster.;W Schuyler Jones.;Manesh R Patel.
来源: Circ Cardiovasc Interv. 2020年13卷10期e009326页
Patients with peripheral artery disease have a high risk of future cardiovascular disease events and mortality. Little is known about the changes in symptom classification over time in patients with peripheral artery disease and the association of changes in symptom classification with subsequent cardiovascular disease events.
547. Effect of Postablation Monitoring Strategy on Long-Term Outcome for Catheter Ablation of Persistent Atrial Fibrillation: A Substudy of the STAR AF II Trial.
作者: Sergio Conti.;Chen-Yang Jiang.;Timothy R Betts.;Jian Chen.;Isabel Deisenhofer.;Roberto Mantovan.;Laurent Macle.;Carlos A Morillo.;Wilhelm Haverkamp.;Rukshen Weerasooriya.;Jean-Paul Albenque.;Stefano Nardi.;Endrj Menardi.;Paul Novak.;Prashanthan Sanders.;Atul Verma.
来源: Circ Arrhythm Electrophysiol. 2020年13卷11期e008682页 548. Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study.
作者: Benedikt Schrage.;Peter Moritz Becher.;Alexander Bernhardt.;Hiram Bezerra.;Stefan Blankenberg.;Stefan Brunner.;Pascal Colson.;Gaston Cudemus Deseda.;Salim Dabboura.;Dennis Eckner.;Matthias Eden.;Ingo Eitel.;Derk Frank.;Norbert Frey.;Masaki Funamoto.;Alina Goßling.;Tobias Graf.;Christian Hagl.;Paulus Kirchhof.;Danny Kupka.;Ulf Landmesser.;Jerry Lipinski.;Mathew Lopes.;Nicolas Majunke.;Octavian Maniuc.;Daniel McGrath.;Sven Möbius-Winkler.;David A Morrow.;Marc Mourad.;Curt Noel.;Peter Nordbeck.;Martin Orban.;Federico Pappalardo.;Sandeep M Patel.;Matthias Pauschinger.;Vittorio Pazzanese.;Hermann Reichenspurner.;Marcus Sandri.;P Christian Schulze.;Robert H G Schwinger.;Jan-Malte Sinning.;Adem Aksoy.;Carsten Skurk.;Lukasz Szczanowicz.;Holger Thiele.;Franziska Tietz.;Anubodh Varshney.;Lukas Wechsler.;Dirk Westermann.
来源: Circulation. 2020年142卷22期2095-2106页
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated with VA-ECMO was associated with lower mortality.
549. Magnetic Resonance Imaging-Guided Fibrosis Ablation for the Treatment of Atrial Fibrillation: The ALICIA Trial.
作者: Felipe Bisbal.;Eva Benito.;Albert Teis.;Francisco Alarcón.;Axel Sarrias.;Gala Caixal.;Roger Villuendas.;Paz Garre.;Nina Soto.;Jennifer Cozzari.;Eduard Guasch.;Gladys Juncà.;Susanna Prat-Gonzalez.;Rosario J Perea.;Victor Bazán.;José María Tolosana.;Elena Arbelo.;Antoni Bayés-Genís.;Lluis Mont.
来源: Circ Arrhythm Electrophysiol. 2020年13卷11期e008707页
Myocardial fibrosis is key for atrial fibrillation maintenance. We aimed to test the efficacy of ablating cardiac magnetic resonance (CMR)-detected atrial fibrosis plus pulmonary vein isolation (PVI).
550. Efficacy of Ertugliflozin on Heart Failure-Related Events in Patients With Type 2 Diabetes Mellitus and Established Atherosclerotic Cardiovascular Disease: Results of the VERTIS CV Trial.
作者: Francesco Cosentino.;Christopher P Cannon.;David Z I Cherney.;Urszula Masiukiewicz.;Richard Pratley.;Sam Dagogo-Jack.;Robert Frederich.;Bernard Charbonnel.;James Mancuso.;Weichung J Shih.;Steven G Terra.;Nilo B Cater.;Ira Gantz.;Darren K McGuire.; .
来源: Circulation. 2020年142卷23期2205-2215页
In patients with type 2 diabetes mellitus, sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure (HHF). We assessed the effect of ertugliflozin on HHF and related outcomes.
551. Treatment of Masked Hypertension with a Chinese Herbal Formula: A Randomized, Placebo-Controlled Trial.
作者: Dong-Yan Zhang.;Yi-Bang Cheng.;Qian-Hui Guo.;Xiao-Li Shan.;Fang-Fei Wei.;Feng Lu.;Chang-Sheng Sheng.;Qi-Fang Huang.;Chuan-Hua Yang.;Yan Li.;Ji-Guang Wang.
来源: Circulation. 2020年142卷19期1821-1830页
Masked hypertension is associated with adverse cardiovascular outcomes. Nonetheless, no randomized controlled trials exist in the treatment of masked hypertension. The aim of this randomized, placebo-controlled trial was to investigate the efficacy and safety of blood pressure (BP)-lowering treatment with a Chinese herbal formula, gastrodia-uncaria granules, in patients with masked hypertension.
552. National Variation in Congenital Heart Surgery Outcomes.
作者: Sara K Pasquali.;Dylan Thibault.;Sean M O'Brien.;Jeffrey P Jacobs.;J William Gaynor.;Jennifer C Romano.;Michael Gaies.;Kevin D Hill.;Marshall L Jacobs.;David M Shahian.;Carl L Backer.;John E Mayer.
来源: Circulation. 2020年142卷14期1351-1360页
Optimal strategies to improve national congenital heart surgery outcomes and reduce variability across hospitals remain unclear. Many policy and quality improvement efforts have focused primarily on higher-risk patients and mortality alone. Improving our understanding of both morbidity and mortality and current variation across the spectrum of complexity would better inform future efforts.
553. Postoperative Atrial Fibrillation and Long-Term Risk of Stroke After Isolated Coronary Artery Bypass Graft Surgery.
作者: Umberto Benedetto.;Mario F Gaudino.;Arnaldo Dimagli.;Stephen Gerry.;Alastair Gray.;Belinda Lees.;Marcus Flather.;David P Taggart.; .
来源: Circulation. 2020年142卷14期1320-1329页
Postoperative atrial fibrillation (pAF) after coronary artery bypass grafting is a common complication. Whether pAF is associated with an increased risk of cerebrovascular accident (CVA) remains uncertain. We investigated the association between pAF and long-term risk of CVA by performing a post hoc analysis of 10-year outcomes of the ART (Arterial Revascularization Trial).
554. Randomized, Controlled Trial Comparing Mitral Valve Repair With Leaflet Resection Versus Leaflet Preservation on Functional Mitral Stenosis: The CAMRA CardioLink-2 Study.
作者: Vincent Chan.;C David Mazer.;Faeez Mohamad Ali.;Adrian Quan.;Marc Ruel.;Benoit E de Varennes.;Alexander J Gregory.;Denis Bouchard.;Richard P Whitlock.;Michael W A Chu.;Aleksander Dokollari.;Thierry Mesana.;Deepak L Bhatt.;David A Latter.;Fei Zuo.;Wendy Tsang.;Hwee Teoh.;Peter Jüni.;Howard Leong-Poi.;Subodh Verma.
来源: Circulation. 2020年142卷14期1342-1350页
Equipoise exists between the use of leaflet resection and preservation for surgical repair of mitral regurgitation caused by prolapse. We therefore performed a randomized, controlled trial comparing these 2 techniques, particularly in regard to functional mitral stenosis.
555. Long-Term Results of the RAPCO Trials.
作者: Brian F Buxton.;Philip A Hayward.;Jai Raman.;Simon C Moten.;Alexander Rosalion.;Ian Gordon.;Siven Seevanayagam.;George Matalanis.;Umberto Benedetto.;Mario Gaudino.;David L Hare.; .
来源: Circulation. 2020年142卷14期1330-1338页
An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV).
556. Long-Term Outcome of the Randomized DAPA Trial.
作者: Danielle M Haanschoten.;Arif Elvan.;Anand R Ramdat Misier.;Peter Paul H M Delnoy.;Jaap Jan J Smit.;Ahmet Adiyaman.;Fatma Demirel.;Hein J J Wellens.;Freek W A Verheugt.;Jan Paul Ottervanger.; .
来源: Circ Arrhythm Electrophysiol. 2020年13卷11期e008484页
The randomized DAPA trial (Defibrillator After Primary Angioplasty) aimed to evaluate the survival benefit of prophylactic implantable cardioverter defibrillator (ICD) implantation in early selected high-risk patients after primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction.
557. First In-Human Experience With Inhaled Acetylsalicylic Acid for Immediate Platelet Inhibition: Comparison With Chewed and Swallowed Acetylsalicylic Acid.
作者: Paul A Gurbel.;Kevin P Bliden.;Rahul Chaudhary.;Udaya S Tantry.
来源: Circulation. 2020年142卷13期1305-1307页 558. Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: The PEARL Study.
作者: Karl B Kern.;Peter Radsel.;Jacob C Jentzer.;David B Seder.;Kwan S Lee.;Kapildeo Lotun.;Rajesh Janardhanan.;Dion Stub.;Chiu-Hsieh Hsu.;Marko Noc.
来源: Circulation. 2020年142卷21期2002-2012页
The benefit of emergency coronary angiography after resuscitation from out-of-hospital cardiac arrest is uncertain for patients without ST-segment elevation. The aim of this randomized trial was to evaluate the efficacy and safety of early coronary angiography and to determine the prevalence of acute coronary occlusion in resuscitated patients with out-of-hospital cardiac arrest without ST-segment elevation.
559. The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study: A Pragmatic Randomized Trial.
作者: Keane K Lee.;Rachel C Thomas.;Thida C Tan.;Thomas K Leong.;Anthony Steimle.;Alan S Go.
来源: Circ Cardiovasc Qual Outcomes. 2020年13卷10期e006553页
In-person clinic follow-up within 7 days after discharge from a heart failure hospitalization is associated with lower 30-day readmission. However, health systems and patients may find it difficult to complete an early postdischarge clinic visit, especially during the current pandemic. We evaluated the effect on 30-day readmission and death of follow-up within 7 days postdischarge guided by an initial structured nonphysician telephone visit compared with follow-up guided by an initial clinic visit with a physician.
560. Permanent His Bundle Pacing Implantation Facilitated by Visualization of the Tricuspid Valve Annulus.
作者: Min Gu.;Hongxia Niu.;Yiran Hu.;Xi Liu.;Nixiao Zhang.;Minsi Cai.;Xuhua Chen.;Xiaohong Zhou.;Michael R Gold.;Wei Hua.;Shu Zhang.
来源: Circ Arrhythm Electrophysiol. 2020年13卷10期e008370页
His bundle pacing (HBP) is the most physiological pacing modality. However, HBP has longer procedure times with frequent high capture thresholds, which likely contributes to the low adoption of this approach. The aim of this study is to compare HBP implantation with a novel imaging technique versus the standard implantation technique.
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