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523. Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial.
作者: Ziwei Zeng.;Shuangling Luo.;Hong Zhang.;Miao Wu.;Dan Ma.;Quan Wang.;Ming Xie.;Qing Xu.;Jun Ouyang.;Yi Xiao.;Yongchun Song.;Bo Feng.;Qingwen Xu.;Yanan Wang.;Yi Zhang.;Lishuo Shi.;Li Ling.;Xingwei Zhang.;Liang Huang.;Zuli Yang.;Junsheng Peng.;Xiaojian Wu.;Donglin Ren.;Meijin Huang.;Ping Lan.;Jianping Wang.;Weidong Tong.;Mingyang Ren.;Huashan Liu.;Liang Kang.; .
来源: JAMA. 2025年333卷9期774-783页
Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared with laparoscopic TME. However, the long-term oncological outcomes of transanal TME remain ambiguous. This study aims to compare 3-year disease-free survival of transanal TME with laparoscopic TME.
536. Polygenic Risk Score Added to Conventional Case Finding to Identify Undiagnosed Chronic Obstructive Pulmonary Disease.
作者: Jingzhou Zhang.;Brian D Hobbs.;Edwin K Silverman.;David Sparrow.;Victor E Ortega.;Hanfei Xu.;Chengyue Zhang.;Josée Dupuis.;Allan J Walkey.;George T O'Connor.;Michael H Cho.;Matthew Moll.
来源: JAMA. 2025年333卷9期784-792页
Chronic obstructive pulmonary disease (COPD) is often undiagnosed. Although genetic risk plays a significant role in COPD susceptibility, its utility in guiding spirometry testing and identifying undiagnosed cases is unclear.
539. A Unified Approach to Health Data Exchange: A Report From the US DHHS.
作者: Ali B Abbasi.;Jennifer Layden.;William Gordon.;Susan Gregurick.;Nancy DeLew.;Jordan Grossman.;Arlene S Bierman.;Susan Monarez.;Lesley H Curtis.;Abigail H Viall.;Mitra Rocca.;Donna R Rivera.;Hilary Marston.;Alexandra Mugge.;Scott R Smith.;Katherine Bent.;James Macrae.;Ann Sheehy.;Renee D Wegrzyn.;R Burciaga Valdez.;Carole Johnson.;Laina Bush.;Jonathan Blum.;Mandy K Cohen.;Monica M Bertagnolli.;Robert M Califf.;Micky Tripathi.
来源: JAMA. 2025年333卷12期1074-1079页
Health information technology, such as electronic health records (EHRs), has been widely adopted, yet accessing and exchanging data in the fragmented US health care system remains challenging. To unlock the potential of EHR data to improve patient health, public health, and health care, it is essential to streamline the exchange of health data. As leaders across the US Department of Health and Human Services (DHHS), we describe how DHHS has implemented fundamental building blocks to achieve this vision.
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