508. Adrenal Aldosterone Synthase Expression Imaging in Primary Aldosteronism.
作者: Erik Årstad.;Kerstin Sander.;Tom R Kurzawinski.;Cameron Anderson.;Yazead Buhidma.;Ramla O Awais.;Fatih Sirindil.;Robert Shortman.;Louise Dickinson.;Aidan G O'Keeffe.;John Dickson.;Teng-Teng Chung.;Morris J Brown.;Bryan Williams.
来源: N Engl J Med. 2025年393卷21期2168-2170页 513. Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia.
作者: Hanny Al-Samkari.;Josefien Hessels.;Antoni Riera-Mestre.;Sophie Dupuis-Girod.;Thibaut Van Zele.;Vicente Gómez Del Olmo.;Pamela G Hodges.;Raquel Torres-Iglesias.;Roberto Bertè.;Pierre Saint-Mezard.;Hedvika Lazar.;Nicholas Benedict.;Debra Barker.;Corrado Bernasconi.;Damien Picard.;Elisabetta Buscarini.;Hans-Jurgen Mager.
来源: N Engl J Med. 2025年393卷21期2131-2141页
Hereditary hemorrhagic telangiectasia (HHT) can cause recurrent, severe epistaxis, as well as anemia and reduced quality of life. The disease remains without licensed therapies worldwide.
514. Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model.
作者: Anna P Durbin.;Liesbeth Van Wesenbeeck.;Kristen K Pierce.;Guillermo Herrera-Taracena.;Laura Ebone.;Annemie Buelens.;Patricia Lutton.;Beulah P Sabundayo.;Veerle Van Eygen.;Kim De Clerck.;Isabel Fetter.;Natalia V Voge.;Xi Fang.;Nele Goeyvaerts.;Yannick Vandendijck.;Jeffrey Mayfield.;Oliver Lenz.;Sandra De Meyer.;Thomas N Kakuda.;Huili He.;Emérito Amaro-Carambot.;Ruxandra Draghia Akli.;Marya Carmolli.;Tine De Marez.;Stephen S Whitehead.;Marnix Van Loock.;Freya Rasschaert.
来源: N Engl J Med. 2025年393卷21期2107-2118页
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis or treatment options are available.
520. Medical Management and Revascularization for Asymptomatic Carotid Stenosis.
作者: Thomas G Brott.;George Howard.;Brajesh K Lal.;Jenifer H Voeks.;Tanya N Turan.;Gary S Roubin.;Ronald M Lazar.;Robert D Brown.;John Huston.;Lloyd J Edwards.;Michael Jones.;Wayne M Clark.;Ángel Chamorro.;Laura Llull.;Carlos Mena-Hurtado.;Donald Heck.;Randolph S Marshall.;Virginia J Howard.;Wesley S Moore.;Kevin M Barrett.;Bart M Demaerschalk.;Navdeep Sangha.;Herbert Aronow.;Malcolm Foster.;W Charles Sternbergh.;Fayaz Shawl.;Giuseppe Lanzino.;Joseph Rapp.;Hoang S Tran.;Robert Ecker.;Ariane Mackey.;Vaqar Ali.;Curtis Given.;Philip Teal.;Vikram S Kashyap.;Dipankar Mukherjee.;Mark Harrigan.;Scott Silverman.;Matthew Koopmann.;Virginia G Wadley.;Yu Zhang.;J David Rhodes.;Seemant Chaturvedi.;James F Meschia.; .
来源: N Engl J Med. 2026年394卷3期219-231页
Improvements in medical therapy, carotid-artery stenting, and carotid endarterectomy call into question the preferred management of asymptomatic carotid stenosis. Whether adding revascularization to intensive medical management would provide greater benefit than intensive medical management alone is unclear.
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