501. Patterns in Mental Health- and Substance Use-Related Visits From 2003 to 2022 Among Registered Ontario Physicians.
作者: Maya A Gibb.;Lyndsay Harrison.;Asnake Y Dumicho.;Manish M Sood.;Peter Tanuseputro.;Aliza Moledina.;Meltem Tuna.;Timite Halilou.;Claire E Kendall.;Ian Colman.;Shannon M Fernando.;Rhiannon L Roberts.;Courtney Maskerine.;Daniel T Myran.
来源: Ann Intern Med. 2026年179卷2期311-313页 503. Management of Sepsis in Hospitalized Patients.
Sepsis is the leading cause of death worldwide. Mortality has improved in the past few decades but remains high, and survivors frequently have long-term complications. Initial diagnostic evaluation focuses on risk stratification and source and pathogen identification. Treatment includes intravenous fluids, vasopressors, steroids if shock is present, antimicrobial therapy targeting the most likely source of infection, and source control. Patients with shock or high-risk organ failure syndromes should be admitted early to an intensive care unit. After initial antimicrobials and resuscitation, care should focus on antimicrobial deescalation, volume management, and high-quality supportive care. Shared decision making about goals of care and transitions is important to support survivors after discharge.
504. Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study.
作者: Amit X Garg.;Eric McArthur.;Jessica M Sontrop.;Neil Boudville.;Dervla M Connaughton.;Meaghan S Cuerden.;Liane S Feldman.;Ngan N Lam.;Krista L Lentine.;Christopher Nguan.;Chirag R Parikh.;Dorry L Segev.;Alp Sener.;Graham Smith.;Carol Wang.;Matthew A Weir.;Seychelle Yohanna.;Ann Young.;Kyla L Naylor.
来源: Ann Intern Med. 2026年179卷1期23-31页
A potential long-term complication of living kidney donation in male donors is scrotal swelling on the same side as the nephrectomy, and some undergo surgery to relieve discomfort from the fluid collection. The long-term risk for this outcome attributable to donation is unknown.
505. Polymerase Chain Reaction-Confirmed Oropouche Virus Disease in Loreto, Perú: A Case Series From December 2023 Through September 2024.
作者: Edgar A Ramírez-García.;Nelson Iván Agudelo Higuita.;Andrés F Henao-Martínez.;Carlos Franco-Paredes.;Luis A Marcos.;Juan C Celis-Salinas.;Cesar Ramal-Asayag.;Martín Casapía Morales.; .
来源: Ann Intern Med. 2026年179卷1期147-149页 506. Implementation of Social Needs Screening and Intervention in Primary Care : A Systematic Review of Program-Level Determinants.
作者: Eva Chang.;Iridian Guzman.;Nicole Glowacki.;Rasha Khatib.
来源: Ann Intern Med. 2026年179卷1期95-106页
Health care systems are investing significant resources in social needs screening and intervention programs.
511. In patients with AF and obesity, catheter ablation vs. lifestyle modification plus antiarrhythmic drugs improved AF freedom at 1 y.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
513. In cancer-associated thrombosis, DOACs reduce VTE and increase clinically relevant nonmajor bleeding vs. LMWH at 3 to 12 mo.
GIM/FP/GP: [Formula: see text] Oncology: [Formula: see text] Hematology: [Formula: see text].
514. In older adults at risk for dementia, a structured vs. self-guided lifestyle intervention improved cognitive function over 2 y.
GIM/FP/GP: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
515. Effectiveness of Psychological Therapies for Depression During the Perinatal Period : A Systematic Review and Meta-analysis.
作者: Elyse Couch.;Htun Ja Mai.;Ghid Kanaan.;Eduardo L Caputo.;Olivia Lewis.;Michael L Zahradnik.;Margaret Howard.;Lauren Connell Bohlen.;Kristin Konnyu.;Ethan M Balk.
来源: Ann Intern Med. 2025年178卷12期1752-1762页
Perinatal depression can have a deleterious impact on mothers and infants.
518. In minor stroke, adding IV thrombolysis to nonthrombolytic usual care does not increase excellent functional outcome at 90 d.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].
519. In adults with obesity but without type 2 diabetes, tirzepatide increased weight loss at 72 wk compared with semaglutide.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
520. In older, frail, VKA-experienced patients with AF, SD-DOACs vs. warfarin reduced thrombotic events without increasing major bleeding.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].
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