507. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
作者: .;Kathryn M Rowan.;Derek C Angus.;Michael Bailey.;Amber E Barnato.;Rinaldo Bellomo.;Ruth R Canter.;Timothy J Coats.;Anthony Delaney.;Elizabeth Gimbel.;Richard D Grieve.;David A Harrison.;Alisa M Higgins.;Belinda Howe.;David T Huang.;John A Kellum.;Paul R Mouncey.;Edvin Music.;Sandra L Peake.;Francis Pike.;Michael C Reade.;M Zia Sadique.;Mervyn Singer.;Donald M Yealy.
来源: N Engl J Med. 2017年376卷23期2223-2234页
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.
515. Long-Acting Reversible Contraception.
A 17-year-old high school student who has never been pregnant presents for advice regarding contraception. She has an unremarkable medical history and is planning to become sexually active with her boyfriend in the near future. Her primary concern is an unintended pregnancy, and she inquires about methods of contraception that are highly effective. How would you counsel her about options for contraception?
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