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501. Improved health-related quality of life for rheumatoid arthritis patients treated with abatacept who have inadequate response to anti-TNF therapy in a double-blind, placebo-controlled, multicentre randomized clinical trial.
作者: R Westhovens.;J C Cole.;T Li.;M Martin.;R Maclean.;P Lin.;B Blaisdell.;G V Wallenstein.;R Aranda.;Y Sherrer.
来源: Rheumatology (Oxford). 2006年45卷10期1238-46页
Rheumatoid arthritis (RA) patients who have inadequate response to anti-tumour necrosis factor (TNF) therapy currently have treatment options that are limited and less than optimal in their risk-to-benefit ratio. Abatacept provides a new generation of RA medications that has previously been demonstrated to have positive clinical outcomes with this population. The current study sought to demonstrate the efficacy of abatacept on quality of life (QoL) for RA patients with inadequate response to anti-TNF therapy.
502. Iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis and the quality of life: a new therapeutic protocol.
作者: G Milio.;E Corrado.;C Genova.;C Amato.;F Raimondi.;P L Almasio.;S Novo.
来源: Rheumatology (Oxford). 2006年45卷8期999-1004页
To evaluate the clinical efficacy and the effects on the quality of life of iloprost, a prostacyclin analogue, used according to a new protocol in patients with Raynaud's phenomenon secondary to systemic sclerosis.
503. Analgesic action of acetaminophen in symptomatic osteoarthritis of the knee.
作者: H Shen.;H Sprott.;A Aeschlimann.;R E Gay.;B A Michel.;S Gay.;H Sprott.
来源: Rheumatology (Oxford). 2006年45卷6期765-70页
The study was designed to investigate the analgesic effects and mechanisms of acetaminophen (paracetamol) in symptomatic osteoarthritis (OA) of the knee.
505. Patient perceptions of physical therapy within a trial for back pain treatments (UK BEAM) [ISRCTN32683578].
To explore the views of participants in a randomized controlled trial of physical treatments for low back pain about the treatment packages they received in the trial.
506. Conservative hand therapy treatments in rheumatoid arthritis--a randomized controlled trial.
作者: A V O'Brien.;P Jones.;R Mullis.;D Mulherin.;K Dziedzic.
来源: Rheumatology (Oxford). 2006年45卷5期577-83页
To evaluate the effectiveness of three different physiotherapeutic approaches in the management of the rheumatoid hand.
507. Pulsed low-intensity ultrasound therapy for chronic lateral epicondylitis: a randomized controlled trial.
作者: A P D'Vaz.;A J K Ostor.;C A Speed.;J R Jenner.;M Bradley.;A T Prevost.;B L Hazleman.
来源: Rheumatology (Oxford). 2006年45卷5期566-70页
Pulsed low-intensity ultrasound therapy (LIUS) has been found to be beneficial in accelerating fracture healing and has produced positive results in animal tendon repair. In the light of this we undertook a randomized, double-blind, placebo controlled trial to assess the effectiveness of LIUS vs placebo therapy daily for 12 weeks in patients with chronic lateral epicondylitis (LE).
508. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.
To assess the efficacy of a cannabis-based medicine (CBM) in the treatment of pain due to rheumatoid arthritis (RA).
509. A double-blind trial of depot corticosteroids in Behçet's syndrome.
作者: C Mat.;S Yurdakul.;S Uysal.;F Gogus.;Y Ozyazgan.;O Uysal.;I Fresko.;H Yazici.
来源: Rheumatology (Oxford). 2006年45卷3期348-52页
Corticosteroids are widely used in Behçet's syndrome despite the absence of controlled studies. We assessed the effect of depot corticosteroids primarily for genital ulcers and secondarily for the other mucocutaneous manifestations of Behçet's syndrome.
510. Patients with stable long-standing rheumatoid arthritis continue to deteriorate despite intensified treatment with traditional disease modifying anti-rheumatic drugs--results of the British Rheumatoid Outcome Study Group randomized controlled clinical trial.
作者: D Symmons.;K Tricker.;M Harrison.;C Roberts.;M Davis.;P Dawes.;A Hassell.;S Knight.;D Mulherin.;D L Scott.; .
来源: Rheumatology (Oxford). 2006年45卷5期558-65页
Patients with rheumatoid arthritis (RA) should start treatment early with the aim of suppressing the inflammatory process completely. It is not known if this strategy should, or can, be continued in later disease.
511. Thymus alterations and systemic sclerosis.
作者: C Ferri.;M Colaci.;L Battolla.;D Giuggioli.;M Sebastiani.
来源: Rheumatology (Oxford). 2006年45卷1期72-5页
The pathogenesis of systemic sclerosis (SSc) includes complex alterations to the immune system, possibly responsible for diffuse microvasculature and fibroblast dysfunction. Previous anecdotal observations suggest a possible role for thymus alterations in some autoimmune rheumatic diseases, including SSc. This study aimed to investigate the prevalence of radiological thymus alterations in SSc patients.
512. A cost consequences analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care.
作者: M James.;E A Stokes.;E Thomas.;K Dziedzic.;E M Hay.
来源: Rheumatology (Oxford). 2005年44卷11期1447-51页
Local steroid injections and community-based physiotherapy have been shown to be of similar benefit for treating shoulder pain presenting to primary care. This paper presents a cost consequences analysis of a prospective economic evaluation, conducted alongside a randomized clinical trial (RCT) of corticosteroid injections versus physiotherapy for new episodes of unilateral shoulder pain, to determine the economic implications of injection versus physiotherapy.
513. Persistent reduction of spinal inflammation as assessed by magnetic resonance imaging in patients with ankylosing spondylitis after 2 yrs of treatment with the anti-tumour necrosis factor agent infliximab.
作者: J Sieper.;X Baraliakos.;J Listing.;J Brandt.;H Haibel.;M Rudwaleit.;J Braun.
来源: Rheumatology (Oxford). 2005年44卷12期1525-30页
Patients with ankylosing spondylitis (AS) benefit from anti-TNF therapy both on a clinical basis and as depicted by magnetic resonance imaging (MRI). It is not known whether spinal inflammation remains suppressed over time. Our objective was to assess spinal inflammation by MRI in AS patients after 2 yr of continuous infliximab treatment.
514. A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WEST study.
作者: N K Arden.;C Price.;I Reading.;J Stubbing.;J Hazelgrove.;C Dunne.;M Michel.;P Rogers.;C Cooper.; .
来源: Rheumatology (Oxford). 2005年44卷11期1399-406页
To determine the effectiveness and predictors of response to lumbar epidural corticosteroid injections (ESI) in patients with sciatica. We performed a 12-month, multicentre, double-blind, randomized, placebo-controlled, parallel-group trial in four secondary pain-care clinics in the Wessex Region.
515. A randomized clinical trial of an individualized home-based exercise programme for women with fibromyalgia.
作者: D Da Costa.;M Abrahamowicz.;I Lowensteyn.;S Bernatsky.;M Dritsa.;M-A Fitzcharles.;P L Dobkin.
来源: Rheumatology (Oxford). 2005年44卷11期1422-7页
To determine the efficacy of a 12-week individualized home-based exercise programme on physical functioning, pain severity and psychological distress for women with fibromyalgia (FM).
516. What factors influence functional ability in patients with rheumatoid arthritis. Do they alter over time?
作者: M J Plant.;M M O'Sullivan.;P A Lewis.;J P Camilleri.;E C Coles.;J D Jessop.
来源: Rheumatology (Oxford). 2005年44卷9期1181-5页
To describe the changes in functional ability (FA) taking place over 5 yr in patients with rheumatoid arthritis (RA) starting disease-modifying anti-rheumatic drug (DMARD) therapy, to investigate the factors having most influence upon FA and to compare these factors at baseline and after 5 yr of treatment.
517. The perceptions of final year medical students in rheumatology workshops when delivered by a consultant and a nurse clinical educator.
To determine whether final year medical students' perceptions of teaching workshops delivered by a consultant rheumatologist are similar those of the same workshops delivered by an experienced nurse clinical educator (NCE).
518. Persistent clinical response to the anti-TNF-alpha antibody infliximab in patients with ankylosing spondylitis over 3 years.
作者: J Braun.;X Baraliakos.;J Brandt.;J Listing.;A Zink.;R Alten.;G Burmester.;E Gromnica-Ihle.;H Kellner.;M Schneider.;H Sörensen.;H Zeidler.;J Sieper.
来源: Rheumatology (Oxford). 2005年44卷5期670-6页
Infliximab, a monoclonal antibody against tumour necrosis factor alpha (TNF-alpha), is approved in Europe for the treatment of patients with active ankylosing spondylitis (AS) who have responded inadequately to conventional therapy. This report provides analyses from a 3-yr extension study, as a follow-up to both the 1- and 2-yr open label extensions of the original 3-month randomized controlled trial of infliximab in patients with AS.
520. Moderately intensive exercise in a temperate pool for patients with rheumatoid arthritis: a randomized controlled study.
The aim of this study was to evaluate the effects of moderately intensive pool exercise therapy on patients with rheumatoid arthritis (RA).
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