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501. Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial.
作者: Jae-Min Kim.;Robert Stewart.;Yong-Seong Lee.;Hee-Joon Lee.;Min Chul Kim.;Ju-Wan Kim.;Hee-Ju Kang.;Kyung-Yeol Bae.;Sung-Wan Kim.;Il-Seon Shin.;Young Joon Hong.;Ju Han Kim.;Youngkeun Ahn.;Myung Ho Jeong.;Jin-Sang Yoon.
来源: JAMA. 2018年320卷4期350-358页
Depression has been associated with poorer medical outcomes in acute coronary syndrome (ACS), but there are few data on the effects of antidepressant treatment on long-term prognosis.
502. Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer: A Randomized Clinical Trial.
作者: Dawn L Hershman.;Joseph M Unger.;Heather Greenlee.;Jillian L Capodice.;Danika L Lew.;Amy K Darke.;Alice T Kengla.;Marianne K Melnik.;Carla W Jorgensen.;William H Kreisle.;Lori M Minasian.;Michael J Fisch.;N Lynn Henry.;Katherine D Crew.
来源: JAMA. 2018年320卷2期167-176页
Musculoskeletal symptoms are the most common adverse effects of aromatase inhibitors and often result in therapy discontinuation. Small studies suggest that acupuncture may decrease aromatase inhibitor-related joint symptoms.
503. Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial.
作者: Pooja Khatri.;Dawn O Kleindorfer.;Thomas Devlin.;Robert N Sawyer.;Matthew Starr.;Jennifer Mejilla.;Joseph Broderick.;Anjan Chatterjee.;Edward C Jauch.;Steven R Levine.;Jose G Romano.;Jeffrey L Saver.;Achala Vagal.;Barbara Purdon.;Jenny Devenport.;Andrey Pavlov.;Sharon D Yeatts.; .
来源: JAMA. 2018年320卷2期156-166页
More than half of patients with acute ischemic stroke have minor neurologic deficits (National Institutes of Health Stroke Scale [NIHSS] score of 0-5) at presentation. Although prior major trials of alteplase included patients with low NIHSS scores, few without clearly disabling deficits were enrolled.
504. Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial.
作者: Steven R Steinhubl.;Jill Waalen.;Alison M Edwards.;Lauren M Ariniello.;Rajesh R Mehta.;Gail S Ebner.;Chureen Carter.;Katie Baca-Motes.;Elise Felicione.;Troy Sarich.;Eric J Topol.
来源: JAMA. 2018年320卷2期146-155页
Opportunistic screening for atrial fibrillation (AF) is recommended, and improved methods of early identification could allow for the initiation of appropriate therapies to prevent the adverse health outcomes associated with AF.
505. Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
作者: Gina Suzanne Ogilvie.;Dirk van Niekerk.;Mel Krajden.;Laurie W Smith.;Darrel Cook.;Lovedeep Gondara.;Kathy Ceballos.;David Quinlan.;Marette Lee.;Ruth Elwood Martin.;Laura Gentile.;Stuart Peacock.;Gavin C E Stuart.;Eduardo L Franco.;Andrew J Coldman.
来源: JAMA. 2018年320卷1期43-52页
There is limited information about the relative effectiveness of cervical cancer screening with primary human papillomavirus (HPV) testing alone compared with cytology in North American populations.
506. Effect of a Multifaceted Quality Improvement Intervention on Hospital Personnel Adherence to Performance Measures in Patients With Acute Ischemic Stroke in China: A Randomized Clinical Trial.
作者: Yilong Wang.;Zixiao Li.;Xingquan Zhao.;Chunjuan Wang.;Xianwei Wang.;David Wang.;Li Liang.;Liping Liu.;Chunxue Wang.;Hao Li.;Haipeng Shen.;Janet Bettger.;Yuesong Pan.;Yong Jiang.;Xiaomeng Yang.;Changqing Zhang.;Xiujie Han.;Xia Meng.;Xin Yang.;Hong Kang.;Weiqiang Yuan.;Gregg C Fonarow.;Eric D Peterson.;Lee H Schwamm.;Ying Xian.;Yongjun Wang.; .
来源: JAMA. 2018年320卷3期245-254页
In China and other parts of the world, hospital personnel adherence to evidence-based stroke care is limited.
507. Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial.
作者: Jin Li.;Shukui Qin.;Rui-Hua Xu.;Lin Shen.;Jianming Xu.;Yuxian Bai.;Lei Yang.;Yanhong Deng.;Zhen-Dong Chen.;Haijun Zhong.;Hongming Pan.;Weijian Guo.;Yongqian Shu.;Ying Yuan.;Jianfeng Zhou.;Nong Xu.;Tianshu Liu.;Dong Ma.;Changping Wu.;Ying Cheng.;Donghui Chen.;Wei Li.;Sanyuan Sun.;Zhuang Yu.;Peiguo Cao.;Haihui Chen.;Jiejun Wang.;Shubin Wang.;Hongbing Wang.;Songhua Fan.;Ye Hua.;Weiguo Su.
来源: JAMA. 2018年319卷24期2486-2496页
Patients with metastatic colorectal cancer (CRC) have limited effective and tolerable treatment options.
508. Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb: The WOLLF Randomized Clinical Trial.
作者: Matthew L Costa.;Juul Achten.;Julie Bruce.;Elizabeth Tutton.;Stavros Petrou.;Sarah E Lamb.;Nick R Parsons.; .
来源: JAMA. 2018年319卷22期2280-2288页
Open fractures of the lower limb occur when a broken bone penetrates the skin. There can be major complications from these fractures, which can be life-changing.
509. Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial.
作者: William F Clark.;Jessica M Sontrop.;Shih-Han Huang.;Kerri Gallo.;Louise Moist.;Andrew A House.;Meaghan S Cuerden.;Matthew A Weir.;Amit Bagga.;Scott Brimble.;Andrew Burke.;Norman Muirhead.;Sanjay Pandeya.;Amit X Garg.
来源: JAMA. 2018年319卷18期1870-1879页
In observational studies, increased water intake is associated with better kidney function.
510. Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.
作者: Edward M Messing.;Catherine M Tangen.;Seth P Lerner.;Deepak M Sahasrabudhe.;Theresa M Koppie.;David P Wood.;Philip C Mack.;Robert S Svatek.;Christopher P Evans.;Khaled S Hafez.;Daniel J Culkin.;Timothy C Brand.;Lawrence I Karsh.;Jeffrey M Holzbeierlein.;Shandra S Wilson.;Guan Wu.;Melissa Plets.;Nicholas J Vogelzang.;Ian M Thompson.
来源: JAMA. 2018年319卷18期1880-1888页
Low-grade non-muscle-invasive urothelial cancer frequently recurs after excision by transurethral resection of bladder tumor (TURBT).
511. Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence.
作者: Benjamin Click.;Paul F Pinsky.;Tom Hickey.;Maryam Doroudi.;Robert E Schoen.
来源: JAMA. 2018年319卷19期2021-2031页
Individuals with adenomatous polyps are advised to undergo repeated colonoscopy surveillance to prevent subsequent colorectal cancer (CRC), but the relationship between adenomas at colonoscopy and long-term CRC incidence is unclear.
512. Effect of Acupuncture vs Sham Acupuncture on Live Births Among Women Undergoing In Vitro Fertilization: A Randomized Clinical Trial.
作者: Caroline A Smith.;Sheryl de Lacey.;Michael Chapman.;Julie Ratcliffe.;Robert J Norman.;Neil P Johnson.;Clare Boothroyd.;Paul Fahey.
来源: JAMA. 2018年319卷19期1990-1998页
Acupuncture is widely used by women undergoing in vitro fertilization (IVF), although the evidence for efficacy is conflicting.
513. Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial.
作者: David W Dodick.;Stephen D Silberstein.;Marcelo E Bigal.;Paul P Yeung.;Peter J Goadsby.;Tricia Blankenbiller.;Melissa Grozinski-Wolff.;Ronghua Yang.;Yuju Ma.;Ernesto Aycardi.
来源: JAMA. 2018年319卷19期1999-2008页
Fremanezumab, a fully humanized monoclonal antibody that targets calcitonin gene-related peptide, may be effective for treating episodic migraine.
514. Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm: The D-Wheeze Randomized Clinical Trial.
作者: Anna Maria Hibbs.;Kristie Ross.;Leigh Ann Kerns.;Carol Wagner.;Mamta Fuloria.;Sharon Groh-Wargo.;Teresa Zimmerman.;Nori Minich.;Curtis Tatsuoka.
来源: JAMA. 2018年319卷20期2086-2094页
Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems.
515. Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer-Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial.
作者: Peer Wille-Jørgensen.;Ingvar Syk.;Kenneth Smedh.;Søren Laurberg.;Dennis T Nielsen.;Sune H Petersen.;Andrew G Renehan.;Erzsébet Horváth-Puhó.;Lars Påhlman.;Henrik T Sørensen.; .
来源: JAMA. 2018年319卷20期2095-2103页
Intensive follow-up of patients after curative surgery for colorectal cancer is common in clinical practice, but evidence of a survival benefit is limited.
516. Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial.
作者: Brian E Driver.;Matthew E Prekker.;Lauren R Klein.;Robert F Reardon.;James R Miner.;Erik T Fagerstrom.;Mitchell R Cleghorn.;John W McGill.;Jon B Cole.
来源: JAMA. 2018年319卷21期2179-2189页
The tracheal tube introducer, known as the bougie, is typically used to aid tracheal intubation in poor laryngoscopic views or after intubation attempts fail. The effect of routine bougie use on first-attempt intubation success is unclear.
517. Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis: A Randomized Clinical Trial.
作者: Ganesh Raghu.;Bernt van den Blink.;Mark J Hamblin.;A Whitney Brown.;Jeffrey A Golden.;Lawrence A Ho.;Marlies S Wijsenbeek.;Martina Vasakova.;Alberto Pesci.;Danielle E Antin-Ozerkis.;Keith C Meyer.;Michael Kreuter.;Hugues Santin-Janin.;Geert-Jan Mulder.;Brian Bartholmai.;Renu Gupta.;Luca Richeldi.
来源: JAMA. 2018年319卷22期2299-2307页
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. Approved therapies do not halt disease progression.
518. Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.
作者: Marie-Victoire Sénat.;Helene Affres.;Alexandra Letourneau.;Magali Coustols-Valat.;Marie Cazaubiel.;Helene Legardeur.;Julie Fort Jacquier.;Nathalie Bourcigaux.;Emmanuel Simon.;Anne Rod.;Isabelle Héron.;Virginie Castera.;Loic Sentilhes.;Florence Bretelle.;Catherine Rolland.;Mathieu Morin.;Philippe Deruelle.;Celine De Carne.;François Maillot.;Gael Beucher.;Eric Verspyck.;Raoul Desbriere.;Sandrine Laboureau.;Delphine Mitanchez.;Jean Bouyer.; .
来源: JAMA. 2018年319卷17期1773-1780页
Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes.
519. Effect of Atropine With Propofol vs Atropine With Atracurium and Sufentanil on Oxygen Desaturation in Neonates Requiring Nonemergency Intubation: A Randomized Clinical Trial.
作者: Xavier Durrmeyer.;Sophie Breinig.;Olivier Claris.;Pierre Tourneux.;Cénéric Alexandre.;Elie Saliba.;Alain Beuchée.;Camille Jung.;Corinne Levy.;Laetitia Marchand-Martin.;Marie-Odile Marcoux.;Agnes Dechartres.;Claude Danan.; .
来源: JAMA. 2018年319卷17期1790-1801页
Propofol or a combination of a synthetic opioid and muscle relaxant are both recommended for premedication before neonatal intubation but have yet to be compared.
520. Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial.
作者: Angela Huttner.;Anna Kowalczyk.;Adi Turjeman.;Tanya Babich.;Caroline Brossier.;Noa Eliakim-Raz.;Katarzyna Kosiek.;Begoña Martinez de Tejada.;Xavier Roux.;Shachaf Shiber.;Ursula Theuretzbacher.;Elodie von Dach.;Dafna Yahav.;Leonard Leibovici.;Maciek Godycki-Cwirko.;Johan W Mouton.;Stephan Harbarth.
来源: JAMA. 2018年319卷17期1781-1789页
The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for lower urinary tract infection (UTI).
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