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501. Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia.
作者: Moritz Döbert.;Anna Nektaria Varouxaki.;An Chi Mu.;Argyro Syngelaki.;Anca Ciobanu.;Ranjit Akolekar.;Catalina De Paco Matallana.;Simona Cicero.;Elena Greco.;Mandeep Singh.;Deepa Janga.;Maria Del Mar Gil.;Jacques C Jani.;José Luis Bartha.;Kate Maclagan.;David Wright.;Kypros H Nicolaides.
来源: Circulation. 2021年144卷9期670-679页
Effective screening for term preeclampsia is provided by a combination of maternal factors with measurements of mean arterial pressure, serum placental growth factor, and serum soluble fms-like tyrosine kinase-1 at 35 to 37 weeks of gestation, with a detection rate of ≈75% at a screen-positive rate of 10%. However, there is no known intervention to reduce the incidence of the disease.
502. Improving the Effectiveness of Psychological Interventions for Depression and Anxiety in Cardiac Rehabilitation: PATHWAY-A Single-Blind, Parallel, Randomized, Controlled Trial of Group Metacognitive Therapy.
作者: Adrian Wells.;David Reeves.;Lora Capobianco.;Calvin Heal.;Linda Davies.;Anthony Heagerty.;Patrick Doherty.;Peter Fisher.
来源: Circulation. 2021年144卷1期23-33页
Depression and anxiety in cardiovascular disease are significant, contributing to poor prognosis. Unfortunately, current psychological treatments offer mixed, usually small improvements in these symptoms. The present trial tested for the first time the effects of group metacognitive therapy (MCT; 6 sessions) on anxiety and depressive symptoms when delivered alongside cardiac rehabilitation (CR).
503. Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial.
作者: Jeffrey A Kline.;David H Adler.;Naomi Alanis.;Joseph R Bledsoe.;Daniel M Courtney.;James P d'Etienne.;Deborah B Diercks.;John S Garrett.;Alan E Jones.;David C Mackenzie.;Troy Madsen.;Andrew J Matuskowitz.;Bryn E Mumma.;Kristen E Nordenholz.;Justine Pagenhardt.;Michael S Runyon.;William B Stubblefield.;Christopher B Willoughby.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷7期e007600页
The objective was to test if low-risk emergency department patients with vitamin K antagonist (venous thromboembolism [VTE]; including venous thrombosis and pulmonary embolism [PE]) can be safely and effectively treated at home with direct acting oral (monotherapy) anticoagulation in a large-scale, real-world pragmatic effectiveness trial.
504. Personalized, Electronic Health Record-Integrated Decision Aid for Stroke Prevention in Atrial Fibrillation: A Small Cluster Randomized Trial and Qualitative Analysis of Efficacy and Acceptability.
作者: Stacey L Schott.;Julia Berkowitz.;Shayne E Dodge.;Curtis L Petersen.;Catherine H Saunders.;Navjot Kaur Sobti.;Keren Xu.;Megan Coylewright.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷6期e007329页
Shared decision-making in cardiology is increasingly recommended to improve patient-centeredness of care. Decision aids can improve patient knowledge and decisional quality but are infrequently used in real-world practice. This mixed-methods study tests the efficacy and acceptability of a decision aid integrated into the electronic health record (Integrated Decision Aid [IDeA]) and delivered by clinicians for patients with atrial fibrillation considering options to reduce stroke risk. We aimed to determine whether the IDeA improves patient knowledge, reduces decisional conflict, and is seen as acceptable by clinicians and patients.
505. Positron Emission Tomography Imaging of Regional Versus Global Myocardial Sympathetic Activity to Improve Risk Stratification in Patients With Ischemic Cardiomyopathy.
作者: Jason G E Zelt.;Jean Zhuo Wang.;Lisa M Mielniczuk.;Rob S B Beanlands.;James A Fallavollita.;John M Canty.;Robert A deKemp.
来源: Circ Cardiovasc Imaging. 2021年14卷6期e012549页
Current risk assessment approaches fail to identify the majority of patients at risk of sudden cardiac arrest (SCA). Noninvasive imaging of the cardiac sympathetic nervous system using single-photon emission computed tomography and positron emission tomography offers the potential for refining SCA risk assessment. While various [11C]meta-hydroxyephedrine quantification parameters have been proposed, it is currently unknown whether regional denervation or global innervation yields greater SCA risk discrimination. The aim of the study was to determine whether the global innervation parameters yield any independent and additive prognostic value over the regional denervation alone.
506. Clinical Characteristics of SCN5A p.R965C Carriers: A Common Founder Variant Predisposing to Brugada Syndrome in Thailand.
作者: Nitinan Chimparlee.;Somchai Prechawat.;Apichai Khongphatthanayothin.;John Mauleekoonphairoj.;Sarin Lekchuensakul.;Wanwarang Wongcharoen.;Pattarapong Makarawate.;Dujdao Sahasatas.;Rungroj Krittayaphong.;Montawatt Amnueypol.;Alisara Anannab.;Tachapong Ngarmukos.;Saran Vardhanabhuti.;Boosamas Sutjaporn.;Pharawee Wandee.;Gumpanart Veerakul.;Connie R Bezzina.;Yong Poovorawan.;Koonlawee Nademanee.
来源: Circ Genom Precis Med. 2021年14卷3期e003229页 507. Atherectomy and Drug-Coated Balloon Angioplasty for the Treatment of Long Infrapopliteal Lesions: A Randomized Controlled Trial.
作者: Aljoscha Rastan.;Marianne Brodmann.;Tanja Böhme.;Roland Macharzina.;Elias Noory.;Ulrich Beschorner.;Peter-Christian Flügel.;Karlheinz Bürgelin.;Franz-Josef Neumann.;Thomas Zeller.
来源: Circ Cardiovasc Interv. 2021年14卷6期e010280页
Prospective, randomized, multicenter trials show no beneficial impact of drug-coated balloon (DCB) therapy alone on the technical and clinical outcomes of infrapopliteal artery lesions in comparison to plain old balloon angioplasty. The aim of this study was to evaluate the performance of directional atherectomy (DA) plus DCB angioplasty versus DCB alone in treatment of long infrapopliteal artery lesions.
508. Five-Year Clinical and Quality of Life Outcomes From the CoreValve US Pivotal Extreme Risk Trial.
作者: Suzanne V Arnold.;George Petrossian.;Michael J Reardon.;Neal S Kleiman.;Steven J Yakubov.;Kaijun Wang.;James Hermiller.;J Kevin Harrison.;G Michael Deeb.;Jian Huang.;David J Cohen.; .
来源: Circ Cardiovasc Interv. 2021年14卷6期e010258页
Older adults with comorbidities who are at extreme risk for surgical aortic valve replacement may be appropriate candidates for transcatheter aortic valve replacement (TAVR). We present the 5-year clinical, echocardiographic, and health status outcomes of such patients treated with CoreValve self-expanding supra-annular TAVR.
509. Health-Related Quality of Life and Angina in Fractional Flow Reserve- Versus Angiography-Guided Coronary Artery Bypass Grafting: FARGO Trial (Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization).
作者: Anne Langhoff Thuesen.;Lars Peter Riber.;Karsten Tange Veien.;Evald Høj Christiansen.;Svend Eggert Jensen.;Ivy Modrau.;Jan Jesper Andreasen.;Britt Borregaard.;Anders Junker.;Poul Erik Mortensen.;Lisette Okkels Jensen.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷6期e007302页
In coronary artery bypass grafting (CABG), the use of fractional flow reserve (FFR) is insufficiently investigated. Stenosis assessment usually relies on visual estimates of lesion severity. This study evaluated health-related quality of life (HRQoL) and angina after FFR- versus angiography-guided CABG.
510. Metabolic Effects of Empagliflozin in Heart Failure: A Randomized, Double-Blind, and Placebo-Controlled Trial (Empire HF Metabolic).
作者: Jesper Jensen.;Massar Omar.;Caroline Kistorp.;Christian Tuxen.;Ida Gustafsson.;Lars Køber.;Finn Gustafsson.;Jens Faber.;Julie L Forman.;Jacob E Møller.;Morten Schou.
来源: Circulation. 2021年143卷22期2208-2210页 511. Polygenic Risk Score-Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain.
作者: Morten Krogh Christiansen.;Simon Winther.;Louise Nissen.;Bjarni Jóhann Vilhjálmsson.;Lars Frost.;Jane Kirk Johansen.;Peter Loof Møller.;Samuel Emil Schmidt.;Jelmer Westra.;Niels Ramsing Holm.;Henrik Kjærulf Jensen.;Evald Høj Christiansen.;Daníel Fannar Guðbjartsson.;Hilma Hólm.;Kári Stefánsson.;Hans Erik Bøtker.;Morten Bøttcher.;Mette Nyegaard.
来源: Circ Genom Precis Med. 2021年14卷3期e003298页
Polygenic risk scores (PRSs) are associated with coronary artery disease (CAD), but the clinical potential of using PRSs at the single-patient level for risk stratification has yet to be established. We investigated whether adding a PRS to clinical risk factors (CRFs) improves risk stratification in patients referred to coronary computed tomography angiography on a suspicion of obstructive CAD.
512. Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation.
作者: Jack W O'Sullivan.;Anna Shcherbina.;Johanne M Justesen.;Mintu Turakhia.;Marco Perez.;Hannah Wand.;Catherine Tcheandjieu.;Shoa L Clarke.;Manuel A Rivas.;Euan A Ashley.
来源: Circ Genom Precis Med. 2021年14卷3期e003168页
Atrial fibrillation (AF) is associated with a five-fold increased risk of ischemic stroke. A portion of this risk is heritable; however, current risk stratification tools (CHA2DS2-VASc) do not include family history or genetic risk. We hypothesized that we could improve ischemic stroke prediction in patients with AF by incorporating polygenic risk scores (PRS).
513. Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.
作者: Daniel H Katz.;Usman A Tahir.;Debby Ngo.;Mark D Benson.;Yan Gao.;Xu Shi.;Matthew Nayor.;Michelle J Keyes.;Martin G Larson.;Michael E Hall.;Adolfo Correa.;Sumita Sinha.;Dongxiao Shen.;Matthew Herzig.;Qiong Yang.;Jeremy M Robbins.;Zsu-Zsu Chen.;Daniel E Cruz.;Bennet Peterson.;Ramachandran S Vasan.;Thomas J Wang.;James G Wilson.;Robert E Gerszten.
来源: Circ Genom Precis Med. 2021年14卷3期e003191页
Increased left ventricular (LV) mass is associated with adverse cardiovascular events including heart failure (HF). Both increased LV mass and HF disproportionately affect Black individuals. To understand the underlying mechanisms, we undertook a proteomic screen in a Black cohort and compared the findings to results from a White cohort.
514. Ten-Year All-Cause Death According to Completeness of Revascularization in Patients With Three-Vessel Disease or Left Main Coronary Artery Disease: Insights From the SYNTAX Extended Survival Study.
作者: Kuniaki Takahashi.;Patrick W Serruys.;Chao Gao.;Masafumi Ono.;Rutao Wang.;Daniel J F M Thuijs.;Michael J Mack.;Nick Curzen.;Friedrich-Wilhelm Mohr.;Piroze Davierwala.;Milan Milojevic.;Joanna J Wykrzykowska.;Robbert J de Winter.;Faisal Sharif.;Yoshinobu Onuma.;Stuart J Head.;Arie Pieter Kappetein.;Marie-Claude Morice.;David R Holmes.; .
来源: Circulation. 2021年144卷2期96-109页
Ten-year all-cause death according to incomplete (IR) versus complete revascularization (CR) has not been fully investigated in patients with 3-vessel disease and left main coronary artery disease undergoing percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG).
515. Changes in Home Blood Pressure Monitored Among Elderly Patients With Hypertension During the COVID-19 Outbreak: A Longitudinal Study in China Leveraging a Smartphone-Based Application.
作者: Shuyuan Zhang.;Xiaoyang Zhou.;Youren Chen.;Lixin Wang.;Bingpo Zhu.;Yinong Jiang.;Peili Bu.;Wei Liu.;Dianfang Li.;Yuming Li.;Yanhua Tao.;Jie Ren.;Li Fu.;Yufeng Li.;Xiaomei Shen.;Hualing Liu.;Gang Sun.;Xinjuan Xu.;Jingjing Bai.;Weili Zhang.;Jun Cai.; .
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷5期e007098页
The coronavirus disease 2019 (COVID-19) pandemic has impacted clinical care worldwide. Evidence of how this health crisis affected common conditions like blood pressure (BP) control is uncertain.
516. Colchicine to Prevent Periprocedural Myocardial Injury in Percutaneous Coronary Intervention: The COPE-PCI Pilot Trial.
作者: Justin Cole.;Nay Htun.;Robert Lew.;Mark Freilich.;Stephen Quinn.;Jamie Layland.
来源: Circ Cardiovasc Interv. 2021年14卷5期e009992页
Periprocedural myocardial infarction and injury (PM-injury) are the most common complications of percutaneous coronary intervention (PCI) and are associated with future adverse cardiac events. Inflammation plays a pivotal role in the development of PM-injury. In this randomized pilot trial, we assessed the effect of an anti-inflammatory medication colchicine on periprocedural myocardial injury.
517. Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Ablation Under Computed Tomographic Guidance in Patients With Neurally Mediated Syncope or Functional Sinus Node Dysfunction.
作者: Philippe Debruyne.;Tom Rossenbacker.;Luc Janssens.;Christine Collienne.;Joris Ector.;Peter Haemers.;Jean-Benoît le Polain de Waroux.;Christine Bazelmans.;Tim Boussy.;William Wijns.
来源: Circ Arrhythm Electrophysiol. 2021年14卷6期e009747页
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518. Plasma Proteomic Profile Predicts Survival in Heart Failure With Reduced Ejection Fraction.
作者: Hongsheng Gui.;Ruicong She.;Jasmine Luzum.;Jia Li.;Timothy D Bryson.;Yigal Pinto.;Hani N Sabbah.;L Keoki Williams.;David E Lanfear.
来源: Circ Genom Precis Med. 2021年14卷3期e003140页
It remains unclear whether the plasma proteome adds value to established predictors in heart failure (HF) with reduced ejection fraction (HFrEF). We sought to derive and validate a plasma proteomic risk score (PRS) for survival in patients with HFrEF (HFrEF-PRS).
519. Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS.
作者: Kristina Lambrakis.;Cynthia Papendick.;John K French.;Stephen Quinn.;Andrew Blyth.;Anil Seshadri.;Michael J R Edmonds.;Anthony Chuang.;Ehsan Khan.;Adam J Nelson.;Deborah Wright.;Matthew Horsfall.;Erin Morton.;Jonathan Karnon.;Tom Briffa.;Louise A Cullen.;Derek P Chew.
来源: Circulation. 2021年144卷2期113-125页
High-sensitivity troponin assays are increasingly being adopted to expedite evaluation of patients with suspected acute coronary syndromes. Few direct comparisons have examined whether the enhanced performance of these assays at low concentrations leads to changes in care that improves longer-term outcomes. This study evaluated late outcomes of participants managed under an unmasked 0/1-hour high-sensitivity cardiac troponin T (hs-cTnT) protocol compared with a 0/3-hour masked hs-cTnT protocol.
520. Text Message Medication Adherence Reminders Automated and Delivered at Scale Across Two Institutions: Testing the Nudge System: Pilot Study.
作者: Phat Luong.;Thomas J Glorioso.;Gary K Grunwald.;Pamela Peterson.;Larry A Allen.;Amber Khanna.;Joy Waughtal.;Lisa Sandy.;P Michael Ho.;Sheana Bull.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷5期e007015页
Medication refill behavior in patients with cardiovascular diseases is suboptimal. Brief behavioral interventions called Nudges may impact medication refill behavior and can be delivered at scale to patients using text messaging.
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