492. Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.
作者: Michail Ignatiadis.;Andrew Bailey.;Heather McArthur.;Sarra El-Abed.;Evandro de Azambuja.;Otto Metzger.;Stephen Y Chui.;Max Dieterich.;Thomas Perretti.;Esther Shearer-Kang.;Luciana Molinero.;Günther G Steger.;Jacek Jassem.;Soo Chin Lee.;Michaela Higgins.;Jose Zarba.;Marcus Schmidt.;Henry Gomez.;Angel Guerrero Zotano.;Luca Moscetti.;Joanne Chiu.;Elisabetta Munzone.;Noa Efrat Ben-Baruch.;Emilio Bajetta.;Shinji Ohno.;Seock-Ah Im.;Gustavo Werutsky.;Einav Nili Gal-Yam.;Xavier Gonzalez Farre.;Ling-Ming Tseng.;William Jacot.;Oleg Gluz.;Zhimin Shao.;Yaroslav Shparyk.;Anastasia Zimina.;Eric Winer.;David A Cameron.;Giuseppe Viale.;Shigehira Saji.;Richard Gelber.;Martine Piccart.
来源: JAMA. 2025年333卷13期1150-60页
Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.
498. Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers: The IN-PEACE Randomized Clinical Trial.
作者: Greg A Sachs.;Nina M Johnson.;Sujuan Gao.;Alexia M Torke.;Susan E Hickman.;Amy Pemberton.;Andrea Vrobel.;Minmin Pan.;Jennifer West.;Kurt Kroenke.
来源: JAMA. 2025年333卷11期962-971页
Care management benefits community-dwelling patients with dementia, but studies include few patients with moderate to severe dementia or from racial and ethnic minority populations, lack palliative care, and seldom reduce health care utilization.
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