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481. TCF19 promotes gastric cancer progression through MCM6.
作者: Jinglei Zhang.;Ya Liu.;Siai Chen.;Yidan Pang.;Jin Zeng.;Juan An.
来源: BMC Gastroenterol. 2025年26卷1期45页
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide with limited therapeutic options. Identifying molecular drivers of GC progression is crucial for developing effective strategies. Transcription Factor 19 (TCF19), a hub gene implicated in various cancers, has not been well reported in GC. Understanding the role of TCF19 in GC could provide novel insights into tumorigenesis and identify potential therapeutic targets.
482. Effect of anesthetic nasal mask on hypoxemia in elderly patients undergoing gastroscopy with deep sedation: a randomized controlled trial.
作者: Huan Liu.;Huisheng Wu.;Lili Tang.;Yangxi Zhao.;Yunping Shi.;Sichen Zhang.;Quan Fang.;Yinguang Fan.;Xuesheng Liu.;Peipei Guo.
来源: BMC Gastroenterol. 2025年26卷1期46页
The risk of hypoxemia is increased in elderly patients who are sedated during gastroscopy. This can be attributed to the physiological changes associated with aging, such as reduced oxygen reserves and an increased sensitivity to sedatives. This study aimed to evaluate whether an anesthetic nasal mask is more effective than a traditional nasal cannula at preventing hypoxemia during gastroscopy in elderly patients.
484. Combined water exchange and cap-assisted colonoscopy reduces cecal intubation time and patient discomfort in patients with unsedated colonoscopy: a randomized controlled trial.
Colonoscopic insertion remains technically challenging. While cap-assisted colonoscopy (CAC) reduces the cecal intubation time (CIT), sigmoid colon water exchange (SWE) enhances linear scope advancement. We hypothesized that combined water exchange and cap-assisted colonoscopy (SWC) would optimize the CIT and improve patient tolerance during unsedated colonoscopy.
485. Retrospective analysis of 331 acute appendicitis patients: how appendicolith and CT features aid in differentiating complicated vs. uncomplicated appendicitis.
作者: Dawei Zhang.;Shengqiang Wang.;Haoyang Li.;Zixuan Fu.;Jing Zhang.;Zhen Liu.;Shikuan Li.
来源: BMC Gastroenterol. 2025年26卷1期40页
Appendicoliths are one of the important causes of acute appendicitis. Currently, there is no consensus on the relationship between appendicoliths and complicated appendicitis, and opinions on the treatment of appendicolith-associated appendicitis vary. This study aims to determine the significance of appendicolith in acute complicated appendicitis and to assess the characteristics of appendicoliths and Computed tomography (CT) features associated with complicated appendicitis.
486. Behavioral changes and delayed colorectal cancer diagnosis during COVID-19: a real-world survey analysis.
作者: Shiki Fujino.;Norikatsu Miyoshi.;Rie Hayashi.;Shinya Kato.;Takashi Takeda.;Katsuki Danno.;Mitsunobu Takeda.;Yuki Sekido.;Tsuyoshi Hata.;Atsushi Hamabe.;Takayuki Ogino.;Mamoru Uemura.;Hirofumi Yamamoto.;Kohei Murata.;Yuichiro Doki.;Hidetoshi Eguchi.; .; .
来源: BMC Gastroenterol. 2025年26卷1期41页
The coronavirus disease 2019 (COVID-19) pandemic profoundly altered healthcare systems and patient behavior worldwide, resulting in a significant decrease in hospital visits and delays in diagnosis and treatment. Thus, we aimed to investigate behavioral changes in patients undergoing colorectal cancer surgery during the pandemic, identify vulnerable populations, and determine the impact of such changes on cancer progression.
487. Multi-Society Expert Panel Consensus Guidance Regarding Clinical Assessment and Clinical Trial Endpoints in Adults With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease.
作者: Rohit Loomba.;Virginia C Clark.;Mattias Mandorfer.;Marc Miravitlles.;Mark Brantly.;Saul J Karpen.;Aleksander Krag.;Paul Y Kwo.;Don C Rockey.;Mark W Russo.;Antonio J Sanchez.;Scott Santarella.;Suzanne R Sharpton.;Charlie Strange.;Jeffrey H Teckman.;Alice M Turner.;Hugo E Vargas.;Pavel Strnad.
来源: Gastroenterology. 2026年170卷4期829-842页
Alpha-1 antitrypsin deficiency-associated liver disease (AATD-LD) remains underrecognized despite its significant contribution to morbidity and mortality in adults with the PiZZ genotype. Lack of standardized definitions, diagnostic criteria, and staging impedes timely diagnosis and therapeutic development. To address these gaps, a multi-disciplinary expert panel convened under the auspices of the American Gastroenterological Association in collaboration with the American Association for the Study of Liver Diseases, European Association for the Study of the Liver, and Alpha-1 Foundation to develop consensus recommendations for nomenclature, diagnosis, staging, and clinical trial endpoints in AATD-LD.
488. Fibulin-5 promotes fibroblast activation through LTBP-4 to improve the pathogenesis of hemorrhoids.
作者: Yongchang Zhao.;Kaihua Xiao.;Yuning Wu.;Danqing Li.;Ruijun Xie.;Muchun Liao.;Feng Sun.
来源: BMC Gastroenterol. 2025年26卷1期33页
Hemorrhoid disease is a widespread gastrointestinal ailment caused by the degeneration of supporting tissues within the anal cushions. Despite its high incidence, the pathogenic processes involved remain poorly elucidated.
489. Aortoenteric fistula: clinical features, diagnostic challenges, and surgical outcomes - a retrospective analysis of 10 cases.
作者: Jia-Wei Wu.;Yue Zhang.;Shi-Rong Chen.;Sharvesh Raj Seeruttun.;Cheng-Lu Ke.;Wei-Xian Hu.;Gang Zhao.;Zheng-Bo Chen.;Chun-Sheng Liu.;Zhi-Yuan Liu.;Jia-Rui Su.;Cheng-Zhi Huang.;Xue-Qing Yao.;Ze-Jian Lyu.
来源: BMC Gastroenterol. 2025年26卷1期38页
Aortoenteric fistula (AEF) is a rare but life-threatening cause of gastrointestinal hemorrhage, often presenting diagnostic challenges and associated with high mortality. Secondary AEF (SAEF), typically related to previous aortic grafting, accounts for most cases. Optimal surgical management and perioperative strategies remain under debate. This study analyzed the clinical characteristics, diagnostic modalities, surgical techniques, and outcomes of patients with AEF to provide insights for guiding future treatment approaches.
490. Association of platelet-lymphocyte ratio with acute pancreatitis severity: systematic review and meta-analysis.
作者: Mohamed Y Ibrahim.;Mona M Alhaj.;Abdelrahim Abdelrazig Ahmed Ibrahim.;Malak Rabih.;Maram Rabih Musa Rabih.;Mohammed Elrayah Hassan Massaad.;Abdelrahman K Elzubir.;Mohammed Mansour Hassan Abdelrahman.;Omer Afifeldin Elmusharf Abdelrahman.;Sagad O O Mohamed.
来源: BMC Gastroenterol. 2025年26卷1期34页
Acute pancreatitis (AP) is an inflammatory disease with a heterogeneous clinical course, ranging from mild symptoms to life-threatening complications. The platelet-to-lymphocyte ratio (PLR), an easily accessible inflammatory biomarker, has shown prognostic value in other conditions but has been understudied in AP. This review aimed to systematically evaluate the association between PLR and AP severity.
491. Confirmation of Helicobacter pylori eradication using ¹³C urea breath test: addressing the regional post-treatment outcomes.
作者: Dinesh Muthuluru.;Sonit Bhusan Patanik.;Pukhraj Singh Jeji.;Akash Dobhada.;Kanishka Uthansingh.;Manoj Kumar Sahu.
来源: BMC Gastroenterol. 2025年25卷1期858页
As a major etiological factor of the gastrointestinal diseases, the presence of Helicobacter pylori (H. pylori) poses a serious concern to the clinical management; however, the confirmation of the eradication post-therapy is of utmost crucial. The purpose of this study was to use the 13C Urea Breath Test (UBT) in measuring the effectiveness of second-line quadruple therapy in assessing treatment failure due to the infection with resistant strains of H. pylori, particularly in the state of Odisha.
493. Clinical significance of the S204 phosphorylation of the Smad3 protein in combination with Ki67 for the metastasis and prognosis of gastric cancer.
作者: Yi-Hui Kang.;Ren-Sheng Chen.;Qing Hu.;Hong-Tao Sun.;Pei Guo.;Shi-Lin Lv.;Ling-Yu Luo.;De-Qiang Huang.
来源: BMC Gastroenterol. 2025年26卷1期37页
The purpose of this study is to explore the prognostic evaluation value of Ki67 and pSmad3L (S204) for gastric cancer (GC) patients by jointly analyzing their expression levels in GC tissues.
494. The relationship between resilience, financial toxicity, and quality of life in patients with primary liver cancer: a cross-sectional study.
Psychological stress and financial hardship are long-standing issues for patients with primary liver cancer. Financial toxicity levels are closely related to quality of life, and resilience is a key psychosocial resource for maintaining quality of life.
495. Hepatitis B and C infections, and co-infections screening among patients attending a tertiary hospital in Addis Ababa, Ethiopia: a retrospective database study.
作者: Balew Arega.;Ermiyas Tefera.;Kibrom Mesfin.;Daniel Achame.;Dawit Tolossa.;Abenezer Worku.;Ermias Kibru.;Nebyu Tafasse.;Amdemeskel Mersha.
来源: BMC Gastroenterol. 2025年26卷1期35页
Hepatitis B and C virus infection is a continuous public health problem in Ethiopia, with the prevalence of the disease significantly varying across administrative regions. Determining seroprevalence among people who are unaware of their infection status is essential for hepatitis diagnosis and treatment. We aimed to determine the seroprevalence of two hepatitis viruses among patients attending different service areas in a tertiary hospital in Ethiopia.
496. Relationship of D-dimer with survival and metastasis in gastric cancer patients: a meta-analysis and systematic review.
作者: Xiaofei Cheng.;Yang Zhang.;Xingyuan Li.;Zhenning Xu.;Yaolin Chen.
来源: BMC Gastroenterol. 2025年26卷1期30页
D-dimer predicts survival in patients with digestive cancers. However, comprehensive analysis focused on gastric cancer patients is lacking. This meta-analysis aimed to investigate the association of D-dimer with survival in gastric cancer patients.
497. The causal relationship between body mass index and perianal abscess: a Mendelian randomization study.
Observational studies suggest an association between elevated body mass index (BMI) and perianal abscess risk, but residual confounding and reverse causality limit causal inference. Mendelian randomization (MR) offers a robust approach to assess causality by leveraging genetic variants as instrumental variables. This study aimed to evaluate the causal relationship between BMI and perianal abscess using a MR framework.
499. Comparative efficacy of different diet modalities on metabolic profiles and liver functions in metabolic dysfunction-associated fatty liver disease: a network meta-analysis.
作者: Jiahui Zou.;Fei Tian.;Shuqing Cui.;Jing Hou.;Zhenhua Li.;Yaochen Wei.;Haozhe Cui.;Yunpeng Li.;Shuanghao Zhou.;Zechao He.;Xiangming Ma.
来源: BMC Gastroenterol. 2025年26卷1期25页
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a global public health challenge that is primarily managed through lifestyle interventions, particularly diet. This network meta-analysis aimed to thoroughly evaluate the effectiveness of four different dietary patterns: Mediterranean diet (MD), intermittent fasting (IF), Dietary Approaches to Stop Hypertension (DASH), and low-fat diet (LF) in improving liver function and metabolic profiles in adults diagnosed with MAFLD.
500. Analysis of risk factors and correlation between the degree of hepatic steatosis and fibrosis in patients with metabolic dysfunction-associated steatohepatitis.
作者: Xiaojin Yang.;Desheng Xie.;Yao Du.;DongHong Zhang.;Houji Chen.;Yinghua Yuan.
来源: BMC Gastroenterol. 2025年26卷1期28页
Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic metabolic liver disease. This study sought to investigate risk factors and correlation between degree of hepatic steatosis and fibrosis in patients with MASH.
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