当前位置: 首页 >> 检索结果
481. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial.
作者: Richard K Burt.;Roumen Balabanov.;Joachim Burman.;Basil Sharrack.;John A Snowden.;Maria Carolina Oliveira.;Jan Fagius.;John Rose.;Flavia Nelson.;Amilton Antunes Barreira.;Kristina Carlson.;Xiaoqiang Han.;Daniela Moraes.;Amy Morgan.;Kathleen Quigley.;Kimberly Yaung.;Regan Buckley.;Carri Alldredge.;Allison Clendenan.;Michelle A Calvario.;Jacquelyn Henry.;Borko Jovanovic.;Irene B Helenowski.
来源: JAMA. 2019年321卷2期165-174页
Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS).
482. Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial.
作者: Samuel P Costello.;Patrick A Hughes.;Oliver Waters.;Robert V Bryant.;Andrew D Vincent.;Paul Blatchford.;Rosa Katsikeros.;Jesica Makanyanga.;Melissa A Campaniello.;Chris Mavrangelos.;Carly P Rosewarne.;Chelsea Bickley.;Cian Peters.;Mark N Schoeman.;Michael A Conlon.;Ian C Roberts-Thomson.;Jane M Andrews.
来源: JAMA. 2019年321卷2期156-164页
High-intensity, aerobically prepared fecal microbiota transplantation (FMT) has demonstrated efficacy in treating active ulcerative colitis (UC). FMT protocols involving anaerobic stool processing methods may enhance microbial viability and allow efficacy with a lower treatment intensity.
483. Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial.
作者: Peter J McCartney.;Hany Eteiba.;Annette M Maznyczka.;Margaret McEntegart.;John P Greenwood.;Douglas F Muir.;Saqib Chowdhary.;Anthony H Gershlick.;Clare Appleby.;James M Cotton.;Andrew Wragg.;Nick Curzen.;Keith G Oldroyd.;Mitchell Lindsay.;J Paul Rocchiccioli.;Aadil Shaukat.;Richard Good.;Stuart Watkins.;Keith Robertson.;Christopher Malkin.;Lynn Martin.;Lynsey Gillespie.;Thomas J Ford.;Mark C Petrie.;Peter W Macfarlane.;R Campbell Tait.;Paul Welsh.;Naveed Sattar.;Robin A Weir.;Keith A Fox.;Ian Ford.;Alex McConnachie.;Colin Berry.; .
来源: JAMA. 2019年321卷1期56-68页
Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated with adverse outcomes.
484. Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial Infarction: The ARTEMIS Randomized Clinical Trial.
作者: Tracy Y Wang.;Lisa A Kaltenbach.;Christopher P Cannon.;Gregg C Fonarow.;Niteesh K Choudhry.;Timothy D Henry.;David J Cohen.;Durgesh Bhandary.;Naeem D Khan.;Kevin J Anstrom.;Eric D Peterson.
来源: JAMA. 2019年321卷1期44-55页
Despite guideline recommendations, many patients discontinue P2Y12 inhibitor therapy earlier than the recommended 1 year after myocardial infarction (MI), and higher-potency P2Y12 inhibitors are underutilized. Cost is frequently cited as an explanation for both of these observations.
485. Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.
作者: .;Tetsuo Shoji.;Masaaki Inaba.;Masafumi Fukagawa.;Ryoichi Ando.;Masanori Emoto.;Hisako Fujii.;Akira Fujimori.;Mitsuru Fukui.;Hiroki Hase.;Tetsuya Hashimoto.;Hideki Hirakata.;Hirokazu Honda.;Tatsuo Hosoya.;Yuji Ikari.;Daijo Inaguma.;Toru Inoue.;Yoshitaka Isaka.;Kunitoshi Iseki.;Eiji Ishimura.;Noritomo Itami.;Chiharu Ito.;Toshitaka Kakuta.;Toru Kawai.;Hideki Kawanishi.;Shuzo Kobayashi.;Junko Kumagai.;Kiyoshi Maekawa.;Ikuto Masakane.;Jun Minakuchi.;Koji Mitsuiki.;Takashi Mizuguchi.;Satoshi Morimoto.;Toyoaki Murohara.;Tatsuya Nakatani.;Shigeo Negi.;Shinichi Nishi.;Mitsushige Nishikawa.;Tetsuya Ogawa.;Kazumichi Ohta.;Takayasu Ohtake.;Mikio Okamura.;Senji Okuno.;Takashi Shigematsu.;Toshitsugu Sugimoto.;Masashi Suzuki.;Hideki Tahara.;Yoshiaki Takemoto.;Kenji Tanaka.;Yoshihiro Tominaga.;Yoshiharu Tsubakihara.;Yoshihiro Tsujimoto.;Kazuhiko Tsuruya.;Shinichiro Ueda.;Yuzo Watanabe.;Kunihiro Yamagata.;Tomoyuki Yamakawa.;Shozo Yano.;Keitaro Yokoyama.;Noriaki Yorioka.;Minoru Yoshiyama.;Yoshiki Nishizawa.
来源: JAMA. 2018年320卷22期2325-2334页
Patients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk. Observational studies in patients treated with hemodialysis showed that the use of active vitamin D sterols was associated with lower risk of all-cause mortality, regardless of parathyroid hormone levels.
486. Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial.
作者: Aleena Banerji.;Marc A Riedl.;Jonathan A Bernstein.;Marco Cicardi.;Hilary J Longhurst.;Bruce L Zuraw.;Paula J Busse.;John Anderson.;Markus Magerl.;Inmaculada Martinez-Saguer.;Mark Davis-Lorton.;Andrea Zanichelli.;H Henry Li.;Timothy Craig.;Joshua Jacobs.;Douglas T Johnston.;Ralph Shapiro.;William H Yang.;William R Lumry.;Michael E Manning.;Lawrence B Schwartz.;Mustafa Shennak.;Daniel Soteres.;Rafael H Zaragoza-Urdaz.;Selina Gierer.;Andrew M Smith.;Raffi Tachdjian.;H James Wedner.;Jacques Hebert.;Syed M Rehman.;Petra Staubach.;Jennifer Schranz.;Jovanna Baptista.;Wolfram Nothaft.;Marcus Maurer.; .
来源: JAMA. 2018年320卷20期2108-2121页
Current treatments for long-term prophylaxis in hereditary angioedema have limitations.
487. Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial.
作者: Esther Meijer.;Folkert W Visser.;Rene M M van Aerts.;Charles J Blijdorp.;Niek F Casteleijn.;Hedwig M A D'Agnolo.;Shosha E I Dekker.;Joost P H Drenth.;Johan W de Fijter.;Maatje D A van Gastel.;Tom J Gevers.;Marten A Lantinga.;Monique Losekoot.;A Lianne Messchendorp.;Myrte K Neijenhuis.;Michelle J Pena.;Dorien J M Peters.;Mahdi Salih.;Darius Soonawala.;Edwin M Spithoven.;Jack F Wetzels.;Robert Zietse.;Ron T Gansevoort.; .
来源: JAMA. 2018年320卷19期2010-2019页
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation in both kidneys and loss of renal function, eventually leading to a need for kidney replacement therapy. There are limited therapeutic management options.
488. Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults: The D-PRESCRIBE Randomized Clinical Trial.
作者: Philippe Martin.;Robyn Tamblyn.;Andrea Benedetti.;Sara Ahmed.;Cara Tannenbaum.
来源: JAMA. 2018年320卷18期1889-1898页
High rates of inappropriate prescribing persist among older adults in many outpatient settings, increasing the risk of adverse drug events and drug-related hospitalizations.
489. Effect of a Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Hospitalized Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
作者: Hanan Aboumatar.;Mohammad Naqibuddin.;Suna Chung.;Hina Chaudhry.;Samuel W Kim.;Jamia Saunders.;Lee Bone.;Ayse P Gurses.;Amy Knowlton.;Peter Pronovost.;Nirupama Putcha.;Cynthia Rand.;Debra Roter.;Carol Sylvester.;Carol Thompson.;Jennifer L Wolff.;Judith Hibbard.;Robert A Wise.
来源: JAMA. 2018年320卷22期2335-2343页
Patients hospitalized for chronic obstructive pulmonary disease (COPD) exacerbations have high rehospitalization rates and reduced quality of life.
490. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial.
作者: Julio Rosenstock.;Vlado Perkovic.;Odd Erik Johansen.;Mark E Cooper.;Steven E Kahn.;Nikolaus Marx.;John H Alexander.;Michael Pencina.;Robert D Toto.;Christoph Wanner.;Bernard Zinman.;Hans Juergen Woerle.;David Baanstra.;Egon Pfarr.;Sven Schnaidt.;Thomas Meinicke.;Jyothis T George.;Maximilian von Eynatten.;Darren K McGuire.; .
来源: JAMA. 2019年321卷1期69-79页
Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease.
491. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial.
作者: Barry A Borlaug.;Kevin J Anstrom.;Gregory D Lewis.;Sanjiv J Shah.;James A Levine.;Gabe A Koepp.;Michael M Givertz.;G Michael Felker.;Martin M LeWinter.;Douglas L Mann.;Kenneth B Margulies.;Andrew L Smith.;W H Wilson Tang.;David J Whellan.;Horng H Chen.;Victor G Davila-Roman.;Steven McNulty.;Patrice Desvigne-Nickens.;Adrian F Hernandez.;Eugene Braunwald.;Margaret M Redfield.; .
来源: JAMA. 2018年320卷17期1764-1773页
There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF.
492. Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants <28 Weeks' Gestational Age: A Randomized Clinical Trial.
作者: Dale L Phelps.;Kristi L Watterberg.;Tracy L Nolen.;Carol A Cole.;C Michael Cotten.;William Oh.;Brenda B Poindexter.;Kristin M Zaterka-Baxter.;Abhik Das.;Conra Backstrom Lacy.;Ann Marie Scorsone.;Michele C Walsh.;Edward F Bell.;Kathleen A Kennedy.;Kurt Schibler.;Gregory M Sokol.;Matthew M Laughon.;Satyanarayana Lakshminrusimha.;William E Truog.;Meena Garg.;Waldemar A Carlo.;Abbot R Laptook.;Krisa P Van Meurs.;David P Carlton.;Amanda Graf.;Sara B DeMauro.;Luc P Brion.;Seetha Shankaran.;Faruk H Orge.;Richard J Olson.;Helen Mintz-Hittner.;Michael B Yang.;Kathryn M Haider.;David K Wallace.;Mina Chung.;Denise Hug.;Irena Tsui.;Martin S Cogen.;John P Donahue.;Michael Gaynon.;Amy K Hutchinson.;Don L Bremer.;Graham Quinn.;Yu-Guang He.;William R Lucas.;Timothy W Winter.;Stephen D Kicklighter.;Kartik Kumar.;Patricia R Chess.;Tarah T Colaizy.;Anna Marie Hibbs.;Namasivayam Ambalavanan.;Heidi M Harmon.;Elisabeth C McGowan.;Rosemary D Higgins.; .
来源: JAMA. 2018年320卷16期1649-1658页
Previous studies of myo-inositol in preterm infants with respiratory distress found reduced severity of retinopathy of prematurity (ROP) and less frequent ROP, death, and intraventricular hemorrhage. However, no large trials have tested its efficacy or safety.
493. Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.
作者: Peter Pickkers.;Ravindra L Mehta.;Patrick T Murray.;Michael Joannidis.;Bruce A Molitoris.;John A Kellum.;Mirjam Bachler.;Eric A J Hoste.;Oscar Hoiting.;Kenneth Krell.;Marlies Ostermann.;Wim Rozendaal.;Miia Valkonen.;David Brealey.;Albertus Beishuizen.;Ferhat Meziani.;Raghavan Murugan.;Hilde de Geus.;Didier Payen.;Erik van den Berg.;Jacques Arend.; .
来源: JAMA. 2018年320卷19期1998-2009页
Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival.
494. Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial.
作者: Elie Azoulay.;Virginie Lemiale.;Djamel Mokart.;Saad Nseir.;Laurent Argaud.;Frédéric Pène.;Loay Kontar.;Fabrice Bruneel.;Kada Klouche.;François Barbier.;Jean Reignier.;Lilia Berrahil-Meksen.;Guillaume Louis.;Jean-Michel Constantin.;Julien Mayaux.;Florent Wallet.;Achille Kouatchet.;Vincent Peigne.;Igor Théodose.;Pierre Perez.;Christophe Girault.;Samir Jaber.;Johanna Oziel.;Martine Nyunga.;Nicolas Terzi.;Lila Bouadma.;Christine Lebert.;Alexandre Lautrette.;Naike Bigé.;Jean-Herlé Raphalen.;Laurent Papazian.;Michael Darmon.;Sylvie Chevret.;Alexandre Demoule.
来源: JAMA. 2018年320卷20期2099-2107页
High-flow nasal oxygen therapy is increasingly used for acute hypoxemic respiratory failure (AHRF).
495. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial.
作者: D James Cooper.;Alistair D Nichol.;Michael Bailey.;Stephen Bernard.;Peter A Cameron.;Sébastien Pili-Floury.;Andrew Forbes.;Dashiell Gantner.;Alisa M Higgins.;Olivier Huet.;Jessica Kasza.;Lynne Murray.;Lynette Newby.;Jeffrey J Presneill.;Stephen Rashford.;Jeffrey V Rosenfeld.;Michael Stephenson.;Shirley Vallance.;Dinesh Varma.;Steven A R Webb.;Tony Trapani.;Colin McArthur.; .
来源: JAMA. 2018年320卷21期2211-2220页
After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.
496. Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in Intensive Care Units: A Randomized Clinical Trial.
作者: Radia El Khamali.;Atika Mouaci.;Sabine Valera.;Marion Cano-Chervel.;Camille Pinglis.;Céline Sanz.;Amel Allal.;Valérie Attard.;Julie Malardier.;Magali Delfino.;Fifina D'Anna.;Pierre Rostini.;Stéphan Aguilard.;Karine Berthias.;Béatrice Cresta.;Frédéric Iride.;Valérie Reynaud.;Jérémie Suard.;Wlady Syja.;Cécile Vankiersbilck.;Nicole Chevalier.;Karen Inthavong.;Jean-Marie Forel.;Karine Baumstarck.;Laurent Papazian.; .
来源: JAMA. 2018年320卷19期1988-1997页
Nurses working in an intensive care unit (ICU) are exposed to occupational stressors that can increase the risk of stress reactions, long-term absenteeism, and turnover.
497. Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial.
作者: .;Fabienne D Simonis.;Ary Serpa Neto.;Jan M Binnekade.;Annemarije Braber.;Karina C M Bruin.;Rogier M Determann.;Geert-Jan Goekoop.;Jeroen Heidt.;Janneke Horn.;Gerard Innemee.;Evert de Jonge.;Nicole P Juffermans.;Peter E Spronk.;Lotte M Steuten.;Pieter Roel Tuinman.;Rob B P de Wilde.;Marijn Vriends.;Marcelo Gama de Abreu.;Paolo Pelosi.;Marcus J Schultz.
来源: JAMA. 2018年320卷18期1872-1880页
It remains uncertain whether invasive ventilation should use low tidal volumes in critically ill patients without acute respiratory distress syndrome (ARDS).
498. Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial.
作者: Gavin D Perkins.;Dipesh Mistry.;Simon Gates.;Fang Gao.;Catherine Snelson.;Nicholas Hart.;Luigi Camporota.;James Varley.;Coralie Carle.;Elankumaran Paramasivam.;Beverley Hoddell.;Daniel F McAuley.;Timothy S Walsh.;Bronagh Blackwood.;Louise Rose.;Sarah E Lamb.;Stavros Petrou.;Duncan Young.;Ranjit Lall.; .
来源: JAMA. 2018年320卷18期1881-1888页
In adults in whom weaning from invasive mechanical ventilation is difficult, noninvasive ventilation may facilitate early liberation, but there is uncertainty about its effectiveness in a general intensive care patient population.
499. Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial.
作者: Bastiaan H Wittekamp.;Nienke L Plantinga.;Ben S Cooper.;Joaquin Lopez-Contreras.;Pere Coll.;Jordi Mancebo.;Matt P Wise.;Matt P G Morgan.;Pieter Depuydt.;Jerina Boelens.;Thierry Dugernier.;Valérie Verbelen.;Philippe G Jorens.;Walter Verbrugghe.;Surbhi Malhotra-Kumar.;Pierre Damas.;Cécile Meex.;Kris Leleu.;Anne-Marie van den Abeele.;Ana Filipa Gomes Pimenta de Matos.;Sara Fernández Méndez.;Andrea Vergara Gomez.;Viktorija Tomic.;Franc Sifrer.;Esther Villarreal Tello.;Jesus Ruiz Ramos.;Irene Aragao.;Claudia Santos.;Roberta H M Sperning.;Patrizia Coppadoro.;Giuseppe Nardi.;Christian Brun-Buisson.;Marc J M Bonten.
来源: JAMA. 2018年320卷20期2087-2098页
The effects of chlorhexidine (CHX) mouthwash, selective oropharyngeal decontamination (SOD), and selective digestive tract decontamination (SDD) on patient outcomes in ICUs with moderate to high levels of antibiotic resistance are unknown.
500. Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial.
作者: Graham Devereux.;Seonaidh Cotton.;Shona Fielding.;Nicola McMeekin.;Peter J Barnes.;Andrew Briggs.;Graham Burns.;Rekha Chaudhuri.;Henry Chrystyn.;Lisa Davies.;Anthony De Soyza.;Simon Gompertz.;John Haughney.;Karen Innes.;Joanna Kaniewska.;Amanda Lee.;Alyn Morice.;John Norrie.;Anita Sullivan.;Andrew Wilson.;David Price.
来源: JAMA. 2018年320卷15期1548-1559页
Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD.
|