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4961. Influence of age on mechanisms and prognosis of heart failure. The V-HeFT VA Cooperative Studies Group.
Advanced age is commonly thought to carry a poor prognosis in congestive heart failure, but the case has not been established. The Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-HeFT I and II) provided a large data base to assess the effect of age on hemodynamic profiles and survival in the failing heart.
4962. The influence of atrial fibrillation on prognosis in mild to moderate heart failure. The V-HeFT Studies. The V-HeFT VA Cooperative Studies Group.
作者: P E Carson.;G R Johnson.;W B Dunkman.;R D Fletcher.;L Farrell.;J N Cohn.
来源: Circulation. 1993年87卷6 Suppl期VI102-10页
Atrial fibrillation occurs commonly in heart failure; however, its importance in terms of prognosis is controversial.
4963. The Vasodilator-Heart Failure Trials (V-HeFT). Mechanistic data from the VA Cooperative Studies. Introduction.4964. The vasodilator-heart failure trials (V-HeFT).
来源: Circulation. 1993年87卷6 Suppl期VI1-117页
4965. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty.
作者: E J Topol.;R Bonan.;D Jewitt.;U Sigwart.;V V Kakkar.;M Rothman.;D de Bono.;J Ferguson.;J T Willerson.;J Strony.
来源: Circulation. 1993年87卷5期1622-9页
Since the inception of coronary angioplasty, heparin with or without aspirin has been routinely given intraprocedurally to avoid coronary thrombotic complications. Recently, the direct thrombin inhibitor hirulog has been demonstrated to inactivate clot-bound thrombin. The present study was a multicenter dose escalation of hirulog to determine its appropriate dose and feasibility as the sole anticoagulant during coronary angioplasty.
4966. Effect of picotamide on the clinical progression of peripheral vascular disease. A double-blind placebo-controlled study. The ADEP Group.
Patients with peripheral vascular disease (PVD) undergo a clinical course that can be complicated by cardiovascular events occurring in several areas of the circulation.
4967. A randomized, prospective comparison of anterior and posterior approaches to radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia.
作者: J J Langberg.;A Leon.;M Borganelli.;S J Kalbfleisch.;R el-Atassi.;H Calkins.;F Morady.
来源: Circulation. 1993年87卷5期1551-6页
Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus selectively affect slow pathway function. The current study compares the safety, efficacy, and electrophysiological effects of these two techniques in a prospective, randomized fashion.
4968. Aspirin versus coumadin in the prevention of reocclusion and recurrent ischemia after successful thrombolysis: a prospective placebo-controlled angiographic study. Results of the APRICOT Study.
作者: A Meijer.;F W Verheugt.;C J Werter.;K I Lie.;J M van der Pol.;M J van Eenige.
来源: Circulation. 1993年87卷5期1524-30页
Successful coronary thrombolysis involves a risk for reocclusion that cannot be prevented by invasive strategies. Therefore, we studied the effects of three antithrombotic regimens on the angiographic and clinical courses after successful thrombolysis.
4969. Improvement of cardiac function by angiotensin converting enzyme inhibition. Sites of action.
作者: R Dietz.;W Waas.;T Süsselbeck.;R Willenbrock.;K J Osterziel.
来源: Circulation. 1993年87卷5 Suppl期IV108-16页
The discovery of new properties of angiotensin converting enzyme (ACE) inhibitors in addition to their well-known ability to lower blood-pressure, such as antiproliferative actions and antiadrenergic and vagal-stimulating effects, has contributed to the usefulness of this class of agents in the prevention and treatment of cardiovascular diseases.
4970. Prognostic significance of progression of coronary atherosclerosis.
Angiographic progression of coronary atherosclerosis is frequently observed in clinical practice and is used as an end point in clinical trials; however, its prognostic significance is unclear.
4971. Genetic determinants of responsiveness to the HMG-CoA reductase inhibitor fluvastatin in patients with molecularly defined heterozygous familial hypercholesterolemia.
作者: E Leitersdorf.;S Eisenberg.;O Eliav.;Y Friedlander.;N Berkman.;E J Dann.;D Landsberger.;E Sehayek.;V Meiner.;M Wurm.
来源: Circulation. 1993年87卷4 Suppl期III35-44页
In familial hypercholesterolemia, plasma lipoproteins can be modulated by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, although the underlying response mechanisms are still unknown.
4972. Assessment of the human splanchnic venous volume-pressure relation using radionuclide plethysmography. Effect of nitroglycerin.
No method exists to assess human splanchnic venous function, the most important region in terms of vascular capacity.
4973. Effects of captopril on ischemia and dysfunction of the left ventricle after myocardial infarction.
Treatment with angiotensin converting enzyme inhibitors has been shown to be beneficial in patients with heart failure and myocardial infarction. Experimental studies have shown beneficial effects on the ischemic myocardium.
4974. Comparison of angioplasty and surgery for unoperated coarctation of the aorta.
作者: R E Shaddy.;M M Boucek.;J E Sturtevant.;H D Ruttenberg.;R B Jaffe.;L Y Tani.;V E Judd.;L G Veasy.;E C McGough.;G S Orsmond.
来源: Circulation. 1993年87卷3期793-9页
The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion.
4975. Determinants of predicted efficacy of antiarrhythmic drugs in the electrophysiologic study versus electrocardiographic monitoring trial. The ESVEM Investigators.
来源: Circulation. 1993年87卷2期323-9页
The Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) study was designed to compare the accuracy of predictions of antiarrhythmic drug efficacy made by electrophysiological study (EPS) with those made by Holter monitoring (HM) combined with exercise testing. The present study describes the baseline characteristics and the response to drug efficacy tests of 486 randomized subjects.
4976. Long-term benefit of 1-year amiodarone treatment for persistent complex ventricular arrhythmias after myocardial infarction.
作者: M E Pfisterer.;W Kiowski.;H Brunner.;D Burckhardt.;F Burkart.
来源: Circulation. 1993年87卷2期309-11页
In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone after 1 year, the long-term outcomes of all patients of the amiodarone-treated group (initially n = 98) and those of the control group (n = 114) were assessed.
4977. Prevalence and prognostic significance of ventricular arrhythmias after acute myocardial infarction in the fibrinolytic era. GISSI-2 results.
作者: A P Maggioni.;G Zuanetti.;M G Franzosi.;F Rovelli.;E Santoro.;L Staszewsky.;L Tavazzi.;G Tognoni.
来源: Circulation. 1993年87卷2期312-22页
Several studies performed before the advent of thrombolysis have shown that the presence of ventricular arrhythmias is an independent risk factor for subsequent mortality in patients recovering from acute myocardial infarction. Since fibrinolysis affects the natural history of infarction and may alter the clinical relevance of different risk factors, the aim of the present study was to establish the prevalence and prognostic value of ventricular arrhythmias in post-myocardial infarction patients treated with fibrinolytic agents during the acute phase.
4978. Early effects of tissue-type plasminogen activator added to conventional therapy on the culprit coronary lesion in patients presenting with ischemic cardiac pain at rest. Results of the Thrombolysis in Myocardial Ischemia (TIMI IIIA) Trial.
来源: Circulation. 1993年87卷1期38-52页
The early effects of tissue-type plasminogen activator (t-PA) on the "culprit" coronary lesion in patients presenting with unstable angina or non-Q wave myocardial infarction were determined by quantitative arteriography.
4979. Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study.
作者: G Fornaro.;P Rossi.;P G Mantica.;M E Caccia.;D Aralda.;M Lavezzari.;F Pamparana.;G Milanesi.
来源: Circulation. 1993年87卷1期162-4页
The purpose of this randomized, double-blind study was to evaluate the efficacy of indobufen, a reversible inhibitor of platelet cyclooxygenase, in the prevention of embolic events of cardiac origin.
4980. Beneficial effects of atrial natriuretic peptide on exercise-induced myocardial ischemia in patients with stable effort angina pectoris.
作者: C P Lai.;K Egashira.;H Tashiro.;H Narabayashi.;S Koyanagi.;T Imaizumi.;A Takeshita.
来源: Circulation. 1993年87卷1期144-51页
It has been shown that atrial natriuretic peptide (ANP), an endogenous vasodilator, dilates coronary arteries and decreases coronary vascular resistance. The purpose of this study was to determine whether an intravenous administration of ANP attenuated exercise-induced myocardial ischemia in 14 patients with stable effort angina pectoris.
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