当前位置: 首页 >> 检索结果
4901. Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure.
作者: C A Sueta.;S W Clarke.;S H Dunlap.;L Jensen.;M B Blauwet.;G Koch.;J H Patterson.;K F Adams.
来源: Circulation. 1994年89卷2期660-6页
There is a high incidence of ventricular arrhythmia and sudden death in patients with heart failure. Unfortunately, currently available antiarrhythmic agents have only limited efficacy and may result in proarrhythmia and hemodynamic deterioration in these patients.
4902. Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina. European Cooperative Study Group.
作者: M L Simoons.;M J de Boer.;M J van den Brand.;A J van Miltenburg.;J C Hoorntje.;G R Heyndrickx.;L R van der Wieken.;D de Bono.;W Rutsch.;T F Schaible.
来源: Circulation. 1994年89卷2期596-603页
Patients with unstable angina despite intensive medical therapy, ie, refractory angina, are at high risk for developing thrombotic complications: myocardial infarction or coronary occlusion during percutaneous transluminal coronary angioplasty (PTCA). Chimeric 7E3 (c7E3) Fab is an antibody fragment that blocks the platelet glycoprotein (GP) IIb/IIIa receptor and potently inhibits platelet aggregation.
4903. Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group.
作者: M Cohen.;P C Adams.;G Parry.;J Xiong.;D Chamberlain.;I Wieczorek.;K A Fox.;J H Chesebro.;J Strain.;C Keller.
来源: Circulation. 1994年89卷1期81-8页
The purpose of this study was to compare combination antithrombotic therapy with aspirin plus anticoagulation versus aspirin alone, when added to conventional antianginal therapy in patients with unstable rest angina or non-Q-wave myocardial infarction who were nonprior aspirin users.
4904. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril.
作者: M St John Sutton.;M A Pfeffer.;T Plappert.;J L Rouleau.;L A Moyé.;G R Dagenais.;G A Lamas.;M Klein.;B Sussex.;S Goldman.
来源: Circulation. 1994年89卷1期68-75页
Left ventricular enlargement after myocardial infarction increases the likelihood of an adverse outcome. In an echocardiographic substudy of the Survival and Ventricular Enlargement (SAVE) Trial, we assessed whether captopril would attenuate progressive left ventricular enlargement in patients with left ventricular dysfunction after acute myocardial infarction and, if so, whether this would be associated with improved clinical outcome.
4905. Long-term prognostic importance of patency of the infarct-related coronary artery after thrombolytic therapy for acute myocardial infarction.
After thrombolytic therapy, long-term patency of the infarct-related artery may reduce arrhythmias, limit ventricular dilatation, and provide collaterals to another infarct zone if further infarction occurs. However, independent long-term prognostic value of infarct artery patency has not been shown.
4906. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.
作者: S E Reis.;S T Gloth.;R S Blumenthal.;J R Resar.;H A Zacur.;G Gerstenblith.;J A Brinker.
来源: Circulation. 1994年89卷1期52-60页
Estrogen administration in postmenopausal women is associated with a 50% reduction in the clinical manifestations of coronary artery disease. The mechanisms are not known, although one potential explanation is estrogen-induced modulation of coronary vasoreactivity. Acetylcholine is an endothelium-dependent vasodilator that may be used to assess coronary vasoreactivity and elicits coronary responses that parallel those found with common daily vasomotor stimuli. Therefore, we tested whether estrogen attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.
4907. Angiotensin-converting enzyme inhibition with fosinopril sodium in the prevention of restenosis after coronary angioplasty.
作者: W Desmet.;M Vrolix.;I De Scheerder.;J Van Lierde.;J L Willems.;J Piessens.
来源: Circulation. 1994年89卷1期385-92页
Several angiotensin-converting enzyme inhibitors have antiproliferative effects in a rat model after carotid artery balloon injury.
4908. A comparison of low- with high-osmolality contrast agents in cardiac angiography. Identification of criteria for selective use.
作者: W H Matthai.;W G Kussmaul.;J Krol.;J E Goin.;J S Schwartz.;J W Hirshfeld.
来源: Circulation. 1994年89卷1期291-301页
Controversy exists as to whether low-osmolality radiographic contrast agents, which have less detrimental pharmacological effects but are considerably more expensive than high-osmolality agents, should be used universally or only for selected high-risk patients.
4909. Rise in chronic defibrillation thresholds in nonthoracotomy implantable defibrillator.
To establish the chronic stability of defibrillation thresholds (DFTs) in a transvenous cardioverter/defibrillator (TCD) system, we studied 37 consecutive patients with TCD systems implanted for > 6 months.
4910. Blood pressure modulation by central venous pressure and respiration. Buffering effects of the heart rate reflexes.
Despite constant fluctuations in cardiac preload caused by the effects of respiration and changes in posture on venous return to the heart, arterial blood pressure remains remarkably constant. The effects of instantaneous lung volume (ILV) and variations of central venous pressure (CVP) on blood pressure (BP) were studied by use of frequency domain techniques to quantify the contribution of heart rate (HR) reflexes to attenuation of the effects of changes in right ventricular preload on arterial pressure.
4911. Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation.
Data continue to accumulate supporting a proatherogenic role for oxidized low-density lipoprotein (Ox-LDL). Antioxidant micronutrients such as ascorbate, alpha-tocopherol, and beta carotene, levels of which can be favorably manipulated by dietary measures without side effects, could be a safe approach in inhibiting LDL oxidation. In fact, in vitro studies have shown that all three antioxidants can inhibit LDL oxidation. The present study was undertaken to ascertain both the safety and antioxidant effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on LDL oxidation.
4912. Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events.
There is considerable evidence that remnants of triglyceride-rich lipoproteins may be particularly atherogenic.
4913. Effects of intensive lipid-lowering therapy on the coronary arteries of asymptomatic subjects with elevated apolipoprotein B.
作者: X Q Zhao.;B G Brown.;L Hillger.;D Sacco.;B Bisson.;L Fisher.;J J Albers.
来源: Circulation. 1993年88卷6期2744-53页
Do the benefits of intensive lipid-lowering therapy seen in symptomatic patients extend to high-risk subjects who have never had symptoms?
4914. Platelet activation during coronary angioplasty in humans.
Previous studies have indicated that balloon angioplasty is associated with local platelet activation. In addition, different contrast media have different effects on thrombus formation during angioplasty in humans. We hypothesized that coronary angioplasty in humans is associated with activation of platelets to specific platelet agonists and that this activation may be differently modified by different angiographic contrast agents.
4915. Low-energy endocardial defibrillation using an axillary or a pectoral thoracic electrode location.
A significant proportion of patients receiving endocardial defibrillation lead systems must accept either high defibrillation thresholds (DFTs) with lower safety margins or lead implantation by thoracotomy. We examined the feasibility of achieving universal application of endocardial leads and lower defibrillation energy requirements by optimizing the lead system location in conjunction with biphasic shocks.
4916. Optimization of biphasic waveforms for human nonthoracotomy defibrillation.
Biphasic waveforms reduce defibrillation threshold (DFT) in a wide variety of models. Although there are several human studies of long-duration, high-tilt biphasic waveform defibrillation, the specific biphasic waveform shape required to achieve optimal DFT reduction is unknown.
4917. Benefit of adding low molecular weight heparin to the conventional treatment of stable angina pectoris. A double-blind, randomized, placebo-controlled trial.
作者: G Melandri.;F Semprini.;V Cervi.;N Candiotti.;E Palazzini.;A Branzi.;B Magnani.
来源: Circulation. 1993年88卷6期2517-23页
Patients with chronic coronary artery disease exhibit a dysfunctioning endothelium, which may be responsible for exercise-induced platelet activation and expression of a procoagulant moiety. In this study, we evaluated the therapeutic efficacy of a low molecular weight heparin (Parnaparin) in patients with stable angina pectoris.
4918. Late reperfusion for acute myocardial infarction limits the dilatation of left ventricle without the reduction of infarct size.
作者: A Hirayama.;T Adachi.;S Asada.;M Mishima.;S Nanto.;H Kusuoka.;K Yamamoto.;Y Matsumura.;M Hori.;M Inoue.
来源: Circulation. 1993年88卷6期2565-74页
While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified.
4919. Factors influencing 1-year patency of coronary artery saphenous vein grafts. Studio Indobufene nel Bypass Aortocoronarico (SINBA).
作者: G Cataldo.;M Braga.;N Pirotta.;M Lavezzari.;F Rovelli.;E Marubini.
来源: Circulation. 1993年88卷5 Pt 2期II93-8页
To evaluate the possible influence of a series of clinical angiographic and surgical variables on the 1-year patency of saphenous vein (SV) coronary graft, data collected prospectively in a multicenter randomized clinical trial were analyzed.
4920. Randomized, prospective assessment of bioprosthetic valve durability. Hancock versus Carpentier-Edwards valves.
作者: G E Sarris.;R C Robbins.;D C Miller.;R S Mitchell.;K A Moore.;E B Stinson.;P E Oyer.;B A Reitz.;N E Shumway.
来源: Circulation. 1993年88卷5 Pt 2期II55-64页
Although the major limitation of porcine valves is their finite durability, no controlled clinical data exist regarding the relative durability of the two porcine bioprostheses implanted most commonly today, the Carpentier-Edwards (C-E) and Medtronic Hancock I (H) valves.
|