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4881. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction.
Plasma endothelin concentrations are increased in the acute phase of myocardial infarction and in chronic heart failure. Since endothelin may contribute to hemodynamic deterioration by potent vasoconstrictory and cardiotoxic actions, increased plasma levels may be associated with an unfavorable prognosis after myocardial infarction.
4882. A pilot, early angiographic patency study using a direct thrombin inhibitor as adjunctive therapy to streptokinase in acute myocardial infarction.
作者: R M Lidón.;P Théroux.;J Lespérance.;B Adelman.;R Bonan.;D Duval.;J Lévesque.
来源: Circulation. 1994年89卷4期1567-72页
The success of streptokinase in acute myocardial infarction is hampered by the high failure rate to achieve early reperfusion. This study evaluates the possible benefit of Hirulog (Biogen, Cambridge, Mass), a direct thrombin inhibitor, as adjunct therapy to streptokinase to enhance early patency and prevent rethrombosis. Heparin has been shown to be of very limited benefits in this setting.
4883. Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial.
作者: E J Topol.;V Fuster.;R A Harrington.;R M Califf.;N S Kleiman.;D J Kereiakes.;M Cohen.;A Chapekis.;H K Gold.;M A Tannenbaum.
来源: Circulation. 1994年89卷4期1557-66页
Coronary artery thrombosis plays an important pathophysiological role in unstable angina and non-Q-wave myocardial infarction. To date, heparin and thrombolytic therapy has not provided complete or consistent benefit. We hypothesized that recombinant hirudin, a direct thrombin inhibitor, would prevent accumulation of coronary artery thrombus in a manner superior to heparin.
4884. Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia.
来源: Circulation. 1994年89卷4期1545-56页
Although coronary thrombosis plays a critical role in the pathogenesis of unstable angina and non-Q-wave myocardial infarction (NQMI), the effects of thrombolytic therapy in these disorders is not clear. Also, the role of routine early coronary arteriography followed by revascularization has not been established.
4885. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium.
作者: K L Gould.;J P Martucci.;D I Goldberg.;M J Hess.;R P Edens.;R Latifi.;S J Dudrick.
来源: Circulation. 1994年89卷4期1530-8页
Cholesterol lowering over 1- to 3-year trials is associated with modest regression or no progression of focal coronary artery stenoses compared with progression in controls, a decrease in cardiac events proportionately more than the modest improvement in percent stenosis, and in experimental animals improved endothelial-mediated coronary vasodilation.
4886. Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators.
作者: M R Bristow.;J B O'Connell.;E M Gilbert.;W J French.;G Leatherman.;N E Kantrowitz.;J Orie.;M L Smucker.;G Marshall.;P Kelly.
来源: Circulation. 1994年89卷4期1632-42页
Small-scale clinical investigations have demonstrated that single doses of beta-blocking agents can improve left ventricular function in heart failure from idiopathic dilated cardiomyopathy (IDC). The purpose of this multicenter clinical trial was to determine the dose-effect characteristics of beta-blockade in a heart failure population that includes ischemic dilated cardiomyopathy (ISCD).
4887. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP).
作者: W L Haskell.;E L Alderman.;J M Fair.;D J Maron.;S F Mackey.;H R Superko.;P T Williams.;I M Johnstone.;M A Champagne.;R M Krauss.
来源: Circulation. 1994年89卷3期975-90页
Recent clinical trials have shown that modification of plasma lipoprotein concentrations can favorably alter progression of coronary atherosclerosis, but no data exist on the effects of a comprehensive program of risk reduction involving both changes in lifestyle and medications. This study tested the hypothesis that intensive multiple risk factor reduction over 4 years would significantly reduce the rate of progression of atherosclerosis in the coronary arteries of men and women compared with subjects randomly assigned to the usual care of their physician.
4888. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial.
作者: D Waters.;L Higginson.;P Gladstone.;B Kimball.;M Le May.;S J Boccuzzi.;J Lespérance.
来源: Circulation. 1994年89卷3期959-68页
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are widely prescribed for hyperlipidemia, yet their effect on the evolution of coronary atherosclerosis has not been defined.
4890. Diagnostic and prognostic value of dipyridamole echocardiography in patients with suspected coronary artery disease. Comparison with exercise electrocardiography.
作者: S Severi.;E Picano.;C Michelassi.;F Lattanzi.;P Landi.;A Distante.;A L'Abbate.
来源: Circulation. 1994年89卷3期1160-73页
Before any new diagnostic test is accepted in clinical practice, such a test should be compared with established diagnostic tools in an appropriately large series of patients encompassing the complete spectrum of challenges to which the test is exposed. The aim of the present study was to assess the relative diagnostic and prognostic accuracies of high-dose dipyridamole echocardiography (two-dimensional echocardiographic monitoring during dipyridamole infusion up to 0.84 mg/kg over 10 hours) versus maximal symptom-limited bicycle exercise ECG test in patients with angina.
4891. Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients. Implications for the control of sodium balance.
作者: D R Singer.;N D Markandu.;M G Buckley.;M A Miller.;G A Sagnella.;D R Lachno.;F P Cappuccio.;A Murday.;M H Yacoub.;G A MacGregor.
来源: Circulation. 1994年89卷3期1153-9页
The role of cardiac extrinsic innervation in the regulation of sodium balance and blood pressure is controversial.
4892. Long-term graft patency (3 years) after coronary artery surgery. Effects of aspirin: results of a VA Cooperative study.
作者: S Goldman.;J Copeland.;T Moritz.;W Henderson.;K Zadina.;T Ovitt.;K B Kern.;G Sethi.;G V Sharma.;S Khuri.
来源: Circulation. 1994年89卷3期1138-43页
The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG).
4893. Major clinical events after coronary stenting. The multicenter registry of acute and elective Gianturco-Roubin stent placement. The Gianturco-Roubin Intracoronary Stent Investigator Group.
作者: J M Sutton.;S G Ellis.;G S Roubin.;C A Pinkerton.;S B King.;A E Raizner.;D R Holmes.;D J Kereiakes.;E J Topol.
来源: Circulation. 1994年89卷3期1126-37页
Abrupt vessel closure and early reocclusion remain the principal vascular events underlying early recurrent ischemia complicating elective percutaneous transluminal coronary angioplasty (PTCA). Intracoronary stenting has been used to circumvent emergency bypass surgery after acute vessel closure and as an adjunct for the elective treatment of restenosis. The initial multicenter experience with the Gianturco-Roubin stent is presented, and predictors for early recurrent ischemic events are identified.
4894. A randomized comparison of the effects of gradual prolonged versus standard primary balloon inflation on early and late outcome. Results of a multicenter clinical trial. Perfusion Balloon Catheter Study Group.
作者: E M Ohman.;J F Marquis.;D R Ricci.;R I Brown.;M L Knudtson.;D J Kereiakes.;J K Samaha.;J R Margolis.;A L Niederman.;L S Dean.
来源: Circulation. 1994年89卷3期1118-25页
Observational studies have suggested that prolonged balloon inflation during coronary angioplasty is associated with a high clinical success rate. This randomized clinical trial sought to evaluate the impact of primary gradual and prolonged inflations versus standard short dilatations in patients undergoing elective angioplasty.
4895. Prospective, randomized comparison in humans of a unipolar defibrillation system with that using an additional superior vena cava electrode.
作者: G H Bardy.;G L Dolack.;P J Kudenchuk.;J E Poole.;R Mehra.;G Johnson.
来源: Circulation. 1994年89卷3期1090-3页
A unipolar defibrillation system using a single right ventricular (RV) electrode and the active shell or "CAN" of the implantable cardioverter-defibrillator itself situated in a left infraclavicular pocket has been shown to be as efficient in defibrillation as an epicardial lead system. The purpose of this study was to determine whether defibrillation efficacy can be improved further by adding a superior vena cava (SVC) electrode to this already efficient defibrillation system.
4896. Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence.
作者: H Heidbüchel.;J Tack.;L Vanneste.;A Ballet.;H Ector.;F Van de Werf.
来源: Circulation. 1994年89卷3期1051-9页
Although early intravenous beta-blocker therapy during acute myocardial infarction (AMI) reduces the incidence of fatal arrhythmias in patients not treated with thrombolytic agents, its antiarrhythmic effect in thrombolysed patients remains controversial. We investigated prospectively the arrhythmia incidence in 244 patients with AMI receiving alteplase and a double-blind randomized adjunctive therapy with intravenous atenolol, alinidine, or placebo. Moreover, the characteristics and prognostic significance of early arrhythmias and their relation with infarct size and coronary patency were evaluated.
4897. Effects on left ventricular hypertrophy of long-term nonpharmacological treatment with sodium restriction in mild-to-moderate essential hypertension.
Cross-sectional studies on human hypertension have suggested an association between sodium intake and left ventricular hypertrophy (LVH).
4898. Morning increase in ambulatory ischemia in patients with stable coronary artery disease. Importance of physical activity and increased cardiac demand.
作者: J D Parker.;M A Testa.;A H Jimenez.;G H Tofler.;J E Muller.;J O Parker.;P H Stone.
来源: Circulation. 1994年89卷2期604-14页
The morning increase in asymptomatic ambulatory ischemia may be due to heightened coronary tone, increased physical activity, or both. If ambulatory ischemia is primarily due to physical activity, then alterations in the schedule of physical activity should be reflected in a corresponding alteration in the occurrence of ischemia. This study was designed to examine the relation between activity patterns and the frequency of ambulatory ischemic episodes and the effect of nadolol on these relations.
4899. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT).
来源: Circulation. 1994年89卷2期588-95页
Aspirin, by nonselectively blocking cyclooxygenase both in platelets and in endothelial cells, not only inhibits the thromboxane A2 pathway of platelet activation but at the same time also the generation of vasodilating and platelet-inhibitory prostanoids, such as prostacyclin, by the endothelial cells. Ridogrel, by inhibiting thromboxane A2 synthase and blocking the thromboxane A2/prostaglandin endoperoxide receptors, is a more potent antiplatelet agent than aspirin and might offer an advantage over aspirin as an adjunct to thrombolysis. This study was performed to compare the efficacy and safety of ridogrel with that of aspirin as conjunctive therapy for thrombolysis in patients with acute myocardial infarction.
4900. Effects of beta-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress.
作者: R J Benschop.;E E Nieuwenhuis.;E A Tromp.;G L Godaert.;R E Ballieux.;L J van Doornen.
来源: Circulation. 1994年89卷2期762-9页
Acute mental stress evokes responses in the cardiovascular and the immune systems. In particular, the subset of natural killer (NK) cells is found to be responsive to mental stress. The role of beta-adrenergic mechanisms in these processes in the subject of this investigation.
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