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461. Protective anti-fibrotic effect of liraglutide and Pirfenidone combination therapy on liver fibrosis in rats: effects on autophagy and NLRP3 inflammasome.
作者: Zeynab Yousefi.;Rayan Rajabi.;Saeed Karima.;Mitra Nourbakhsh.;Abbas Sahebghadam Lotfi.
来源: BMC Gastroenterol. 2025年26卷1期57页
Liver fibrosis is a significant complication of chronic liver diseases. While Pirfenidone (PFD) and Liraglutide (LIR) have shown promise individually in treating fibrosis, their combined effect on autophagy and NLRP3 inflammasome pathways remains largely unexplored.
462. "Noninvasive predictive marker for esophageal variceal bleeding".
作者: Shuo Zhang.;Tomohiko Akahoshi.;Tomoharu Yoshizumi.;Masatoshi Eto.
来源: BMC Gastroenterol. 2025年26卷1期56页
Esophageal varices are common in cirrhosis with portal hypertension; some patients face high risk of life-threatening esophageal variceal bleeding (EVB). Because few noninvasive markers predict EVB, this study sought to identify accessible predictors.
465. A retrospective study on the efficacy of ex vivo liver resection combined with autologous liver transplantation in treating advanced alveolar echinococcosis at high altitude.
To evaluate the Feasibility and efficacy of total ex vivo liver resection combined with autologous liver transplantation for the treatment of advanced alveolar echinococcosis in high-altitude regions.
466. Feasibility and histological basis of predicting post-operative pancreatic fistula by pre-operative shear wave elastography: a prospective study.
作者: Jiayao Huang.;Lili Chen.;Qingyu Wu.;Xiaoer Zhang.;Lu Yao.;Jiaming Lai.;Xiaoyan Xie.;Manxia Lin.
来源: BMC Gastroenterol. 2025年25卷1期866页
This study aimed to explore the feasibility and histological basis of pancreatic two-dimensional shear wave elastography (2D-SWE) measurement in predicting post-operative pancreatic fistula (POPF) following partial pancreatectomy and to build a prediction model by pre-operative features.
467. Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.
作者: Tomonobu Hioki.;Koji Imoto.;Takeshi Goya.;Yuki Azuma.;Atsushi Horiuchi.;Tomomi Aoyagi.;Motoi Takahashi.;Yoshinao Oda.;Masaki Kato.;Motoyuki Kohjima.;Masatake Tanaka.;Yoshihiro Ogawa.
来源: BMC Gastroenterol. 2025年26卷1期49页
Mycophenolate mofetil (MMF) is a second-line agent for steroid-refractory immune checkpoint inhibitor-induced immune-mediated hepatotoxicity (IMH). However, the clinicopathologic characteristics and the efficacy and safety of MMF for steroid-refractory IMH are not fully understood.
468. Exploring the biliary microbiome in hepatopancreatobiliary disorders: a comprehensive systematic review of microbial signatures and diagnostic potential.
作者: Hossein Halimi.;Zeinab Hesami.;Nastaran Asri.;Babak Khorsand.;Mohammad Rostami-Nejad.;Hamidreza Houri.
来源: BMC Gastroenterol. 2025年26卷1期55页
Hepatopancreatobiliary (HPB) diseases, encompassing hepatobiliary and pancreatic disorders, pose substantial global health challenges due to their high morbidity and mortality rates. Recent research highlights the crucial role of the biliary microbiome in the development of these diseases.
473. Comparative study of endocuff assisted colonoscopy and artificial intelligence in colonoscopy in adenoma and polyp detection: a randomized, back-to-back study.
作者: Patarapong Kamalaporn.;Supphamat Chirnaksorn.;Taya Kitiyakara.;Sasivimol Rattanasiri.
来源: BMC Gastroenterol. 2025年26卷1期58页
An endocuff is attached at the tip of colonoscope to improve mucosal visualization. An artificial intelligence (AI) assisted colonoscopy is a computer system designed to enhance detection and differentiation polyps. The aim of this study was to evaluate the endocuff assisted colonoscopy (E) and the AI assisted colonoscopy (A) in the detection of adenomas and polyps, in a randomized, back-to-back study.
474. The rate of complicated appendicitis during a nonpharmaceutical intervention in two territories with different COVID-19 incidence.
作者: G Bauci.;M Arigoni.;S Passoni.;K Ukegjini.;L Marti.;T Steffen.
来源: BMC Gastroenterol. 2025年25卷1期863页
During the COVID-19 pandemic, many worldwide governmental agencies implemented non-pharmaceutical interventions (NPIs) to contain its spread. Many general surgeons reported higher rates of complicated appendicitis in this period. Reports in the literature need to be more consistent. This study aimed to compare the rates of complicated appendicitis in two Swiss territories with very different COVID-19 incidences during the first lockdown period.
475. Days alive and out of hospital at 90 days as a composite outcome measure in patients undergoing elective surgery for colorectal cancer- a nationwide, observational study.
作者: Karoline Bendix Bräuner.;Maliha Mashkoor.;Rasmus Peuliche Vogelsang.;Rasmus Dahlin Bojesen.;Andreas Weinberger Rosen.;Ismail Gögenur.
来源: BMC Gastroenterol. 2025年26卷1期47页
The aim of this study was to investigate the validity of DAOH-90 in a contemporary cohort of electively operated patients with colorectal cancer and explore its relationship with postoperative outcomes.
476. Trends in the disease burden of inflammatory bowel disease among the working-age population (20-64 years) from 1990 to 2021: a population-based study.
作者: Tao Zhang.;Siyuan Bu.;Xiaozhen Cheng.;Xiaowen Liu.;Qi Si.;Wenwen Zheng.;Lin Wang.;Ru Man.;Yongduo Yu.
来源: BMC Gastroenterol. 2025年26卷1期44页
As a major demographic within the workforce, individuals with inflammatory bowel disease (IBD) represent a unique and significant burden on society's productivity. The impact of IBD on this population is substantial, with serious long-term consequences. However, the trend of this disease burden remains unclear. This study aims to comprehensively assess the current status and changing trends of the disease burden associated with IBD in the working population, with the goal of providing valuable insights for the prevention, treatment, and formulation of healthcare policies.
477. Development of a nomogram for predicting the long-term risk of hepatocellular carcinoma after antiviral treatment for hepatitis C.
作者: Jing Li.;Baima Yangjin.;Chengbin Zhu.;Weicheng Xu.;Yingli He.
来源: BMC Gastroenterol. 2025年25卷1期860页
The impact of direct acting antivirals (DAAs) on hepatitis C virus related hepatocellular carcinoma (HCV-HCC) incidence after sustained virologic response (SVR) remains controversial. We aimed to compare long-term HCC incidence after SVR induced by interferon (IFN) and DAA therapy, also to construct a nomogram model for predicting long-term HCC incidence after HCV cure.
478. Clinical characteristics of familial and sporadic inflammatory bowel disease in Egyptian patients.
作者: Abobakr K A Talha.;Sara Abdelhakam.;Ahmed Nagah.;Marwa Rushdy.;Marwa A Karim.;Nada H Abdel-Fattah.;Shimaa Y Kamel.;Mohamed Eltabbakh.
来源: BMC Gastroenterol. 2025年26卷1期43页
Familial aggregation of inflammatory bowel disease (IBD) has been observed, but data from the Middle East, particularly Egypt, remain limited. This study investigated clinical differences, treatment responses, and predictors of response in familial and sporadic IBD patients.
479. Development of a prediction model for peptic ulcer disease using the fusion of a feature selection strategy and ensemble algorithms.
Peptic ulcer disease is a prevalent gastric and duodenal disorder associated with H. pylori infection, which is related to numerous complications and diseases. Early prediction of this disease plays a significant role in reducing and eliminating its complications. So far, machine learning has shown promise for efficiently predicting health conditions in healthcare settings. So, this study aimed to establish a prediction model by getting assistance from machine learning and risk factors for peptic ulcer disease to predict this disease efficiently and achieve preventive purposes.
480. Development and validation of healthy dietary decision-making competence scale for inflammatory bowel disease: an instrument design study.
作者: Yiting Li.;Yongqi Liang.;Murong Wang.;Tingting Yin.;Tianxu Chen.;Ling Ji.;Ping Zhang.;Qiong Li.;Wenjing Tu.;Guihua Xu.
来源: BMC Gastroenterol. 2025年25卷1期859页
Dietary decision-making plays a crucial role in the management of patients with inflammatory bowel disease (IBD). However, it is complex and involves multiple challenges. Decision-making competence may assist healthcare professionals (HCPs) in evaluating patients' competence to make healthy dietary decisions and to design targeted dietary support programs. Assessment of healthy dietary decision-making competence is essential for guiding IBD patients in daily dietary management. Currently, no valid instrument is available to measure this construct. This study aimed to develop an instrument to evaluate healthy dietary decision-making competence in patients with IBD.
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