462. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
作者: Hongchao Pan.;Richard Gray.;Jeremy Braybrooke.;Christina Davies.;Carolyn Taylor.;Paul McGale.;Richard Peto.;Kathleen I Pritchard.;Jonas Bergh.;Mitch Dowsett.;Daniel F Hayes.; .
来源: N Engl J Med. 2017年377卷19期1836-1846页
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment.
469. Delirium in Hospitalized Older Adults.
A 75-year-old man is admitted for scheduled major abdominal surgery. He is functionally independent, with mild forgetfulness. His intraoperative course is uneventful, but on postoperative day 2, severe confusion and agitation develop. What is going on? How would you manage this patient’s care? Could his condition have been prevented?
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