当前位置: 首页 >> 检索结果
461. The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma.
作者: Paul M O'Byrne.;Carl Johan Lamm.;William W Busse.;Wan C Tan.;Søren Pedersen.; .
来源: Chest. 2009年136卷6期1514-1520页
Previous studies have suggested a reduced benefit from therapy with inhaled corticosteroids (ICSs) in asthmatic patients who smoke. The objective of this post hoc study was to study the effects of low-dose inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma.
462. Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study.
作者: Gary T Ferguson.;Peter M A Calverley.;Julie A Anderson.;Christine R Jenkins.;Paul W Jones.;Lisa R Willits.;Julie C Yates.;Jørgen Vestbo.;Bartolome Celli.
来源: Chest. 2009年136卷6期1456-1465页
Osteoporosis is common in patients with COPD, but its prevalence and progression are not well characterized. Concerns have been raised over the possible deleterious effect of long-term therapy with inhaled corticosteroids (ICSs) on bone density in this population. Here, we investigated the long-term effects of therapy with fluticasone propionate (FP) alone, salmeterol (SAL) alone, and a SAL/FP combination (SFC) on bone mineral density (BMD) and bone fractures in patients with moderate-to-severe COPD in the TOwards a Revolution in COPD Health (TORCH) study.
463. Pressure reduction during exhalation in sleep apnea patients treated by continuous positive airway pressure.
作者: Jean-Louis Pépin.;Jean-François Muir.;Thibaut Gentina.;Yves Dauvilliers.;Renaud Tamisier.;Marc Sapene.;Pierre Escourrou.;Bernard Fleury.;François Philip-Joet.;Pierre Philip.;Marie-Pia d'Ortho.
来源: Chest. 2009年136卷2期490-497页
This French, multicenter, randomized double-blind controlled trial tested the hypothesis that pressure reduction during exhalation (C-Flex; Respironics; Murrysville, PA) would improve continuous positive airway pressure (CPAP) compliance, comfort, and quality of life.
464. Sedative use during continuous positive airway pressure titration improves subsequent compliance: a randomized, double-blind, placebo-controlled trial.
作者: Christopher J Lettieri.;Jacob F Collen.;Arn H Eliasson.;Timothy M Quast.
来源: Chest. 2009年136卷5期1263-1268页
The initial experience with continuous positive airway pressure (CPAP) may predict subsequent compliance. In a retrospective study, we found that premedication with nonbenzodiazepine sedative-hypnotic agents during CPAP titration polysomnography independently predicted short-term compliance. To validate these findings, we conducted a prospective clinical trial to assess whether premedication with eszopiclone prior to CPAP titration would improve short-term CPAP compliance.
465. In-hospital treatment of obstructive sleep apnea during decompensation of heart failure.
作者: Rami N Khayat.;William T Abraham.;Brian Patt.;Min Pu.;David Jarjoura.
来源: Chest. 2009年136卷4期991-997页
Treatment of obstructive sleep apnea (OSA) in outpatients with systolic heart failure improves cardiac function. We evaluated the impact of immediate inpatient diagnosis and treatment of OSA in hospitalized patients with acutely decompensated heart failure (ADHF) on in-hospital cardiac outcomes.
466. Effects of unsupported upper extremity exercise training in patients with COPD: a randomized clinical trial.
作者: Stefania Costi.;Ernesto Crisafulli.;Francesca Degli Antoni.;Claudio Beneventi.;Leonardo M Fabbri.;Enrico M Clini.
来源: Chest. 2009年136卷2期387-395页
Current guidelines on pulmonary rehabilitation (PR) recommend upper extremity exercise training (UEET) in patients with COPD. However, the literature still questions the effectiveness of systematic UEET in this population. We studied the effects of 15 sessions of unsupported UEET on functional exercise capacity, the ability to perform activities of daily living (ADL), and symptoms perceived during activities involving arms in patients with COPD.
467. A randomized trial of dental brushing for preventing ventilator-associated pneumonia.
作者: Angel Pobo.;Thiago Lisboa.;Alejandro Rodriguez.;Ramiro Sole.;Mónica Magret.;Sandra Trefler.;Frederic Gómez.;Jordi Rello.; .
来源: Chest. 2009年136卷2期433-439页
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection. The impact of adding electric toothbrushing to oral care in order to reduce ventilator-associated pneumonia (VAP) incidence is unknown.
468. Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study.
FEV(1) is used for the classification of disease severity and is a good predictor of COPD mortality. However, it is a poor predictor of clinical symptoms, exercise tolerance, and response to bronchodilators in COPD. Progressive reduction in inspiratory capacity (IC) during exercise reflects dynamic hyperinflation and is a good predictor of decreased exercise ability as well as increased exertional dyspnea. In animal models of COPD, N-acetylcysteine (NAC), an antioxidant/mucous modifier, has been shown to modify small airways, which mainly causes lung hyperinflation.
469. Efficacy and safety of inhaled aztreonam lysine for airway pseudomonas in cystic fibrosis.
作者: George Z Retsch-Bogart.;Alexandra L Quittner.;Ronald L Gibson.;Christopher M Oermann.;Karen S McCoy.;A Bruce Montgomery.;Peter J Cooper.
来源: Chest. 2009年135卷5期1223-1232页
We assessed the short-term efficacy and safety of aztreonam lysine for inhalation (AZLI [an aerosolized monobactam antibiotic]) in patients with cystic fibrosis (CF) and Pseudomonas aeruginosa (PA) airway infection.
470. Oropharyngeal cleansing with 0.2% chlorhexidine for prevention of nosocomial pneumonia in critically ill patients: an open-label randomized trial with 0.01% potassium permanganate as control.
作者: Tanmay S Panchabhai.;Neha S Dangayach.;Anand Krishnan.;Vatsal M Kothari.;Dilip R Karnad.
来源: Chest. 2009年135卷5期1150-1156页
Oral cleansing with chlorhexidine decreases the incidence of nosocomial pneumonia in patients after cardiac surgery. However, evidence of its benefit in ICU patients is conflicting.
471. Changes in chest roentgenogram of sarcoidosis patients during a clinical trial of infliximab therapy: comparison of different methods of evaluation.
作者: Robert P Baughman.;Ralph Shipley.;Sujal Desai.;Marjolein Drent.;Marc A Judson.;Ulrich Costabel.;Roland M du Bois.;Mani Kavuru.;Rozsa Schlenker-Herceg.;Susan Flavin.;Kim Hung Lo.;Elliot S Barnathan.; .
来源: Chest. 2009年136卷2期526-535页
The best method to interpret the chest roentgenogram and its sensitivity to detect effect of treatment for sarcoidosis remains unclear. In a double-blind, randomized trial of infliximab for chronic pulmonary sarcoidosis, changes in serial chest roentgenograms were examined by radiologists, blinded to order or treatment.
472. Is full postpleurodesis lung expansion a determinant of a successful outcome after talc pleurodesis?
作者: Ricardo Mingarini Terra.;Jader Joel Machado Junqueira.;Lisete Ribeiro Teixeira.;Francisco Suso Vargas.;Paulo Manuel Pêgo-Fernandes.;Fáabio Biscegli Jatene.
来源: Chest. 2009年136卷2期361-368页
To analyze and compare radiologic lung expansion after talc pleurodesis performed either by videothoracoscopy or chest tube and correlate it with clinical outcome. Secondary end points evaluated were as follows: clinical efficacy; quality of life; safety; and survival.
473. Effect of the management of patients with chronic cough by pulmonologists and certified respiratory educators on quality of life: a randomized trial.
作者: Stephen K Field.;Diane P Conley.;Amin M Thawer.;Richard Leigh.;Robert L Cowie.
来源: Chest. 2009年136卷4期1021-1028页
The role of certified respiratory educators (CREs) is to educate, assess, and help to manage patients with asthma and COPD in Canada. This study was undertaken to see whether CREs could assist pulmonologists (MDs) in managing patients with chronic cough.
474. Application of a shortened inhaled adenosine-5'-monophosphate challenge in young children using the forced oscillation technique.
作者: Graham L Hall.;Catherine Gangell.;Takayoshi Fukushima.;Friedrich Horak.;Hilary Patterson.;Stephen M Stick.;Peter D Sly.;Peter J Franklin.
来源: Chest. 2009年136卷1期184-189页
Adenosine-5'-monophosphate (AMP) is an indirect challenge agent thought to reflect allergic airway inflammation. The forced oscillation technique (FOT) is ideal for use in young children and is suitable for inhaled challenge studies in patients who are in this age group. We assessed the agreement between a shortened and a standard AMP challenge and the repeatability of the shortened AMP challenge using FOT as a primary outcome variable.
475. Anticholinergic premedication for flexible bronchoscopy: a randomized, double-blind, placebo-controlled study of atropine and glycopyrrolate.
作者: Javid Ahmad Malik.;Dheeraj Gupta.;Ashutosh N Agarwal.;Surinder K Jindal.
来源: Chest. 2009年136卷2期347-354页
Anticholinergic premedication is commonly used during flexible bronchoscopy, although the benefits are unproven and potential risks exist.
476. Maximal response plateau to adenosine 5'-monophosphate in asthma. Relationship with the response to methacholine, exhaled nitric oxide, and exhaled breath condensate pH.
作者: Luis Prieto.;Saioa Esnal.;Victoria Lopez.;Desire Barato.;Rocio Rojas.;Julio Marín.
来源: Chest. 2009年135卷6期1521-1526页
No information is available on the plateau in response to adenosine 5'-monophosphate(AMP). The aims of the present study were (1) to determine whether plateau can be detected with AMP and the relation with the plateau in response to methacholine, and (2) to identify the relation between the plateau and indirect markers of airway inflammation, such as exhaled nitric oxide (ENO) and exhaled breath condensate (EBC) pH.
477. "Real-world" effectiveness of reactive telephone counseling for smoking cessation: a randomized controlled trial.
作者: Akshay Sood.;Jennifer Andoh.;Steven Verhulst.;Mathany Ganesh.;Billie Edson.;Patricia Hopkins-Price.
来源: Chest. 2009年136卷5期1229-1236页
Reactive telephone helplines for smoking cessation (where all calls to counselors are smoker initiated) are increasingly used in the United States. However, limited data from randomized controlled trials are available on their effectiveness. The study objective was to evaluate the real-world effectiveness of reactive telephone counseling for smoking cessation using a randomized controlled trial study design.
478. Diagnosis of obstructive sleep apnea syndrome and its outcomes with home portable monitoring.
作者: Ana Claudia Tonelli de Oliveira.;Denis Martinez.;Luiz Felipe T Vasconcelos.;Sandro Cadaval Gonçalves.;Maria do Carmo Lenz.;Sandra Costa Fuchs.;Miguel Gus.;Erlon Oliveira de Abreu-Silva.;Leila Beltrami Moreira.;Flávio Danni Fuchs.
来源: Chest. 2009年135卷2期330-336页
The use of portable respiratory monitoring (PM) has been proposed for the diagnosis of obstructive sleep apnea syndrome (OSAS), but most studies that validate PM accuracy have not followed the best standards for diagnostic test validation. The objective of the present study was to evaluate the accuracy of PM performed at home to diagnose OSAS and its outcomes after first validating PM in the laboratory setting by comparing it to polysomnography (PSG).
479. Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia.
作者: Vitalie Faoro.;Saskia Boldingh.;Mickael Moreels.;Sarah Martinez.;Michel Lamotte.;Philippe Unger.;Serge Brimioulle.;Sandrine Huez.;Robert Naeije.
来源: Chest. 2009年135卷5期1215-1222页
Altitude exposure is associated with mild pulmonary hypertension and decreased exercise capacity. We tested the hypothesis that pulmonary vascular resistance (PVR) contributes to decreased exercise capacity in hypoxic healthy subjects.
480. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis.
作者: Alain Tremblay.;David R Stather.;Paul MacEachern.;Moosa Khalil.;Stephen K Field.
来源: Chest. 2009年136卷2期340-346页
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) of mediastinal lymph nodes has been found to be more accurate than standard TBNA in the setting of malignancy. In patients with suspected sarcoidosis, the smaller ultrasound needle may yield inadequate material to make a histologic diagnosis of granulomatous inflammation. The aim of this study was to compare the diagnostic yield of EBUS-guided TBNA to TBNA performed with a standard 19-gauge needle in patients with mediastinal adenopathy and a clinical suspicion of sarcoidosis.
|