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461. Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients With Atrial Fibrillation: The CAPTAF Randomized Clinical Trial.
作者: Carina Blomström-Lundqvist.;Sigfus Gizurarson.;Jonas Schwieler.;Steen M Jensen.;Lennart Bergfeldt.;Göran Kennebäck.;Aigars Rubulis.;Helena Malmborg.;Pekka Raatikainen.;Stefan Lönnerholm.;Niklas Höglund.;David Mörtsell.
来源: JAMA. 2019年321卷11期1059-1068页
Quality of life is not a standard primary outcome in ablation trials, even though symptoms drive the indication.
462. Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.
作者: Daniel B Mark.;Kevin J Anstrom.;Shubin Sheng.;Jonathan P Piccini.;Khaula N Baloch.;Kristi H Monahan.;Melanie R Daniels.;Tristram D Bahnson.;Jeanne E Poole.;Yves Rosenberg.;Kerry L Lee.;Douglas L Packer.; .
来源: JAMA. 2019年321卷13期1275-1285页
Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain.
463. High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years.
作者: Nicklas Brustad.;Anders U Eliasen.;Jakob Stokholm.;Klaus Bønnelykke.;Hans Bisgaard.;Bo L Chawes.
来源: JAMA. 2019年321卷10期1003-1005页
This long-term follow-up of a randomized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplementation on wheezing in children at the age of 3 years extends the findings an additional 3 years and describes asthma risk at the age of 6 years.
464. Effect of a Behavioral Intervention Strategy on Sustained Change in Physical Activity and Sedentary Behavior in Patients With Type 2 Diabetes: The IDES_2 Randomized Clinical Trial.
作者: Stefano Balducci.;Valeria D'Errico.;Jonida Haxhi.;Massimo Sacchetti.;Giorgio Orlando.;Patrizia Cardelli.;Martina Vitale.;Lucilla Bollanti.;Francesco Conti.;Silvano Zanuso.;Giuseppe Lucisano.;Antonio Nicolucci.;Giuseppe Pugliese.; .
来源: JAMA. 2019年321卷9期880-890页
There is no definitive evidence that changes in physical activity/sedentary behavior can be maintained long term in individuals with type 2 diabetes.
465. Effect of Integrated Behavioral Weight Loss Treatment and Problem-Solving Therapy on Body Mass Index and Depressive Symptoms Among Patients With Obesity and Depression: The RAINBOW Randomized Clinical Trial.
作者: Jun Ma.;Lisa Goldman Rosas.;Nan Lv.;Lan Xiao.;Mark B Snowden.;Elizabeth M Venditti.;Megan A Lewis.;Jeremy D Goldhaber-Fiebert.;Philip W Lavori.
来源: JAMA. 2019年321卷9期869-879页
Coexisting obesity and depression exacerbate morbidity and disability, but effective treatments remain elusive.
466. Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults With Subsyndromal Depressive Symptoms: The MooDFOOD Randomized Clinical Trial.
作者: Mariska Bot.;Ingeborg A Brouwer.;Miquel Roca.;Elisabeth Kohls.;Brenda W J H Penninx.;Ed Watkins.;Gerard van Grootheest.;Mieke Cabout.;Ulrich Hegerl.;Margalida Gili.;Matthew Owens.;Marjolein Visser.; .
来源: JAMA. 2019年321卷9期858-868页
Effects of nutritional interventions on the prevention of major depressive disorder (MDD) in overweight adults are unknown.
467. Effect of Patient-Centered Transitional Care Services on Clinical Outcomes in Patients Hospitalized for Heart Failure: The PACT-HF Randomized Clinical Trial.
作者: Harriette G C Van Spall.;Shun Fu Lee.;Feng Xie.;Urun Erbas Oz.;Richard Perez.;Peter R Mitoff.;Manish Maingi.;Michael C Tjandrawidjaja.;Michael Heffernan.;Mohammad I Zia.;Liane Porepa.;Mohamed Panju.;Lehana Thabane.;Ian D Graham.;R Brian Haynes.;Dilys Haughton.;Kim D Simek.;Dennis T Ko.;Stuart J Connolly.
来源: JAMA. 2019年321卷8期753-761页
Health care services that support the hospital-to-home transition can improve outcomes in patients with heart failure (HF).
468. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial.
作者: David M Fleischer.;Matthew Greenhawt.;Gordon Sussman.;Philippe Bégin.;Anna Nowak-Wegrzyn.;Daniel Petroni.;Kirsten Beyer.;Terri Brown-Whitehorn.;Jacques Hebert.;Jonathan O'B Hourihane.;Dianne E Campbell.;Stephanie Leonard.;R Sharon Chinthrajah.;Jacqueline A Pongracic.;Stacie M Jones.;Lars Lange.;Hey Chong.;Todd D Green.;Robert Wood.;Amarjit Cheema.;Susan L Prescott.;Peter Smith.;William Yang.;Edmond S Chan.;Aideen Byrne.;Amal Assa'ad.;J Andrew Bird.;Edwin H Kim.;Lynda Schneider.;Carla M Davis.;Bruce J Lanser.;Romain Lambert.;Wayne Shreffler.
来源: JAMA. 2019年321卷10期946-955页
There are currently no approved treatments for peanut allergy.
469. Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.
作者: Balachundhar Subramaniam.;Puja Shankar.;Shahzad Shaefi.;Ariel Mueller.;Brian O'Gara.;Valerie Banner-Goodspeed.;Jackie Gallagher.;Doris Gasangwa.;Melissa Patxot.;Senthil Packiasabapathy.;Pooja Mathur.;Matthias Eikermann.;Daniel Talmor.;Edward R Marcantonio.
来源: JAMA. 2019年321卷7期686-696页
Postoperative delirium is common following cardiac surgery and may be affected by choice of analgesic and sedative.
470. Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial.
作者: Dorothy M Wade.;Paul R Mouncey.;Alvin Richards-Belle.;Jerome Wulff.;David A Harrison.;M Zia Sadique.;Richard D Grieve.;Lydia M Emerson.;Alexina J Mason.;David Aaronovitch.;Nicole Als.;Chris R Brewin.;Sheila E Harvey.;David C J Howell.;Nicholas Hudson.;Monty G Mythen.;Deborah Smyth.;John Weinman.;John Welch.;Chris Whitman.;Kathryn M Rowan.; .
来源: JAMA. 2019年321卷7期665-675页
A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%.
471. Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
作者: Jeremy R Beitler.;Todd Sarge.;Valerie M Banner-Goodspeed.;Michelle N Gong.;Deborah Cook.;Victor Novack.;Stephen H Loring.;Daniel Talmor.; .
来源: JAMA. 2019年321卷9期846-857页
Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure might attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome (ARDS).
472. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.
作者: Glenn Hernández.;Gustavo A Ospina-Tascón.;Lucas Petri Damiani.;Elisa Estenssoro.;Arnaldo Dubin.;Javier Hurtado.;Gilberto Friedman.;Ricardo Castro.;Leyla Alegría.;Jean-Louis Teboul.;Maurizio Cecconi.;Giorgio Ferri.;Manuel Jibaja.;Ronald Pairumani.;Paula Fernández.;Diego Barahona.;Vladimir Granda-Luna.;Alexandre Biasi Cavalcanti.;Jan Bakker.; .;Glenn Hernández.;Gustavo Ospina-Tascón.;Lucas Petri Damiani.;Elisa Estenssoro.;Arnaldo Dubin.;Javier Hurtado.;Gilberto Friedman.;Ricardo Castro.;Leyla Alegría.;Jean-Louis Teboul.;Maurizio Cecconi.;Maurizio Cecconi.;Giorgio Ferri.;Manuel Jibaja.;Ronald Pairumani.;Paula Fernández.;Diego Barahona.;Alexandre Biasi Cavalcanti.;Jan Bakker.;Glenn Hernández.;Leyla Alegría.;Giorgio Ferri.;Nicolás Rodriguez.;Patricia Holger.;Natalia Soto.;Mario Pozo.;Jan Bakker.;Deborah Cook.;Jean-Louis Vincent.;Andrew Rhodes.;Bryan P Kavanagh.;Phil Dellinger.;Wim Rietdijk.;David Carpio.;Nicolás Pavéz.;Elizabeth Henriquez.;Sebastian Bravo.;Emilio Daniel Valenzuela.;Magdalena Vera.;Jorge Dreyse.;Vanessa Oviedo.;Maria Alicia Cid.;Macarena Larroulet.;Edward Petruska.;Claudio Sarabia.;David Gallardo.;Juan Eduardo Sanchez.;Hugo González.;José Miguel Arancibia.;Alex Muñoz.;Germán Ramirez.;Florencia Aravena.;Andrés Aquevedo.;Fabián Zambrano.;Milan Bozinovic.;Felipe Valle.;Manuel Ramirez.;Victor Rossel.;Pilar Muñoz.;Carolina Ceballos.;Christian Esveile.;Cristian Carmona.;Eva Candia.;Daniela Mendoza.;Aída Sanchez.;Daniela Ponce.;Daniela Ponce.;Jaime Lastra.;Bárbara Nahuelpán.;Fabrizio Fasce.;Cecilia Luengo.;Nicolas Medel.;Cesar Cortés.;Luz Campassi.;Paolo Rubatto.;Nahime Horna.;Mariano Furche.;Juan Carlos Pendino.;Lisandro Bettini.;Carlos Lovesio.;María Cecilia González.;Jésica Rodruguez.;Héctor Canales.;Francisco Caminos.;Cayetano Galletti.;Estefanía Minoldo.;Maria Jose Aramburu.;Daniela Olmos.;Nicolás Nin.;Jordán Tenzi.;Carlos Quiroga.;Pablo Lacuesta.;Agustín Gaudín.;Richard Pais.;Ana Silvestre.;Germán Olivera.;Gloria Rieppi.;Dolores Berrutti.;Marcelo Ochoa.;Paul Cobos.;Fernando Vintimilla.;Vanessa Ramirez.;Milton Tobar.;Fernanda García.;Fabricio Picoita.;Nelson Remache.;Vladimir Granda.;Fernando Paredes.;Eduardo Barzallo.;Paul Garcés.;Fausto Guerrero.;Santiago Salazar.;German Torres.;Cristian Tana.;José Calahorrano.;Freddy Solis.;Pedro Torres.;Luís Herrera.;Antonio Ornes.;Verónica Peréz.;Glenda Delgado.;Alexei López.;Eliana Espinosa.;José Moreira.;Blanca Salcedo.;Ivonne Villacres.;Jhonny Suing.;Marco Lopez.;Luis Gomez.;Guillermo Toctaquiza.;Mario Cadena Zapata.;Milton Alonso Orazabal.;Ruben Pardo Espejo.;Jorge Jimenez.;Alexander Calderón.;Gustavo Paredes.;José Luis Barberán.;Tatiana Moya.;Horacio Atehortua.;Rodolfo Sabogal.;Guillermo Ortiz.;Antonio Lara.;Fabio Sanchez.;Alvaro Hernán Portilla.;Humberto Dávila.;Jorge Antonio Mora.;Luis Eduardo Calderón.;Ingrid Alvarez.;Elena Escobar.;Alejandro Bejarano.;Luis Alfonso Bustamante.;José Luis Aldana.
来源: JAMA. 2019年321卷7期654-664页
Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.
473. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial.
作者: Kasper Højgaard Thybo.;Daniel Hägi-Pedersen.;Jørgen Berg Dahl.;Jørn Wetterslev.;Mariam Nersesjan.;Janus Christian Jakobsen.;Niels Anker Pedersen.;Søren Overgaard.;Henrik M Schrøder.;Harald Schmidt.;Jan Gottfrid Bjørck.;Kamilla Skovmand.;Rune Frederiksen.;Morten Buus-Nielsen.;Charlotte Voss Sørensen.;Laura Smedegaard Kruuse.;Peter Lindholm.;Ole Mathiesen.
来源: JAMA. 2019年321卷6期562-571页
Multimodal postoperative analgesia is widely used but lacks evidence of benefit.
474. Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial.
作者: Troy S Wildes.;Angela M Mickle.;Arbi Ben Abdallah.;Hannah R Maybrier.;Jordan Oberhaus.;Thaddeus P Budelier.;Alex Kronzer.;Sherry L McKinnon.;Daniel Park.;Brian A Torres.;Thomas J Graetz.;Daniel A Emmert.;Ben J Palanca.;Shreya Goswami.;Katherine Jordan.;Nan Lin.;Bradley A Fritz.;Tracey W Stevens.;Eric Jacobsohn.;Eva M Schmitt.;Sharon K Inouye.;Susan Stark.;Eric J Lenze.;Michael S Avidan.; .
来源: JAMA. 2019年321卷5期473-483页
Intraoperative electroencephalogram (EEG) waveform suppression, often suggesting excessive general anesthesia, has been associated with postoperative delirium.
475. Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in Rheumatoid Arthritis: The IMAGINE-RA Randomized Clinical Trial.
作者: Signe Møller-Bisgaard.;Kim Hørslev-Petersen.;Bo Ejbjerg.;Merete Lund Hetland.;Lykke Midtbøll Ørnbjerg.;Daniel Glinatsi.;Jakob Møller.;Mikael Boesen.;Robin Christensen.;Kristian Stengaard-Pedersen.;Ole Rintek Madsen.;Bente Jensen.;Jan Alexander Villadsen.;Ellen-Margrethe Hauge.;Philip Bennett.;Oliver Hendricks.;Karsten Asmussen.;Marcin Kowalski.;Hanne Lindegaard.;Sabrina Mai Nielsen.;Henning Bliddal.;Niels Steen Krogh.;Torkell Ellingsen.;Agnete H Nielsen.;Lone Balding.;Anne Grethe Jurik.;Henrik S Thomsen.;Mikkel Østergaard.
来源: JAMA. 2019年321卷5期461-472页
Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown.
476. Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: Wes Onland.;Filip Cools.;Andre Kroon.;Karin Rademaker.;Maruschka P Merkus.;Peter H Dijk.;Henrica L van Straaten.;Arjan B Te Pas.;Thilo Mohns.;Els Bruneel.;Arno F van Heijst.;Boris W Kramer.;Anne Debeer.;Inge Zonnenberg.;Yoann Marechal.;Henry Blom.;Katleen Plaskie.;Martin Offringa.;Anton H van Kaam.; .
来源: JAMA. 2019年321卷4期354-363页
Dexamethasone initiated after the first week of life reduces the rate of death or bronchopulmonary dysplasia (BPD) but may cause long-term adverse effects in very preterm infants. Hydrocortisone is increasingly used as an alternative, but evidence supporting its efficacy and safety is lacking.
477. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.
作者: .;Jeff D Williamson.;Nicholas M Pajewski.;Alexander P Auchus.;R Nick Bryan.;Gordon Chelune.;Alfred K Cheung.;Maryjo L Cleveland.;Laura H Coker.;Michael G Crowe.;William C Cushman.;Jeffrey A Cutler.;Christos Davatzikos.;Lisa Desiderio.;Guray Erus.;Larry J Fine.;Sarah A Gaussoin.;Darrin Harris.;Meng-Kang Hsieh.;Karen C Johnson.;Paul L Kimmel.;Manjula Kurella Tamura.;Lenore J Launer.;Alan J Lerner.;Cora E Lewis.;Jennifer Martindale-Adams.;Claudia S Moy.;Ilya M Nasrallah.;Linda O Nichols.;Suzanne Oparil.;Paula K Ogrocki.;Mahboob Rahman.;Stephen R Rapp.;David M Reboussin.;Michael V Rocco.;Bonnie C Sachs.;Kaycee M Sink.;Carolyn H Still.;Mark A Supiano.;Joni K Snyder.;Virginia G Wadley.;Jennifer Walker.;Daniel E Weiner.;Paul K Whelton.;Valerie M Wilson.;Nancy Woolard.;Jackson T Wright.;Clinton B Wright.
来源: JAMA. 2019年321卷6期553-561页
There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.
478. Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial.
作者: Jeffrey B Schwimmer.;Patricia Ugalde-Nicalo.;Jean A Welsh.;Jorge E Angeles.;Maria Cordero.;Kathryn E Harlow.;Adina Alazraki.;Janis Durelle.;Jack Knight-Scott.;Kimberly P Newton.;Rebecca Cleeton.;Cynthia Knott.;Juna Konomi.;Michael S Middleton.;Curtis Travers.;Claude B Sirlin.;Albert Hernandez.;Ahlia Sekkarie.;Courtney McCracken.;Miriam B Vos.
来源: JAMA. 2019年321卷3期256-265页
Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction of sugary foods and beverages is a plausible but unproven treatment.
479. Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia.
作者: Françoise Bernaudin.;Suzanne Verlhac.;Régis Peffault de Latour.;Jean-Hugues Dalle.;Valentine Brousse.;Eléonore Petras.;Isabelle Thuret.;Catherine Paillard.;Bénédicte Neven.;Claire Galambrun.;Lydia Divialle-Doumdo.;Corinne Pondarré.;Corinne Guitton.;Florence Missud.;Camille Runel.;Charlotte Jubert.;Gisèle Elana.;Elisabeth Ducros-Miralles.;Elise Drain.;Olivier Taïeb.;Cécile Arnaud.;Annie Kamdem.;Aurore Malric.;Monique Elmaleh-Bergès.;Manuela Vasile.;Emmanuella Leveillé.;Gérard Socié.;Sylvie Chevret.; .
来源: JAMA. 2019年321卷3期266-276页
In children with sickle cell anemia (SCA), high transcranial Doppler (TCD) velocities are associated with stroke risk, which is reduced by chronic transfusion. Whether matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) can reduce velocities in patients with SCA is unknown.
480. Two-Year Survival Comparing Web-Based Symptom Monitoring vs Routine Surveillance Following Treatment for Lung Cancer.
作者: Fabrice Denis.;Ethan Basch.;Anne-Lise Septans.;Jaafar Bennouna.;Thierry Urban.;Amylou C Dueck.;Christophe Letellier.
来源: JAMA. 2019年321卷3期306-307页
This study reports 2-year survival outcomes among patients with advanced nonprogressive stage IIA to IV lung cancer randomized to symptom monitoring during chemotherapy via web-based patient-reported outcomes vs standard scheduled imaging after treatment to detect symptomatic recurrence.
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