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4741. Early and 1-year clinical outcome of patients' evolving non-Q-wave versus Q-wave myocardial infarction after thrombolysis. Results from The TIMI II Study.
作者: F V Aguirre.;L T Younis.;B R Chaitman.;A M Ross.;R P McMahon.;M J Kern.;P B Berger.;G Sopko.;W J Rogers.;L Shaw.
来源: Circulation. 1995年91卷10期2541-8页
There are few data comparing clinical outcome and potential indications for routine post-myocardial infarction cardiac catheterization and revascularization of patients who sustain a non-Q-wave versus Q-wave infarct after thrombolytic therapy.
4742. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS).
作者: J W Jukema.;A V Bruschke.;A J van Boven.;J H Reiber.;E T Bal.;A H Zwinderman.;H Jansen.;G J Boerma.;F M van Rappard.;K I Lie.
来源: Circulation. 1995年91卷10期2528-40页
Intensive lowering of serum cholesterol may retard progression of coronary atherosclerosis in selected groups of patients. However, few data are available on the potential benefit of serum cholesterol reduction in the broad range of patients with coronary atherosclerosis and normal to moderately elevated serum cholesterol levels who undergo various forms of treatment. The Regression Growth Evaluation Statin Study (REGRESS) addresses this group of patients.
4744. Long-term temporal patterns of ventricular tachyarrhythmias.
作者: M A Wood.;P M Simpson.;B S Stambler.;J M Herre.;R C Bernstein.;K A Ellenbogen.
来源: Circulation. 1995年91卷9期2371-7页
Technological limitations have precluded investigation of long-term temporal patterns of ventricular tachyarrhythmia recurrences. Newer implantable cardioverter-defibrillators permit such analyses by accurately recording the time and date of tachycardia detections during long-term follow-up. This study tests the hypothesis that ventricular tachycardia occurrences are randomly distributed over time in individual patients.
4745. Comparison of surgical and medical group survival in patients with left main equivalent coronary artery disease. Long-term CASS experience.
作者: E A Caracciolo.;K B Davis.;G Sopko.;G C Kaiser.;S D Corley.;H Schaff.;H A Taylor.;B R Chaitman.
来源: Circulation. 1995年91卷9期2335-44页
Combined severe proximal left anterior descending and proximal left circumflex coronary artery disease, or left main equivalent (LMEQ) disease, defines a prognostic high-risk angiographic subset of patients with chronic ischemic heart disease. While numerous observational and randomized clinical trials showed prolonged survival in surgically compared with medically treated patients with left main coronary artery disease, relatively few observational studies compared surgical and medical therapies in patients with LMEQ disease. The present report of 912 patients with LMEQ disease in the Coronary Artery Surgery Study (CASS) Registry extends the originally published 5-year surgical and medical group survival analysis to more than 16 years of follow-up and permits analysis of LMEQ patient subgroups.
4746. Comparison of surgical and medical group survival in patients with left main coronary artery disease. Long-term CASS experience.
作者: E A Caracciolo.;K B Davis.;G Sopko.;G C Kaiser.;S D Corley.;H Schaff.;H A Taylor.;B R Chaitman.
来源: Circulation. 1995年91卷9期2325-34页
Observational and randomized studies designed to compare surgical and medical therapies in patients with left main coronary artery disease (LMCD) have shown that coronary artery bypass graft (CABG) surgery prolongs life in most patients with LMCD. The present report of 1484 patients with LMCD in the Coronary Artery Surgery Study (CASS) Registry extends the originally published 5-year surgical and medical group survival analysis to more than 16 years of follow-up and permits analysis of LMCD patient subgroups.
4747. N-terminal proANF and prognosis after myocardial infarction.4749. Randomized study of implantable defibrillator as first-choice therapy versus conventional strategy in postinfarct sudden death survivors.
作者: E F Wever.;R N Hauer.;F L van Capelle.;J G Tijssen.;H J Crijns.;A Algra.;A C Wiesfeld.;P F Bakker.;E O Robles de Medina.
来源: Circulation. 1995年91卷8期2195-203页
In retrospective studies of sudden cardiac death survivors, the implantable cardioverter-defibrillator (ICD) compares favorably with medical and surgical therapy. Thus, use of the conventional strategy of starting treatment with antiarrhythmic drugs (AD), at least in certain patient categories, may be questionable. The goal of this study was to analyze the effectiveness of ICD implantation as first-choice therapy versus the conventional therapeutic strategy of starting with AD.
4750. Reversal of heparin anticoagulation by recombinant platelet factor 4 in humans.
Protamine is used to reverse the anticoagulant effects of heparin, but it can have important side effects. Platelet factor 4 (PF4) is a protein found in platelet alpha granules that binds to and thereby neutralizes heparin. We evaluated the safety and effectiveness of intravenous recombinant PF4 to neutralize heparin anticoagulation after cardiac catheterization in a phase 1, open-label trial.
4751. Comparison of effects of high-dose and low-dose aspirin on restenosis after femoropopliteal percutaneous transluminal angioplasty.
作者: E Minar.;A Ahmadi.;R Koppensteiner.;T Maca.;A Stümpflen.;A Ugurluoglu.;H Ehringer.
来源: Circulation. 1995年91卷8期2167-73页
Long-term treatment with aspirin is recommended in patients with large-vessel peripheral arterial disease since these patients have a high risk of death from cardiovascular causes. Recent studies have demonstrated the prophylactic effect of low-dose aspirin in reducing the risk of cardiovascular events. Since aspirin is also recommended for prevention of late recurrence after peripheral angioplasty, the present study was undertaken to compare the effects of high-dose (1000 mg/d) and low-dose (100 mg/d) aspirin on long-term patency after femoropopliteal angioplasty.
4752. One-year follow-up in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT I).
作者: J M Elliott.;L G Berdan.;D R Holmes.;J M Isner.;S B King.;G P Keeler.;M Kearney.;R M Califf.;E J Topol.
来源: Circulation. 1995年91卷8期2158-66页
Directional atherectomy is a frequently used percutaneous revascularization strategy, but its long-term outcomes have not previously been compared with those of balloon angioplasty in a prospective trial.
4753. Multicenter, randomized, double-blind, placebo-controlled trial of the platelet integrin glycoprotein IIb/IIIa blocker Integrelin in elective coronary intervention. IMPACT Investigators.
作者: J E Tcheng.;R A Harrington.;K Kottke-Marchant.;N S Kleiman.;S G Ellis.;D J Kereiakes.;M J Mick.;F I Navetta.;J E Smith.;S J Worley.
来源: Circulation. 1995年91卷8期2151-7页
Platelet aggregation and thrombosis have been implicated in the pathogenesis of coronary angioplasty complications. Integrelin, a synthetic cyclic heptapeptide with high affinity and marked specificity for platelet integrin glycoprotein IIb/IIIa, effectively blocks ADP-induced platelet aggregation.
4754. Long-term luminal renarrowing after successful elective coronary angioplasty of total occlusions. A quantitative angiographic analysis.
The long-term angiographic outcome after successful dilatation of coronary occlusions remains unclear. The objective of this study was to examine long-term restenosis after successful balloon dilatation of coronary occlusions at a predetermined time interval with quantitative angiography and compare this with a control population of stenoses.
4755. Randomized double-blind comparison of two doses of Hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction.
作者: P Théroux.;F Pérez-Villa.;D Waters.;J Lespérance.;F Shabani.;R Bonan.
来源: Circulation. 1995年91卷8期2132-9页
An improved survival rate is a consequence of successful reperfusion of the infarct-related artery. This double-blind, randomized trial investigated the potential of Hirulog, a direct thrombin inhibitor, to improve the early patency rates obtained with streptokinase and aspirin.
4756. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina.
Acute coronary ischemia is usually initiated by rupture of atherosclerotic plaque, leading to intracoronary thrombosis and clinical sequelae. The proximate cause of plaque rupture is unknown. Accordingly, we investigated the potential role of the 92-kD gelatinase member of the matrix metalloproteinase family in acute coronary ischemia.
4758. Significance and incidence of concordance of drug efficacy predictions by Holter monitoring and electrophysiological study in the ESVEM Trial. Electrophysiologic Study Versus Electrocardiographic Monitoring.
Selection of antiarrhythmic therapy may be based on either suppression of spontaneous ventricular arrhythmias assessed by Holter monitoring or by suppression of inducible ventricular arrhythmias during electrophysiological study. This study examines the frequency and significance of concordance of these two approaches in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial.
4759. Aging and endothelial function in normotensive subjects and patients with essential hypertension.
作者: S Taddei.;A Virdis.;P Mattei.;L Ghiadoni.;A Gennari.;C B Fasolo.;I Sudano.;A Salvetti.
来源: Circulation. 1995年91卷7期1981-7页
Experimental data from normotensive and hypertensive animals indicate that aging is associated with impaired endothelium-dependent relaxations to acetylcholine, and this possibility appears to be confirmed in the human coronary artery. In the present study, we evaluated the effect of age on endothelial responsiveness in the forearm vessels of either normotensive control subjects or essential hypertensive patients.
4760. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions. CAVEAT-II Investigators.
作者: D R Holmes.;E J Topol.;R M Califf.;L G Berdan.;F Leya.;P B Berger.;P L Whitlow.;R D Safian.;A G Adelman.;M A Kellett.
来源: Circulation. 1995年91卷7期1966-74页
Directional coronary atherectomy and percutaneous transluminal coronary angioplasty have both been used in symptomatic patients with coronary saphenous vein bypass graft stenoses. The relative merits of plaque excision and removal versus balloon dilatation remain uncertain. We compared outcomes after directional coronary atherectomy or angioplasty in patients with de novo bypass graft stenoses.
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