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4641. Ultrafast computed tomography as a diagnostic modality in the detection of coronary artery disease: a multicenter study.
作者: M J Budoff.;D Georgiou.;A Brody.;A S Agatston.;J Kennedy.;C Wolfkiel.;W Stanford.;P Shields.;R J Lewis.;W R Janowitz.;S Rich.;B H Brundage.
来源: Circulation. 1996年93卷5期898-904页
Ultrafast computed tomography (CT), by acquiring images of the proximal coronary arteries, detects coronary calcifications and has been demonstrated to be highly sensitive for the detection of coronary artery disease in many small studies. The aim of this study was to determine the relationship between ultrafast CT scanning and coronary angiography in a large number of symptomatic patients.
4642. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: results from the GUSTO-I trial.
作者: C B Granger.;J Hirsch.;R M Califf.;J Col.;H D White.;A Betriu.;L H Woodlief.;K L Lee.;E G Bovill.;R J Simes.;E J Topol.
来源: Circulation. 1996年93卷5期870-8页
Although intravenous heparin is commonly used after thrombolytic therapy, few reports have addressed the relationship between the degree of anticoagulation and clinical outcomes. We examined the activated partial thromboplastin time (aPTT) in 29,656 patients in the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO-I) trial and analyzed the relationship between the aPTT and both baseline patient characteristics and clinical outcomes.
4643. Diagnostic value of echocardiography in suspected endocarditis. An evaluation based on the pretest probability of disease.
作者: J R Lindner.;R A Case.;J M Dent.;R D Abbott.;W M Scheld.;S Kaul.
来源: Circulation. 1996年93卷4期730-6页
We hypothesized that for the diagnosis of endocarditis, (1) transthoracic echocardiography (TTE) would be most valuable in patients with an intermediate clinical probability of the disease and (2) transesophageal echocardiography (TEE) would be most useful in patients with an intermediate probability when TTE either does not yield an adequate study or indicates an intermediate probability of endocarditis. We also sought to investigate the influence of echocardiographic results on antibiotic usage and its duration.
4644. Effects of diuretic therapy on the development of tolerance to nitroglycerin and exercise capacity in patients with chronic stable angina.
Therapy with diuretics has been reported to prevent the development of nitrate tolerance. Importantly, diuretics may have independent antianginal effects through their effects on intravascular volume. The present investigation was designed to determine whether diuretic therapy could prevent the development of tolerance to continuous transdermal nitroglycerin. The study was also designed to examine whether diuretic therapy has an independent antianginal effect.
4645. Value of magnetic resonance imaging in assessing patency and function of coronary artery bypass grafts. An angiographically controlled study.
作者: M A Galjee.;A C van Rossum.;T Doesburg.;M J van Eenige.;C A Visser.
来源: Circulation. 1996年93卷4期660-6页
Previous studies have demonstrated the high sensitivity and moderate specificity of standard magnetic resonance (MR) spin-echo (SE) and gradient-echo (GE) techniques in predicting the patency of coronary artery bypass grafts. These techniques, however, do not provide quantitative information. Therefore, the objectives of this study were first to investigate whether MR cine GE images, performed in addition to standard SE images, have additional value for the assessment of graft patency and second to assess the graft function by measuring the flow pattern and flow rate with MR phase velocity imaging.
4647. Cost-effectiveness of implantable defibrillator as first-choice therapy versus electrophysiologically guided, tiered strategy in postinfarct sudden death survivors. A randomized study.
作者: E F Wever.;R N Hauer.;G Schrijvers.;F J van Capelle.;J G Tijssen.;H J Crijns.;A Algra.;H Ramanna.;P F Bakker.;E O Robles de Medina.
来源: Circulation. 1996年93卷3期489-96页
Rising costs of health care, partly as a result of costly therapeutic innovations, are of concern to both the medical profession and healthcare authorities. The implantable cardioverter-defibrillator (ICD) is still not remunerated by Dutch healthcare insurers. The aim of this study was to evaluate the cost-effectiveness of early implantation of the ICD in postinfarct sudden death survivors.
4648. Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure. Time- and dose-dependence analysis based on pressure-volume relations.
作者: M D Feldman.;P H Pak.;C C Wu.;H L Haber.;C M Heesch.;J D Bergin.;E R Powers.;T D Cowart.;W Johnson.;A M Feldman.;D A Kass.
来源: Circulation. 1996年93卷3期474-83页
OPC-18790 is a water-soluble quinolinone derivative that shares the pharmacological properties of vesnarinone and that may be useful for treating heart failure. We studied the contribution and relative dose sensitivities of the inotropic, lusitropic, and vascular effects of OPC-18790 in patients with dilated cardiomyopathy.
4649. Simultaneous transmission/emission myocardial perfusion tomography. Diagnostic accuracy of attenuation-corrected 99mTc-sestamibi single-photon emission computed tomography.
作者: E P Ficaro.;J A Fessler.;P D Shreve.;J N Kritzman.;P A Rose.;J R Corbett.
来源: Circulation. 1996年93卷3期463-73页
The purpose of the present study was to assess the diagnostic performance of attenuation-corrected (AC) stress 99mTc-sestamibi cardiac single-photon emission computed tomography (SPECT) for the identification of coronary heart disease (CHD).
4650. Heparin-coated Palmaz-Schatz stents in human coronary arteries. Early outcome of the Benestent-II Pilot Study.
作者: P W Serruys.;H Emanuelsson.;W van der Giessen.;A C Lunn.;F Kiemeney.;C Macaya.;W Rutsch.;G Heyndrickx.;H Suryapranata.;V Legrand.;J J Goy.;P Materne.;H Bonnier.;M C Morice.;J Fajadet.;J Belardi.;A Colombo.;E Garcia.;P Ruygrok.;P de Jaegere.;M A Morel.
来源: Circulation. 1996年93卷3期412-22页
The purpose of the Benestent-II Pilot Study was to evaluate the safety of delaying and eliminating anticoagulant therapy in patients receiving a heparin-coated stent in conjunction with antiplatelet drugs.
4652. Chelation therapy for intermittent claudication: a double-blind, randomized, controlled trial.4653. A randomized comparison of combined ticlopidine and aspirin therapy versus aspirin therapy alone after successful intravascular ultrasound-guided stent implantation.
作者: P Hall.;S Nakamura.;L Maiello.;A Itoh.;S Blengino.;G Martini.;M Ferraro.;A Colombo.
来源: Circulation. 1996年93卷2期215-22页
Previous studies have shown that it is feasible to withhold anticoagulation after a successful intracoronary stent procedure with a low incidence of stent thrombosis. The importance of specific antiplatelet agents when stenting is performed without anticoagulation is unknown.
4654. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study.
作者: S M Bode-Böger.;R H Böger.;H Alfke.;D Heinzel.;D Tsikas.;A Creutzig.;K Alexander.;J C Frölich.
来源: Circulation. 1996年93卷1期85-90页
L-Arginine is the precursor of endogenous nitric oxide (NO), which is a potent vasodilator acting via the intracellular second-messenger cGMP. In healthy humans, L-arginine induces peripheral vasodilation and inhibits platelet aggregation due to an increased NO production. Prostaglandin E1 (PGE1) induces peripheral vasodilation via stimulating prostacyclin receptors.
4655. Low-molecular-weight heparinoid orgaran is more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture.
作者: M Gent.;J Hirsh.;J S Ginsberg.;P J Powers.;M N Levine.;W H Geerts.;R M Jay.;J Leclerc.;J A Neemeh.;A G Turpie.
来源: Circulation. 1996年93卷1期80-4页
The study objective was to determine the relative efficacy and safety of a low-molecular-weight heparinoid (Orgaran) compared with aspirin for the prevention of postoperative venous thromboembolism in patients undergoing surgery for fractured hips. A double-blind, randomized, controlled trial was used to study 251 consecutive eligible and consenting patients undergoing surgery for hip fracture in seven participating hospitals.
4656. Prospective 12-year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Zürich study).
作者: U K Franzeck.;I Schalch.;K A Jäger.;E Schneider.;J Grimm.;A Bollinger.
来源: Circulation. 1996年93卷1期74-9页
No prospective study of the long-term sequelae of more than 10 years after acute deep vein thrombosis exists so far. Therefore, 58 low-risk patients with DVT were included in a prospective study to evaluate the natural history of postthrombotic syndrome.
4657. Blood pressure in young blacks and whites: relevance of obesity and lifestyle factors in determining differences. The CARDIA Study. Coronary Artery Risk Development in Young Adults.
作者: K Liu.;K J Ruth.;J M Flack.;R Jones-Webb.;G Burke.;P J Savage.;S B Hulley.
来源: Circulation. 1996年93卷1期60-6页
Middle-aged black men and women have higher blood pressure, on average, than whites. However, this pattern is inconsistent in children and adolescents. This study explores how differences in lifestyle factors in young adulthood may influence blood pressure patterns in the two races.
4658. Relation between symptom duration before thrombolytic therapy and final myocardial infarct size.
作者: M H Raitt.;C Maynard.;G S Wagner.;M D Cerqueira.;R H Selvester.;W D Weaver.
来源: Circulation. 1996年93卷1期48-53页
Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation between final myocardial infarct size and duration of symptoms before initiation of thrombolytic therapy in patients treated within 6 hours of symptom onset.
4659. Smoking and cardiac events after venous coronary bypass surgery. A 15-year follow-up study.
作者: A A Voors.;B L van Brussel.;H W Plokker.;S M Ernst.;N M Ernst.;E M Koomen.;J G Tijssen.;F E Vermeulen.
来源: Circulation. 1996年93卷1期42-7页
The long-term clinical effects of smoking and smoking cessation after venous coronary bypass surgery have not been well established.
4660. Progression of coronary artery disease predicts clinical coronary events. Long-term follow-up from the Cholesterol Lowering Atherosclerosis Study.
作者: S P Azen.;W J Mack.;L Cashin-Hemphill.;L LaBree.;A M Shircore.;R H Selzer.;D H Blankenhorn.;H N Hodis.
来源: Circulation. 1996年93卷1期34-41页
Progression of coronary artery disease is assumed to be a surrogate end point for clinical coronary events. Because no single method or measure for a coronary angiographic end point is uniformly accepted as optimal, the utility and validity of surrogate end points for predicting clinical coronary events remain unsettled.
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