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4621. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure.
作者: T S Rector.;A J Bank.;K A Mullen.;L K Tschumperlin.;R Sih.;K Pillai.;S H Kubo.
来源: Circulation. 1996年93卷12期2135-41页
Patients with heart failure have reduced peripheral blood flow at rest, during exercise, and in response to endothelium-dependent vasodilators. Nitric oxide formed from L-arginine metabolism in endothelial cells contributes to regulation of blood flow under these conditions. A randomized, double-blind crossover study design was used to determine whether supplemental oral L-arginine can augment peripheral blood flow and improve functional status in patients with moderate to severe heart failure.
4622. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.
作者: B M Massie.;S G Fisher.;M Radford.;P C Deedwania.;B N Singh.;R D Fletcher.;S N Singh.
来源: Circulation. 1996年93卷12期2128-34页
Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy. In the present study, we determined whether this increase in ejection fraction is associated with an improvement in the symptoms and/or physical findings of heart failure or a reduction in the number of hospitalizations for heart failure.
4623. Diabetics with coronary disease have a prevalence of asymptomatic ischemia during exercise treadmill testing and ambulatory ischemia monitoring similar to that of nondiabetic patients. An ACIP database study. ACIP Investigators. Asymptomatic Cardiac Ischemia Pilot Investigators.
作者: E A Caracciolo.;B R Chaitman.;S A Forman.;P H Stone.;M G Bourassa.;G Sopko.;N L Geller.;C R Conti.
来源: Circulation. 1996年93卷12期2097-105页
There are conflicting data as to whether diabetics have a higher prevalence of asymptomatic ST-segment depression during exercise treadmill testing (ETT) and ambulatory ECG (AECG) monitoring. This study was conducted to determine whether diabetic patients with coronary disease enrolled in the Asymptomatic Cardiac Ischemia Pilot (ACIP) have more episodes of asymptomatic ischemia during ETT and 48-hour AECG monitoring than nondiabetic patients and to compare differences in angiographic variables and the magnitude of ischemia as measured by standard ETT and AECG criteria.
4624. Effects of brain natriuretic peptide on exercise hemodynamics and neurohormones in isolated diastolic heart failure.
作者: P B Clarkson.;N M Wheeldon.;R J MacFadyen.;S D Pringle.;T M MacDonald.
来源: Circulation. 1996年93卷11期2037-42页
Experimental models suggest that brain natriuretic peptide (BNP) can modify left ventricular diastolic performance. The aim of this study was to evaluate the effects of BNP on resting and exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure.
4625. Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques.
作者: E U Nitzsche.;Y Choi.;J Czernin.;C K Hoh.;S C Huang.;H R Schelbert.
来源: Circulation. 1996年93卷11期2000-6页
[13N]Ammonia has been validated in dog studies as a myocardial blood flow tracer. Estimates of myocardial blood flow by [13N]ammonia were highly linearly correlated to those by the microsphere and blood sample techniques. However, estimates of myocardial blood flow with [13N]ammonia in humans have not yet been compared with those by an independent technique. This study therefore tested the hypothesis that the [13N]ammonia positron emission tomographic technique in humans gives estimates of myocardial blood flow comparable to those obtained with the [15O]water technique.
4626. Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide.
作者: T Omland.;A Aakvaag.;V V Bonarjee.;K Caidahl.;R T Lie.;D W Nilsen.;J A Sundsfjord.;K Dickstein.
来源: Circulation. 1996年93卷11期1963-9页
Elevated plasma levels of atrial natriuretic peptide (ANP) and the N-terminal fragment of the ANP prohormone (N-ANP) are associated with decreased left ventricular function and decreased long-term survival after acute myocardial infarction (AMI). Previous data suggest that plasma brain natriuretic peptide (BNP) may increase proportionally more than plasma ANP after AMI and in chronic heart failure. The diagnostic and prognostic value of plasma BNP as an indicator of left ventricular dysfunction and long-term survival after AMI, relative to that of ANP and N-ANP, remain to be established.
4627. Effectiveness of revascularization in the Emory angioplasty versus surgery trial. A randomized comparison of coronary angioplasty with bypass surgery.
作者: X Q Zhao.;B G Brown.;D K Stewart.;L A Hillger.;H X Barnhart.;A S Kosinski.;W S Weintraub.;S B King.
来源: Circulation. 1996年93卷11期1954-62页
The Emory Angioplasty Versus Surgery Trial (EAST) was designed to determine whether percutaneous transluminal coronary angioplasty (PTCA) is as effective as coronary artery bypass graft surgery (CABG) in restoring arterial perfusion capacity in eligible patients with multivessel disease.
4628. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans.
作者: W G Haynes.;C J Ferro.;K P O'Kane.;D Somerville.;C C Lomax.;D J Webb.
来源: Circulation. 1996年93卷10期1860-70页
Although local inhibition of the generation or actions of endothelin-1 has been shown to cause forearm vasodilatation, the systemic effects of endothelin receptor blockade in healthy humans are unknown. We therefore investigated the cardiovascular effects of a potent peptide endothelin ETA/B receptor antagonist, TAK-044, in healthy men.
4629. LDL-Apheresis Atherosclerosis Regression Study (LAARS). Effect of aggressive versus conventional lipid lowering treatment on coronary atherosclerosis.
作者: A A Kroon.;W R Aengevaeren.;T van der Werf.;G J Uijen.;J H Reiber.;A V Bruschke.;A F Stalenhoef.
来源: Circulation. 1996年93卷10期1826-35页
Intensive lipid lowering may retard the progression of coronary atherosclerosis. LDL-apheresis has the potential to decrease LDL cholesterol to very low levels. To assess the effect of more aggressive lipid lowering with LDL-apheresis, we set up a randomized study in men with hypercholesterolemia and severe coronary atherosclerosis.
4630. Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study.
作者: T R Pedersen.;J Kjekshus.;K Berg.;A G Olsson.;L Wilhelmsen.;H Wedel.;K Pyörälä.;T Miettinen.;T Haghfelt.;O Faergeman.;G Thorgeirsson.;B Jönsson.;J S Schwartz.
来源: Circulation. 1996年93卷10期1796-802页
Advances in the treatment of cardiovascular disease have increased costs; annual cardiovascular healthcare expenditure in the United States currently exceeds $100 billion. Physicians and third-party payers need to assess the economic impact of treatments that reduce cardiovascular morbidity and mortality.
4631. Electrophysiological mechanisms in successful radiofrequency catheter modification of atrioventricular junction for patients with medically refractory paroxysmal atrial fibrillation.
作者: S A Chen.;S H Lee.;C E Chiang.;C T Tai.;T J Wu.;C C Cheng.;Z C Wen.;C W Chiou.;K C Ueng.;M S Chang.
来源: Circulation. 1996年93卷9期1690-701页
Mechanisms and changes of electrophysiological (EP) characteristics in successful radiofrequency (RF) modification of right midseptal and posteroseptal areas for controlling rapid ventricular response to atrial fibrillation (Af) are not clear.
4632. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy.
作者: G Brevetti.;F di Lisa.;S Perna.;R Menabó.;R Barbato.;V D Martone.;N Siliprandi.
来源: Circulation. 1996年93卷9期1685-9页
Carnitine metabolism is altered in peripheral arterial disease. L-carnitine supplementation may correct these alterations and improve walking performance.
4633. Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. The FRISC study group.
Early risk assessment is important in patients with unstable coronary artery disease, ie, unstable angina or non-Q-wave myocardial infarction. Some previous small studies have indicated that patients with unstable angina and elevation of troponin T (tn-T) have worse short-term and long-term prognoses. In this study, the prognostic value of tn-T was evaluated and compared with other early available risk indicators.
4634. Leukocyte depletion attenuates reperfusion injury in patients with left ventricular hypertrophy.
作者: Y Sawa.;K Taniguchi.;K Kadoba.;M Nishimura.;H Ichikawa.;A Amemiya.;T Kuratani.;H Matsuda.
来源: Circulation. 1996年93卷9期1640-6页
Reperfusion injury can occur after a long period of aortic cross-clamping in patients with left ventricular hypertrophy during open-heart surgery, even with the most up-to-date techniques of myocardial protection. In the present study, we examined whether leukocyte depletion as an adjunct to terminal blood cardioplegia (LDTC) attenuates reperfusion injury in patients with left ventricular hypertrophy (LV mass, >300 g; left ventricular end-systolic volume index, >100 mL/m2) in a group of 30 patients undergoing aortic valve replacement.
4635. Thrombin activity and early outcome in unstable angina pectoris.
作者: D Ardissino.;P A Merlini.;G Gamba.;P Barberis.;G Demicheli.;S Testa.;E Colombi.;A Poli.;R Fetiveau.;C Montemartini.
来源: Circulation. 1996年93卷9期1634-9页
The blood coagulation system is frequently activated in the acute phase of unstable angina, but it is unknown whether the augmented function of the hemostatic mechanism may serve as a marker of increased risk for an early unfavorable outcome.
4636. Ischemic stroke and the gene for angiotensin-converting enzyme in Japanese hypertensives.
The ACE insertion/deletion (I/D) polymorphism is reported to be associated with myocardial infarction in both whites and Japanese. However, there have been no reports on the association of this polymorphism with stroke in each race. Furthermore, there are some racial differences in the demographics of cardiovascular disease. In Japanese, stroke (especially that which occurs in preexisting hypertension) is more common and coronary artery disease much less common than in whites. We propose that the ACE I/D polymorphism might be associated with hypertensive cerebrovascular disease in Japanese.
4637. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
作者: G N Levine.;B Frei.;S N Koulouris.;M D Gerhard.;J F Keaney.;J A Vita.
来源: Circulation. 1996年93卷6期1107-13页
In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease.
4638. Prediction of successful ablation site of concealed posteroseptal accessory pathways by a novel algorithm using baseline electrophysiological parameters: implication for an abbreviated ablation procedure.
作者: C E Chiang.;S A Chen.;C T Tai.;T J Wu.;S H Lee.;C C Cheng.;C W Chiou.;K C Ueng.;Z C Wen.;M S Chang.
来源: Circulation. 1996年93卷5期982-91页
Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteristics of concealed posteroseptal APs and defined criteria from baseline parameters to predict the successful ablation site. Validity of the criteria was prospectively verified.
4639. Failure of reflex venoconstriction during exercise in patients with vasovagal syncope.
In this study, we tested two hypotheses. First, we tested the hypothesis that reflex constriction of the venous capacitance beds in patients with vasovagal syncope is impaired during both subhypotensive lower-body negative pressure. Second, we proposed that splenic venoconstriction may be impaired during exercise in patients with vasovagal syncope.
4640. Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training.
作者: M Piepoli.;A L Clark.;M Volterrani.;S Adamopoulos.;P Sleight.;A J Coats.
来源: Circulation. 1996年93卷5期940-52页
A neural linkage between peripheral abnormalities and the exaggerated exercise responses in chronic heart failure (CHF) was postulated. We studied the ergoreceptors (afferents sensitive to skeletal muscle work) in CHF and whether training can affect their activity.
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