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4581. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans.
作者: Juris J Meier.;Alexandra E Butler.;Yoshifumi Saisho.;Travis Monchamp.;Ryan Galasso.;Anil Bhushan.;Robert A Rizza.;Peter C Butler.
来源: Diabetes. 2008年57卷6期1584-94页
Little is known about the capacity, mechanisms, or timing of growth in beta-cell mass in humans. We sought to establish if the predominant expansion of beta-cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant beta-cell replication. We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence.
4582. Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2.
作者: Claudio Tiberti.;Carla Giordano.;Mattia Locatelli.;Emanuele Bosi.;Gian Franco Bottazzo.;Raffaella Buzzetti.;Domenico Cucinotta.;Aldo Galluzzo.;Alberto Falorni.;Francesco Dotta.
来源: Diabetes. 2008年57卷5期1276-83页
The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADA]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasian LADA patients, identifying the most sensitive construct to evaluate IA-2 immunoreactivity and comparing LADA IA-2 epitope specificities to those found in type 1 diabetes.
4583. Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity.
作者: Marcelo A Mori.;Ronaldo C Araújo.;Felipe C G Reis.;Daniela G Sgai.;Raphael G Fonseca.;Carlos C Barros.;Vanessa F Merino.;Mariana Passadore.;Ana M Barbosa.;Bernard Ferrari.;Pierre Carayon.;Charlles H M Castro.;Suma I Shimuta.;Jacqueline Luz.;Jean-Loup Bascands.;Joost P Schanstra.;Patrick C Even.;Suzana M Oliveira.;Michael Bader.;João B Pesquero.
来源: Diabetes. 2008年57卷6期1491-500页
Kinins mediate pathophysiological processes related to hypertension, pain, and inflammation through the activation of two G-protein-coupled receptors, named B(1) and B(2). Although these peptides have been related to glucose homeostasis, their effects on energy balance are still unknown.
4584. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.
作者: John M Stafford.;Fang Yu.;Richard Printz.;Alyssa H Hasty.;Larry L Swift.;Kevin D Niswender.
来源: Diabetes. 2008年57卷6期1482-90页
Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients and contributes to cardiovascular morbidity in these disorders. We sought to identify novel mechanisms leading to hypertriglyceridemia. Resistance to negative feedback signals from adipose tissue in key central nervous system (CNS) energy homeostatic circuits contributes to the development of obesity. Because triglycerides both represent the largest energy depot in the body and are elevated in both the plasma and adipose in obesity and diabetes, we hypothesized that the same neural circuits that regulate energy balance also regulate the secretion of TGs into plasma.
4585. Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice.
作者: Souad Belmadani.;Desiree I Palen.;Romer A Gonzalez-Villalobos.;Hamid A Boulares.;Khalid Matrougui.
来源: Diabetes. 2008年57卷6期1629-37页
We previously showed epidermal growth factor receptor (EGFR) transactivation to be key mechanism in the regulation of resistance artery myogenic tone. Type 2 diabetes is associated with microvascular complications. We hypothesized that elevated EGFR phosphorylation contributes to resistance artery dysfunction in type 2 diabetes.
4586. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes.
作者: Brett Phillips.;Karen Nylander.;Jo Harnaha.;Jennifer Machen.;Robert Lakomy.;Alexis Styche.;Kimberly Gillis.;Larry Brown.;Debra Lafreniere.;Michael Gallo.;Janet Knox.;Kenneth Hogeland.;Massimo Trucco.;Nick Giannoukakis.
来源: Diabetes. 2008年57卷6期1544-55页
This study was aimed at ascertaining the efficacy of antisense oligonucleotide-formulated microspheres to prevent type 1 diabetes and to reverse new-onset disease.
4587. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.
作者: Karim Bouzakri.;Reginald Austin.;Anna Rune.;Michael E Lassman.;Pablo M Garcia-Roves.;Joel P Berger.;Anna Krook.;Alexander V Chibalin.;Bei B Zhang.;Juleen R Zierath.
来源: Diabetes. 2008年57卷6期1508-16页
Malonyl coenzyme A (CoA) decarboxylase (MCD) is a key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism. We utilized RNA interference (siRNA)-based gene silencing to determine the direct role of MCD on metabolic responses in primary human skeletal muscle.
4588. Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
作者: Camilla Cervin.;Valeriya Lyssenko.;Ekaterine Bakhtadze.;Eero Lindholm.;Peter Nilsson.;Tiinamaija Tuomi.;Corrado M Cilio.;Leif Groop.
来源: Diabetes. 2008年57卷5期1433-7页
Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes.
4589. PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
作者: Deborah J Smyth.;Jason D Cooper.;Joanna M M Howson.;Neil M Walker.;Vincent Plagnol.;Helen Stevens.;David G Clayton.;John A Todd.
来源: Diabetes. 2008年57卷6期1730-7页
The disease association of the common 1858C>T Arg620Trp (rs2476601) nonsynonymous single nucleotide polymorphism (SNP) of protein tyrosine phosphatase; nonreceptor type 22 (PTPN22) on chromosome 1p13 has been confirmed in type 1 diabetes and also in other autoimmune diseases, including rheumatoid arthritis and Graves' disease. Some studies have reported additional associated SNPs independent of rs2476601/Trp(620), suggesting that it may not be the sole causal variant in the region and that the relative risk of rs2476601/Trp(620) is greater in lower risk by HLA class II genotypes than in the highest risk class II risk category.
4590. Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
作者: Christian Pfleger.;Henrik B Mortensen.;Lars Hansen.;Christian Herder.;Bart O Roep.;Hillary Hoey.;Henk-Jan Aanstoot.;Mirjana Kocova.;Nanette C Schloot.; .
来源: Diabetes. 2008年57卷4期929-37页
We investigated the association of anti-inflammatory cytokine interleukin (IL)-1 receptor antagonist (IL-1ra), adiponectin, proinflammatory cytokines IL-1 beta, IL-6, and CCL2, and tumor necrosis factor-alpha with beta-cell function, metabolic status, and clinical remission in patients with recent-onset type 1 diabetes.
4591. Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance.
作者: K Sreekumaran Nair.;Maureen L Bigelow.;Yan W Asmann.;Lisa S Chow.;Jill M Coenen-Schimke.;Katherine A Klaus.;Zeng-Kui Guo.;Raghavakaimal Sreekumar.;Brian A Irving.
来源: Diabetes. 2008年57卷5期1166-75页
Type 2 diabetes has become a global epidemic, and Asian Indians have a higher susceptibility to diabetes than Europeans. We investigated whether Indians had any metabolic differences compared with Northern European Americans that may render them more susceptible to diabetes.
4592. Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate.
作者: Jose E Galgani.;Leonie K Heilbronn.;Koichiro Azuma.;David E Kelley.;Jeanine B Albu.;Xavier Pi-Sunyer.;Steven R Smith.;Eric Ravussin.; .
来源: Diabetes. 2008年57卷4期841-5页
Compared with nondiabetic subjects, type 2 diabetic subjects are metabolically inflexible with impaired fasting fat oxidation and impaired carbohydrate oxidation during a hyperinsulinemic clamp. We hypothesized that impaired insulin-stimulated glucose oxidation is a consequence of the lower cellular glucose uptake rate in type 2 diabetes. Therefore, we compared metabolic flexibility to glucose adjusted for glucose disposal rate in nondiabetic versus type 2 diabetic subjects and in the latter group after 1 year of lifestyle intervention (the Look AHEAD [Action For Health in Diabetes] trial).
4593. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.
作者: Henry Erlich.;Ana Maria Valdes.;Janelle Noble.;Joyce A Carlson.;Mike Varney.;Pat Concannon.;Josyf C Mychaleckyj.;John A Todd.;Persia Bonella.;Anna Lisa Fear.;Eva Lavant.;Anthony Louey.;Priscilla Moonsamy.; .
来源: Diabetes. 2008年57卷4期1084-92页
The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes.
4594. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.
作者: Allison B Lehtinen.;Christopher Newton-Cheh.;Julie T Ziegler.;Carl D Langefeld.;Barry I Freedman.;Kurt R Daniel.;David M Herrington.;Donald W Bowden.
来源: Diabetes. 2008年57卷4期1108-14页
Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (SCD). Diabetic individuals are at increased risk for prolonged QT interval and SCD. We sought to replicate the finding that genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sample of European ancestry.
4595. Variations of the perforin gene in patients with type 1 diabetes.
作者: Elisabetta Orilieri.;Giuseppe Cappellano.;Rita Clementi.;Angela Cometa.;Massimo Ferretti.;Elisa Cerutti.;Francesco Cadario.;Miryam Martinetti.;Daniela Larizza.;Valeria Calcaterra.;Giuseppe D'Annunzio.;Renata Lorini.;Franco Cerutti.;Graziella Bruno.;Annalisa Chiocchetti.;Umberto Dianzani.
来源: Diabetes. 2008年57卷4期1078-83页
Perforin plays a key role in cell-mediated cytotoxicity. Mutations of its gene, PRF1, cause familial hemophagocytic lymphohistiocytosis but have also been associated with lymphomas and the autoimmune/lymphoproliferative syndrome. The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes.
4596. The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men.
作者: Nadir Cheurfa.;Danièle Dubois-Laforgue.;Daniela A F Ferrarezi.;André F Reis.;Guilherme M Brenner.;Clara Bouché.;Claude Le Feuvre.;Frédéric Fumeron.;José Timsit.;Michel Marre.;Gilberto Velho.
来源: Diabetes. 2008年57卷4期1063-8页
Uncoupling protein 2 (UCP2) is a physiological downregulator of reactive oxygen species generation and plays an antiatherogenic role in the vascular wall. A common variant in the UCP2 promoter (-866G>A) modulates mRNA expression, with increased expression associated with the A allele. We investigated association of this variant with coronary artery disease (CAD) in two cohorts of type 2 diabetic subjects.
4597. Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program.
作者: Kieren J Mather.;Tohru Funahashi.;Yuji Matsuzawa.;Sharon Edelstein.;George A Bray.;Steven E Kahn.;Jill Crandall.;Santica Marcovina.;Barry Goldstein.;Ronald Goldberg.; .
来源: Diabetes. 2008年57卷4期980-6页
To determine whether baseline adiponectin levels or intervention-associated change in adiponectin levels were independently associated with progression to diabetes in the Diabetes Prevention Program (DPP).
4598. Quantitative linkage analysis for pancreatic B-cell function and insulin resistance in a large twin cohort.
作者: Mario Falchi.;Scott G Wilson.;Dimitrios Paximadas.;Ramasamyiyer Swaminathan.;Tim D Spector.
来源: Diabetes. 2008年57卷4期1120-4页
Insulin resistance and disturbed glucose homeostasis are key characteristics of metabolic syndrome, diabetes, and cardiovascular disease. The recent nonlinear computer version of homeostasis model assessment (HOMA)2 provides an appropriate and convenient assessment of glucose metabolism, enabling gene-mapping studies in large population samples.
4599. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas.
作者: Xinyuan Zhang.;Shisan Bao.;Donna Lai.;Robert W Rapkins.;Mark C Gillies.
来源: Diabetes. 2008年57卷4期1026-33页
To elucidate the mechanism of the unique beneficial effect of intravitreal steroid therapy on diabetic macular edema, we investigated the effect of locally administered triamcinolone acetonide (TA) on the expression of vascular endothelial growth factor (VEGF)-A and its receptors in retinas of rats with streptozotocin (STZ)-induced diabetes. We then correlated the expression of these proteins with breakdown of the blood-retinal barrier (BRB).
4600. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.
作者: Junqin Chen.;Geetu Saxena.;Imran N Mungrue.;Aldons J Lusis.;Anath Shalev.
来源: Diabetes. 2008年57卷4期938-44页
In diabetes, glucose toxicity affects different organ systems, including pancreatic islets where it leads to beta-cell apoptosis, but the mechanisms are not fully understood. Recently, we identified thioredoxin-interacting protein (TXNIP) as a proapoptotic beta-cell factor that is induced by glucose, raising the possibility that TXNIP may play a role in beta-cell glucose toxicity.
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