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441. Interventional MRI-Guided Ablation of Left Ventricular Tachycardia.
作者: Luuk H G A Hopman.;Marco J W Götte.;Jules L Nelissen.;Raschel D van Luijk.;Marjolein F Koster.;Mika J Sybrandi.;Katherine Lindborg.;Pieter G Postema.;Steven A J Chamuleau.;Cornelis P Allaart.;Michiel J B Kemme.
来源: Circulation. 2026年153卷25期2106-2109页 442. Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
作者: Daniel W Jones.;Keith C Ferdinand.;Sandra J Taler.;Heather M Johnson.;Daichi Shimbo.;Marwah Abdalla.;M Martine Altieri.;Nisha Bansal.;Natalie A Bello.;Adam P Bress.;Jocelyn Carter.;Jordana B Cohen.;Karen J Collins.;Yvonne Commodore-Mensah.;Leslie L Davis.;Brent Egan.;Sadiya S Khan.;Donald M Lloyd-Jones.;Bernadette Mazurek Melnyk.;Eva A Mistry.;Modele O Ogunniyi.;Stacey L Schott.;Sidney C Smith.;Amy W Talbot.;Wanpen Vongpatanasin.;Karol E Watson.;Paul K Whelton.;Jeff D Williamson.
来源: Circulation. 2026年153卷15期e1121页 443. Dysregulated Aldosterone Production in Obesity Is Associated With Adverse Cardiac Structure, Function, and Adiposity.
作者: Cheng-Hsuan Tsai.;Justin M Chan.;Julia Milks.;Arnaldo Ferrebus.;Isabelle Hanna.;Sanan Mahrokhian.;Andrew J Newman.;Stéfanie Parisien-La Salle.;Isabela Reis Marques.;Kristen Foote.;Gail K Adler.;Raymond Y Kwong.;Michael Jerosch-Herold.;Bertram Pitt.;Anand Vaidya.;Jenifer M Brown.
来源: Circulation. 2026年153卷15期1174-1177页 445. Letter by Zhuang et al Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".447. Response by Murchland et al to Letter Regarding Article, "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II".
作者: Audrey R Murchland.;Karestan C Koenen.;Rebecca B Lawn.
来源: Circulation. 2026年153卷15期e1119-e1120页 449. Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics.
作者: Lei Wang.;Maximilian Staps.;Stefan Günther.;Elie El Agha.;Saverio Bellusci.;Carsten Kuenne.;Junhua Du.;Andre Schneider.;Thomas Braun.
来源: Circulation. 2026年154卷6期565-583页
The Cre/loxP recombination system is the main tool for cell type-specific lineage tracing and gene targeting. Currently available smooth muscle cell (SMC)-specific Cre mouse lines show off-target activity outside the SMC lineage and are unable to distinguish among arterial SMCs (ASMCs), venous SMCs, and nonvascular SMCs (NVSMCs). These limitations prevent ASMC- and NVSMC-specific gene targeting, which is required to characterize the role of SMCs in different organs and diseases.
450. Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis.
作者: Jan-Christian Reil.;Vasco Sequeira.;Cédric Coppée.;Karina Peters.;Jan M Federspiel.;Paul Steendijk.;Christoph Maack.;Mark T Waddingham.;Volker Rudolph.;Gert-Hinrich Reil.;Smita Scholtz.
来源: Circ Heart Fail. 2026年19卷5期e013392页
Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by left ventricular (LV) outflow tract obstruction, which increases afterload and chronically activates the Anrep response, a compensatory (afterload-driven) state of hyperdynamic systole, prolonged systolic ejection time, and increased myocardial workload. We investigated whether the myosin inhibitor mavacamten reverses this state, comparing its effects to the anatomic relief achieved by alcohol septal ablation.
451. Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis.
作者: Zachary A Patel.;Meg K Ospina.;Roxanne Mittelstaedt.;Jacob Peller.;Stephanie Samani.;Charlotte Marchell.;Kelly Ohlrich.;Brady Gunn.;Michael Varrone.;Kaylen Dodson.;Lindsey Bull.;Hajj Jennifer.;Mathew J Gregoski.;Molly Silkowski.;Michele Esposito.;Ryan J Tedford.;Jeffrey D McMurray.;Lucas Witer.;Arman Kilic.;Brian A Houston.;Anthony P Carnicelli.
来源: Circ Heart Fail. 2026年e013742页
Temporary mechanical support (tMCS) devices are often placed for cardiogenic shock (CS) at regional referral centers (RRCs) before transfer to CS hub centers (HCs). We sought to assess for differences in device-related adverse events (DRAEs) and outcomes between patients with tMCS placement for CS at an RRC before transfer to an HC compared with initial tMCS device placement at an HC.
452. Female Sex-Related Stroke Risk in Atrial Fibrillation: A Thing From the Past?
作者: Konsta Teppo.;K E Juhani Airaksinen.;Jari Haukka.;Ville L Langén.;Olli Halminen.;Jukka Putaala.;Miika Linna.;Pirjo Mustonen.;Juha Hartikainen.;Gregory Y H Lip.;Mika Lehto.
来源: Circ Arrhythm Electrophysiol. 2026年19卷4期e014728页 453. Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging.
作者: Brett W Sperry.;Evan O'Keefe.;Eric V Burgett.;Erika Hutt.;Philip G Jones.;James A Case.;Timothy M Bateman.
来源: Circ Cardiovasc Imaging. 2026年19卷5期e019371页
Technetium-labeled bone-avid tracers have been repurposed to diagnose transthyretin cardiac amyloidosis without rigorous kinetic studies. Supply shortages have necessitated the use of hydroxymethylene diphosphonate (HMDP) as an alternative to technetium-99m pyrophosphate, though comparative data remain limited. This study characterizes tracer kinetics using quantitative single-photon emission computed tomography with computed tomography.
454. Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.
作者: Jianfeng Xu.;Zhuqing Shi.;Sumeet A Khetarpal.;Ashley J Mulford.;Osama Siddiqui.;Huy Tran.;Jun Wei.;Annabelle Ashworth.;S Lilly Zheng.;David Duggan.;Brian T Helfand.;Henry M Dunnenberger.;Peter J Hulick.;David J Davidson.;Amit V Khera.;Aniruddh P Patel.;Alan R Sanders.;Arman Qamar.
来源: Circ Genom Precis Med. 2026年19卷3期e005494页
Current genetic testing for coronary artery disease (CAD) primarily targets monogenic variants in individuals with severe hypercholesterolemia. Whether supplementing monogenic testing with polygenic risk scores for CAD and Lp(a; lipoprotein[a]) levels [PRSLp(a)] improves identification of high-risk individuals in the general population remains understudied.
455. Novel RYR2-A4510T Variant Presenting Both as Autosomal Dominant and Autosomal Recessive Catecholaminergic Polymorphic Ventricular Tachycardia.
作者: Auke T Bergeman.;Peter Lauffer.;Johanna C Herkert.;Frederik M A van den Heuvel.;Sally-Ann B Clur.;Alexa M C Vermeer.;Alexander J A Groffen.;Jan D H Jongbloed.;Ingrid P C Krapels.;Christian Schroer.;Sabine C M Eijsbouts.;Paul G A Volders.;Vincent van der Pas.;Shanshan Tian.;Hai-Lei Zhu.;Ruiwu Wang.;John Paul Estillore.;Arthur A M Wilde.;Christian van der Werf.;S R Wayne Chen.;Saskia N van der Crabben.
来源: Circ Genom Precis Med. 2026年19卷3期e005625页 458. Rapid Genome Sequencing Shows Diagnostic Utility in Infants With Congenital Heart Defects.
作者: Matthew D Durbin.;Lindsey R Helvaty.;Alyx Posorske.;Samuel X Zhang.;Manyan Huang.;Ming Li.;Daniel Abreu.;Korre Fairman.;Gabrielle C Geddes.;Benjamin M Helm.;Benjamin J Landis.;Alexis McEntire.;Dana K Mitchell.;Stephanie M Ware.
来源: Circ Genom Precis Med. 2026年19卷3期e005367页
Congenital heart disease (CHD) is the most common birth defect and a leading cause of infant mortality. CHD often has a genetic cause, and recent studies demonstrate the utility of genetic testing. In clinical practice, genetic testing continues to evolve, and the incorporation of rapid genome sequencing (rGS) in CHD is a recent development that requires evaluation. Although smaller studies demonstrate the value of rGS, they also highlight the burden of results interpretation.
459. Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.
作者: Frits I Mulder.;Noori A M Guman.;Job van Riet.;Roos J van Geffen.;Thijs F van Haaps.;Vahram Hovsepjan.;Hanneke W M van Laarhoven.;Geert A Cirkel.;Filip Y F L de Vos.;Hans M Westgeest.;Laurens V Beerepoot.;Judith de Vos-Geelen.;Mariette Labots.;Paul Hamberg.;Annelie J E Vulink.;Maartje Los.;Aeilko H Zwinderman.;Debbie G J Robbrecht.;Maja J A de Jonge.;Harry R Büller.;Pieter W Kamphuisen.;Bart Ferwerda.;Neeltje Steeghs.;Nick van Es.
来源: Circ Genom Precis Med. 2026年19卷3期e005182页
International guidelines suggest prophylactic anticoagulation for patients with cancer at high risk of venous thromboembolism (VTE). Here, we evaluated whether tumor whole-genome sequencing data may improve the selection of high-risk patients.
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