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441. Temporal Changes in Procedural Success and Clinical Outcomes of MTEER by Mechanism of MR: Analysis of the STS/TVT Registry.
作者: Zach Rozenbaum.;Sreekanth Vemulapalli.;Miloni Shah.;Andrzej Stanislaw Kosinski.;Eric Gnall.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014819页
With the expansion of indications for mitral transcatheter edge-to-edge repair into nondegenerative etiologies, it is unknown whether changes in technical success and clinical outcomes have occurred.
442. Impact of Bypass Conduit and Early Technical Failure on Revascularization for Chronic Limb-Threatening Ischemia.
作者: Michael S Conte.;Alik Farber.;Andrew Barleben.;Emiliano Chisci.;Gheorghe Doros.;Vikram S Kashyap.;Ahmed Kayssi.;Philippe Kolh.;Carla C Moreira.;Timothy Nypaver.;Kenneth Rosenfield.;Vincent L Rowe.;Andres Schanzer.;Niten Singh.;Jeffrey J Siracuse.;Michael B Strong.;Matthew T Menard.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014716页
The optimal strategy for lower extremity revascularization (surgical bypass versus endovascular intervention) in patients with chronic limb-threatening ischemia (CLTI) is unclear. We examined the effectiveness of open surgical bypass using single-segment great saphenous vein conduit (SSGSV), alternative conduits (AC), or endovascular interventions (ENDO) among patients with CLTI deemed acceptable for either open surgical bypass or ENDO treatment.
443. Characteristics and Outcomes of PCI Among Patients Ineligible for Surgical Revascularization in the Veterans Affairs Healthcare System.
作者: Christopher P Kovach.;Jerry Lipinski.;Elise C Mesenbring.;Peter Boulos.;Abby Pribish.;Michael Sola.;Thomas J Glorioso.;William F Fearon.;Robert W Yeh.;Stephen W Waldo.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014899页
Ineligibility for surgical revascularization is increasingly prevalent and associated with increased mortality after percutaneous coronary intervention (PCI). High-quality, contemporary, multicenter data regarding clinical outcomes after PCI is scarce and poses a barrier to clinical decision-making for surgically ineligible patients. The aim of this study was to describe and compare the clinical characteristics, institutional variation, and longitudinal outcomes of PCI among surgically eligible and ineligible patients in the Veterans Affairs Healthcare System.
444. Intravascular Imaging-Guided Versus Angiography-Guided Complex PCI in Patients With High Bleeding Risk: A Secondary Analysis of the RENOVATE-COMPLEX PCI Trial.
作者: Jinhwan Jo.;Sang Yoon Lee.;Woochan Kwon.;Seung-Jae Lee.;Jong-Young Lee.;Seung Hun Lee.;Doosup Shin.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Ki Hong Choi.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Young Bin Song.;Joo-Yong Hahn.;Sang Yeub Lee.;Joo Myung Lee.; .
来源: Circ Cardiovasc Interv. 2025年18卷3期e014952页
Although patients with high bleeding risk (HBR) often have complex coronary artery lesions, it is not known whether intravascular imaging-guided percutaneous coronary intervention (PCI) improves their prognosis. We sought to investigate the benefit of intravascular imaging-guided PCI for complex coronary artery lesions in patients with HBR.
445. Prognosis and Risk Stratification in Dilated Cardiomyopathy With LVEF≤35%: Cardiac MRI Insights for Better Outcomes.
作者: Di Zhou.;Leyi Zhu.;Shuang Li.;Weichun Wu.;Baiyan Zhuang.;Jing Xu.;Wenjing Yang.;Jian He.;Yining Wang.;Yuhui Zhang.;Guanshu Liu.;Xiaoxin Sun.;Qiang Zhang.;Zhongzhao Teng.;Arlene Sirajuddin.;Andrew E Arai.;Shihua Zhao.;Minjie Lu.
来源: Circ Cardiovasc Imaging. 2025年18卷3期e017246页
Current guidelines recommend implantable cardioverter defibrillators for the primary prevention of sudden cardiac death (SCD) in patients with dilated cardiomyopathy with left ventricular ejection fraction (LVEF)≤35%. However, its effectiveness is hindered by the inability to reliably discriminate between the risk of SCD and competing death of heart failure deterioration, thereby limiting its clinical utility. We aimed to refine the SCD risk stratification model based on cardiac magnetic resonance imaging for patients with dilated cardiomyopathy with LVEF≤35%.
447. Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2.
作者: Qishan Chen.;Ancheng Zheng.;Xiaolei Xu.;Zhenning Shi.;Mei Yang.;Shasha Sun.;Leyu Wang.;Yumeng Wang.;Haige Zhao.;Qingzhong Xiao.;Li Zhang.
来源: Circulation. 2025年151卷14期1024-1046页
Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in regulating redox signaling and tissue homeostasis. Here, we aimed to evaluate the role and mechanism of Nrf3 in injury-induced pathological cardiac remodeling.
448. Atrial Translocation of Porphyromonas gingivalis Exacerbates Atrial Fibrosis and Atrial Fibrillation.
作者: Shunsuke Miyauchi.;Miki Kawada-Matsuo.;Hisako Furusho.;Hiromi Nishi.;Ayako Nakajima.;Pham Trong Phat.;Fumie Shiba.;Masae Kitagawa.;Kazuhisa Ouhara.;Noboru Oda.;Takehito Tokuyama.;Yousaku Okubo.;Sho Okamura.;Taiichi Takasaki.;Shinya Takahashi.;Toru Hiyama.;Hiroyuki Kawaguchi.;Hitoshi Komatsuzawa.;Mutsumi Miyauchi.;Yukiko Nakano.
来源: Circulation. 2025年151卷21期1527-1540页
Recent studies have indicated an association between periodontitis and atrial fibrillation (AF), although the underlying mechanisms remain unclear. Porphyromonas gingivalis (P ginigivalis) is a causative agent of periodontal disease and is highly pathogenic. This study focused on Pgingivalis and aimed to investigate the relationship among periodontitis, atrial translocation of Pgingivalis, and atrial fibrosis and AF.
449. A Novel Hidden Protein p-414aa Encoded by circSETD2(14,15) Inhibits Vascular Remodeling.
作者: Si-Fan Wang.;Li-Yun Yang.;An-Qi Zhao.;Zhao-Yi Wang.;Sen Wang.;Miao Gong.;Ming-Qi Zheng.;Gang Liu.;Shu-Yan Yang.;Jia-Jie Lin.;Shao-Guang Sun.
来源: Circulation. 2025年151卷22期1568-1582页
Phenotypic switching of vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia, is a fundamental cause of vascular remodeling diseases such as atherosclerosis and hypertension. Novel hidden proteins encoded by circular RNAs play crucial roles in disease progression, yet their involvement in vascular remodeling diseases has not been comprehensively studied. This study identifies a novel protein derived from a circular RNA in VSMCs and demonstrates its potential role in regulating vascular remodeling.
451. Cost-Effectiveness of Aortic Valve Replacement in Low- and Intermediate-Risk Chinese Patients With Severe Aortic Stenosis.
作者: Jin Peng.;Xinglong Zheng.;Minghuan Jiang.;Xuelin Yao.;Yue Ma.;Mao Fu.;Tao Ma.;Xiaolong Shang.;Yang Yan.;Vinod H Thourani.;Yu Fang.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷4期e010858页
Transcatheter aortic valve replacement (TAVR) remains debated as an alternative to surgical aortic valve replacement (SAVR). We aimed to evaluate the cost-effectiveness of aortic valve replacement strategies in low- and intermediate-risk patients with severe aortic stenosis in China.
453. Correction to: Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study.
作者: Marius M Hoeper.;Britta Oerke.;Max Wissmüller.;Hanno Leuchte.;Christian Opitz.;Michael Halank.;Hans-Juergen Seyfarth.;Stephan Baldus.;Johann Bauersachs.;Michael Böhm.;Hossein-Ardeschir Ghofrani.;Stavros Konstantinides.;Karen M Olsson.;Rolf Wachter.;Carolyn S P Lam.;Behnaz Aminossadati.;Stephan Rosenkranz.
来源: Circulation. 2025年151卷11期e763页 454. Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.
作者: Joshua K Meisner.;Aaron Renberg.;Eric D Smith.;Yao-Chang Tsan.;Brynn Elder.;Abbey Bullard.;Owen L Merritt.;Sean L Zheng.;Neal K Lakdawala.;Anjali T Owens.;Thomas D Ryan.;Erin M Miller.;Joseph W Rossano.;Kimberly Y Lin.;Brian L Claggett.;Euan A Ashley.;Michelle Michels.;Rachel Lampert.;John C Stendahl.;Dominic Abrams.;Christopher Semsarian.;Victoria N Parikh.;Matthew T Wheeler.;Jodie Ingles.;Iacopo Olivotto.;Sharlene M Day.;Sara Saberi.;Mark W Russell.;Michael Previs.;Carolyn Y Ho.;James S Ware.;Adam S Helms.
来源: Circulation. 2025年151卷11期e762页 460. Risk of Cancer in Newborns With Congenital Heart Disease and Their Mothers: A Nationwide Cohort Study.
作者: Danbee Kang.;Gwang-Jun Choi.;Jihye Heo.;Seung Woo Park.;Juyoung Sung.;Insung Kim.;Taegyun Park.;Juhee Cho.;June Huh.
来源: Circulation. 2025年151卷11期807-809页 |