441. Psychotherapy for Military-Related PTSD: A Review of Randomized Clinical Trials.
作者: Maria M Steenkamp.;Brett T Litz.;Charles W Hoge.;Charles R Marmar.
来源: JAMA. 2015年314卷5期489-500页
Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder common among military personnel and veterans. First-line psychotherapies most often recommended for PTSD consist mainly of "trauma-focused" psychotherapies that involve focusing on details of the trauma or associated cognitive and emotional effects.
442. Treatment of Atrial Fibrillation.
Atrial fibrillation is a common arrhythmia that affects more than 2.5 million people in the United States and causes substantial morbidity and mortality, especially regarding the increased risk of stroke.
443. Polypharmacy in the Aging Patient: Management of Hypertension in Octogenarians.
作者: Athanase Benetos.;Patrick Rossignol.;Antonio Cherubini.;Laure Joly.;Tomasz Grodzicki.;Chakravarthi Rajkumar.;Timo E Strandberg.;Mirko Petrovic.
来源: JAMA. 2015年314卷2期170-80页
Hypertension treatment is beneficial for most hypertensive patients. The benefits for patients who are very old and frail, especially those taking numerous medications, are less certain.
444. Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review.
As of March 2015, 23 states and the District of Columbia had medical marijuana laws in place. Physicians should know both the scientific rationale and the practical implications for medical marijuana laws.
445. Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
作者: Penny F Whiting.;Robert F Wolff.;Sohan Deshpande.;Marcello Di Nisio.;Steven Duffy.;Adrian V Hernandez.;J Christiaan Keurentjes.;Shona Lang.;Kate Misso.;Steve Ryder.;Simone Schmidlkofer.;Marie Westwood.;Jos Kleijnen.
来源: JAMA. 2015年313卷24期2456-73页
Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear.
446. Nonalcoholic fatty liver disease: a systematic review.
Nonalcoholic fatty liver disease and its subtype nonalcoholic steatohepatitis affect approximately 30% and 5%, respectively, of the US population. In patients with nonalcoholic steatohepatitis, half of deaths are due to cardiovascular disease and malignancy, yet awareness of this remains low. Cirrhosis, the third leading cause of death in patients with nonalcoholic fatty liver disease, is predicted to become the most common indication for liver transplantation.
447. Stroke prevention in atrial fibrillation: a systematic review.
Atrial fibrillation (AF) is associated with an increase in mortality and morbidity, with a substantial increase in stroke and systemic thromboembolism. Strokes related to AF are associated with higher mortality, greater disability, longer hospital stays, and lower chance of being discharged home than strokes unrelated to AF.
449. Acute stroke intervention: a systematic review.
Acute ischemic stroke is a major cause of mortality and morbidity in the United States. We review the latest data and evidence supporting catheter-directed treatment for proximal artery occlusion as an adjunct to intravenous thrombolysis in patients with acute stroke.
450. Irritable bowel syndrome: a clinical review.
Irritable bowel syndrome (IBS) affects 7% to 21% of the general population. It is a chronic condition that can substantially reduce quality of life and work productivity.
451. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review.
Because early-stage kidney disease is asymptomatic and is associated with both morbidity and mortality, laboratory measurements are required for its detection.
452. Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis.
作者: Connor A Emdin.;Kazem Rahimi.;Bruce Neal.;Thomas Callender.;Vlado Perkovic.;Anushka Patel.
来源: JAMA. 2015年313卷6期603-15页
Lowering blood pressure (BP) is widely used to reduce vascular risk in individuals with diabetes.
453. Diagnosis and treatment of Clostridium difficile in adults: a systematic review.
Since 2000, the incidence and severity of Clostridium difficile infection (CDI) have increased.
455. Resective epilepsy surgery for drug-resistant focal epilepsy: a review.
Epilepsy surgery is indicated for patients with focal seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medications.
456. Traveler's diarrhea: a clinical review.
Acute diarrhea is the most common illness that affects travelers to low-income regions of the world. Although improved hygiene has reduced the risk of traveler's diarrhea in many destinations, the risk remains high in others.
457. Metformin in patients with type 2 diabetes and kidney disease: a systematic review.
作者: Silvio E Inzucchi.;Kasia J Lipska.;Helen Mayo.;Clifford J Bailey.;Darren K McGuire.
来源: JAMA. 2014年312卷24期2668-75页
Metformin is widely viewed as the best initial pharmacological option to lower glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is contraindicated in many individuals with impaired kidney function because of concerns of lactic acidosis.
458. The diagnosis and management of mild cognitive impairment: a clinical review.
Cognitive decline is a common and feared aspect of aging. Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that is not severe enough to require help with usual activities of daily living.
459. Chronic lymphocytic leukemia: a clinical review.
The most common leukemia is chronic lymphocytic leukemia (CLL). Every year, there are 15 000 new diagnoses and 5000 CLL deaths in the United States. Although therapeutic choices were once limited, treatment of this disease has vastly improved in the last decade.
460. Treatment of syphilis: a systematic review.
The incidence of syphilis in the United States is increasing; it is estimated that more than 55,000 new infections will occur in 2014. Treatment regimens are controversial, especially in specific populations, and assessing treatment response based on serology remains a challenge.
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