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4561. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.
作者: T G Deloughery.;A Evans.;A Sadeghi.;J McWilliams.;W D Henner.;L M Taylor.;R D Press.
来源: Circulation. 1996年94卷12期3074-8页
Increased homocysteine levels are a risk factor for atherosclerosis and its sequelae. A common genetic mutation in methylenetetrahydrofolate reductase (MTHFR), an enzyme required for efficient homocysteine metabolism, creates a thermolabile enzyme with reduced activity. We determined the prevalence of this mutation in many subjects with and without vascular disease and related it to homocysteine and folate levels.
4562. Delayed surgery of traumatic aortic rupture. Role of magnetic resonance imaging.
作者: R Fattori.;F Celletti.;P Bertaccini.;R Galli.;D Pacini.;A Pierangeli.;G Gavelli.
来源: Circulation. 1996年94卷11期2865-70页
Traumatic aortic rupture (TAR) is a pathological entity with a high mortality, both spontaneous and perioperative. Delayed surgical repair has been proposed when associated lesions are stabilized. The aim of this study was to validate MRI for detecting both the presence and type of TAR and to monitor posttraumatic aneurysm and associated lesions.
4563. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart.
作者: E M Gilbert.;W T Abraham.;S Olsen.;B Hattler.;M White.;P Mealy.;P Larrabee.;M R Bristow.
来源: Circulation. 1996年94卷11期2817-25页
The basic pharmacology of the third-generation beta-blocking agent carvedilol differs considerably from second-generation compounds such as metoprolol. Moreover, carvedilol may produce different, ie, more favorable, clinical effects in chronic heart failure. For these reasons, we compared the effects of carvedilol and metoprolol on adrenergic activity, receptor expression, degree of clinical beta-blockade, hemodynamics, and left ventricular function in patients with mild or moderate chronic heart failure.
4564. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.
作者: M R Bristow.;E M Gilbert.;W T Abraham.;K F Adams.;M B Fowler.;R E Hershberger.;S H Kubo.;K A Narahara.;H Ingersoll.;S Krueger.;S Young.;N Shusterman.
来源: Circulation. 1996年94卷11期2807-16页
We conducted a multicenter, placebo-controlled trial designed to establish the efficacy and safety of carvedilol, a "third-generation" beta -blocking agent with vasodilator properties, in chronic heart failure.
4565. Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure. US Carvedilol Heart Failure Study Group.
作者: W S Colucci.;M Packer.;M R Bristow.;E M Gilbert.;J N Cohn.;M B Fowler.;S K Krueger.;R Hershberger.;B F Uretsky.;J A Bowers.;J D Sackner-Bernstein.;S T Young.;T L Holcslaw.;M A Lukas.
来源: Circulation. 1996年94卷11期2800-6页
We tested the hypothesis that carvedilol inhibits clinical progression in patients with mildly symptomatic heart failure due to left ventricular (LV) systolic dysfunction.
4566. Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise.
作者: M Packer.;W S Colucci.;J D Sackner-Bernstein.;C S Liang.;D A Goldscher.;I Freeman.;M L Kukin.;V Kinhal.;J E Udelson.;M Klapholz.;S S Gottlieb.;D Pearle.;R J Cody.;J J Gregory.;N E Kantrowitz.;T H LeJemtel.;S T Young.;M A Lukas.;N H Shusterman.
来源: Circulation. 1996年94卷11期2793-9页
Carvedilol has improved the symptomatic status of patients with moderate to severe heart failure in single-center studies, but its clinical effects have not been evaluated in large, multicenter trials.
4567. Left ventricular, peripheral vascular, and neurohumoral responses to mental stress in normal middle-aged men and women. Reference Group for the Psychophysiological Investigations of Myocardial Ischemia (PIMI) Study.
作者: L C Becker.;C J Pepine.;R Bonsall.;J D Cohen.;A D Goldberg.;C Coghlan.;P H Stone.;S Forman.;G Knatterud.;D S Sheps.;P G Kaufmann.
来源: Circulation. 1996年94卷11期2768-77页
The normal cardiovascular response to mental stress in middle-aged and older people has not been well characterized.
4568. Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
作者: P Pietinen.;E B Rimm.;P Korhonen.;A M Hartman.;W C Willett.;D Albanes.;J Virtamo.
来源: Circulation. 1996年94卷11期2720-7页
Even though dietary fiber has been hypothesized to reduce the risk of coronary heart disease, few large epidemiological studies have examined this relation with good methodology.
4569. Effects of low-dose heparin infusion on arterial endothelin-1 release in humans.
作者: P M Piatti.;L D Monti.;G Valsecchi.;M Conti.;R Nasser.;B Guazzini.;E Fochesato.;C V Phan.;A E Pontiroli.;G Pozza.
来源: Circulation. 1996年94卷11期2703-7页
The aim of this study was to evaluate the effect of low-dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans.
4570. Multicenter comparison of truncated biphasic shocks and standard damped sine wave monophasic shocks for transthoracic ventricular defibrillation. Transthoracic Investigators.
作者: G H Bardy.;F E Marchlinski.;A D Sharma.;S J Worley.;R M Luceri.;R Yee.;B D Halperin.;C L Fellows.;T S Ahern.;D A Chilson.;D L Packer.;D J Wilber.;T A Mattioni.;R Reddy.;R A Kronmal.;R Lazzara.
来源: Circulation. 1996年94卷10期2507-14页
The most important factor for improving out-of-hospital ventricular fibrillation survival rates is early defibrillation. This can be achieved if small, lightweight, inexpensive automatic external defibrillators are widely disseminated. Because automatic external defibrillator size and cost are directly affected by defibrillation waveform shape and because of the favorable experience with truncated biphasic waveforms in implantable cardioverter-defibrillators, we compared the efficacy of a truncated biphasic waveform with that of a standard damped sine monophasic waveform for transthoracic defibrillation.
4571. Lanreotide reduces serum free and total insulin-like growth factor-I after angioplasty.
作者: J Frystyk.;C Skjaerbaek.;N Alexander.;H Emanuelsson.;H Suryapranata.;H Beyer.;M Foegh.;H Orskov.
来源: Circulation. 1996年94卷10期2465-71页
Several experiments point to a participating role of insulin-like growth factor-I (IGF-I) in the vascular events leading to restenosis after percutaneous transluminal coronary angioplasty (PTCA).
4572. Evolution of early TIMI 2 flow after thrombolysis for acute myocardial infarction. GUSTO-1 Angiographic Investigators.
作者: J S Reiner.;C F Lundergan.;A Fung.;K Coyne.;S Cho.;N Israel.;J Kazmierski.;G Pilcher.;J Smith.;S Rohrbeck.;M Thompson.;F Van de Werf.;A M Ross.
来源: Circulation. 1996年94卷10期2441-6页
Patients with early Thrombolysis in Myocardial Infarction (TIMI) grade 2 flow after thrombolysis appear to have outcomes similar to thrombolytic failures. To evaluate the origin and evolution of early TIMI 2 flow, we examined early and late angiographic and ventriculographic data from the Global Utilization of Streptokinase and TPA for Occluded Arteries (GUSTO-1) angiographic study.
4573. Relationship to blood pressure of combinations of dietary macronutrients. Findings of the Multiple Risk Factor Intervention Trial (MRFIT).
作者: J Stamler.;A Caggiula.;G A Grandits.;M Kjelsberg.;J A Cutler.
来源: Circulation. 1996年94卷10期2417-23页
Elevated blood pressure remains a widespread major impediment to health. Obesity and specific dietary factors such as high salt and alcohol intake and low potassium intake adversely affect blood pressure. It is a reasonable hypothesis that additional dietary constituents, particularly macronutrients, may also influence blood pressure.
4574. Distinct effects of recombinant desulfatohirudin (Revasc) and heparin on plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in unstable angina. A multicenter trial.
作者: A K Rao.;L Sun.;J H Chesebro.;V Fuster.;R A Harrington.;D Schwartz.;P Gallo.;D Matos.;E J Topol.
来源: Circulation. 1996年94卷10期2389-95页
Thrombin plays an important role in the pathogenesis of acute coronary thrombosis. We studied the effects of a direct thrombin inhibitor, recombinant desulfatohirudin, and heparin on plasma levels (at 0, 4, 12, and 24 hours) of fibrinopeptide A (FPA), which reflects thrombin action, and prothrombin fragment F1.2, which reflects thrombin generation, in patients with unstable angina.
4575. Serum lipids and incidence of coronary heart disease. Findings from the Systolic Hypertension in the Elderly Program (SHEP).
作者: P H Frost.;B R Davis.;A J Burlando.;J D Curb.;G P Guthrie.;J L Isaacsohn.;S Wassertheil-Smoller.;A C Wilson.;J Stamler.
来源: Circulation. 1996年94卷10期2381-8页
The association of serum lipids with coronary heart disease has been studied extensively in middle-aged men and, to a lesser extent, in similar women. Less well defined are lipid variables predictive of CHD in individuals of age > or = 60 years.
4576. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering.
作者: S P Azen.;D Qian.;W J Mack.;A Sevanian.;R H Selzer.;C R Liu.;C H Liu.;H N Hodis.
来源: Circulation. 1996年94卷10期2369-72页
There is accumulating experimental, epidemiological, and clinical evidence of an association between anti-oxidant vitamin intake and reduced risk of coronary heart disease. Using data from the Cholesterol Lowering Atherosclerosis Study (CLAS), we explored the association of self-selected supplementary antioxidant vitamin intake on the rate of progression of early preintrusive atherosclerosis.
4577. Phase 1 human trial of adenosine-potassium cardioplegia.
作者: S E Fremes.;S L Levy.;G T Christakis.;S E Walker.;J Iazetta.;H R Mallidi.;R Feder-Elituv.;K A Deemar.;E A Cohen.;B I Wong.;B S Goldman.
来源: Circulation. 1996年94卷9 Suppl期II370-5页
The cardioprotective role of adenosine in various models of ischemia-reperfusion, including adenosine supplementation to cardioplegic formulations, has been studied extensively. The appropriate dose of adenosine in humans is uncertain and could be limited by systemic hypotension or AV block.
4578. Randomized trial of recombinant platelet factor 4 versus protamine for the reversal of heparin anticoagulation in humans.
作者: G J Dehmer.;R A Lange.;D A Tate.;M Pirwitz.;W Daniel.;M Fisher.;E M Bonnem.
来源: Circulation. 1996年94卷9 Suppl期II347-52页
Protamine reverses heparin anticoagulation, but it can have important side effects. We compared the safety and effectiveness of intravenous recombinant platelet factor 4 (rPF4) as an alternative to protamine in a randomized blinded trial.
4579. Surgical aspects of a randomized trial of defibrillator implantation during coronary artery bypass surgery. The CABG Patch Trial.
作者: H M Spotnitz.;J M Herre.;L D Baker.;D M Fitzgerald.;I L Kron.;J T Bigger.
来源: Circulation. 1996年94卷9 Suppl期II248-53页
Whether prophylactic insertion of an implantable cardioverter defibrillator (ICD) improves the survival of high-risk patients undergoing coronary artery bypass graft surgery (CABG) is being assessed in the CABG Patch Trial. This report describes the surgical aspects of the study.
4580. Vasodilator effects of endothelin-converting enzyme inhibition and endothelin ETA receptor blockade in chronic heart failure patients treated with ACE inhibitors.
The importance of endothelin-1 in chronic heart failure (CHF) is unclear. We therefore investigated the effects of endothelin-converting enzyme (ECE) inhibition and endothelin ETA receptor blockade in CHF patients treated with ACE inhibitors. We also compared the function of ETA and ETB receptors in healthy subjects and patients with CHF.
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