4521. Association of timing of surgery for hip fracture and patient outcomes.
作者: Gretchen M Orosz.;Jay Magaziner.;Edward L Hannan.;R Sean Morrison.;Kenneth Koval.;Marvin Gilbert.;Maryann McLaughlin.;Ethan A Halm.;Jason J Wang.;Ann Litke.;Stacey B Silberzweig.;Albert L Siu.
来源: JAMA. 2004年291卷14期1738-43页
Previous studies of surgical timing in patients with hip fracture have yielded conflicting findings on mortality and have not focused on functional outcomes.
4522. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial.
作者: Garnet L Anderson.;Marian Limacher.;Annlouise R Assaf.;Tamsen Bassford.;Shirley A A Beresford.;Henry Black.;Denise Bonds.;Robert Brunner.;Robert Brzyski.;Bette Caan.;Rowan Chlebowski.;David Curb.;Margery Gass.;Jennifer Hays.;Gerardo Heiss.;Susan Hendrix.;Barbara V Howard.;Judith Hsia.;Allan Hubbell.;Rebecca Jackson.;Karen C Johnson.;Howard Judd.;Jane Morley Kotchen.;Lewis Kuller.;Andrea Z LaCroix.;Dorothy Lane.;Robert D Langer.;Norman Lasser.;Cora E Lewis.;JoAnn Manson.;Karen Margolis.;Judith Ockene.;Mary Jo O'Sullivan.;Lawrence Phillips.;Ross L Prentice.;Cheryl Ritenbaugh.;John Robbins.;Jacques E Rossouw.;Gloria Sarto.;Marcia L Stefanick.;Linda Van Horn.;Jean Wactawski-Wende.;Robert Wallace.;Sylvia Wassertheil-Smoller.; .
来源: JAMA. 2004年291卷14期1701-12页
Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain.
4524. Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke.
作者: Steven R Levine.;Robin L Brey.;Barbara C Tilley.;J L P Thompson.;Ralph L Sacco.;Robert R Sciacca.;A Murphy.;Yimeng Lu.;Teresa M Costigan.;Candi Rhine.;Bruce Levin.;Douglas A Triplett.;J P Mohr.; .
来源: JAMA. 2004年291卷5期576-84页
The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial.
4525. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes.
Control of blood glucose levels, blood pressure, and cholesterol levels is proven to reduce the risk of vascular disease among individuals with diabetes mellitus; however, the current state of control of these risk factors among individuals in the United States is uncertain.
4527. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study.
The Diabetes Control and Complications Trial (DCCT) demonstrated the benefits of intensive treatment of diabetes in reducing glycemic levels and slowing the progression of diabetic nephropathy. The DCCT cohort has been examined annually for another 8 years as part of the follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study. During the EDIC study, glycemic levels no longer differed substantially between the 2 original treatment groups.
4528. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial.
作者: Linda Teri.;Laura E Gibbons.;Susan M McCurry.;Rebecca G Logsdon.;David M Buchner.;William E Barlow.;Walter A Kukull.;Andrea Z LaCroix.;Wayne McCormick.;Eric B Larson.
来源: JAMA. 2003年290卷15期2015-22页
Exercise training for patients with Alzheimer disease combined with teaching caregivers how to manage behavioral problems may help decrease the frailty and behavioral impairment that are often prevalent in patients with Alzheimer disease.
4530. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial.
作者: Jane A Cauley.;John Robbins.;Zhao Chen.;Steven R Cummings.;Rebecca D Jackson.;Andrea Z LaCroix.;Meryl LeBoff.;Cora E Lewis.;Joan McGowan.;Joan Neuner.;Mary Pettinger.;Marcia L Stefanick.;Jean Wactawski-Wende.;Nelson B Watts.; .
来源: JAMA. 2003年290卷13期1729-38页
In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures.
4531. Educational levels of hospital nurses and surgical patient mortality.
作者: Linda H Aiken.;Sean P Clarke.;Robyn B Cheung.;Douglas M Sloane.;Jeffrey H Silber.
来源: JAMA. 2003年290卷12期1617-23页
Growing evidence suggests that nurse staffing affects the quality of care in hospitals, but little is known about whether the educational composition of registered nurses (RNs) in hospitals is related to patient outcomes.
4533. Impact of an annual dollar limit or "cap" on prescription drug benefits for Medicare patients.
Annual dollar limits, or "caps," on drug benefits are common in Medicare managed care (Medicare + Choice) and have been part of several proposals for a national Medicare drug benefit.
4534. Depressive symptoms and health-related quality of life: the Heart and Soul Study.
作者: Bernice Ruo.;John S Rumsfeld.;Mark A Hlatky.;Haiying Liu.;Warren S Browner.;Mary A Whooley.
来源: JAMA. 2003年290卷2期215-21页
Little is known regarding the extent to which patient-reported health status, including symptom burden, physical limitation, and quality of life, is determined by psychosocial vs physiological factors among patients with chronic disease.
4535. Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression.
作者: J Douglas Bremner.;Meena Vythilingam.;Chin K Ng.;Eric Vermetten.;Ahsan Nazeer.;Dan A Oren.;Robert M Berman.;Dennis S Charney.
来源: JAMA. 2003年289卷23期3125-34页
We previously used positron emission tomography (PET) measurement of brain metabolism with 18fluorodeoxyglucose to show that patients receiving selective serotonin reuptake inhibitors (SSRIs) who have a tryptophan depletion-induced return of depressive symptoms have an acute decrease in metabolism in orbitofrontal cortex, dorsolateral prefrontal cortex, and thalamus. Many patients with depression in remission while taking norepinephrine reuptake inhibitors (NRIs) (but not SSRIs) experience a return of depressive symptoms with depletion of norepinephrine and dopamine using alpha-methylparatyrosine (AMPT).
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