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4521. Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.
作者: Toshihide Kurihara.;Yoko Ozawa.;Norihiro Nagai.;Kei Shinoda.;Kousuke Noda.;Yutaka Imamura.;Kazuo Tsubota.;Hideyuki Okano.;Yuichi Oike.;Susumu Ishida.
来源: Diabetes. 2008年57卷8期2191-8页
Pathogenic mechanisms underlying diabetes-induced retinal dysfunction are not fully understood. The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina.
4522. Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake.
作者: Darleen A Sandoval.;Didier Bagnol.;Stephen C Woods.;David A D'Alessio.;Randy J Seeley.
来源: Diabetes. 2008年57卷8期2046-54页
Glucagon-like peptide-1 (GLP-1) promotes glucose homeostasis through regulation of islet hormone secretion, as well as hepatic and gastric function. Because GLP-1 is also synthesized in the brain, where it regulates food intake, we hypothesized that the central GLP-1 system regulates glucose tolerance as well.
4523. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.
作者: Naoki Kumashiro.;Yoshifumi Tamura.;Toyoyoshi Uchida.;Takeshi Ogihara.;Yoshio Fujitani.;Takahisa Hirose.;Hideki Mochizuki.;Ryuzo Kawamori.;Hirotaka Watada.
来源: Diabetes. 2008年57卷8期2083-91页
Recent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism.
4524. Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance.
作者: Ming Bell.;Hong Wang.;Hui Chen.;John C McLenithan.;Da-Wei Gong.;Rong-Zee Yang.;Daozhan Yu.;Susan K Fried.;Michael J Quon.;Constantine Londos.;Carole Sztalryd.
来源: Diabetes. 2008年57卷8期2037-45页
Accumulation of intracellular lipid droplets (LDs) in non-adipose tissues is recognized as a strong prognostic factor for the development of insulin resistance in obesity. LDs are coated with perilipin, adipose differentiation-related protein, tail interacting protein of 47 kd (PAT) proteins that are thought to regulate LD turnover by modulating lipolysis. Our hypothesis is that PAT proteins modulate LD metabolism and therefore insulin resistance.
4525. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
作者: Yi-Cheng Chang.;Pi-Hua Liu.;Wei-Jei Lee.;Tien-Jyun Chang.;Yi-Der Jiang.;Hung-Yuan Li.;Shan-Shan Kuo.;Kuang-Chin Lee.;Lee-Ming Chuang.
来源: Diabetes. 2008年57卷8期2245-52页
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population.
4526. Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.
作者: Michelle Goldsworthy.;Alison Hugill.;Helen Freeman.;Emma Horner.;Kenju Shimomura.;Debora Bogani.;Guido Pieles.;Vesna Mijat.;Ruth Arkell.;Shoumo Bhattacharya.;Frances M Ashcroft.;Roger D Cox.
来源: Diabetes. 2008年57卷8期2234-44页
To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion.
4527. Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice.
作者: Junyan Han.;Jinxin Zhong.;Wenzhong Wei.;Ying Wang.;Yafei Huang.;Ping Yang.;Sharad Purohit.;Zheng Dong.;Mong-Heng Wang.;Jin-Xiong She.;Feili Gong.;David M Stern.;Cong-Yi Wang.
来源: Diabetes. 2008年57卷8期2118-27页
The implication of innate immunity in type 1 diabetes development has long been proposed. High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was recently recognized to be a potent innate inflammatory mediator when released extracellularly. We sought to test the hypothesis that HMGB1 acts as an innate immune mediator implicated in type 1 diabetes pathogenesis.
4528. Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes.
作者: Laura Tedesco.;Alessandra Valerio.;Cristina Cervino.;Annalisa Cardile.;Claudio Pagano.;Roberto Vettor.;Renato Pasquali.;Michele O Carruba.;Giovanni Marsicano.;Beat Lutz.;Uberto Pagotto.;Enzo Nisoli.
来源: Diabetes. 2008年57卷8期2028-36页
Cannabinoid type 1 (CB1) receptor blockade decreases body weight and adiposity in obese subjects; however, the underlying mechanism is not yet fully understood. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) induces mitochondrial biogenesis and function in adipocytes. This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes.
4529. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.
作者: Carina P Tan.;Yue Feng.;Yun-Ping Zhou.;George J Eiermann.;Aleksandr Petrov.;Changyou Zhou.;Songnian Lin.;Gino Salituro.;Peter Meinke.;Ralph Mosley.;Taro E Akiyama.;Monica Einstein.;Sanjeev Kumar.;Joel P Berger.;Sander G Mills.;Nancy A Thornberry.;Lihu Yang.;Andrew D Howard.
来源: Diabetes. 2008年57卷8期2211-9页
Acute activation of G protein-coupled receptor 40 (GPR40) by free fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter of debate whether activation of GPR40 would be beneficial for the treatment of type 2 diabetes, since chronic exposure to FFAs impairs islet function. We sought to evaluate the specific role of GPR40 in islets and its potential as a therapeutic target using compounds that specifically activate GPR40.
4530. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
作者: Gilles Besin.;Simon Gaudreau.;Michaël Ménard.;Chantal Guindi.;Gilles Dupuis.;Abdelaziz Amrani.
来源: Diabetes. 2008年57卷8期2107-17页
Autoimmune diabetes in the nonobese diabetic (NOD) mouse model results from a breakdown of T-cell tolerance caused by impaired tolerogenic dendritic cell development and regulatory T-cell (Treg) differentiation. Re-establishment of the Treg pool has been shown to confer T-cell tolerance and protection against diabetes. Here, we have investigated whether murine thymic stromal lymphopoietin (TSLP) re-established tolerogenic function of dendritic cells and induced differentiation and/or expansion of Tregs in NOD mice and protection against diabetes.
4531. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
作者: Maggie C Y Ng.;Kyong Soo Park.;Bermseok Oh.;Claudia H T Tam.;Young Min Cho.;Hyoung Doo Shin.;Vincent K L Lam.;Ronald C W Ma.;Wing Yee So.;Yoon Shin Cho.;Hyung-Lae Kim.;Hong Kyu Lee.;Juliana C N Chan.;Nam H Cho.
来源: Diabetes. 2008年57卷8期2226-33页
Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed TCF7L2 as the major type 2 diabetes gene to date in Europeans. However, the implications of these genes in Asians are unclear.
4532. PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.
作者: Zhao V Wang.;James Mu.;Todd D Schraw.;Laurent Gautron.;Joel K Elmquist.;Bei B Zhang.;Michael Brownlee.;Philipp E Scherer.
来源: Diabetes. 2008年57卷8期2137-48页
Islet transplantations have been performed clinically, but their practical applications are limited. An extensive effort has been made toward the identification of pancreatic beta-cell stem cells that has yielded many insights to date, yet targeted reconstitution of beta-cell mass remains elusive. Here, we present a mouse model for inducible and reversible ablation of pancreatic beta-cells named the PANIC-ATTAC (pancreatic islet beta-cell apoptosis through targeted activation of caspase 8) mouse.
4533. Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes.
作者: Susan Sam.;Steven Haffner.;Michael H Davidson.;Ralph B D'Agostino.;Steven Feinstein.;George Kondos.;Alfonso Perez.;Theodore Mazzone.
来源: Diabetes. 2008年57卷8期2022-7页
Insulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile. We examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated with type 2 diabetes.
4534. Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
作者: Santhosh Satapati.;Tianteng He.;Takeshi Inagaki.;Matthew Potthoff.;Matthew E Merritt.;Victoria Esser.;David J Mangelsdorf.;Steven A Kliewer.;Jeffrey D Browning.;Shawn C Burgess.
来源: Diabetes. 2008年57卷8期2012-21页
Fluxes through mitochondrial pathways are defective in insulin-resistant skeletal muscle, but it is unclear whether similar mitochondrial defects play a role in the liver during insulin resistance and/or diabetes. The purpose of this study is to determine whether abnormal mitochondrial metabolism plays a role in the dysregulation of both hepatic fat and glucose metabolism during diabetes.
4535. Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
作者: Toyonori Kato.;Hitoshi Shimano.;Takashi Yamamoto.;Mayumi Ishikawa.;Shin Kumadaki.;Takashi Matsuzaka.;Yoshimi Nakagawa.;Naoya Yahagi.;Masanori Nakakuki.;Alyssa H Hasty.;Yoshinori Takeuchi.;Kazuto Kobayashi.;Akimitsu Takahashi.;Shigeru Yatoh.;Hiroaki Suzuki.;Hirohito Sone.;Nobuhiro Yamada.
来源: Diabetes. 2008年57卷9期2382-92页
Chronic exposure to fatty acids causes beta-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis.
4536. The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.
作者: Victoria A Payne.;Neil Grimsey.;Antoinette Tuthill.;Sam Virtue.;Sarah L Gray.;Edoardo Dalla Nora.;Robert K Semple.;Stephen O'Rahilly.;Justin J Rochford.
来源: Diabetes. 2008年57卷8期2055-60页
Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder featuring near complete absence of adipose tissue. Remarkably, although the causative gene, BSCL2, has been known for several years, its molecular function and its role in adipose tissue development have not been elucidated. Therefore, we examined whether BSCL2 is involved in the regulation of adipocyte differentiation and the mechanism whereby pathogenic mutations in BSCL2 cause lipodystrophy.
4537. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.
作者: Patrice Dallaire.;Kerstin Bellmann.;Mathieu Laplante.;Stéphanie Gélinas.;Carolina Centeno-Baez.;Patrice Penfornis.;Marie-Line Peyot.;Martin G Latour.;Julien Lamontagne.;Maria E Trujillo.;Philipp E Scherer.;Marc Prentki.;Yves Deshaies.;André Marette.
来源: Diabetes. 2008年57卷8期1999-2011页
Synthetic ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) improve insulin sensitivity in obesity, but it is still unclear whether inflammatory signals modulate their metabolic actions. In this study, we tested whether targeted disruption of inducible nitric oxide (NO) synthase (iNOS), a key inflammatory mediator in obesity, modulates the metabolic effects of rosiglitazone in obese mice.
4538. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.
作者: Reginald L Austin.;Anna Rune.;Karim Bouzakri.;Juleen R Zierath.;Anna Krook.
来源: Diabetes. 2008年57卷8期2066-73页
Proinflammatory cytokines contribute to systemic low-grade inflammation and insulin resistance. Tumor necrosis factor (TNF)-alpha impedes insulin signaling in insulin target tissues. We determined the role of inhibitor of nuclear factor-kappaB kinase (IKK)beta in TNF-alpha-induced impairments in insulin signaling and glucose metabolism in skeletal muscle.
4539. Exposure to maternal diabetes induces salt-sensitive hypertension and impairs renal function in adult rat offspring.
作者: Touria Nehiri.;Jean-Paul Duong Van Huyen.;Mélanie Viltard.;Céline Fassot.;Didier Heudes.;Nicole Freund.;Georges Deschênes.;Pascal Houillier.;Patrick Bruneval.;Martine Lelièvre-Pégorier.
来源: Diabetes. 2008年57卷8期2167-75页
Epidemiological and experimental studies have led to the hypothesis of fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. We have previously demonstrated in the rat that in utero exposure to maternal diabetes impairs renal development leading to a reduction in nephron number. Little is known on the long-term consequences of in utero exposure to maternal diabetes. The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood.
4540. Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.
作者: Alicia G Gómez-Valadés.;Andrés Méndez-Lucas.;Anna Vidal-Alabró.;Francese X Blasco.;Miguel Chillon.;Ramon Bartrons.;Jordi Bermúdez.;José C Perales.
来源: Diabetes. 2008年57卷8期2199-210页
Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C; encoded by Pck1) catalyzes the first committed step in gluconeogenesis. Extensive evidence demonstrates a direct correlation between PEPCK-C activity and glycemia control. Therefore, we aimed to evaluate the metabolic impact and their underlying mechanisms of knocking down hepatic PEPCK-C in a type 2 diabetic model.
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