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4481. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training.
作者: H E Montgomery.;P Clarkson.;C M Dollery.;K Prasad.;M A Losi.;H Hemingway.;D Statters.;M Jubb.;M Girvain.;A Varnava.;M World.;J Deanfield.;P Talmud.;J R McEwan.;W J McKenna.;S Humphries.
来源: Circulation. 1997年96卷3期741-7页
The absence (deletion allele [D]) of a 287-base pair marker in the ACE gene is associated with higher ACE levels than its presence (insertion allele [I]). If renin-angiotensin systems regulate left ventricular (LV) growth, then individuals of DD genotype might show a greater hypertrophic response than those of II genotype. We tested this hypothesis by studying exercise-induced LV hypertrophy.
4482. Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans.
作者: J A Condado.;R Waksman.;O Gurdiel.;R Espinosa.;J Gonzalez.;B Burger.;G Villoria.;H Acquatella.;I R Crocker.;K B Seung.;S F Liprie.
来源: Circulation. 1997年96卷3期727-32页
Ionizing radiation has been shown to reduce neointimal formation after balloon angioplasty in experimental models of restenosis. This study was designed to evaluate the feasibility, safety, and effectiveness of intracoronary radiation therapy (ICRT) after percutaneous transluminal coronary angioplasty (PTCA) for preventing restenosis in human coronary arteries.
4483. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia.
作者: G Jacob.;J R Shannon.;B Black.;I Biaggioni.;R Mosqueda-Garcia.;R M Robertson.;D Robertson.
来源: Circulation. 1997年96卷2期575-80页
Idiopathic orthostatic tachycardia (IOT) is characterized by an increase in heart rate (HR) with standing of > or = 30 bpm that is associated with elevated catecholamine levels and orthostatic symptoms. A dynamic orthostatic hypovolemia and alpha1-adrenoreceptor hypersensitivity have been demonstrated in IOT patients. There is evidence of an autonomic neuropathy affecting the lower-extremity blood vessels.
4484. Restenosis after coronary stent placement and randomization to a 4-week combined antiplatelet or anticoagulant therapy: six-month angiographic follow-up of the Intracoronary Stenting and Antithrombotic Regimen (ISAR) Trial.
作者: A Kastrati.;H Schühlen.;J Hausleiter.;H Walter.;E Zitzmann-Roth.;M Hadamitzky.;S Elezi.;K Ulm.;J Dirschinger.;F J Neumann.;A Schömig.
来源: Circulation. 1997年96卷2期462-7页
Platelets and mural thrombus at the lesion site may play a key role in initiating the restenosis process after coronary interventions. The ISAR Trial provides a comparison of the outcomes of patients randomized to two different antithrombotic regimens administered for 4 weeks after successful coronary stent placement: combined antiplatelet therapy (aspirin plus ticlopidine) or a conventional anticoagulant regimen (phenprocoumon with initial overlapping heparin plus aspirin). Within the first 4 weeks after stent placement, combined antiplatelet therapy has been associated with a significant reduction of ischemic complications. In the present study, we examined whether combined antiplatelet therapy administered for 4 weeks after stent placement is able to reduce the process of restenosis at 6 months.
4485. Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators.
作者: D E Vaughan.;J L Rouleau.;P M Ridker.;J M Arnold.;F J Menapace.;M A Pfeffer.
来源: Circulation. 1997年96卷2期442-7页
The long-term administration of ACE inhibitors to selected patients with left ventricular dysfunction appears to reduce the incidence of recurrent myocardial infarction (MI) and unstable angina pectoris. The mechanisms responsible for the reduction in ischemic events are unknown, but likely candidates include effects on the atherosclerotic process, thrombosis, and/or vascular tone.
4486. Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS).
作者: W R Aengevaeren.;G J Uijen.;J W Jukema.;A V Bruschke.;T van der Werf.
来源: Circulation. 1997年96卷2期429-35页
Lipid-lowering therapy during 2 years in the Regression Growth Evaluation Statin Study (REGRESS) was associated with less progression of coronary atherosclerosis in the pravastatin group compared with the placebo group. The effect of lipid-lowering therapy on the functional state of the coronary circulation is less well known. The purpose of this study was to evaluate this effect.
4487. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction.
作者: S Gupta.;E W Leatham.;D Carrington.;M A Mendall.;J C Kaski.;A J Camm.
来源: Circulation. 1997年96卷2期404-7页
The clinical significance of the association between elevated anti-Chlamydia pneumoniae (Cp) antibody titres and coronary heart disease (CHD) is unclear. We explored the relationship between antibodies against Cp and future cardiovascular events in male survivors of myocardial infarction (MI). The effect of azithromycin antibiotic therapy was assessed in a subgroup of post-MI patients.
4488. Crystalloid versus cold blood cardioplegia and cardiac troponin I release.
作者: H Pichon.;S Chocron.;K Alwan.;G Toubin.;D Kaili.;P Falcoz.;L Latini.;F Clement.;J F Viel.;J P Etievent.
来源: Circulation. 1997年96卷1期316-20页
Cardiac troponin I (CTnI) has been shown to be a marker of myocardial injury. The aim of this study was to compare antegrade crystalloid cardioplegia with antegrade cold blood cardioplegia with warm reperfusion using CTnI release as the criteria for evaluating the adequacy of myocardial protection.
4489. Sympathetic and vascular effects of short-term passive smoke exposure in healthy nonsmokers.
The physiological effects of cigarette smoking have been widely studied; however, little is known about the effects of acute exposure to sidestream smoke (passive smoking). We examined the effects of sidestream smoke on muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) at rest and during stressful stimuli, including the cold pressor test (CPT), sustained handgrip (SHG), and mental stress (MS).
4490. Heart rate during obstructive sleep apnea depends on individual hypoxic chemosensitivity of the carotid body.
作者: F Sato.;M Nishimura.;H Shinano.;H Saito.;K Miyamoto.;Y Kawakami.
来源: Circulation. 1997年96卷1期274-81页
In patients with obstructive sleep apnea syndrome (OSAS), there are cyclic fluctuations in heart rate (HR), that is, bradycardia during apnea followed by abrupt tachycardia on resumption of ventilation. Although a previous study suggested that the degree of bradycardia observed during central apnea at high altitude was determined by individual hypoxic chemosensitivity of the carotid body, it is not known whether this is true for subjects with obstructive sleep apnea syndrome.
4491. A population-based method for the estimation of defibrillation energy requirements in humans. Assessment of time-dependent effects with a transvenous defibrillation system.
作者: D Newman.;A Barr.;M Greene.;D Martin.;M Ham.;S Thorne.;P Dorian.
来源: Circulation. 1997年96卷1期267-73页
A weighted logistic regression analysis was developed to allow pooling of patient data for the study of the stability of defibrillation energy requirements with a new nonthoracotomy lead defibrillation system.
4492. Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial.
作者: P Alboni.;C Menozzi.;M Brignole.;N Paparella.;G Gaggioli.;G Lolli.;R Cappato.
来源: Circulation. 1997年96卷1期260-6页
Pacemakers and theophylline are currently being used to relieve symptoms in patients with sick sinus syndrome (SSS). However, the impact of either therapy on the natural course of the disease is unknown. We conducted a randomized controlled trial to prospectively assess the effects of pacemakers and theophylline in patients with SSS.
4493. Low-energy cardioversion of spontaneous atrial fibrillation. Immediate and long-term results.
作者: S Lévy.;P Ricard.;M Gueunoun.;F Yapo.;J Trigano.;C Mansouri.;F Paganelli.
来源: Circulation. 1997年96卷1期253-9页
Recent studies have suggested that induced atrial fibrillation (AF) could be successfully terminated by using a two-catheter electrode system and low energy (< 400 V). This study evaluated the efficacy and safety of low-energy cardioversion in spontaneous chronic and paroxysmal AF.
4494. Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability.
作者: A Mortara.;P Sleight.;G D Pinna.;R Maestri.;A Prpa.;M T La Rovere.;F Cobelli.;L Tavazzi.
来源: Circulation. 1997年96卷1期246-52页
Reduced heart rate variability, particularly in the Very-low-frequency (VLF) spectral band, has been found to be a marker for poor prognosis in patients after myocardial infarction, but the origin of the VLF oscillations is unclear. In this study, we demonstrate that the power of cardiovascular oscillations in the VLF band in awake patients with mild to severe chronic heart failure is greatly increased by the common occurrence of unrecognized irregularity of breathing, which may confound the use of heart rate variability measures as indexes of autonomic tone or prognosis.
4495. Effect of sympathoinhibition on exercise performance in patients with heart failure.
In patients with heart failure, excessive sympathetic activation during exercise could interfere with exercise performance by impairing arteriolar dilation in working muscle and by adversely altering skeletal muscle metabolic behavior. To test this hypothesis, we examined the effect of sympathoinhibition with clonidine, a central sympatholytic agent, on skeletal muscle blood flow and metabolism in patients with heart failure.
4496. Long-term sequential changes in exercise capacity and chronotropic responsiveness after cardiac transplantation.
Peak exercise capacity improves early after orthotopic cardiac transplantation. However, the physiological response to exercise remains abnormal, with a reduced rate of heart rate (HR) rise and reductions in peak exercise HR and the increment in HR from rest to peak exercise. This chronotropic incompetence is due in large part to cardiac denervation. If reinnervation occurs after transplantation, it might result in an improvement in both chronotropic responsiveness and maximal exercise capacity. We therefore hypothesized that the chronotropic response to exercise and maximal exercise capacity would improve with time after transplantation.
4497. Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Collaborative Organization for RheothRx Evaluation (CORE).
来源: Circulation. 1997年96卷1期192-201页
Previous studies suggested that RheothRx (poloxamer 188) reduces infarct size and improves left ventricular (LV) function in acute myocardial infarction (AMI). We therefore evaluated the effects of various doses of RheothRx in 2948 patients presenting with AMI.
4498. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial.
作者: S Basu.;R Senior.;U Raval.;R van der Does.;T Bruckner.;A Lahiri.
来源: Circulation. 1997年96卷1期183-91页
Evidence of efficacy and safety of beta-blockers after thrombolysis for acute myocardial infarction (AMI) is equivocal. Newer beta-blockers such as carvedilol have not been tested in this setting.
4499. Perindopril chronically inhibits angiotensin-converting enzyme in both the endothelium and adventitia of the internal mammary artery in patients with ischemic heart disease.
作者: J L Zhuo.;P Froomes.;D Casley.;J J Liu.;C Murone.;S Y Chai.;B Buxton.;F A Mendelsohn.
来源: Circulation. 1997年96卷1期174-82页
ACE inhibitors are widely used in treating hypertension and heart failure, but the sites and mechanisms of ACE inhibition in human blood vessels are not understood. The present study was undertaken to assess the sites and extent of in vivo inhibition of ACE by long-term perindopril treatment in different layers of the internal mammary artery in patients with ischemic heart disease.
4500. Site-specific intracoronary heparin delivery in humans after balloon angioplasty. A radioisotopic assessment of regional pharmacokinetics.
作者: E Camenzind.;W H Bakker.;A Reijs.;I M van Geijlswijk.;E Boersma.;M J Kutryk.;E P Krenning.;J R Roelandt.;P W Serruys.
来源: Circulation. 1997年96卷1期154-65页
Demonstration and quantification of site-specific intracoronary administration of compounds has been confined thus far to the experimental animal laboratory. The aim of this study was to describe a scintigraphic method to demonstrate site-specific intracoronary drug delivery in humans. The methods allow on-line visualization and off-line quantification of site-specifically infused gamma-emitting compounds.
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