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4461. High homocysteine levels are independently related to isolated systolic hypertension in older adults.
The association between homocysteine and isolated systolic hypertension in older adults was evaluated using a case-control design, and the relationship between homocysteine and clinical or subclinical atherosclerosis was explored.
4462. Two- and three-dimensional transesophageal echocardiography in patient selection and assessment of atrial septal defect closure by the new DAS-Angel Wings device: initial clinical experience.
作者: G Magni.;Z M Hijazi.;N G Pandian.;A Delabays.;L Sugeng.;C Laskari.;G R Marx.
来源: Circulation. 1997年96卷6期1722-8页
Transcatheter closure of atrial septal defects (ASDs) has been feasible and successful. Two-dimensional echocardiography (2DE) was applied to patients before selection and during device deployment. Three-dimensional echocardiography (3DE) can provide unique anatomic perspectives that might aid in improving device closure of ASDs.
4463. A prospective evaluation of catheter ablation of ventricular tachycardia as adjuvant therapy in patients with coronary artery disease and an implantable cardioverter-defibrillator.
作者: S A Strickberger.;K C Man.;E G Daoud.;R Goyal.;K Brinkman.;C Hasse.;F Bogun.;B P Knight.;R Weiss.;M Bahu.;F Morady.
来源: Circulation. 1997年96卷5期1525-31页
Implantable cardioverter-defibrillator (ICD) therapy is integral to current therapy for ventricular tachycardia. Patients with an ICD frequently require concomitant antiarrhythmic drug therapy. Despite this, some patients still receive frequent ICD therapies for ventricular tachycardia. Therefore, the purpose of this prospective study was to determine the utility of ablation of ventricular tachycardia in patients with an ICD who experience frequent ICD therapies.
4464. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy.
作者: M Hamada.;Y Shigematsu.;S Ikeda.;Y Hara.;H Okayama.;K Kodama.;T Ochi.;K Hiwada.
来源: Circulation. 1997年96卷5期1520-4页
The class Ia antiarrhythmic drug disopyramide relieves the outflow tract obstruction of hypertrophic obstructive cardiomyopathy (HOCM). Disopyramide, however, has several adverse effects, such as dysuria and thirst, resulting from its anticholinergic activity. A new class Ia antiarrhythmic drug, cibenzoline, has little anticholinergic activity. The aim of this study is to elucidate whether cibenzoline attenuates left ventricular pressure gradient (LVPG) in patients with HOCM.
4465. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients.
There is evidence for increased formation of free radicals in patients with hypertension, raising the possibility that NO is inactivated by free radicals, which impairs coronary endothelial function. Therefore, we tested the hypothesis that the antioxidant vitamin C could improve abnormal endothelial function of coronary arteries in patients with hypertension.
4466. Enalapril does not enhance exercise capacity in patients after Fontan procedure.
作者: A A Kouatli.;J A Garcia.;T M Zellers.;E M Weinstein.;L Mahony.
来源: Circulation. 1997年96卷5期1507-12页
Angiotensin-converting enzyme inhibitors improve exercise capacity in adults with congestive heart failure by decreasing systemic vascular resistance and improving ventricular diastolic function. Patients who have undergone the Fontan procedure have decreased cardiac output, increased systemic vascular resistance, abnormal diastolic function, and decreased exercise capacity compared with normal people.
4467. Effects of octreotide treatment on restenosis after coronary angioplasty: results of the VERAS study. VErringerung der Restenoserate nach Angioplastie durch ein Somatostatin-analogon.
作者: R von Essen.;R Ostermaier.;E Grube.;W Mäurer.;U Tebbe.;R Erbel.;M Roth.;W Oel.;J Brom.;G Weidinger.
来源: Circulation. 1997年96卷5期1482-7页
The VERAS study (VErringerung der Restenoserate nach Angioplastie durch ein Somatostatin-analogon [Prevention of Restenosis Following Angioplasty With a Somatostatin Analogue]) was a placebo-controlled trial to evaluate the effects of octreotide for the prevention of restenosis after coronary angioplasty. Octreotide is a somatostatin analogue with antiproliferative properties on smooth muscle cell growth in vitro that limits myointimal thickening of arteries in balloon injury models.
4468. Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. The RESTORE Investigators. Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis.
来源: Circulation. 1997年96卷5期1445-53页
Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platelet glycoprotein (GP) IIb/IIIa that inhibits ex vivo platelet aggregation in response to a variety of agonists.
4469. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial.
作者: K Wenke.;B Meiser.;J Thiery.;D Nagel.;W von Scheidt.;G Steinbeck.;D Seidel.;B Reichart.
来源: Circulation. 1997年96卷5期1398-402页
Accelerated graft vessel disease (GVD) represents the most serious long-term complication of heart transplantation. A possible cause underlying this progressive coronary vascular disease is believed to be post-transplantation hypercholesterolemia.
4470. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men.
作者: T H Müller.;H Weisenberger.;R Brickl.;H Narjes.;F Himmelsbach.;J Krause.
来源: Circulation. 1997年96卷4期1130-8页
Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute thrombotic events. Orally active GP IIb/IIIa antagonists are essential to evaluate the clinical benefit of long-term treatment. We therefore investigated platelet inhibition by the GP IIb/IIIa antagonist Fradafiban (BIBU 52; Fradafiban is the recommended INN of BIBU 52) and its orally administered prodrug, Lefradafiban (BIBU 104; Lefradafiban is the recommended INN of BIBU 104) in healthy subjects.
4471. Sustained platelet glycoprotein IIb/IIIa blockade with oral xemilofiban in 170 patients after coronary stent deployment.
作者: D J Kereiakes.;N Kleiman.;J J Ferguson.;J P Runyon.;T M Broderick.;N A Higby.;L H Martin.;G Hantsbarger.;S McDonald.;R J Anders.
来源: Circulation. 1997年96卷4期1117-21页
Inhibition of platelet aggregation with parenteral glycoprotein (GP) IIb/IIIa receptor blockers can reduce the ischemic complications of angioplasty. Sustained efficacy and safety of protracted GP IIb/IIIa blockade with an orally administered agent have not previously been determined. This study is the first randomized, dose-ranging, single-blind, placebo-controlled trial of xemilofiban, an oral platelet GP IIb/IIIa receptor antagonist, administered to patients after intracoronary stent deployment. The pharmacodynamic efficacy of xemilofiban-induced platelet inhibition and clinical safety of this agent was evaluated during chronic therapy.
4472. Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
作者: F Cipollone.;P Patrignani.;A Greco.;M R Panara.;R Padovano.;F Cuccurullo.;C Patrono.;A G Rebuzzi.;G Liuzzo.;G Quaranta.;A Maseri.
来源: Circulation. 1997年96卷4期1109-16页
We have previously reported aspirin failure in suppressing enhanced thromboxane (TX) biosynthesis in a subset of episodes of platelet activation during the acute phase of unstable angina. The recent discovery of a second prostaglandin H synthase (PGHS-2), inducible in response to inflammatory or mitogenic stimuli, prompted us to reexamine TXA2 biosynthesis in unstable angina as modified by two cyclooxygenase inhibitors differentially affecting PGHS-2 despite a comparable impact on platelet PGHS-1.
4473. Association between cigarette smoking and lipid peroxidation in a controlled feeding study.
Cigarette smoke may promote atherogenesis by producing oxygen-derived free radicals that damage lipids. However, evidence in support of this hypothesis is inconsistent because most studies did not control for aspects of diet (antioxidants and lipid substrate) that may confound the association between smoking and measures of lipid peroxidation.
4474. ACE inhibition: postsynaptic adrenergic sympatholytic action in men.
The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body negative pressure [LBNP]) and exogenously mediated (brachial artery infusions of norepinephrine) sympathetic vasoconstriction.
4475. Comparative effects of enalapril and verapamil on myocardial blood flow in systemic hypertension.
作者: O Parodi.;D Neglia.;C Palombo.;G Sambuceti.;A Giorgetti.;C Marabotti.;M Gallopin.;I Simonetti.;A L'Abbate.
来源: Circulation. 1997年96卷3期864-73页
The comparative effects of calcium channel blockers and ACE inhibitors on myocardial blood flow (MBF) in hypertensive patients after long-term treatment are still unknown.
4476. Effect of the calcium antagonist felodipine as supplementary vasodilator therapy in patients with chronic heart failure treated with enalapril: V-HeFT III. Vasodilator-Heart Failure Trial (V-HeFT) Study Group.
作者: J N Cohn.;S Ziesche.;R Smith.;I Anand.;W B Dunkman.;H Loeb.;G Cintron.;W Boden.;L Baruch.;P Rochin.;L Loss.
来源: Circulation. 1997年96卷3期856-63页
Despite therapy with diuretics, ACE inhibitors and digoxin morbidity and mortality in heart failure remain high and might respond favorably to an additional vasodilator.
4477. Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators.
作者: G A Lamas.;G F Mitchell.;G C Flaker.;S C Smith.;B J Gersh.;L Basta.;L Moyé.;E Braunwald.;M A Pfeffer.
来源: Circulation. 1997年96卷3期827-33页
Mitral regurgitation (MR) may complicate acute myocardial infarction (MI). However, it is not known whether mild MR is an independent predictor of post-MI outcome.
4478. Detection of coronary artery disease with myocardial contrast echocardiography: comparison with 99mTc-sestamibi single-photon emission computed tomography.
The purpose of this study was to determine whether myocardial contrast echocardiography (MCE) can be used to detect coronary artery disease (CAD) during rest and pharmacological stress in humans through the use of venous injections of contrast.
4479. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: a pilot study. Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators.
来源: Circulation. 1997年96卷3期769-77页
Despite the use of aspirin and heparin, patients with acute ischemic syndromes are at risk of myocardial infarction (MI) or refractory ischemia. Therefore, evaluation of more potent antithrombotic therapies is warranted.
4480. Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction.
作者: J K Madsen.;P Grande.;K Saunamäki.;P Thayssen.;E Kassis.;U Eriksen.;K Rasmussen.;S Haunsø.;T T Nielsen.;T Haghfelt.;P Fritz-Hansen.;E Hjelms.;P K Paulsen.;P Alstrup.;H Arendrup.;U Niebuhr-Jørgensen.;L I Andersen.
来源: Circulation. 1997年96卷3期748-55页
The aim of the DANish trial in Acute Myocardial Infarction (DANAMI) study was to compare an invasive strategy of percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) with a conservative strategy in patients with inducible myocardial ischemia who received thrombolytic treatment for a first acute myocardial infarction (AMI).
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