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4441. Applicability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease. TRIM Study Group. Thrombin Inhibition in Myocardial ischemia.
Studies have demonstrated that troponin T is a strong independent indicator of a poor prognosis in patients with unstable coronary artery disease. Up to the present, no study has compared the prognostic value of troponin T with that of troponin I in the same cohort of patients.
4442. Efficacy of mibefradil compared with amlodipine in suppressing exercise-induced and daily silent ischemia: results of a multicenter, placebo-controlled trial.
作者: D Tzivoni.;H Kadr.;S Braat.;W Rutsch.;J A Ramires.;I Kobrin.
来源: Circulation. 1997年96卷8期2557-64页
Mibefradil is a new benzimidazolyl-substituted tetraline-derivative calcium antagonist. Its vasodilatory activity combined with an ability to lower heart rate without negative inotropic effects as well as its long duration of action make it a promising anti-ischemic agent.
4443. Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance.
The attenuation of intracellular production of cGMP has been known to be a mechanism of nitrate tolerance. A recent in vitro study showed an increase in superoxide levels and a reduced activation of guanylate cyclase in tolerant vessels. We investigated the preventive effect of an antioxidant, vitamin E, on the development of nitrate tolerance.
4444. Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise.
作者: J Niebauer.;R Hambrecht.;T Velich.;K Hauer.;C Marburger.;B Kälberer.;C Weiss.;E von Hodenberg.;G Schlierf.;G Schuler.;R Zimmermann.;W Kübler.
来源: Circulation. 1997年96卷8期2534-41页
It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patients (80%) could be reevaluated after 6 years.
4445. Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: the Dietary Intervention Study in Children (DISC).
作者: P O Kwiterovich.;B A Barton.;R P McMahon.;E Obarzanek.;S Hunsberger.;D Simons-Morton.;S Y Kimm.;L A Friedman.;N Lasser.;A Robson.;R Lauer.;V Stevens.;L Van Horn.;S Gidding.;L Snetselaar.;V W Hartmuller.;M Greenlick.;F Franklin.
来源: Circulation. 1997年96卷8期2526-33页
The Dietary Intervention Study in Children (DISC) is a multicenter, randomized, controlled clinical trial designed to examine the efficacy and safety of a dietary intervention to reduce serum LDL cholesterol (LDL-C) in children with elevated LDL-C.
4446. Simplified electrophysiologically directed catheter ablation of recurrent common atrial flutter.
作者: D C Shah.;M Haïssaguerre.;P Jaïs.;B Fischer.;A Takahashi.;M Hocini.;J Clementy.
来源: Circulation. 1997年96卷8期2505-8页
Despite verification of bidirectional conduction block after radiofrequency (RF) catheter ablation in the inferior vena cava (IVC)-tricuspid annulus (TA) isthmus, recurrence of common atrial flutter is relatively common. Although complete linear reablation is usually performed, we evaluated a simplified electrophysiological strategy selectively targeting recovered conducting isthmus tissue.
4447. Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency BIsoprolol Study (CIBIS).
作者: P Lechat.;S Escolano.;J L Golmard.;H Lardoux.;S Witchitz.;J A Henneman.;B Maisch.;M Hetzel.;P Jaillon.;J P Boissel.;A Mallet.
来源: Circulation. 1997年96卷7期2197-205页
To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS).
4448. Treatment of in-stent restenosis with excimer laser coronary angioplasty: mechanisms and results compared with PTCA alone.
作者: R Mehran.;G S Mintz.;L F Satler.;A D Pichard.;K M Kent.;T A Bucher.;J J Popma.;M B Leon.
来源: Circulation. 1997年96卷7期2183-9页
This study determined the clinical safety, mechanisms, and 6-month results of excimer laser angioplasty (ELCA)+adjunct PTCA for the treatment of in-stent restenosis and (via lesion matching) compared the results of ELCA+PTCA to PTCA alone.
4449. Anti-ischemic and anti-anginal effects of thoracic epidural anesthesia versus those of conventional medical therapy in the treatment of severe refractory unstable angina pectoris.
作者: K Olausson.;H Magnusdottir.;L Lurje.;B Wennerblom.;H Emanuelsson.;S E Ricksten.
来源: Circulation. 1997年96卷7期2178-82页
Cardiac sympathetic blockade by thoracic epidural anesthesia (TEA) dilates stenotic coronary arteries and has been used to control pain in patients with unstable angina. The aim of the present study was to evaluate the potential anti-ischemic effects of cardiac sympathetic blockade by TEA in severe, refractory, unstable angina.
4450. Phentolamine prevents adaptation to ischemia during coronary angioplasty: role of alpha-adrenergic receptors in ischemic preconditioning.
作者: F Tomai.;F Crea.;A Gaspardone.;F Versaci.;A S Ghini.;R De Paulis.;L Chiariello.;P A Gioffrè.
来源: Circulation. 1997年96卷7期2171-7页
Experimental studies indicate that alpha-adrenergic receptors are involved in ischemic preconditioning. Their role in humans is unknown.
4451. Myocardial infarction and cardiac mortality in the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial.
作者: B R Chaitman.;A D Rosen.;D O Williams.;M G Bourassa.;F V Aguirre.;B Pitt.;P M Rautaharju.;W J Rogers.;B Sharaf.;M Attubato.;R M Hardison.;S Srivatsa.;N T Kouchoukos.;K Stocke.;G Sopko.;K Detre.;R Frye.
来源: Circulation. 1997年96卷7期2162-70页
Cardiac mortality and myocardial infarction (MI) rates are used to evaluate the efficacy of coronary artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA). We compared 5-year cardiac mortality and MI rates in 1829 patients with multivessel disease randomized to CABG or PTCA.
4452. Randomized, double-blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction (HERO). Hirulog Early Reperfusion/Occlusion (HERO) Trial Investigators.
作者: H D White.;P E Aylward.;M J Frey.;A A Adgey.;R Nair.;W S Hillis.;Y Shalev.;M A Brown.;J K French.;R Collins.;J Maraganore.;B Adelman.
来源: Circulation. 1997年96卷7期2155-61页
Thrombolytic therapy improves survival after myocardial infarction through reperfusion of the infarct-related artery. Thrombin generated during thrombolytic administration may reduce the efficacy of thrombolysis. A direct thrombin inhibitor may improve early patency rates.
4453. Normalization of acquired QT prolongation in humans by intravenous potassium.
作者: A M Choy.;C C Lang.;D M Chomsky.;G H Rayos.;J R Wilson.;D M Roden.
来源: Circulation. 1997年96卷7期2149-54页
QT interval prolongation and dispersion have been implicated in serious arrhythmias in congestive heart failure (CHF) and the congenital and drug-induced long-QT syndromes (LQTS). In a subset of the congenital LQTS, infusion of potassium can correct QT abnormalities, consistent with in vitro increases in outward currents such as I(Kr) or I(Kl) when extracellular potassium concentration ([K+]o) is increased. Furthermore, increasing [K+]o decreases the potency of I(Kr)-blocking drugs in vitro. The purpose of this study was to test the hypothesis that increasing [K+]o corrects QT abnormalities in CHF and in subjects treated with quinidine.
4454. Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group.
作者: M H Frick.;M Syvänne.;M S Nieminen.;H Kauma.;S Majahalme.;V Virtanen.;Y A Kesäniemi.;A Pasternack.;M R Taskinen.
来源: Circulation. 1997年96卷7期2137-43页
Studies have shown that treatment of hyperlipidemia, especially lowering of plasma LDL levels, retards the progression of coronary atherosclerosis and prevents clinical cardiovascular events. No such studies have focused on subjects with low levels of HDL cholesterol.
4455. Predictors of arrhythmic death and cardiac arrest in the ESVEM trial. Electrophysiologic Study Versus Electromagnetic Monitoring.
The purpose of this study was to determine if the presenting ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation/cardiac arrest) predicted the type of arrhythmia recurrence in patients treated with antiarrhythmic drugs.
4456. Aortic function in arterial hypertension determined by pressure-diameter relation: effects of diltiazem.
作者: C Stefanadis.;J Dernellis.;C Vlachopoulos.;C Tsioufis.;E Tsiamis.;K Toutouzas.;C Pitsavos.;P Toutouzas.
来源: Circulation. 1997年96卷6期1853-8页
Aortic elastic properties, important determinants of left ventricular function and coronary blood flow, are compromised in hypertension. The aim of this study was to determine aortic function in hypertensive patients and in normal subjects before and after administration of diltiazem, a calcium antagonist widely used in the treatment of essential hypertension.
4457. Direct vascular effects of furosemide in humans.
作者: P Pickkers.;T P Dormans.;F G Russel.;A D Hughes.;T Thien.;N Schaper.;P Smits.
来源: Circulation. 1997年96卷6期1847-52页
In humans, hemodynamic changes observed within minutes after systemic administration of furosemide are often referred to as direct vasoactivity. However, these immediate changes do not per se imply a direct vascular effect. We examined the genuine direct vascular effects of furosemide on the human forearm vascular bed and dorsal hand vein.
4458. Attenuation of unfavorable remodeling by exercise training in postinfarction patients with left ventricular dysfunction: results of the Exercise in Left Ventricular Dysfunction (ELVD) trial.
作者: P Giannuzzi.;P L Temporelli.;U Corrà.;M Gattone.;A Giordano.;L Tavazzi.
来源: Circulation. 1997年96卷6期1790-7页
Exercise is currently recommended for patients after myocardial infarction; however, the effects of regular exercise on the remodeling process remain to be defined. The aim of this multicenter, randomized study was to investigate whether a long-term physical training program influences left ventricular size and function in postinfarction patients with systolic dysfunction.
4459. Assessment of coronary reperfusion after thrombolysis with a model combining myoglobin, creatine kinase-MB, and clinical variables. TAMI-7 Study Group. Thrombolysis and Angioplasty in Myocardial Infarction-7.
作者: R H Christenson.;E M Ohman.;E J Topol.;S Peck.;L K Newby.;S H Duh.;D J Kereiakes.;S J Worley.;G L Alosozana.;T C Wall.;R M Califf.
来源: Circulation. 1997年96卷6期1776-82页
Several biochemical markers have been investigated for the noninvasive assessment of reperfusion after myocardial infarction. Because myoglobin is released very soon after myocardial injury and clears rapidly after reperfusion, it may prove to be an excellent marker of occlusion and reperfusion.
4460. Influence of diabetes on 5-year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease: the Bypass Angioplasty Revascularization Investigation (BARI).
来源: Circulation. 1997年96卷6期1761-9页
Patients with diabetes mellitus have increased morbidity and mortality after coronary revascularization. The Bypass Angioplasty Revascularization Investigation (BARI), a trial of percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass graft surgery (CABG) in patients with multivessel disease, reported a 5-year survival advantage of CABG over PTCA in patients with treated diabetes mellitus (TDM). This report examines these findings in more detail.
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