当前位置: 首页 >> 检索结果
4442. A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group.
The prognosis of patients with systemic lupus erythematosus who have glomerulonephritis is poor, despite treatment with immunosuppressive therapy. Plasmapheresis therapy has been used, but there have been few controlled clinical observations of its efficacy.
4443. Controlled trial of plasma exchange and leukapheresis in polymyositis and dermatomyositis.
作者: F W Miller.;S F Leitman.;M E Cronin.;J E Hicks.;R L Leff.;R Wesley.;D D Fraser.;M Dalakas.;P H Plotz.
来源: N Engl J Med. 1992年326卷21期1380-4页
The therapeutic options for patients with polymyositis or dermatomyositis that is resistant to corticosteroids are limited, unproved, and often toxic. Uncontrolled trials concluded that both plasma exchange and leukapheresis are beneficial, but despite the considerable use of these approaches, proof of their efficacy is lacking.
4444. Aspirin for cerebral transient ischemic attacks or minor ischemic strokes.4445. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
作者: M B Max.;S A Lynch.;J Muir.;S E Shoaf.;B Smoller.;R Dubner.
来源: N Engl J Med. 1992年326卷19期1250-6页
Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions. Selective agents might be safer and more effective.
4446. Inositol supplementation in premature infants with respiratory distress syndrome.
Inositol influences cellular function and organ maturation. Feeding premature infants inositol-rich breast milk increases their serum inositol concentrations. Whether inositol supplementation benefits infants receiving fluids for parenteral nutrition, which are inositol-free, is not known.
4448. Treatment of chronic congestive heart failure.4450. A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation.
作者: T C Merigan.;D G Renlund.;S Keay.;M R Bristow.;V Starnes.;J B O'Connell.;S Resta.;D Dunn.;P Gamberg.;R M Ratkovec.
来源: N Engl J Med. 1992年326卷18期1182-6页
Because of the immunosuppression required, heart-transplant recipients frequently have complications caused by cytomegalovirus (CMV), including pneumonia, esophagitis, gastritis, and a syndrome of fever, hepatitis, and leukopenia. We undertook a controlled trial to evaluate the prophylactic administration of ganciclovir to prevent CMV-induced disease after heart transplantation.
4453. A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain-Barré syndrome. Dutch Guillain-Barré Study Group.
The subacute demyelinating polyneuropathy known as Guillain-Barré syndrome improves more rapidly with plasma exchange than with supportive care alone. We conducted a multicenter trial to determine whether intravenous immune globulin is as effective as the more complicated treatment with plasma exchange.
4455. Thalidomide for the treatment of chronic graft-versus-host disease.
作者: G B Vogelsang.;E R Farmer.;A D Hess.;V Altamonte.;W E Beschorner.;D A Jabs.;R L Corio.;L S Levin.;O M Colvin.;J R Wingard.
来源: N Engl J Med. 1992年326卷16期1055-8页
Allogeneic bone marrow transplantation is an accepted therapy for hematologic cancer, aplastic anemia, and inherited immunodeficiencies. Chronic graft-versus-host disease (GVHD) is the principal complication in patients surviving more than 100 days. Thalidomide has been shown experimentally to be effective in treating GVHD.
4456. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.
作者: E H Giannini.;E J Brewer.;N Kuzmina.;A Shaikov.;A Maximov.;I Vorontsov.;C W Fink.;A J Newman.;J T Cassidy.;L S Zemel.
来源: N Engl J Med. 1992年326卷16期1043-9页
The antimetabolite methotrexate has been shown in placebo-controlled trials to be effective in adults with rheumatoid arthritis. Methotrexate may also be effective in children with resistant juvenile rheumatoid arthritis, but the supporting data are from uncontrolled trials.
4457. The effects on survival of early treatment of human immunodeficiency virus infection.
作者: N M Graham.;S L Zeger.;L P Park.;S H Vermund.;R Detels.;C R Rinaldo.;J P Phair.
来源: N Engl J Med. 1992年326卷16期1037-42页
Zidovudine has been shown to prolong survival in patients with the acquired immunodeficiency syndrome (AIDS) and, in persons with human immunodeficiency virus (HIV) infection but not AIDS, to delay the progression to AIDS. However, it is still uncertain whether treatment before the development of AIDS prolongs survival.
4458. Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis.
作者: R D Hull.;G E Raskob.;G F Pineo.;D Green.;A A Trowbridge.;C G Elliott.;R G Lerner.;J Hall.;T Sparling.;H R Brettell.
来源: N Engl J Med. 1992年326卷15期975-82页
Low-molecular-weight heparin has a high bioavailability and a prolonged half-life in comparison with conventional unfractionated heparin. Limited data are available for low-molecular-weight heparin as compared with unfractionated heparin for the treatment of deep-vein thrombosis.
4459. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia.
作者: S De Marchi.;E Cecchin.;D Villalta.;G Sepiacci.;G Santini.;E Bartoli.
来源: N Engl J Med. 1992年326卷15期969-74页
The pathophysiologic aspects of pruritus in patients with chronic renal insufficiency are poorly understood, and there is no universally effective treatment. The improvement of pruritus in several patients receiving erythropoietin therapy raised the possibility that erythropoietin affects uremic pruritus directly.
|