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4422. Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D.
作者: Jeanne M Madden.;Amy J Graves.;Fang Zhang.;Alyce S Adams.;Becky A Briesacher.;Dennis Ross-Degnan.;Jerry H Gurwitz.;Marsha Pierre-Jacques.;Dana Gelb Safran.;Gerald S Adler.;Stephen B Soumerai.
来源: JAMA. 2008年299卷16期1922-8页
Cost-related medication nonadherence (CRN) has been a persistent problem for individuals who are elderly and disabled in the United States. The impact of Medicare prescription drug coverage (Part D) on CRN is unknown.
4423. Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial.
作者: Barbara V Howard.;Mary J Roman.;Richard B Devereux.;Jerome L Fleg.;James M Galloway.;Jeffrey A Henderson.;Wm James Howard.;Elisa T Lee.;Mihriye Mete.;Bryce Poolaw.;Robert E Ratner.;Marie Russell.;Angela Silverman.;Mario Stylianou.;Jason G Umans.;Wenyu Wang.;Matthew R Weir.;Neil J Weissman.;Charlton Wilson.;Fawn Yeh.;Jianhui Zhu.
来源: JAMA. 2008年299卷14期1678-89页
Individuals with diabetes are at increased risk for cardiovascular disease (CVD), but more aggressive targets for risk factor control have not been tested.
4426. Gene variants associated with deep vein thrombosis.
作者: Irene D Bezemer.;Lance A Bare.;Carine J M Doggen.;Andre R Arellano.;Carmen Tong.;Charles M Rowland.;Joseph Catanese.;Bradford A Young.;Pieter H Reitsma.;James J Devlin.;Frits R Rosendaal.
来源: JAMA. 2008年299卷11期1306-14页
The genetic causes of deep vein thrombosis (DVT) are not fully understood.
4427. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
作者: Elisabeth B Binder.;Rebekah G Bradley.;Wei Liu.;Michael P Epstein.;Todd C Deveau.;Kristina B Mercer.;Yilang Tang.;Charles F Gillespie.;Christine M Heim.;Charles B Nemeroff.;Ann C Schwartz.;Joseph F Cubells.;Kerry J Ressler.
来源: JAMA. 2008年299卷11期1291-305页
In addition to trauma exposure, other factors contribute to risk for development of posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors are contributory, with child abuse providing significant risk liability.
4428. Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
作者: Joyce B J van Meurs.;Thomas A Trikalinos.;Stuart H Ralston.;Susana Balcells.;Maria Luisa Brandi.;Kim Brixen.;Douglas P Kiel.;Bente L Langdahl.;Paul Lips.;Osten Ljunggren.;Roman Lorenc.;Barbara Obermayer-Pietsch.;Claes Ohlsson.;Ulrika Pettersson.;David M Reid.;Francois Rousseau.;Serena Scollen.;Wim Van Hul.;Lidia Agueda.;Kristina Akesson.;Lidia I Benevolenskaya.;Serge L Ferrari.;Göran Hallmans.;Albert Hofman.;Lise Bjerre Husted.;Marcin Kruk.;Stephen Kaptoge.;David Karasik.;Magnus K Karlsson.;Mattias Lorentzon.;Laura Masi.;Fiona E A McGuigan.;Dan Mellström.;Leif Mosekilde.;Xavier Nogues.;Huibert A P Pols.;Jonathan Reeve.;Wilfried Renner.;Fernando Rivadeneira.;Natasja M van Schoor.;Kurt Weber.;John P A Ioannidis.;André G Uitterlinden.; .
来源: JAMA. 2008年299卷11期1277-90页
Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.
4429. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.
作者: Tamali Bhattacharyya.;Stephen J Nicholls.;Eric J Topol.;Renliang Zhang.;Xia Yang.;David Schmitt.;Xiaoming Fu.;Mingyuan Shao.;Danielle M Brennan.;Stephen G Ellis.;Marie-Luise Brennan.;Hooman Allayee.;Aldons J Lusis.;Stanley L Hazen.
来源: JAMA. 2008年299卷11期1265-76页
Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. The relationship between PON1 genotypes and functional activity with systemic measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been systematically investigated.
4431. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin.
作者: Gerardo Heiss.;Robert Wallace.;Garnet L Anderson.;Aaron Aragaki.;Shirley A A Beresford.;Robert Brzyski.;Rowan T Chlebowski.;Margery Gass.;Andrea LaCroix.;JoAnn E Manson.;Ross L Prentice.;Jacques Rossouw.;Marcia L Stefanick.; .
来源: JAMA. 2008年299卷9期1036-45页
The Women's Health Initiative (WHI) trial of estrogen plus progestin vs placebo was stopped early, after a mean 5.6 years of follow-up, because the overall health risks of hormone therapy exceeded its benefits.
4432. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial.
作者: David Brent.;Graham Emslie.;Greg Clarke.;Karen Dineen Wagner.;Joan Rosenbaum Asarnow.;Marty Keller.;Benedetto Vitiello.;Louise Ritz.;Satish Iyengar.;Kaleab Abebe.;Boris Birmaher.;Neal Ryan.;Betsy Kennard.;Carroll Hughes.;Lynn DeBar.;James McCracken.;Michael Strober.;Robert Suddath.;Anthony Spirito.;Henrietta Leonard.;Nadine Melhem.;Giovanna Porta.;Matthew Onorato.;Jamie Zelazny.
来源: JAMA. 2008年299卷8期901-913页
Only about 60% of adolescents with depression will show an adequate clinical response to an initial treatment trial with a selective serotonin reuptake inhibitor (SSRI). There are no data to guide clinicians on subsequent treatment strategy.
4433. Atherosclerotic plaque composition and occurrence of restenosis after carotid endarterectomy.
作者: Willem E Hellings.;Frans L Moll.;Jean-Paul P M De Vries.;Rob G A Ackerstaff.;Kees A Seldenrijk.;Rosemarie Met.;Evelyn Velema.;Wouter J M Derksen.;Dominique P V De Kleijn.;Gerard Pasterkamp.
来源: JAMA. 2008年299卷5期547-54页
Previous studies have assessed the predictive value of clinical and angiographic parameters for development of restenosis after vascular interventions. The composition of the atherosclerotic plaque at the intervention site has had limited evaluated as a marker for restenosis [corrected].
4434. Cannabis smoking and periodontal disease among young adults.
作者: W Murray Thomson.;Richie Poulton.;Jonathan M Broadbent.;Terrie E Moffitt.;Avshalom Caspi.;James D Beck.;David Welch.;Robert J Hancox.
来源: JAMA. 2008年299卷5期525-31页
Tobacco smoking is a recognized behavioral risk factor for periodontal disease (through its systemic effects), and cannabis smoking may contribute in a similar way.
4435. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.
作者: Aaron J Schetter.;Suet Yi Leung.;Jane J Sohn.;Krista A Zanetti.;Elise D Bowman.;Nozomu Yanaihara.;Siu Tsan Yuen.;Tsun Leung Chan.;Dora L W Kwong.;Gordon K H Au.;Chang-Gong Liu.;George A Calin.;Carlo M Croce.;Curtis C Harris.
来源: JAMA. 2008年299卷4期425-36页
MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome.
4436. Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease.
作者: J Michael Collaco.;Lori Vanscoy.;Lindsay Bremer.;Kathryn McDougal.;Scott M Blackman.;Amanda Bowers.;Kathleen Naughton.;Jacky Jennings.;Jonathan Ellen.;Garry R Cutting.
来源: JAMA. 2008年299卷4期417-24页
Disease variation can be substantial even in conditions with a single gene etiology such as cystic fibrosis (CF). Simultaneously studying the effects of genes and environment may provide insight into the causes of variation.
4437. Serum micronutrient concentrations and decline in physical function among older persons.
作者: Benedetta Bartali.;Edward A Frongillo.;Jack M Guralnik.;Martha H Stipanuk.;Heather G Allore.;Antonio Cherubini.;Stefania Bandinelli.;Luigi Ferrucci.;Thomas M Gill.
来源: JAMA. 2008年299卷3期308-15页
Maintaining independence of older persons is a public health priority, and identifying the factors that contribute to decline in physical function is needed to prevent or postpone the disablement process. The potential deleterious effect of poor nutrition on decline in physical function in older persons is unclear.
4438. Variation of breast cancer risk among BRCA1/2 carriers.
作者: Colin B Begg.;Robert W Haile.;Ake Borg.;Kathleen E Malone.;Patrick Concannon.;Duncan C Thomas.;Bryan Langholz.;Leslie Bernstein.;Jørgen H Olsen.;Charles F Lynch.;Hoda Anton-Culver.;Marinela Capanu.;Xiaolin Liang.;Amanda J Hummer.;Cami Sima.;Jonine L Bernstein.
来源: JAMA. 2008年299卷2期194-201页
The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers.
4439. Cardiorespiratory fitness and adiposity as mortality predictors in older adults.
作者: Xuemei Sui.;Michael J LaMonte.;James N Laditka.;James W Hardin.;Nancy Chase.;Steven P Hooker.;Steven N Blair.
来源: JAMA. 2007年298卷21期2507-16页
Although levels of physical activity and aerobic capacity decline with age and the prevalence of obesity tends to increase with age, the independent and joint associations among fitness, adiposity, and mortality in older adults have not been adequately examined.
4440. Telephone screening, outreach, and care management for depressed workers and impact on clinical and work productivity outcomes: a randomized controlled trial.
作者: Philip S Wang.;Gregory E Simon.;Jerry Avorn.;Francisca Azocar.;Evette J Ludman.;Joyce McCulloch.;Maria Z Petukhova.;Ronald C Kessler.
来源: JAMA. 2007年298卷12期1401-11页
Although guideline-concordant depression treatment is clearly effective, treatment often falls short of evidence-based recommendations. Organized depression care programs significantly improve treatment quality, but employer purchasers have been slow to adopt these programs based on lack of evidence for cost-effectiveness from their perspective.
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