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4421. Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function.
作者: Christopher T Kodl.;Daniel T Franc.;Jyothi P Rao.;Fiona S Anderson.;William Thomas.;Bryon A Mueller.;Kelvin O Lim.;Elizabeth R Seaquist.
来源: Diabetes. 2008年57卷11期3083-9页
Long-standing type 1 diabetes is associated with deficits on neurocognitive testing that suggest central white matter dysfunction. This study investigated whether diffusion tensor imaging (DTI), a type of magnetic resonance imaging that measures white matter integrity quantitatively, could identify white matter microstructural deficits in patients with long-standing type 1 diabetes and whether these differences would be associated with deficits found by neurocognitive tests.
4422. Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.
作者: Paolo Fiorina.;Andrea Vergani.;Shirine Dada.;Mollie Jurewicz.;Masie Wong.;Kenneth Law.;Erxi Wu.;Ze Tian.;Reza Abdi.;Indira Guleria.;Scott Rodig.;Kyri Dunussi-Joannopoulos.;Jeffrey Bluestone.;Mohamed H Sayegh.
来源: Diabetes. 2008年57卷11期3013-24页
To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice.
4423. Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.
作者: Christophe M Filippi.;Amy E Juedes.;Janine E Oldham.;Ellie Ling.;Lisa Togher.;Yufeng Peng.;Richard A Flavell.;Matthias G von Herrath.
来源: Diabetes. 2008年57卷10期2684-92页
Transforming growth factor-beta (TGF-beta) can exhibit strong immune suppression but has also been shown to promote T-cell growth. We investigated the differential effect of this cytokine on CD8(+) T-cells in autoimmunity and antiviral immunity.
4424. Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.
作者: Kyle J Gaulton.;Cristen J Willer.;Yun Li.;Laura J Scott.;Karen N Conneely.;Anne U Jackson.;William L Duren.;Peter S Chines.;Narisu Narisu.;Lori L Bonnycastle.;Jingchun Luo.;Maurine Tong.;Andrew G Sprau.;Elizabeth W Pugh.;Kimberly F Doheny.;Timo T Valle.;Gonçalo R Abecasis.;Jaakko Tuomilehto.;Richard N Bergman.;Francis S Collins.;Michael Boehnke.;Karen L Mohlke.
来源: Diabetes. 2008年57卷11期3136-44页
Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene-based approach to identify single nucleotide polymorphism (SNP) variants in 222 candidate genes that influence susceptibility to type 2 diabetes.
4425. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
作者: Heiko Bugger.;Sihem Boudina.;Xiao Xuan Hu.;Joseph Tuinei.;Vlad G Zaha.;Heather A Theobald.;Ui Jeong Yun.;Alfred P McQueen.;Benjamin Wayment.;Sheldon E Litwin.;E Dale Abel.
来源: Diabetes. 2008年57卷11期2924-32页
Fatty acid-induced mitochondrial uncoupling and oxidative stress have been proposed to reduce cardiac efficiency and contribute to cardiac dysfunction in type 2 diabetes. We hypothesized that mitochondrial uncoupling may also contribute to reduced cardiac efficiency and contractile dysfunction in the type 1 diabetic Akita mouse model (Akita).
4426. Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.
作者: Esther Phielix.;Vera B Schrauwen-Hinderling.;Marco Mensink.;Ellen Lenaers.;Ruth Meex.;Joris Hoeks.;Marianne Eline Kooi.;Esther Moonen-Kornips.;Jean-Pierre Sels.;Matthijs K C Hesselink.;Patrick Schrauwen.
来源: Diabetes. 2008年57卷11期2943-9页
A lower in vivo mitochondrial function has been reported in both type 2 diabetic patients and first-degree relatives of type 2 diabetic patients. The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients.
4427. Persistence of pre-diabetes in overweight and obese Hispanic children: association with progressive insulin resistance, poor beta-cell function, and increasing visceral fat.
作者: Michael I Goran.;Christianne Lane.;Claudia Toledo-Corral.;Marc J Weigensberg.
来源: Diabetes. 2008年57卷11期3007-12页
To examine changes in risk factors in overweight and obese Hispanic children at high risk of developing type 2 diabetes.
4428. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.
作者: Marju Orho-Melander.;Olle Melander.;Candace Guiducci.;Pablo Perez-Martinez.;Dolores Corella.;Charlotta Roos.;Ryan Tewhey.;Mark J Rieder.;Jennifer Hall.;Goncalo Abecasis.;E Shyong Tai.;Cullan Welch.;Donna K Arnett.;Valeriya Lyssenko.;Eero Lindholm.;Richa Saxena.;Paul I W de Bakker.;Noel Burtt.;Benjamin F Voight.;Joel N Hirschhorn.;Katherine L Tucker.;Thomas Hedner.;Tiinamaija Tuomi.;Bo Isomaa.;Karl-Fredrik Eriksson.;Marja-Riitta Taskinen.;Björn Wahlstrand.;Thomas E Hughes.;Laurence D Parnell.;Chao-Qiang Lai.;Göran Berglund.;Leena Peltonen.;Erkki Vartiainen.;Pekka Jousilahti.;Aki S Havulinna.;Veikko Salomaa.;Peter Nilsson.;Leif Groop.;David Altshuler.;Jose M Ordovas.;Sekar Kathiresan.
来源: Diabetes. 2008年57卷11期3112-21页
Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metabolic phenotypes, including measures of glucose homeostasis, to evaluate the GCKR locus in samples of non-European ancestry and to fine- map across the associated genomic interval.
4429. Oxidative stress regulates adipocyte apolipoprotein e and suppresses its expression in obesity.
Endogenous expression of apolipoprotein E (apoE) has a significant impact on adipocyte lipid metabolism and is markedly suppressed in obesity. Adipose tissue oxidant stress is emerging as an important mediator of adipocyte dysfunction. These studies were undertaken to evaluate the role of oxidant stress for regulation of adipocyte apoE.
4430. Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease.
作者: Hong Lan.;Lizbeth M Hoos.;Li Liu.;Glen Tetzloff.;Weiwen Hu.;Susan J Abbondanzo.;Galya Vassileva.;Eric L Gustafson.;Joseph A Hedrick.;Harry R Davis.
来源: Diabetes. 2008年57卷11期2999-3006页
FFAR1/GPR40 is a G-protein-coupled receptor expressed predominantly in pancreatic islets mediating free fatty acid-induced insulin secretion. However, the physiological role of FFAR1 remains controversial. It was previously reported that FFAR1 knockout (Ffar1(-/-)) mice were resistant to high-fat diet-induced hyperinuslinemia, hyperglycemia, hypertriglyceridemia, and hepatic steatosis. A more recent report suggested that although FFAR1 was necessary for fatty acid-induced insulin secretion in vivo, deletion of FFAR1 did not protect pancreatic islets against fatty acid-induced islet dysfunction. This study is designed to investigate FFAR1 function in vivo using a third line of independently generated Ffar1(-/-) mice in the C57BL/6 background.
4431. Plasma YKL-40: a BMI-independent marker of type 2 diabetes.
作者: Anders R Nielsen.;Christian Erikstrup.;Julia S Johansen.;Christian P Fischer.;Peter Plomgaard.;Rikke Krogh-Madsen.;Sarah Taudorf.;Birgitte Lindegaard.;Bente K Pedersen.
来源: Diabetes. 2008年57卷11期3078-82页
YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation. In the present study, YKL-40 was examined in relation to obesity, inflammation, and type 2 diabetes.
4432. Lymphocytes of type 2 diabetic women carry a high load of stable chromosomal aberrations: a novel risk factor for disease-related early death.
作者: Bernhard O Boehm.;Peter Möller.;Josef Högel.;Bernhard R Winkelmann.;Wilfried Renner.;Silke Rosinger.;Ursula Seelhorst.;Britta Wellnitz.;Winfried März.;Julia Melzner.;Silke Brüderlein.
来源: Diabetes. 2008年57卷11期2950-7页
Diabetes is associated with an increased risk of death in women. Oxidative stress due to chronic hyperglycemia leads to the generation of reactive oxygen species and loss of chromosomal integrity. To clarify whether diabetes is a premature aging syndrome, we determined telomere erosion dynamics and occurrence of structural chromosomal aberrations in women of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study.
4433. Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines.
作者: Irene Cozar-Castellano.;George Harb.;Karen Selk.;Karen Takane.;Rupangi Vasavada.;Brian Sicari.;Brian Law.;Pili Zhang.;Donald K Scott.;Nathalie Fiaschi-Taesch.;Andrew F Stewart.
来源: Diabetes. 2008年57卷11期3056-68页
Rodent insulinoma cell lines may serve as a model for designing continuously replicating human beta-cell lines and provide clues as to the central cell cycle regulatory molecules in the beta-cell.
4434. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation.
作者: Mohan R Dasu.;Sridevi Devaraj.;Ling Zhao.;Daniel H Hwang.;Ishwarlal Jialal.
来源: Diabetes. 2008年57卷11期3090-8页
Hyperglycemia-induced inflammation is central in diabetes complications, and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. However, there is a paucity of data examining the expression and activity of TLRs in hyperglycemic conditions. Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions.
4435. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice.
作者: Ching-Hsin Ku.;Kathryn E White.;Alessandra Dei Cas.;Anthea Hayward.;Zoe Webster.;Rudy Bilous.;Sally Marshall.;Giancarlo Viberti.;Luigi Gnudi.
来源: Diabetes. 2008年57卷10期2824-33页
Podocyte-specific, doxycycline (DOX)-inducible overexpression of soluble vascular endothelial growth factor (VEGF) receptor-1 (sFlt-1) in adult mice was used to investigate the role of the VEGF-A/VEGF receptor (VEGFR) system in diabetic glomerulopathy.
4436. PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.
作者: Lijun Ma.;Robert L Hanson.;Lorem N Que.;Yan Guo.;Sayuko Kobes.;Clifton Bogardus.;Leslie J Baier.
来源: Diabetes. 2008年57卷11期3156-60页
A prior genome-wide association (GWA) study in Pima Indians identified variants within PCLO that were associated with early-onset type 2 diabetes. PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes.
4437. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.
作者: Lu Qi.;Kihwa Kang.;Cuilin Zhang.;Rob M van Dam.;Peter Kraft.;David Hunter.;Chih-Hao Lee.;Frank B Hu.
来源: Diabetes. 2008年57卷11期3145-51页
To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse.
4438. Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose.
Recent epidemiological studies have shown that background exposure to persistent organic pollutants (POPs)--xenobiotics accumulated in adipose tissue--is strongly associated with type 2 diabetes. Hyperglycemia is the cause of long-term complications of diabetes as well as diabetes itself, and POPs are well-known neurotoxicants. This study was performed to explore whether POPs are associated with peripheral neuropathy, a common long-term complication of diabetes, in people with glucose abnormalities.
4439. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
作者: Patrick Concannon.;Suna Onengut-Gumuscu.;John A Todd.;Deborah J Smyth.;Flemming Pociot.;Regine Bergholdt.;Beena Akolkar.;Henry A Erlich.;Joan E Hilner.;Cécile Julier.;Grant Morahan.;Jørn Nerup.;Concepcion R Nierras.;Wei-Min Chen.;Stephen S Rich.; .
来源: Diabetes. 2008年57卷10期2858-61页
The Type 1 Diabetes Genetics Consortium (T1DGC) has assembled and genotyped a large collection of multiplex families for the purpose of mapping genomic regions linked to type 1 diabetes. In the current study, we tested for evidence of loci associated with type 1 diabetes utilizing genome-wide linkage scan data and family-based association methods.
4440. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.
作者: Mingzhan Xue.;Qingwen Qian.;Antonysunil Adaikalakoteswari.;Naila Rabbani.;Roya Babaei-Jadidi.;Paul J Thornalley.
来源: Diabetes. 2008年57卷10期2809-17页
Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). Nrf2 regulates the transcription of a battery of protective and metabolic enzymes. The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia.
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