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4421. Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S).
作者: T A Miettinen.;K Pyörälä.;A G Olsson.;T A Musliner.;T J Cook.;O Faergeman.;K Berg.;T Pedersen.;J Kjekshus.
来源: Circulation. 1997年96卷12期4211-8页
The Scandinavian Simvastatin Survival Study (4S) demonstrated pronounced reductions in mortality and major coronary events in a cohort of patients with established coronary heart disease (CHD). The present study provides a detailed, post hoc assessment of the efficacy and safety of simvastatin therapy in the following subgroups of 4S patients: those > or = 65 years of age, those < 65 years of age, women, and men.
4422. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease.
The prognostic influences of fibrinogen and C-reactive protein levels and their relations to myocardial damage in unstable coronary artery syndromes have not been well described.
4423. Short-term anti-ischemic effect of 17beta-estradiol in postmenopausal women with coronary artery disease.
作者: G M Rosano.;A M Caixeta.;S Chierchia.;S Arie.;M Lopez-Hidalgo.;W I Pereira.;F Leonardo.;C M Webb.;F Pileggi.;P Collins.
来源: Circulation. 1997年96卷9期2837-41页
Short-term administration of 17beta-estradiol improves effort-induced myocardial ischemia in female patients with coronary artery disease. 17Beta-estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17beta-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease.
4424. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death.
Some randomized clinical trials of amiodarone therapy to prevent sudden cardiac death have had positive results and others have had negative results, but all were relatively small. This meta-analysis aimed to pool all trials to assess the effect of amiodarone on mortality and the impact of differences in patient population and study design on trial outcomes.
4425. Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: a double-blind placebo-controlled study.
Marine fish oils improve vascular function, but the mechanism of benefit is unclear. We conducted a study to examine the effects of fish oils given to hypercholesterolemic patients on small artery function in vitro.
4426. A prospective randomized trial of arginine vasopressin in the treatment of vasodilatory shock after left ventricular assist device placement.
作者: M Argenziano.;A F Choudhri.;M C Oz.;E A Rose.;C R Smith.;D W Landry.
来源: Circulation. 1997年96卷9 Suppl期II-286-90页
Vasodilatory shock requiring catecholamine pressors occurs in some patients following cardiopulmonary bypass. Prompted by a clinical observation, we investigated the use of vasopressin as a treatment for this syndrome in a randomized, controlled trial.
4427. Beneficial effect of both tranexamic acid and aprotinin on blood loss reduction in reoperative valve replacement surgery.
作者: W R Jamieson.;P J Dryden.;J P O'Connor.;H Sadeghi.;D M Ansley.;P M Merrick.
来源: Circulation. 1997年96卷9 Suppl期II-96-100; discussion II-100-1页
Blood loss after cardiac surgery is a continuing concern of caregivers and patients. The acute inflammatory reaction initiated by the extracorporeal circuitry, necessary to perform the procedure, stimulates the coagulation cascade, and the resultant hyperfibrinolysis is considered to be a major contributing factor of blood loss. The necessity to reduce transfused blood products after cardiac surgery is important, as it reduces the potential transmission of serious viral infections, improves operative outcomes, and provides containment of costs. The purpose of this study was to compare the effect of synthetic antifibrinolytic tranexamic acid with naturally occurring antifibrinolytic aprotinin on blood loss and to study requirements for transfusion of blood products after repeat cardiac valve surgery.
4428. The risks of reoperative coronary artery bypass in chronic ischemic cardiomyopathy: results of the CABG Patch Trial.
Coronary artery bypass grafting in patients with chronic ischemic cardiomyopathy is increasing in frequency, as is reoperative bypass. However, there exist very little data on early outcomes of patients with severe left ventricular dysfunction undergoing reoperation. Hence, we tested the following hypotheses: (1) in the presence of severe left ventricular dysfunction, repeat coronary bypass carries a higher surgical mortality than the primary operation and (2) among reoperative patients with left ventricular dysfunction, the surgical mortality is higher in those with the lowest preoperative ejection fractions (EFs).
4429. Cognitive function 5 years after randomization to coronary angioplasty or coronary artery bypass graft surgery.
作者: M A Hlatky.;C Bacon.;D Boothroyd.;E Mahanna.;J G Reves.;M F Newman.;I Johnstone.;C Winston.;M M Brooks.;A D Rosen.;D B Mark.;B Pitt.;W Rogers.;T Ryan.;R Wiens.;J A Blumenthal.
来源: Circulation. 1997年96卷9 Suppl期II-11-4; discussion II-15页
Coronary bypass surgery often leads to short-term cognitive dysfunction, whereas coronary angioplasty does not. Perioperative cognitive dysfunction usually resolves, although a subgroup of surgical patients may continue to exhibit long-term cognitive dysfunction. The purpose of this study was to compare cognitive function 5 years after randomization to a strategy of either initial coronary surgery or initial angioplasty.
4430. Five-year outcome after coronary angioplasty versus bypass surgery in multivessel coronary artery disease: results from the French Monocentric Study.
作者: D Carrié.;M Elbaz.;J Puel.;J Fourcade.;E Karouny.;G Fournial.;M Galinier.
来源: Circulation. 1997年96卷9 Suppl期II-1-6页
The clinical benefit of percutaneous transluminal coronary angioplasty (PTCA) as compared with coronary artery bypass grafting (CABG) for patients with multivessel coronary artery disease (CAD) has not been established. To determine the outcomes of these treatments in patients referred for the first time for coronary revascularization, we conducted a 5-year prospective trial comparing the two procedures.
4431. Instant power spectrum analysis of heart rate variability during orthostatic tilt using a time-/frequency-domain method.
作者: S Jasson.;C Médigue.;P Maison-Blanche.;N Montano.;L Meyer.;C Vermeiren.;P Mansier.;P Coumel.;A Malliani.;B Swynghedauw.
来源: Circulation. 1997年96卷10期3521-6页
Spectral analysis of heart rate (HR) variability (HRV) requires, as a rule, some level of stationarity and, as a result, is inadequate to quantify biological transients. A time-/frequency-domain method (TF) was developed to obtain an instant spectral power (SP) of HRV during tilt.
4432. Strength-duration relationship for human transvenous defibrillation.
One of the basic characteristics of electrical defibrillation is the strength-duration relationship, or the effect of pulse width on defibrillation efficacy. This relationship is important for understanding the mechanism of defibrillation and for the design of optimal waveforms. However, a detailed evaluation of the strength-duration relationship for human transvenous defibrillation has not been performed previously.
4433. Effect of nadroparin, a low-molecular-weight heparin, on clinical and angiographic restenosis after coronary balloon angioplasty: the FACT study. Fraxiparine Angioplastie Coronaire Transluminale.
作者: J M Lablanche.;E P McFadden.;N Meneveau.;J R Lusson.;B Bertrand.;J P Metzger.;V Legrand.;G Grollier.;C Macaya.;B de Bruyne.;A Vahanian.;A Grentzinger.;C Masquet.;J E Wolf.;G Tobelem.;S Fontecave.;A Vacheron.;P d'Azemar.;M E Bertrand.
来源: Circulation. 1997年96卷10期3396-402页
Experimental studies suggest that the antiproliferative effect of heparin after arterial injury is maximized by pretreatment. No previous studies of restenosis have used a pretreatment strategy. We designed this study to determine whether treatment with nadroparin, a low-molecular-weight heparin, started 3 days before the procedure and continued for 3 months, affected angiographic restenosis or clinical outcome after coronary angioplasty.
4434. Silent myocardial ischemia in Kawasaki disease: evaluation of percutaneous transluminal coronary angioplasty by dobutamine stress testing.
作者: S Ogawa.;R Fukazawa.;T Ohkubo.;J Zhang.;N Takechi.;Y Kuramochi.;Y Hino.;O Jimbo.;Y Katsube.;M Kamisago.;Y Genma.;M Yamamoto.
来源: Circulation. 1997年96卷10期3384-9页
Myocardial ischemia and myocardial infarction are the most serious complications of coronary artery lesions in children with Kawasaki disease (KD). Therefore, early detection and treatment of myocardial ischemia in patients with KD is essential. We studied the effectiveness of percutaneous transluminal coronary angioplasty (PTCA) in patients with silent myocardial ischemia detected by dobutamine stress 99mTc myocardial scintigraphy (TMS), body surface mapping (BMS), and signal-averaged ECG late potentials (ELP).
4435. Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short- and long-term outcomes of coronary balloon angioplasty: the DEBATE Study (Doppler Endpoints Balloon Angioplasty Trial Europe).
作者: P W Serruys.;C di Mario.;J Piek.;E Schroeder.;C Vrints.;P Probst.;B de Bruyne.;C Hanet.;E Fleck.;M Haude.;E Verna.;V Voudris.;H Geschwind.;H Emanuelsson.;V Mühlberger.;G Danzi.;H O Peels.;A J Ford.;E Boersma.
来源: Circulation. 1997年96卷10期3369-77页
The aim of this prospective, multicenter study was the identification of Doppler flow velocity measurements predictive of clinical outcome of patients undergoing single-vessel balloon angioplasty with no previous Q-wave myocardial infarction.
4436. Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial.
作者: M St John Sutton.;M A Pfeffer.;L Moye.;T Plappert.;J L Rouleau.;G Lamas.;J Rouleau.;J O Parker.;M O Arnold.;B Sussex.;E Braunwald.
来源: Circulation. 1997年96卷10期3294-9页
We quantified cardiovascular death and/or left ventricular (LV) dilatation in patients from the SAVE trial to determine whether dilatation continued beyond 1 year, whether ACE inhibitor therapy attenuated late LV dilatation, and whether any baseline descriptors predicted late dilatation.
4437. Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study.
作者: J J Blanc.;Y Etienne.;M Gilard.;J Mansourati.;S Munier.;J Boschat.;D G Benditt.;K G Lurie.
来源: Circulation. 1997年96卷10期3273-7页
Multisite ventricular pacing has recently been proposed as an additional treatment for patients with severe congestive heart failure. To further assess the potential value of this technique, we compared the acute hemodynamic changes associated with pacing the right ventricular apex (RVA) or outflow tract (RVOT) alone, the left ventricle (LV) alone, or biventricular (BIV) pacing of the RVA and LV together.
4438. Significance of morphological abnormalities detected by MRI in patients undergoing successful ablation of right ventricular outflow tract tachycardia.
作者: S Globits.;G Kreiner.;H Frank.;G Heinz.;U Klaar.;B Frey.;H Gössinger.
来源: Circulation. 1997年96卷8期2633-40页
MRI can demonstrate subtle morphological changes of the right ventricle in patients with idiopathic right ventricular outflow tract tachycardia (RVOT). The present study examines the incidence and significance of right ventricular (RV) abnormalities detected by MRI with respect to the site of successful radiofrequency catheter ablation of the clinical tachycardia.
4439. Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators.
来源: Circulation. 1997年96卷8期2625-32页
Atrial fibrillation and paroxysmal supraventricular tachycardia are common disorders of the heart rhythm for which antiarrhythmic drug therapy is commonly prescribed. The Atrial Fibrillation Investigation with Bidisomide (AFIB) study was a randomized, placebo-controlled clinical trial designed to accomplish three goals in a single protocol: (1) to determine the efficacy of the antiarrhythmic drug bidisomide in the treatment of these two arrhythmias; (2) to establish the appropriate dose range for bidisomide; and (3) to detect an adverse mortality effect of bidisomide if one were present in patients with atrial fibrillation.
4440. Assessment of atrioventricular junction ablation and DDDR mode-switching pacemaker versus pharmacological treatment in patients with severely symptomatic paroxysmal atrial fibrillation: a randomized controlled study.
作者: M Brignole.;L Gianfranchi.;C Menozzi.;P Alboni.;G Musso.;M G Bongiorni.;M Gasparini.;A Raviele.;G Lolli.;N Paparella.;S Acquarone.
来源: Circulation. 1997年96卷8期2617-24页
The purpose of the study was to evaluate the effect of AV junction ablation and pacemaker implantation on quality of life and specific symptoms in patients with paroxysmal atrial fibrillation (AF) not controlled by drugs.
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