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4401. Effects of moderate exercise training on thallium uptake and contractile response to low-dose dobutamine of dysfunctional myocardium in patients with ischemic cardiomyopathy.
There is evidence that exercise training can induce myocardial and coronary adaptations in both animals and humans. However, the significance of these potentially important changes remains to be determined in patients with ischemic heart disease and left ventricular (LV) systolic dysfunction.
4402. Non-Q-wave versus Q-wave myocardial infarction after thrombolytic therapy: angiographic and prognostic insights from the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries-I angiographic substudy. GUSTO-I Angiographic Investigators.
作者: S G Goodman.;A Langer.;A M Ross.;N M Wildermann.;A Barbagelata.;E B Sgarbossa.;G S Wagner.;C B Granger.;R M Califf.;E J Topol.;M L Simoons.;P W Armstrong.
来源: Circulation. 1998年97卷5期444-50页
Although the stratification of patients with myocardial infarction into ECG subsets based on the presence or absence of new Q waves has important clinical and prognostic utility, systematic evaluation of the impact of thrombolytic therapy on the subsequent development and prognosis of non-Q-wave infarction has been limited to date.
4403. Prevention of restenosis after angioplasty in small coronary arteries with probucol.
作者: J Rodés.;G Côté.;J Lespérance.;M G Bourassa.;S Doucet.;L Bilodeau.;O F Bertrand.;F Harel.;R Gallo.;J C Tardif.
来源: Circulation. 1998年97卷5期429-36页
Restenosis remains the major limitation of coronary angioplasty. Coronary stents have reduced the incidence of restenosis in selected patients with relatively large vessels. No strategies to date have demonstrated a beneficial effect in vessels < 3.0 mm in diameter. We have shown in the MultiVitamins and Probucol (MVP) Trial that probucol, a potent antioxidant, reduces restenosis after balloon angioplasty. The purpose of this study was to determine whether the benefit of probucol therapy is maintained in the subgroup of patients with smaller coronary vessels.
4404. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease.
作者: P M Ridker.;M Cushman.;M J Stampfer.;R P Tracy.;C H Hennekens.
来源: Circulation. 1998年97卷5期425-8页
Among apparently healthy men, elevated levels of C-reactive protein (CRP), a marker for systemic inflammation, predict risk of myocardial infarction and thromboembolic stroke. Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown.
4405. Body surface mapping during pacing at multiple sites in the human atrium: P-wave morphology of ectopic right atrial activation.
作者: A SippensGroenewegen.;H A Peeters.;E R Jessurun.;A C Linnenbank.;E O Robles de Medina.;M D Lesh.;N M van Hemel.
来源: Circulation. 1998年97卷4期369-80页
The morphology and polarity of the P wave on 12-lead ECG are of limited clinical value in localizing ectopic atrial rhythms. It was the aim of this study to assess the spatial resolution of body surface P-wave integral mapping in identifying the site of origin of ectopic right atrial (RA) impulse formation in patients without structural atrial disease.
4406. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure.
Chronic heart failure (CHF) is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). There is evidence for increased radical formation in CHF, raising the possibility that nitric oxide is inactivated by radicals, thereby impairing endothelial function. To test this hypothesis, we determined the effect of the antioxidant vitamin C on FDD in patients with CHF.
4407. Randomized trial of an oral platelet glycoprotein IIb/IIIa antagonist, sibrafiban, in patients after an acute coronary syndrome: results of the TIMI 12 trial. Thrombolysis in Myocardial Infarction.
作者: C P Cannon.;C H McCabe.;S Borzak.;T D Henry.;M D Tischler.;H S Mueller.;R Feldman.;S T Palmeri.;K Ault.;S A Hamilton.;J M Rothman.;W F Novotny.;E Braunwald.
来源: Circulation. 1998年97卷4期340-9页
Inhibitors of the platelet glycoprotein IIb/IIIa receptor given intravenously have been shown to be effective in reducing ischemic complications after coronary angioplasty and in unstable angina, making this a promising new class of agents for the treatment and prevention of ischemic events in patients with acute coronary syndromes. Sibrafiban (Ro 48-3657) is an oral, peptidomimetic, selective antagonist of the glycoprotein IIb/IIIa receptor.
4408. 'Optimal' directional coronary atherectomy: final results of the Optimal Atherectomy Restenosis Study (OARS).
作者: C A Simonton.;M B Leon.;D S Baim.;T Hinohara.;K M Kent.;R M Bersin.;B H Wilson.;G S Mintz.;P J Fitzgerald.;P G Yock.;J J Popma.;K K Ho.;D E Cutlip.;C Senerchia.;R E Kuntz.
来源: Circulation. 1998年97卷4期332-9页
Previous clinical trials of directional coronary atherectomy (DCA) have failed to show significant improvement in early or late outcomes compared with balloon angioplasty (PTCA). The present study tested the hypothesis that more aggressive "optimal" atherectomy could be performed safely to produce larger initial lumen diameters and a lower late restenosis rate.
4409. Final results of the Balloon vs Optimal Atherectomy Trial (BOAT).
作者: D S Baim.;D E Cutlip.;S K Sharma.;K K Ho.;R Fortuna.;T L Schreiber.;R L Feldman.;J Shani.;C Senerchia.;Y Zhang.;A J Lansky.;J J Popma.;R E Kuntz.
来源: Circulation. 1998年97卷4期322-31页
Previous directional coronary atherectomy (DCA) trials have shown no significant reduction in angiographic restenosis, more in-hospital complications, and higher 1-year mortality than conventional balloon angioplasty (percutaneous transluminal coronary angioplasty [PTCA]). DCA, however, has subsequently evolved toward a more "optimal" technique (larger devices, more extensive tissue removal, and routine postdilation to obtain diameter stenosis <20%).
4410. Six-month angiographic outcome after successful repeat percutaneous intervention for in-stent restenosis.
作者: C Bauters.;J L Banos.;E Van Belle.;E P Mc Fadden.;J M Lablanche.;M E Bertrand.
来源: Circulation. 1998年97卷4期318-21页
In-stent restenosis is an increasing clinical problem. Discordant results have been published regarding the risk of recurrent restenosis after repeat angioplasty for the treatment of in-stent restenosis.
4411. Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study.
作者: J Rasanen.;D C Wood.;R H Debbs.;J Cohen.;S Weiner.;J C Huhta.
来源: Circulation. 1998年97卷3期257-62页
The aims of the present study were to determine whether maternal hyperoxygenation affects human fetal pulmonary circulation and whether there is a gestational age-related response in the fetal pulmonary circulation to maternal hyperoxygenation during the second half of gestation.
4412. Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor.
The growing use of heparin in acute thrombotic disorders, coupled with the availability of many new antithrombotic agents, emphasizes the need for adequate characterization of the platelet effects of the various anticoagulants. Controversial platelet effects have been reported with heparin (eg, enhanced platelet activation in vitro with high doses and no such effect in vivo at therapeutic doses). This study examined platelet receptor activation and platelet aggregation at therapeutic concentrations of unfractionated heparin (UFH), of enoxaparin, a low-molecular-weight heparin, and of argatroban, a direct thrombin inhibitor.
4413. Percutaneous balloon versus surgical closed and open mitral commissurotomy: seven-year follow-up results of a randomized trial.
作者: M Ben Farhat.;M Ayari.;F Maatouk.;F Betbout.;H Gamra.;M Jarra.;M Tiss.;S Hammami.;R Thaalbi.;F Addad.
来源: Circulation. 1998年97卷3期245-50页
Percutaneous balloon mitral commissurotomy (BMC) has been proposed as an alternative to surgical closed mitral commissurotomy (CMC) and open mitral commissurotomy (OMC) for the management of rheumatic mitral valve stenosis (MS).
4414. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
作者: M C Verhaar.;R M Wever.;J J Kastelein.;T van Dam.;H A Koomans.;T J Rabelink.
来源: Circulation. 1998年97卷3期237-41页
Impaired nitric oxide (NO) activity is an early event in the pathogenesis of cardiovascular disease, resulting from either reduced NO formation or increased NO degradation. Administration of tetrahydrobiopterin (BH4), an essential cofactor for NO production, could restore NO activity in familial hypercholesterolemia (FH). Because folates have been suggested to stimulate endogenous BH4 regeneration, we hypothesized that administration of 5-methyltetrahydrofolate (5-MTHF, the active circulating form of folate) might improve NO formation in FH.
4415. Conjugated estrogens acutely abolish abnormal cold-induced coronary vasoconstriction in male cardiac allografts.
作者: S E Reis.;V Bhoopalam.;K A Zell.;P J Counihan.;A J Smith.;S Pham.;S Murali.
来源: Circulation. 1998年97卷1期23-5页
Transplant-associated coronary arteriopathy is manifested in its early stages by paradoxical coronary artery constriction in response to endothelium-dependent vasodilator stimuli such as the cold pressor test (CPT) and is a major cause of death or retransplantation. Estrogen has vasoactive properties that abolish coronary artery endothelial dysfunction in native hearts. We hypothesized that estrogen attenuates inappropriate coronary artery constriction in cardiac allografts.
4416. Antiarrhythmic actions of intravenous ibutilide compared with procainamide during human atrial flutter and fibrillation: electrophysiological determinants of enhanced conversion efficacy.
The selective class III antiarrhythmic agent ibutilide prolongs action potential duration and terminates atrial flutter (AFL) and fibrillation (AF), but the mechanism of its antiarrhythmic efficacy in humans has not been fully characterized. This study compared the antiarrhythmic effects of ibutilide with the class IA agent procainamide in humans during AFL and AF. Antiarrhythmic drug actions and electrophysiological characteristics of AFL and AF that enhanced pharmacological termination were investigated.
4417. Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular Enlargement.
作者: G F Mitchell.;L A Moyé.;E Braunwald.;J L Rouleau.;V Bernstein.;E M Geltman.;G C Flaker.;M A Pfeffer.
来源: Circulation. 1997年96卷12期4254-60页
There is increasing evidence of a link between conduit vessel stiffness and cardiovascular events, although the association has never been tested in a large post-myocardial infarction patient population.
4418. Effect of the ACE inhibitor lisinopril on mortality in diabetic patients with acute myocardial infarction: data from the GISSI-3 study.
作者: G Zuanetti.;R Latini.;A P Maggioni.;M Franzosi.;L Santoro.;G Tognoni.
来源: Circulation. 1997年96卷12期4239-45页
Mortality of diabetic patients with acute myocardial infarction (MI) remains high despite recent improvement in their management. There is a need to evaluate efficacy and safety of novel treatments of MI in this high-risk population. We evaluated whether treatment with an ACE inhibitor begun within 24 hours from the onset of symptoms is able to decrease mortality and morbidity of diabetic patients with acute MI.
4419. Cyclosporin A inhibits monocyte tissue factor activation in cardiac transplant recipients.
作者: H Hölschermann.;O Kohl.;U Maus.;F Dürfeld.;A Bierhaus.;P P Nawroth.;J Lohmeyer.;H Tillmanns.;W Haberbosch.
来源: Circulation. 1997年96卷12期4232-8页
Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation. Because monocytes play a pivotal role in the pathophysiology of intravascular coagulation activation through their ability to synthesize tissue factor (TF), we asked (1) whether monocyte TF activation occurs in cardiac transplant recipients and (2) whether monocyte TF expression is affected by treatment with cyclosporin A (CsA).
4420. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol.
Reduction of serum cholesterol decreases mortality in primary and especially in secondary prevention. We investigated how effectively postmenopausal women with a previous myocardial infarction reduced their serum cholesterol with dietary means by using sitostanol ester rapeseed oil margarine, alone and in combination with statins, and to what extent cholesterol metabolism was affected.
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